SK281535B6 - Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy - Google Patents
Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy Download PDFInfo
- Publication number
- SK281535B6 SK281535B6 SK930-95A SK93095A SK281535B6 SK 281535 B6 SK281535 B6 SK 281535B6 SK 93095 A SK93095 A SK 93095A SK 281535 B6 SK281535 B6 SK 281535B6
- Authority
- SK
- Slovakia
- Prior art keywords
- liquid
- contrast medium
- ultrasonic imaging
- surfactant
- phase
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- 239000002872 contrast media Substances 0.000 title claims description 29
- 238000002604 ultrasonography Methods 0.000 title abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 84
- 238000009835 boiling Methods 0.000 claims abstract description 64
- 238000001246 colloidal dispersion Methods 0.000 claims abstract description 48
- 239000002245 particle Substances 0.000 claims abstract description 46
- 238000003384 imaging method Methods 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims description 77
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 54
- 239000004094 surface-active agent Substances 0.000 claims description 45
- 239000000463 material Substances 0.000 claims description 43
- 239000006185 dispersion Substances 0.000 claims description 22
- 229910052731 fluorine Inorganic materials 0.000 claims description 19
- -1 polyoxypropylene Polymers 0.000 claims description 19
- 239000011737 fluorine Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 18
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 11
- 150000002430 hydrocarbons Chemical class 0.000 claims description 11
- 229930195733 hydrocarbon Natural products 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 125000001153 fluoro group Chemical group F* 0.000 claims description 8
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- 229920001400 block copolymer Polymers 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 239000003945 anionic surfactant Substances 0.000 claims description 3
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 3
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- 229950006451 sorbitan laurate Drugs 0.000 claims 2
- 235000011067 sorbitan monolaureate Nutrition 0.000 claims 2
- 238000000527 sonication Methods 0.000 claims 1
- 239000000839 emulsion Substances 0.000 abstract description 131
- 239000012071 phase Substances 0.000 abstract description 109
- 239000003795 chemical substances by application Substances 0.000 abstract description 17
- 239000002961 echo contrast media Substances 0.000 abstract description 17
- 230000036760 body temperature Effects 0.000 abstract description 12
- 230000008859 change Effects 0.000 abstract description 11
- 239000004530 micro-emulsion Substances 0.000 abstract description 10
- 238000001990 intravenous administration Methods 0.000 abstract description 8
- 230000002708 enhancing effect Effects 0.000 abstract description 5
- 239000006260 foam Substances 0.000 abstract description 5
- 241001465754 Metazoa Species 0.000 abstract description 3
- 238000007912 intraperitoneal administration Methods 0.000 abstract description 3
- 239000007791 liquid phase Substances 0.000 abstract description 3
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000001361 intraarterial administration Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 69
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 description 66
- 229950010592 dodecafluoropentane Drugs 0.000 description 65
- 239000000126 substance Substances 0.000 description 50
- 238000009472 formulation Methods 0.000 description 46
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 35
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 31
- 239000007789 gas Substances 0.000 description 28
- 210000004072 lung Anatomy 0.000 description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 20
- 238000003756 stirring Methods 0.000 description 19
- 238000007792 addition Methods 0.000 description 18
- 238000002347 injection Methods 0.000 description 18
- 239000007924 injection Substances 0.000 description 18
- 229920001993 poloxamer 188 Polymers 0.000 description 18
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 17
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 16
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 16
- 108090000623 proteins and genes Proteins 0.000 description 16
- 229960002920 sorbitol Drugs 0.000 description 16
- 239000011780 sodium chloride Substances 0.000 description 15
- 239000000725 suspension Substances 0.000 description 15
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 14
- 239000000600 sorbitol Substances 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 13
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 12
- 229920002415 Pluronic P-123 Polymers 0.000 description 11
- 239000011521 glass Substances 0.000 description 11
- 230000003993 interaction Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 239000011550 stock solution Substances 0.000 description 11
- XNMQEEKYCVKGBD-UHFFFAOYSA-N dimethylacetylene Natural products CC#CC XNMQEEKYCVKGBD-UHFFFAOYSA-N 0.000 description 10
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 10
- 150000004820 halides Chemical class 0.000 description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 10
- 102000009123 Fibrin Human genes 0.000 description 9
- 108010073385 Fibrin Proteins 0.000 description 9
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 9
- 239000012736 aqueous medium Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 229950003499 fibrin Drugs 0.000 description 9
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 8
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 8
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 8
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 8
- IAQRGUVFOMOMEM-UHFFFAOYSA-N but-2-ene Chemical compound CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 8
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 8
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 8
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 description 8
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 8
- QMMOXUPEWRXHJS-UHFFFAOYSA-N pentene-2 Natural products CCC=CC QMMOXUPEWRXHJS-UHFFFAOYSA-N 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 241000282472 Canis lupus familiaris Species 0.000 description 7
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 7
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 7
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 7
- 238000001816 cooling Methods 0.000 description 7
- 150000002170 ethers Chemical class 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 230000001965 increasing effect Effects 0.000 description 7
- 229960001025 iohexol Drugs 0.000 description 7
- 235000013336 milk Nutrition 0.000 description 7
- 239000008267 milk Substances 0.000 description 7
- 210000004080 milk Anatomy 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- BYKNGMLDSIEFFG-UHFFFAOYSA-N 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptan-1-ol Chemical compound OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)F BYKNGMLDSIEFFG-UHFFFAOYSA-N 0.000 description 6
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- KDKYADYSIPSCCQ-UHFFFAOYSA-N but-1-yne Chemical compound CCC#C KDKYADYSIPSCCQ-UHFFFAOYSA-N 0.000 description 6
- 239000001273 butane Substances 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
- 239000004005 microsphere Substances 0.000 description 6
- CRSOQBOWXPBRES-UHFFFAOYSA-N neopentane Chemical compound CC(C)(C)C CRSOQBOWXPBRES-UHFFFAOYSA-N 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 229950011087 perflunafene Drugs 0.000 description 6
- UWEYRJFJVCLAGH-IJWZVTFUSA-N perfluorodecalin Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)[C@@]2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[C@@]21F UWEYRJFJVCLAGH-IJWZVTFUSA-N 0.000 description 6
- 229920001983 poloxamer Polymers 0.000 description 6
- 239000001294 propane Substances 0.000 description 6
- LWHQXUODFPPQTL-UHFFFAOYSA-M sodium;2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoate Chemical compound [Na+].[O-]C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F LWHQXUODFPPQTL-UHFFFAOYSA-M 0.000 description 6
- 108010088751 Albumins Proteins 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 5
- PMPVIKIVABFJJI-UHFFFAOYSA-N Cyclobutane Chemical compound C1CCC1 PMPVIKIVABFJJI-UHFFFAOYSA-N 0.000 description 5
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 5
- 229910000831 Steel Inorganic materials 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 229920002301 cellulose acetate Polymers 0.000 description 5
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 5
- 230000035800 maturation Effects 0.000 description 5
- 229960004624 perflexane Drugs 0.000 description 5
- ZJIJAJXFLBMLCK-UHFFFAOYSA-N perfluorohexane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F ZJIJAJXFLBMLCK-UHFFFAOYSA-N 0.000 description 5
- 239000010959 steel Substances 0.000 description 5
- 208000011580 syndromic disease Diseases 0.000 description 5
- BKOOMYPCSUNDGP-UHFFFAOYSA-N 2-methylbut-2-ene Chemical compound CC=C(C)C BKOOMYPCSUNDGP-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 4
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000004341 Octafluorocyclobutane Substances 0.000 description 4
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- LLCSWKVOHICRDD-UHFFFAOYSA-N buta-1,3-diyne Chemical compound C#CC#C LLCSWKVOHICRDD-UHFFFAOYSA-N 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- RWRIWBAIICGTTQ-UHFFFAOYSA-N difluoromethane Chemical compound FCF RWRIWBAIICGTTQ-UHFFFAOYSA-N 0.000 description 4
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 4
- 238000007710 freezing Methods 0.000 description 4
- 230000008014 freezing Effects 0.000 description 4
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 description 4
- 229960003132 halothane Drugs 0.000 description 4
- 230000000004 hemodynamic effect Effects 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 4
- 235000019407 octafluorocyclobutane Nutrition 0.000 description 4
- BCCOBQSFUDVTJQ-UHFFFAOYSA-N octafluorocyclobutane Chemical compound FC1(F)C(F)(F)C(F)(F)C1(F)F BCCOBQSFUDVTJQ-UHFFFAOYSA-N 0.000 description 4
- KAVGMUDTWQVPDF-UHFFFAOYSA-N perflubutane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F KAVGMUDTWQVPDF-UHFFFAOYSA-N 0.000 description 4
- 229950003332 perflubutane Drugs 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 230000000087 stabilizing effect Effects 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 4
- WSJULBMCKQTTIG-OWOJBTEDSA-N (e)-1,1,1,2,3,4,4,4-octafluorobut-2-ene Chemical compound FC(F)(F)C(/F)=C(\F)C(F)(F)F WSJULBMCKQTTIG-OWOJBTEDSA-N 0.000 description 3
- PWMJXZJISGDARB-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5-decafluorocyclopentane Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F PWMJXZJISGDARB-UHFFFAOYSA-N 0.000 description 3
- PBIJFSCPEFQXBB-UHFFFAOYSA-N 1,1-dimethylcyclopropane Chemical compound CC1(C)CC1 PBIJFSCPEFQXBB-UHFFFAOYSA-N 0.000 description 3
- SNGREZUHAYWORS-UHFFFAOYSA-M 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoate Chemical compound [O-]C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F SNGREZUHAYWORS-UHFFFAOYSA-M 0.000 description 3
- 229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 description 3
- YHQXBTXEYZIYOV-UHFFFAOYSA-N 3-methylbut-1-ene Chemical compound CC(C)C=C YHQXBTXEYZIYOV-UHFFFAOYSA-N 0.000 description 3
- 108010056388 Albunex Proteins 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 3
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- XOBKSJJDNFUZPF-UHFFFAOYSA-N Methoxyethane Chemical compound CCOC XOBKSJJDNFUZPF-UHFFFAOYSA-N 0.000 description 3
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical compound CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 241000282898 Sus scrofa Species 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- QNRMTGGDHLBXQZ-UHFFFAOYSA-N buta-1,2-diene Chemical compound CC=C=C QNRMTGGDHLBXQZ-UHFFFAOYSA-N 0.000 description 3
- WFYPICNXBKQZGB-UHFFFAOYSA-N butenyne Chemical group C=CC#C WFYPICNXBKQZGB-UHFFFAOYSA-N 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- 210000000038 chest Anatomy 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- HGFAGBHAGYXJKZ-UHFFFAOYSA-N fluoromethanesulfonamide Chemical compound NS(=O)(=O)CF HGFAGBHAGYXJKZ-UHFFFAOYSA-N 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 3
- WMIYKQLTONQJES-UHFFFAOYSA-N hexafluoroethane Chemical compound FC(F)(F)C(F)(F)F WMIYKQLTONQJES-UHFFFAOYSA-N 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- 235000013847 iso-butane Nutrition 0.000 description 3
- ULYZAYCEDJDHCC-UHFFFAOYSA-N isopropyl chloride Chemical compound CC(C)Cl ULYZAYCEDJDHCC-UHFFFAOYSA-N 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 description 3
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 3
- 244000309715 mini pig Species 0.000 description 3
- QYZLKGVUSQXAMU-UHFFFAOYSA-N penta-1,4-diene Chemical compound C=CCC=C QYZLKGVUSQXAMU-UHFFFAOYSA-N 0.000 description 3
- 229920001992 poloxamer 407 Polymers 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 3
- JFHAGWAOOHJDEP-UHFFFAOYSA-N trifluoromethylcyclopropane Chemical compound FC(F)(F)C1CC1 JFHAGWAOOHJDEP-UHFFFAOYSA-N 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 239000002888 zwitterionic surfactant Substances 0.000 description 3
- 230000006269 (delayed) early viral mRNA transcription Effects 0.000 description 2
- GZFDAWWYGPIJCP-UHFFFAOYSA-N 1,1,1,2,2,3,3-heptafluoro-3-nitrosopropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)N=O GZFDAWWYGPIJCP-UHFFFAOYSA-N 0.000 description 2
- SUAMPXQALWYDBK-UHFFFAOYSA-N 1,1,1,2,2,3-hexafluoropropane Chemical compound FCC(F)(F)C(F)(F)F SUAMPXQALWYDBK-UHFFFAOYSA-N 0.000 description 2
- ONNGDXIHDFMCJB-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoro-2,2-dimethylpropane Chemical compound FC(F)(F)C(C)(C)C(F)(F)F ONNGDXIHDFMCJB-UHFFFAOYSA-N 0.000 description 2
- NZEXBCLLEJJKOM-UHFFFAOYSA-N 1,1,1,5,5,5-hexafluoropentane Chemical compound FC(F)(F)CCCC(F)(F)F NZEXBCLLEJJKOM-UHFFFAOYSA-N 0.000 description 2
- KUGBQWBWWNPMIT-UHFFFAOYSA-N 1,1,2,2,3,3,4,4-octafluoropentan-1-ol Chemical compound CC(F)(F)C(F)(F)C(F)(F)C(O)(F)F KUGBQWBWWNPMIT-UHFFFAOYSA-N 0.000 description 2
- WXGNWUVNYMJENI-UHFFFAOYSA-N 1,1,2,2-tetrafluoroethane Chemical compound FC(F)C(F)F WXGNWUVNYMJENI-UHFFFAOYSA-N 0.000 description 2
- KTQWCMCCOUNOOV-UHFFFAOYSA-N 1,1,2,2-tetrafluorospiro[2.2]pentane Chemical compound FC1(F)C(F)(F)C11CC1 KTQWCMCCOUNOOV-UHFFFAOYSA-N 0.000 description 2
- ZVJOQYFQSQJDDX-UHFFFAOYSA-N 1,1,2,3,3,4,4,4-octafluorobut-1-ene Chemical compound FC(F)=C(F)C(F)(F)C(F)(F)F ZVJOQYFQSQJDDX-UHFFFAOYSA-N 0.000 description 2
- LGPPATCNSOSOQH-UHFFFAOYSA-N 1,1,2,3,4,4-hexafluorobuta-1,3-diene Chemical compound FC(F)=C(F)C(F)=C(F)F LGPPATCNSOSOQH-UHFFFAOYSA-N 0.000 description 2
- UBOXGVDOUJQMTN-UHFFFAOYSA-N 1,1,2-trichloroethane Chemical compound ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 2
- WGZYQOSEVSXDNI-UHFFFAOYSA-N 1,1,2-trifluoroethane Chemical compound FCC(F)F WGZYQOSEVSXDNI-UHFFFAOYSA-N 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 2
- LGXVIGDEPROXKC-UHFFFAOYSA-N 1,1-dichloroethene Chemical group ClC(Cl)=C LGXVIGDEPROXKC-UHFFFAOYSA-N 0.000 description 2
- FPINXLNVVRLATN-UHFFFAOYSA-N 1,1-difluoro-2-methyl-2-(trifluoromethyl)cyclopropane Chemical compound FC(F)(F)C1(C)CC1(F)F FPINXLNVVRLATN-UHFFFAOYSA-N 0.000 description 2
- DXBHBZVCASKNBY-UHFFFAOYSA-N 1,2-Benz(a)anthracene Chemical compound C1=CC=C2C3=CC4=CC=CC=C4C=C3C=CC2=C1 DXBHBZVCASKNBY-UHFFFAOYSA-N 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 2
- JEBATGWBOZORSI-UHFFFAOYSA-N 1,2-bis(trifluoromethyl)cyclopropane Chemical compound FC(F)(F)C1CC1C(F)(F)F JEBATGWBOZORSI-UHFFFAOYSA-N 0.000 description 2
- VKJLDXGFBJBTRQ-UHFFFAOYSA-N 1,2-dimethylcyclopropane Chemical compound CC1CC1C VKJLDXGFBJBTRQ-UHFFFAOYSA-N 0.000 description 2
- OWXJKYNZGFSVRC-UHFFFAOYSA-N 1-chloroprop-1-ene Chemical compound CC=CCl OWXJKYNZGFSVRC-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 2
- OHMHBGPWCHTMQE-UHFFFAOYSA-N 2,2-dichloro-1,1,1-trifluoroethane Chemical compound FC(F)(F)C(Cl)Cl OHMHBGPWCHTMQE-UHFFFAOYSA-N 0.000 description 2
- KJGXPVLCSICDQG-UHFFFAOYSA-N 2-chloro-1,1,1,2,3,3,3-heptafluoropropane Chemical class FC(F)(F)C(F)(Cl)C(F)(F)F KJGXPVLCSICDQG-UHFFFAOYSA-N 0.000 description 2
- PNLQPWWBHXMFCA-UHFFFAOYSA-N 2-chloroprop-1-ene Chemical group CC(Cl)=C PNLQPWWBHXMFCA-UHFFFAOYSA-N 0.000 description 2
- PRNZBCYBKGCOFI-UHFFFAOYSA-N 2-fluoropropane Chemical compound CC(C)F PRNZBCYBKGCOFI-UHFFFAOYSA-N 0.000 description 2
- BOFLDKIFLIFLJA-UHFFFAOYSA-N 2-methylbut-1-en-3-yne Chemical compound CC(=C)C#C BOFLDKIFLIFLJA-UHFFFAOYSA-N 0.000 description 2
- MHNNAWXXUZQSNM-UHFFFAOYSA-N 2-methylbut-1-ene Chemical compound CCC(C)=C MHNNAWXXUZQSNM-UHFFFAOYSA-N 0.000 description 2
- USCSRAJGJYMJFZ-UHFFFAOYSA-N 3-methyl-1-butyne Chemical compound CC(C)C#C USCSRAJGJYMJFZ-UHFFFAOYSA-N 0.000 description 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- 102000013563 Acid Phosphatase Human genes 0.000 description 2
- 108010051457 Acid Phosphatase Proteins 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 108010074051 C-Reactive Protein Proteins 0.000 description 2
- 102100032752 C-reactive protein Human genes 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 108010075016 Ceruloplasmin Proteins 0.000 description 2
- 102100023321 Ceruloplasmin Human genes 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 102000004420 Creatine Kinase Human genes 0.000 description 2
- 108010042126 Creatine kinase Proteins 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- AWFLCBLWDVCXSQ-UHFFFAOYSA-N FC1CC11CC1 Chemical compound FC1CC11CC1 AWFLCBLWDVCXSQ-UHFFFAOYSA-N 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 102000008857 Ferritin Human genes 0.000 description 2
- 108050000784 Ferritin Proteins 0.000 description 2
- 238000008416 Ferritin Methods 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 102100021022 Gastrin Human genes 0.000 description 2
- 108010052343 Gastrins Proteins 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
- 102000017055 Lipoprotein Lipase Human genes 0.000 description 2
- 108010013563 Lipoprotein Lipase Proteins 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 108010062374 Myoglobin Proteins 0.000 description 2
- 102000036675 Myoglobin Human genes 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- 238000001016 Ostwald ripening Methods 0.000 description 2
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 2
- 229910018503 SF6 Inorganic materials 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000002535 acidifier Substances 0.000 description 2
- 230000003113 alkalizing effect Effects 0.000 description 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 2
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 description 2
- 229940024142 alpha 1-antitrypsin Drugs 0.000 description 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 description 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000011888 autopsy Methods 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- RJCQBQGAPKAMLL-UHFFFAOYSA-N bromotrifluoromethane Chemical compound FC(F)(F)Br RJCQBQGAPKAMLL-UHFFFAOYSA-N 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 2
- UUAGAQFQZIEFAH-UHFFFAOYSA-N chlorotrifluoroethylene Chemical group FC(F)=C(F)Cl UUAGAQFQZIEFAH-UHFFFAOYSA-N 0.000 description 2
- AFYPFACVUDMOHA-UHFFFAOYSA-N chlorotrifluoromethane Chemical compound FC(F)(F)Cl AFYPFACVUDMOHA-UHFFFAOYSA-N 0.000 description 2
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- LTVOKYUPTHZZQH-UHFFFAOYSA-N difluoromethane Chemical group F[C]F LTVOKYUPTHZZQH-UHFFFAOYSA-N 0.000 description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
- LQBJSCLVMKFNIZ-UHFFFAOYSA-N dimethyl-bis(trifluoromethyl)silane Chemical compound FC(F)(F)[Si](C)(C)C(F)(F)F LQBJSCLVMKFNIZ-UHFFFAOYSA-N 0.000 description 2
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 2
- 229960003750 ethyl chloride Drugs 0.000 description 2
- FOTXAJDDGPYIFU-UHFFFAOYSA-N ethylcyclopropane Chemical compound CCC1CC1 FOTXAJDDGPYIFU-UHFFFAOYSA-N 0.000 description 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- FVXDNACXXMHWSB-UHFFFAOYSA-N hepta-1,5-diyne Chemical compound CC#CCCC#C FVXDNACXXMHWSB-UHFFFAOYSA-N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229960004647 iopamidol Drugs 0.000 description 2
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 description 2
- 239000001282 iso-butane Substances 0.000 description 2
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- BDJAEZRIGNCQBZ-UHFFFAOYSA-N methylcyclobutane Chemical compound CC1CCC1 BDJAEZRIGNCQBZ-UHFFFAOYSA-N 0.000 description 2
- VNXBKJFUJUWOCW-UHFFFAOYSA-N methylcyclopropane Chemical compound CC1CC1 VNXBKJFUJUWOCW-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- DAZXVJBJRMWXJP-UHFFFAOYSA-N n,n-dimethylethylamine Chemical compound CCN(C)C DAZXVJBJRMWXJP-UHFFFAOYSA-N 0.000 description 2
- 238000011587 new zealand white rabbit Methods 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000004789 organ system Anatomy 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 125000006353 oxyethylene group Chemical group 0.000 description 2
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- WTWWXOGTJWMJHI-UHFFFAOYSA-N perflubron Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)Br WTWWXOGTJWMJHI-UHFFFAOYSA-N 0.000 description 2
- 229960001217 perflubron Drugs 0.000 description 2
- YVBBRRALBYAZBM-UHFFFAOYSA-N perfluorooctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F YVBBRRALBYAZBM-UHFFFAOYSA-N 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 2
- 229960000909 sulfur hexafluoride Drugs 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- AQRLNPVMDITEJU-UHFFFAOYSA-N triethylsilane Chemical compound CC[SiH](CC)CC AQRLNPVMDITEJU-UHFFFAOYSA-N 0.000 description 2
- GHVOECJFQKLZHU-UHFFFAOYSA-N trifluoromethylcyclobutane Chemical compound FC(F)(F)C1CCC1 GHVOECJFQKLZHU-UHFFFAOYSA-N 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- TUGYBZUOSTTYMP-RFZPGFLSSA-N (1R,2R)-1,2-difluorocyclopentane Chemical compound F[C@H]1[C@@H](CCC1)F TUGYBZUOSTTYMP-RFZPGFLSSA-N 0.000 description 1
- VWLXFCDOMNKRTN-QWWZWVQMSA-N (1r,2r)-1-methyl-2-(trifluoromethyl)cyclopropane Chemical compound C[C@@H]1C[C@H]1C(F)(F)F VWLXFCDOMNKRTN-QWWZWVQMSA-N 0.000 description 1
- MESXUXRSZSSKIO-RQOWECAXSA-N (1z)-1,2,3-trichlorobuta-1,3-diene Chemical compound Cl\C=C(/Cl)C(Cl)=C MESXUXRSZSSKIO-RQOWECAXSA-N 0.000 description 1
- QACKABMXGDZLJE-IMJSIDKUSA-N (2s,3s)-1,1-difluoro-2,3-dimethylcyclopropane Chemical compound C[C@H]1[C@H](C)C1(F)F QACKABMXGDZLJE-IMJSIDKUSA-N 0.000 description 1
- WWCNSXIDMFOOGT-VRKGVYIXSA-N (4S,5R)-1,2,3,3,4,5-hexafluorocyclopentene Chemical compound F[C@@H]1[C@H](F)C(F)(F)C(F)=C1F WWCNSXIDMFOOGT-VRKGVYIXSA-N 0.000 description 1
- PMJHHCWVYXUKFD-SNAWJCMRSA-N (E)-1,3-pentadiene Chemical compound C\C=C\C=C PMJHHCWVYXUKFD-SNAWJCMRSA-N 0.000 description 1
- NLOLSXYRJFEOTA-OWOJBTEDSA-N (e)-1,1,1,4,4,4-hexafluorobut-2-ene Chemical compound FC(F)(F)\C=C\C(F)(F)F NLOLSXYRJFEOTA-OWOJBTEDSA-N 0.000 description 1
- UPVJEODAZWTJKZ-OWOJBTEDSA-N (e)-1,2-dichloro-1,2-difluoroethene Chemical group F\C(Cl)=C(\F)Cl UPVJEODAZWTJKZ-OWOJBTEDSA-N 0.000 description 1
- LWDGFGTYBDRKHU-UPHRSURJSA-N (e)-1,2-dichloro-1-fluoroethene Chemical group F\C(Cl)=C/Cl LWDGFGTYBDRKHU-UPHRSURJSA-N 0.000 description 1
- WFLOTYSKFUPZQB-OWOJBTEDSA-N (e)-1,2-difluoroethene Chemical group F\C=C\F WFLOTYSKFUPZQB-OWOJBTEDSA-N 0.000 description 1
- JNODEIRSLUOUMY-OWOJBTEDSA-N (e)-1-bromo-2-fluoroethene Chemical group F\C=C\Br JNODEIRSLUOUMY-OWOJBTEDSA-N 0.000 description 1
- MTKHTBWXSHYCGS-OWOJBTEDSA-N (e)-1-chloro-2-fluoroethene Chemical group F\C=C\Cl MTKHTBWXSHYCGS-OWOJBTEDSA-N 0.000 description 1
- OWXJKYNZGFSVRC-NSCUHMNNSA-N (e)-1-chloroprop-1-ene Chemical compound C\C=C\Cl OWXJKYNZGFSVRC-NSCUHMNNSA-N 0.000 description 1
- WSJULBMCKQTTIG-UPHRSURJSA-N (z)-1,1,1,2,3,4,4,4-octafluorobut-2-ene Chemical compound FC(F)(F)C(/F)=C(/F)C(F)(F)F WSJULBMCKQTTIG-UPHRSURJSA-N 0.000 description 1
- JRENXZBKMHPULY-UPHRSURJSA-N (z)-2-chloro-1,1,1,4,4,4-hexafluorobut-2-ene Chemical compound FC(F)(F)\C=C(/Cl)C(F)(F)F JRENXZBKMHPULY-UPHRSURJSA-N 0.000 description 1
- PRNGGQSBEXAZJP-UHFFFAOYSA-N 1,1,1,2,2,3,3,4,4,5,5,5-dodecafluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F PRNGGQSBEXAZJP-UHFFFAOYSA-N 0.000 description 1
- KWXGJTSJUKTDQU-UHFFFAOYSA-N 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-8-iodooctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)I KWXGJTSJUKTDQU-UHFFFAOYSA-N 0.000 description 1
- WDICBCKFIPDPKG-UHFFFAOYSA-N 1,1,1,2,2,3,3,4,5-nonafluoropentane Chemical compound FCC(F)C(F)(F)C(F)(F)C(F)(F)F WDICBCKFIPDPKG-UHFFFAOYSA-N 0.000 description 1
- AFTRQVQLPMYCGG-UHFFFAOYSA-N 1,1,1,2,2,3,3-heptafluoro-3-nitropropane Chemical compound [O-][N+](=O)C(F)(F)C(F)(F)C(F)(F)F AFTRQVQLPMYCGG-UHFFFAOYSA-N 0.000 description 1
- OGZDKMQVKSJUHM-UHFFFAOYSA-N 1,1,1,2,2,4,5,5,5-nonafluoropentane Chemical compound FC(F)(F)C(F)CC(F)(F)C(F)(F)F OGZDKMQVKSJUHM-UHFFFAOYSA-N 0.000 description 1
- NYAZEAIBIYGMKL-UHFFFAOYSA-N 1,1,1,2,2-pentafluoro-2-nitroethane Chemical compound [O-][N+](=O)C(F)(F)C(F)(F)F NYAZEAIBIYGMKL-UHFFFAOYSA-N 0.000 description 1
- FGUGXWGCSKSQFY-UHFFFAOYSA-N 1,1,1,2,2-pentafluoro-2-nitrosoethane Chemical compound FC(F)(F)C(F)(F)N=O FGUGXWGCSKSQFY-UHFFFAOYSA-N 0.000 description 1
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
- WPWUVNDGTPDXSN-UHFFFAOYSA-N 1,1,1,2,3,3,5,5,5-nonafluoropentane Chemical compound FC(F)(F)C(F)C(F)(F)CC(F)(F)F WPWUVNDGTPDXSN-UHFFFAOYSA-N 0.000 description 1
- GWIFSTLOZXPPSU-UHFFFAOYSA-N 1,1,1,2,3,3-hexafluoro-2-methylbutane Chemical compound CC(F)(F)C(C)(F)C(F)(F)F GWIFSTLOZXPPSU-UHFFFAOYSA-N 0.000 description 1
- ZFLGZRKZAAHFBI-UHFFFAOYSA-N 1,1,1,2,3,3-hexafluoropentane Chemical compound CCC(F)(F)C(F)C(F)(F)F ZFLGZRKZAAHFBI-UHFFFAOYSA-N 0.000 description 1
- FYIRUPZTYPILDH-UHFFFAOYSA-N 1,1,1,2,3,3-hexafluoropropane Chemical compound FC(F)C(F)C(F)(F)F FYIRUPZTYPILDH-UHFFFAOYSA-N 0.000 description 1
- VVMQLAKDFBLCHB-UHFFFAOYSA-N 1,1,1,2,3,4,4,5,5,5-decafluoropent-2-ene Chemical compound FC(F)(F)C(F)=C(F)C(F)(F)C(F)(F)F VVMQLAKDFBLCHB-UHFFFAOYSA-N 0.000 description 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
- IMRLDNHHTCXOOR-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propane Chemical compound FC(F)(F)C(C(F)(F)F)C(F)(F)F IMRLDNHHTCXOOR-UHFFFAOYSA-N 0.000 description 1
- NSGXIBWMJZWTPY-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropane Chemical compound FC(F)(F)CC(F)(F)F NSGXIBWMJZWTPY-UHFFFAOYSA-N 0.000 description 1
- WQAWXRFLNDAOON-UHFFFAOYSA-N 1,1,1,3,3-pentafluoropropan-2-one Chemical compound FC(F)C(=O)C(F)(F)F WQAWXRFLNDAOON-UHFFFAOYSA-N 0.000 description 1
- ZLLFAXODNBYNCI-UHFFFAOYSA-N 1,1,1,4,4,4-hexafluoro-2-(trifluoromethyl)butane Chemical compound FC(F)(F)CC(C(F)(F)F)C(F)(F)F ZLLFAXODNBYNCI-UHFFFAOYSA-N 0.000 description 1
- ROGZZXCEOGSLFC-UHFFFAOYSA-N 1,1,1,4,4,4-hexafluoro-2-methyl-2-(trifluoromethyl)butane Chemical compound FC(F)(F)C(C(F)(F)F)(C)CC(F)(F)F ROGZZXCEOGSLFC-UHFFFAOYSA-N 0.000 description 1
- CXIGIYYQHHRBJC-UHFFFAOYSA-N 1,1,1,4,4,4-hexafluorobutane Chemical compound FC(F)(F)CCC(F)(F)F CXIGIYYQHHRBJC-UHFFFAOYSA-N 0.000 description 1
- WDTCMFNXBZHCPK-UHFFFAOYSA-N 1,1,1,4,4,5,5,5-octafluoropent-2-yne Chemical compound FC(F)(F)C#CC(F)(F)C(F)(F)F WDTCMFNXBZHCPK-UHFFFAOYSA-N 0.000 description 1
- WQNXYRAMEVXDPW-UHFFFAOYSA-N 1,1,1-trifluoro-2,2-dimethylpropane Chemical compound CC(C)(C)C(F)(F)F WQNXYRAMEVXDPW-UHFFFAOYSA-N 0.000 description 1
- MIMLLEXTFXWJLP-UHFFFAOYSA-N 1,1,1-trifluoro-2-(trifluoromethyl)butane Chemical compound CCC(C(F)(F)F)C(F)(F)F MIMLLEXTFXWJLP-UHFFFAOYSA-N 0.000 description 1
- QXALUNHYJJONQH-UHFFFAOYSA-N 1,1,1-trifluoro-2-methylpropane Chemical compound CC(C)C(F)(F)F QXALUNHYJJONQH-UHFFFAOYSA-N 0.000 description 1
- LDRPULCXZDDSGE-UHFFFAOYSA-N 1,1,1-trifluorobutane Chemical compound CCCC(F)(F)F LDRPULCXZDDSGE-UHFFFAOYSA-N 0.000 description 1
- UJPMYEOUBPIPHQ-UHFFFAOYSA-N 1,1,1-trifluoroethane Chemical compound CC(F)(F)F UJPMYEOUBPIPHQ-UHFFFAOYSA-N 0.000 description 1
- GENRYAJRHIWOJI-UHFFFAOYSA-N 1,1,1-trifluoropentane Chemical compound CCCCC(F)(F)F GENRYAJRHIWOJI-UHFFFAOYSA-N 0.000 description 1
- KDWQLICBSFIDRM-UHFFFAOYSA-N 1,1,1-trifluoropropane Chemical compound CCC(F)(F)F KDWQLICBSFIDRM-UHFFFAOYSA-N 0.000 description 1
- OIKXQLOBQOWHOA-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,4-nonafluorobutylsilane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)[SiH3] OIKXQLOBQOWHOA-UHFFFAOYSA-N 0.000 description 1
- SOJZMJXWEOBDIC-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5-nonafluorocyclopentane Chemical compound FC1C(F)(F)C(F)(F)C(F)(F)C1(F)F SOJZMJXWEOBDIC-UHFFFAOYSA-N 0.000 description 1
- QVEJLBREDQLBKB-UHFFFAOYSA-N 1,1,2,2,3,3,4,5-octafluorocyclopentane Chemical compound FC1C(F)C(F)(F)C(F)(F)C1(F)F QVEJLBREDQLBKB-UHFFFAOYSA-N 0.000 description 1
- IDBYQQQHBYGLEQ-UHFFFAOYSA-N 1,1,2,2,3,3,4-heptafluorocyclopentane Chemical compound FC1CC(F)(F)C(F)(F)C1(F)F IDBYQQQHBYGLEQ-UHFFFAOYSA-N 0.000 description 1
- WAECBMNQMWVHQC-UHFFFAOYSA-N 1,1,2,2,3,4,4,5-octafluorocyclopentane Chemical compound FC1C(F)(F)C(F)C(F)(F)C1(F)F WAECBMNQMWVHQC-UHFFFAOYSA-N 0.000 description 1
- PZNPGRDEAHUVLN-UHFFFAOYSA-N 1,1,2,2,3-pentafluoro-3-(1,2,2-trifluoroethenyl)cyclopropane Chemical compound FC(F)=C(F)C1(F)C(F)(F)C1(F)F PZNPGRDEAHUVLN-UHFFFAOYSA-N 0.000 description 1
- LJXLCTDIORMIEA-UHFFFAOYSA-N 1,1,2,2,5,5-hexafluorospiro[2.2]pentane Chemical compound FC1(C(C12C(C2)(F)F)(F)F)F LJXLCTDIORMIEA-UHFFFAOYSA-N 0.000 description 1
- NVPQSHJCSFSTAU-UHFFFAOYSA-N 1,1,2,2-tetrafluoro-3-(trifluoromethyl)cyclobutane Chemical compound FC(F)(F)C1CC(F)(F)C1(F)F NVPQSHJCSFSTAU-UHFFFAOYSA-N 0.000 description 1
- UERAGWQPCSLYTB-UHFFFAOYSA-N 1,1,2,2-tetrafluoro-3-methylcyclobutane Chemical compound CC1CC(F)(F)C1(F)F UERAGWQPCSLYTB-UHFFFAOYSA-N 0.000 description 1
- PBWHQPOHADDEFU-UHFFFAOYSA-N 1,1,2,3,3,4,4,5,5,5-decafluoropent-1-ene Chemical compound FC(F)=C(F)C(F)(F)C(F)(F)C(F)(F)F PBWHQPOHADDEFU-UHFFFAOYSA-N 0.000 description 1
- CPAQQPJFMVGXBQ-UHFFFAOYSA-N 1,1,2,3,4,4,4-heptafluoro-3-(trifluoromethyl)but-1-ene Chemical compound FC(F)=C(F)C(F)(C(F)(F)F)C(F)(F)F CPAQQPJFMVGXBQ-UHFFFAOYSA-N 0.000 description 1
- JPMVRUQJBIVGTQ-UHFFFAOYSA-N 1,1,2,3,4,5,5,5-octafluoropenta-1,3-diene Chemical compound FC(F)=C(F)C(F)=C(F)C(F)(F)F JPMVRUQJBIVGTQ-UHFFFAOYSA-N 0.000 description 1
- ZWNVWKJQDMKWPJ-UHFFFAOYSA-N 1,1,2,3-tetrafluoro-2,3-bis(trifluoromethyl)cyclopropane Chemical compound FC(F)(F)C1(F)C(F)(F)C1(F)C(F)(F)F ZWNVWKJQDMKWPJ-UHFFFAOYSA-N 0.000 description 1
- ORUDPULBDFPCBC-UHFFFAOYSA-N 1,1,2-trifluoro-2-(1,2,2-trifluoroethenyl)cyclopropane Chemical compound FC1(C(C1)(C(=C(F)F)F)F)F ORUDPULBDFPCBC-UHFFFAOYSA-N 0.000 description 1
- MIZLGWKEZAPEFJ-UHFFFAOYSA-N 1,1,2-trifluoroethene Chemical group FC=C(F)F MIZLGWKEZAPEFJ-UHFFFAOYSA-N 0.000 description 1
- OUXFUVVGTNLSGQ-UHFFFAOYSA-N 1,1,2-trifluoroethylcyclopropane Chemical compound FCC(F)(F)C1CC1 OUXFUVVGTNLSGQ-UHFFFAOYSA-N 0.000 description 1
- GVCRTNZXOSPJOQ-UHFFFAOYSA-N 1,1,2-trifluoropentane Chemical compound CCCC(F)C(F)F GVCRTNZXOSPJOQ-UHFFFAOYSA-N 0.000 description 1
- QAERDLQYXMEHEB-UHFFFAOYSA-N 1,1,3,3,3-pentafluoroprop-1-ene Chemical compound FC(F)=CC(F)(F)F QAERDLQYXMEHEB-UHFFFAOYSA-N 0.000 description 1
- UKBFRPDBVNHLQG-UHFFFAOYSA-N 1,1,3,3,5,5-hexafluoropentane Chemical compound FC(F)CC(F)(F)CC(F)F UKBFRPDBVNHLQG-UHFFFAOYSA-N 0.000 description 1
- RXDKFQHTMZFNOL-UHFFFAOYSA-N 1,1,4,4,4-pentafluoro-3-(trifluoromethyl)buta-1,2-diene Chemical compound FC(F)=C=C(C(F)(F)F)C(F)(F)F RXDKFQHTMZFNOL-UHFFFAOYSA-N 0.000 description 1
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical group FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 1
- KRAPPQJTUDJLDN-UHFFFAOYSA-N 1,1-bis(trifluoromethyl)cyclopropane Chemical compound FC(F)(F)C1(C(F)(F)F)CC1 KRAPPQJTUDJLDN-UHFFFAOYSA-N 0.000 description 1
- FRCHKSNAZZFGCA-UHFFFAOYSA-N 1,1-dichloro-1-fluoroethane Chemical compound CC(F)(Cl)Cl FRCHKSNAZZFGCA-UHFFFAOYSA-N 0.000 description 1
- MSHXSYMNYJAOSS-UHFFFAOYSA-N 1,1-dichloro-2-fluoroethene Chemical group FC=C(Cl)Cl MSHXSYMNYJAOSS-UHFFFAOYSA-N 0.000 description 1
- FLVRFJHILAAZAM-UHFFFAOYSA-N 1,1-difluoro-2,2-bis(trifluoromethyl)cyclopropane Chemical compound FC(F)(F)C1(C(F)(F)F)CC1(F)F FLVRFJHILAAZAM-UHFFFAOYSA-N 0.000 description 1
- AMPACFIJFCLUDK-UHFFFAOYSA-N 1,1-difluoro-2,2-dimethylcyclopropane Chemical compound CC1(C)CC1(F)F AMPACFIJFCLUDK-UHFFFAOYSA-N 0.000 description 1
- ZIQRGVDDGJVKIK-UHFFFAOYSA-N 1,1-difluoro-2-methylidenecyclobutane Chemical compound FC1(F)CCC1=C ZIQRGVDDGJVKIK-UHFFFAOYSA-N 0.000 description 1
- CYICOSUAVXTZOD-UHFFFAOYSA-N 1,1-difluorobut-1-ene Chemical compound CCC=C(F)F CYICOSUAVXTZOD-UHFFFAOYSA-N 0.000 description 1
- DPPHNCGGFCAZGX-UHFFFAOYSA-N 1,1-difluorocyclobutane Chemical compound FC1(F)CCC1 DPPHNCGGFCAZGX-UHFFFAOYSA-N 0.000 description 1
- QPTDDOUBRQFLQW-UHFFFAOYSA-N 1,1-difluorocyclopentane Chemical compound FC1(F)CCCC1 QPTDDOUBRQFLQW-UHFFFAOYSA-N 0.000 description 1
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 description 1
- JLWGYBPAAOQNPH-UHFFFAOYSA-N 1,1-difluoroethylcyclopropane Chemical compound CC(F)(F)C1CC1 JLWGYBPAAOQNPH-UHFFFAOYSA-N 0.000 description 1
- VNBZPLUIMSAHJY-UHFFFAOYSA-N 1,2,2,3,4,4-hexafluorobicyclo[1.1.1]pentane Chemical compound C1C2(F)C(F)(F)C1(F)C2(F)F VNBZPLUIMSAHJY-UHFFFAOYSA-N 0.000 description 1
- IVXQJJGISUGWQN-UHFFFAOYSA-N 1,2,2-trifluoro-3-methylbutane Chemical compound CC(C)C(F)(F)CF IVXQJJGISUGWQN-UHFFFAOYSA-N 0.000 description 1
- XOHBQQMRQDOVAK-UHFFFAOYSA-N 1,2,2-trifluoroethylcyclopropane Chemical compound FC(F)C(F)C1CC1 XOHBQQMRQDOVAK-UHFFFAOYSA-N 0.000 description 1
- YBMDPYAEZDJWNY-UHFFFAOYSA-N 1,2,3,3,4,4,5,5-octafluorocyclopentene Chemical compound FC1=C(F)C(F)(F)C(F)(F)C1(F)F YBMDPYAEZDJWNY-UHFFFAOYSA-N 0.000 description 1
- JQAHBADBSNZKFG-UHFFFAOYSA-N 1,2,3,3,4,4,5-heptafluorocyclopentene Chemical compound FC1C(F)=C(F)C(F)(F)C1(F)F JQAHBADBSNZKFG-UHFFFAOYSA-N 0.000 description 1
- QVHWOZCZUNPZPW-UHFFFAOYSA-N 1,2,3,3,4,4-hexafluorocyclobutene Chemical compound FC1=C(F)C(F)(F)C1(F)F QVHWOZCZUNPZPW-UHFFFAOYSA-N 0.000 description 1
- DEQVOMCLWYTNBL-UHFFFAOYSA-N 1,2,3,3,4,5,5-heptafluorocyclopentene Chemical compound FC1C(F)(F)C(F)=C(F)C1(F)F DEQVOMCLWYTNBL-UHFFFAOYSA-N 0.000 description 1
- WWCNSXIDMFOOGT-UHFFFAOYSA-N 1,2,3,3,4,5-hexafluorocyclopentene Chemical compound FC1C(F)C(F)(F)C(F)=C1F WWCNSXIDMFOOGT-UHFFFAOYSA-N 0.000 description 1
- IHTWAWAESDSLST-UHFFFAOYSA-N 1,2,3,3,4,5-hexafluoropentane Chemical compound FCC(F)C(F)(F)C(F)CF IHTWAWAESDSLST-UHFFFAOYSA-N 0.000 description 1
- XTLSITUJHHOIFO-UHFFFAOYSA-N 1,2,3,3,4-pentafluoro-4-(trifluoromethyl)cyclobutene Chemical compound FC1=C(F)C(F)(C(F)(F)F)C1(F)F XTLSITUJHHOIFO-UHFFFAOYSA-N 0.000 description 1
- UTKGAJXLTPHQFV-UHFFFAOYSA-N 1,2,3,4,5-pentafluorocyclopentene Chemical compound FC1C(F)C(F)=C(F)C1F UTKGAJXLTPHQFV-UHFFFAOYSA-N 0.000 description 1
- TYYDGUZLRCIVTR-UHFFFAOYSA-N 1,2,3,4-tetrafluorocyclopenta-1,3-diene Chemical compound FC1=C(F)C(F)=C(F)C1 TYYDGUZLRCIVTR-UHFFFAOYSA-N 0.000 description 1
- LCFJTOAYEKVUSX-UHFFFAOYSA-N 1,2,3,5,5-pentafluorocyclopenta-1,3-diene Chemical compound FC1=CC(F)(F)C(F)=C1F LCFJTOAYEKVUSX-UHFFFAOYSA-N 0.000 description 1
- RIWAPWDHHMWTRA-UHFFFAOYSA-N 1,2,3-triiodobenzene Chemical class IC1=CC=CC(I)=C1I RIWAPWDHHMWTRA-UHFFFAOYSA-N 0.000 description 1
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
- JSEUKVSKOHVLOV-UHFFFAOYSA-N 1,2-dichloro-1,1,2,3,3,3-hexafluoropropane Chemical class FC(F)(F)C(F)(Cl)C(F)(F)Cl JSEUKVSKOHVLOV-UHFFFAOYSA-N 0.000 description 1
- YMRMDGSNYHCUCL-UHFFFAOYSA-N 1,2-dichloro-1,1,2-trifluoroethane Chemical compound FC(Cl)C(F)(F)Cl YMRMDGSNYHCUCL-UHFFFAOYSA-N 0.000 description 1
- ZRDJBRPBHDZBBO-UHFFFAOYSA-N 1,2-difluoro-1,2-bis(trifluoromethyl)cyclopropane Chemical compound FC(F)(F)C1(F)CC1(F)C(F)(F)F ZRDJBRPBHDZBBO-UHFFFAOYSA-N 0.000 description 1
- AHFMSNDOYCFEPH-UHFFFAOYSA-N 1,2-difluoroethane Chemical compound FCCF AHFMSNDOYCFEPH-UHFFFAOYSA-N 0.000 description 1
- ZJQXYMPUNJARJR-UHFFFAOYSA-N 1,2-difluorospiro[2.2]pentane Chemical compound FC1C(F)C11CC1 ZJQXYMPUNJARJR-UHFFFAOYSA-N 0.000 description 1
- QMLFNWUDGIAXSI-UHFFFAOYSA-N 1,3,3,4,4,5-hexafluorocyclopentene Chemical compound FC1C(F)=CC(F)(F)C1(F)F QMLFNWUDGIAXSI-UHFFFAOYSA-N 0.000 description 1
- FRHTXJKWBGIZCM-UHFFFAOYSA-N 1,3,3,4,4-pentafluoro-2-methylcyclobutene Chemical compound CC1=C(F)C(F)(F)C1(F)F FRHTXJKWBGIZCM-UHFFFAOYSA-N 0.000 description 1
- GZPSNAONUGNAKA-UHFFFAOYSA-N 1,3,3,4,5,5-hexafluorocyclopentene Chemical compound FC1C(F)(F)C=C(F)C1(F)F GZPSNAONUGNAKA-UHFFFAOYSA-N 0.000 description 1
- MYOHYXZQYYKZQU-UHFFFAOYSA-N 1,3,4,4,4-pentafluoro-3-(trifluoromethyl)but-1-yne Chemical compound FC#CC(F)(C(F)(F)F)C(F)(F)F MYOHYXZQYYKZQU-UHFFFAOYSA-N 0.000 description 1
- YLRHMKHDOSPHHE-UHFFFAOYSA-N 1,3,4,5,5-pentafluorocyclopentene Chemical compound FC1C=C(F)C(F)(F)C1F YLRHMKHDOSPHHE-UHFFFAOYSA-N 0.000 description 1
- AKZARGRIJXNCBQ-UHFFFAOYSA-N 1,3-difluorobicyclo[1.1.1]pentane Chemical compound C1C2(F)CC1(F)C2 AKZARGRIJXNCBQ-UHFFFAOYSA-N 0.000 description 1
- RBOPXRJOTRBMFD-UHFFFAOYSA-N 1,4,4,5,5-pentafluorocyclopentene Chemical compound FC1=CCC(F)(F)C1(F)F RBOPXRJOTRBMFD-UHFFFAOYSA-N 0.000 description 1
- PQOGMIBDTMTLKY-UHFFFAOYSA-N 1,4,5,5-tetrafluorocyclopentene Chemical compound FC1CC=C(F)C1(F)F PQOGMIBDTMTLKY-UHFFFAOYSA-N 0.000 description 1
- RFCAUADVODFSLZ-UHFFFAOYSA-N 1-Chloro-1,1,2,2,2-pentafluoroethane Chemical compound FC(F)(F)C(F)(F)Cl RFCAUADVODFSLZ-UHFFFAOYSA-N 0.000 description 1
- LANNRYWUUQMNPF-UHFFFAOYSA-N 1-bromo-1,1,2,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)Br LANNRYWUUQMNPF-UHFFFAOYSA-N 0.000 description 1
- JQZFYIGAYWLRCC-UHFFFAOYSA-N 1-chloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)C(F)(F)Cl JQZFYIGAYWLRCC-UHFFFAOYSA-N 0.000 description 1
- BHNZEZWIUMJCGF-UHFFFAOYSA-N 1-chloro-1,1-difluoroethane Chemical compound CC(F)(F)Cl BHNZEZWIUMJCGF-UHFFFAOYSA-N 0.000 description 1
- BOUGCJDAQLKBQH-UHFFFAOYSA-N 1-chloro-1,2,2,2-tetrafluoroethane Chemical compound FC(Cl)C(F)(F)F BOUGCJDAQLKBQH-UHFFFAOYSA-N 0.000 description 1
- YACLCMMBHTUQON-UHFFFAOYSA-N 1-chloro-1-fluoroethane Chemical compound CC(F)Cl YACLCMMBHTUQON-UHFFFAOYSA-N 0.000 description 1
- FPBWSPZHCJXUBL-UHFFFAOYSA-N 1-chloro-1-fluoroethene Chemical group FC(Cl)=C FPBWSPZHCJXUBL-UHFFFAOYSA-N 0.000 description 1
- LRHPLDYGYMQRHN-QYKNYGDISA-N 1-deuteriobutan-1-ol Chemical compound C(CCC)(O)[2H] LRHPLDYGYMQRHN-QYKNYGDISA-N 0.000 description 1
- IJDNQMDRQITEOD-MICDWDOJSA-N 1-deuteriobutane Chemical compound [2H]CCCC IJDNQMDRQITEOD-MICDWDOJSA-N 0.000 description 1
- ZJSKEGAHBAHFON-UHFFFAOYSA-N 1-ethenyl-3-fluorobenzene Chemical compound FC1=CC=CC(C=C)=C1 ZJSKEGAHBAHFON-UHFFFAOYSA-N 0.000 description 1
- PDUJPCBHGQMGIR-UHFFFAOYSA-N 1-ethyl-2-fluorocyclopropane Chemical compound CCC1CC1F PDUJPCBHGQMGIR-UHFFFAOYSA-N 0.000 description 1
- QXNDYAQIYCLBJC-UHFFFAOYSA-N 1-fluoro-1-methylcyclobutane Chemical compound CC1(F)CCC1 QXNDYAQIYCLBJC-UHFFFAOYSA-N 0.000 description 1
- FCBJLBCGHCTPAQ-UHFFFAOYSA-N 1-fluorobutane Chemical compound CCCCF FCBJLBCGHCTPAQ-UHFFFAOYSA-N 0.000 description 1
- BKCDSYUMWOBEJI-UHFFFAOYSA-N 1-fluorocyclopenta-1,3-diene Chemical compound FC1=CC=CC1 BKCDSYUMWOBEJI-UHFFFAOYSA-N 0.000 description 1
- IFRIJEKNVVMZBB-UHFFFAOYSA-N 1-fluorocyclopentene Chemical compound FC1=CCCC1 IFRIJEKNVVMZBB-UHFFFAOYSA-N 0.000 description 1
- OEPRBXUJOQLYID-UHFFFAOYSA-N 1-fluoropentane Chemical compound CCCCCF OEPRBXUJOQLYID-UHFFFAOYSA-N 0.000 description 1
- HUKCWCNQJHRMBR-UHFFFAOYSA-N 1-methyl-1-(trifluoromethyl)cyclopropane Chemical compound FC(F)(F)C1(C)CC1 HUKCWCNQJHRMBR-UHFFFAOYSA-N 0.000 description 1
- NALZTFARIYUCBY-UHFFFAOYSA-N 1-nitrobutane Chemical compound CCCC[N+]([O-])=O NALZTFARIYUCBY-UHFFFAOYSA-N 0.000 description 1
- RZUIWXXZNWWSHF-UHFFFAOYSA-N 2,2,2-trifluoroethylcyclopropane Chemical compound FC(F)(F)CC1CC1 RZUIWXXZNWWSHF-UHFFFAOYSA-N 0.000 description 1
- ITPSWWWVHCKVQK-UHFFFAOYSA-N 2,2,3,3,3-pentafluoro-N-(trifluoromethyl)propanimidoyl fluoride Chemical compound FC(F)(F)N=C(F)C(F)(F)C(F)(F)F ITPSWWWVHCKVQK-UHFFFAOYSA-N 0.000 description 1
- ABPOYGBBUCBTKY-UHFFFAOYSA-N 2,2,3,3-tetrafluorobicyclo[2.1.0]pentane Chemical compound FC1(F)C(F)(F)C2CC21 ABPOYGBBUCBTKY-UHFFFAOYSA-N 0.000 description 1
- CCJLENSREHVIFZ-UHFFFAOYSA-N 2,2,3-trifluoro-3-methylbutane Chemical compound CC(C)(F)C(C)(F)F CCJLENSREHVIFZ-UHFFFAOYSA-N 0.000 description 1
- BKDYHPIFXIPHMV-UHFFFAOYSA-N 2,2,3-trifluoropentane Chemical compound CCC(F)C(C)(F)F BKDYHPIFXIPHMV-UHFFFAOYSA-N 0.000 description 1
- LFMOARVPPXAAJE-UHFFFAOYSA-N 2,2,4-trifluoropentane Chemical compound CC(F)CC(C)(F)F LFMOARVPPXAAJE-UHFFFAOYSA-N 0.000 description 1
- RDAZIKBRMRQQGA-UHFFFAOYSA-N 2,2,5,5-tetrafluorospiro[2.2]pentane Chemical compound FC1(F)CC11C(F)(F)C1 RDAZIKBRMRQQGA-UHFFFAOYSA-N 0.000 description 1
- GJSXOCUADDBHLP-UHFFFAOYSA-N 2,2-difluoroethylcyclopropane Chemical compound FC(F)CC1CC1 GJSXOCUADDBHLP-UHFFFAOYSA-N 0.000 description 1
- YZXSQDNPKVBDOG-UHFFFAOYSA-N 2,2-difluoropropane Chemical compound CC(C)(F)F YZXSQDNPKVBDOG-UHFFFAOYSA-N 0.000 description 1
- HEBURKQRCLALEQ-UHFFFAOYSA-N 2,2-difluorospiro[2.2]pentane Chemical compound FC1(F)CC11CC1 HEBURKQRCLALEQ-UHFFFAOYSA-N 0.000 description 1
- OVESXTHFTBNFNF-UHFFFAOYSA-N 2,3,3-trifluoro-1-(trifluoromethyl)cyclobutene Chemical compound FC1=C(CC1(F)F)C(F)(F)F OVESXTHFTBNFNF-UHFFFAOYSA-N 0.000 description 1
- ASPSKAWHQBLRHH-UHFFFAOYSA-N 2,3,4,4-tetrafluorocyclobut-2-en-1-one Chemical compound FC1=C(F)C(F)(F)C1=O ASPSKAWHQBLRHH-UHFFFAOYSA-N 0.000 description 1
- AAUSLOKBERXEER-UHFFFAOYSA-N 2,3,4,5,6-pentachlorobenzoyl chloride Chemical compound ClC(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl AAUSLOKBERXEER-UHFFFAOYSA-N 0.000 description 1
- VPTSQBHQXVQANU-UHFFFAOYSA-N 2,3,6-trimethylpiperidine Chemical compound CC1CCC(C)C(C)N1 VPTSQBHQXVQANU-UHFFFAOYSA-N 0.000 description 1
- VOZKAJLKRJDJLL-UHFFFAOYSA-N 2,4-diaminotoluene Chemical compound CC1=CC=C(N)C=C1N VOZKAJLKRJDJLL-UHFFFAOYSA-N 0.000 description 1
- ILMMTOZCLNPKOV-UHFFFAOYSA-N 2,5-difluorospiro[2.2]pentane Chemical compound FC1CC11C(F)C1 ILMMTOZCLNPKOV-UHFFFAOYSA-N 0.000 description 1
- ZASBKNPRLPFSCA-UHFFFAOYSA-N 2-(difluoromethoxy)-1,1,1-trifluoroethane Chemical compound FC(F)OCC(F)(F)F ZASBKNPRLPFSCA-UHFFFAOYSA-N 0.000 description 1
- SYNPRNNJJLRHTI-UHFFFAOYSA-N 2-(hydroxymethyl)butane-1,4-diol Chemical compound OCCC(CO)CO SYNPRNNJJLRHTI-UHFFFAOYSA-N 0.000 description 1
- CYXIKYKBLDZZNW-UHFFFAOYSA-N 2-Chloro-1,1,1-trifluoroethane Chemical compound FC(F)(F)CCl CYXIKYKBLDZZNW-UHFFFAOYSA-N 0.000 description 1
- HAIGSNHRJAADFJ-UHFFFAOYSA-N 2-bromobutanal Chemical compound CCC(Br)C=O HAIGSNHRJAADFJ-UHFFFAOYSA-N 0.000 description 1
- JRENXZBKMHPULY-UHFFFAOYSA-N 2-chloro-1,1,1,4,4,4-hexafluorobut-2-ene Chemical compound FC(F)(F)C=C(Cl)C(F)(F)F JRENXZBKMHPULY-UHFFFAOYSA-N 0.000 description 1
- ATEBGNALLCMSGS-UHFFFAOYSA-N 2-chloro-1,1-difluoroethane Chemical compound FC(F)CCl ATEBGNALLCMSGS-UHFFFAOYSA-N 0.000 description 1
- HTHNTJCVPNKCPZ-UHFFFAOYSA-N 2-chloro-1,1-difluoroethene Chemical group FC(F)=CCl HTHNTJCVPNKCPZ-UHFFFAOYSA-N 0.000 description 1
- PDMNHCOWNZISJG-UHFFFAOYSA-N 2-chloro-1,3-difluoropropane Chemical compound FCC(Cl)CF PDMNHCOWNZISJG-UHFFFAOYSA-N 0.000 description 1
- XXVGLXNVQQFQOB-UHFFFAOYSA-N 2-fluoro-1,1-dimethylcyclopropane Chemical compound CC1(C)CC1F XXVGLXNVQQFQOB-UHFFFAOYSA-N 0.000 description 1
- GSMZLBOYBDRGBN-UHFFFAOYSA-N 2-fluoro-2-methylpropane Chemical compound CC(C)(C)F GSMZLBOYBDRGBN-UHFFFAOYSA-N 0.000 description 1
- BQHQZFUAEAVJRE-UHFFFAOYSA-N 2-fluorobuta-1,3-diene Chemical compound FC(=C)C=C BQHQZFUAEAVJRE-UHFFFAOYSA-N 0.000 description 1
- DAGWSDFKLAQZJR-UHFFFAOYSA-N 2-fluoroethylcyclopropane Chemical compound FCCC1CC1 DAGWSDFKLAQZJR-UHFFFAOYSA-N 0.000 description 1
- RMGHERXMTMUMMV-UHFFFAOYSA-N 2-methoxypropane Chemical compound COC(C)C RMGHERXMTMUMMV-UHFFFAOYSA-N 0.000 description 1
- BPEQDTTUKAJORX-UHFFFAOYSA-N 2-methyl-3-(3-methyloxiran-2-yl)oxyoxirane Chemical compound CC1OC1OC1C(C)O1 BPEQDTTUKAJORX-UHFFFAOYSA-N 0.000 description 1
- VJOAJCOCCYFXPR-UHFFFAOYSA-N 3,3,3-trifluoro-2-methylprop-1-ene Chemical compound CC(=C)C(F)(F)F VJOAJCOCCYFXPR-UHFFFAOYSA-N 0.000 description 1
- FDMFUZHCIRHGRG-UHFFFAOYSA-N 3,3,3-trifluoroprop-1-ene Chemical compound FC(F)(F)C=C FDMFUZHCIRHGRG-UHFFFAOYSA-N 0.000 description 1
- LQAPOTKKMIZDGP-UHFFFAOYSA-N 3,3,4,4,5,5,5-heptafluoropent-1-ene Chemical compound FC(F)(F)C(F)(F)C(F)(F)C=C LQAPOTKKMIZDGP-UHFFFAOYSA-N 0.000 description 1
- GUHFVBYQXMBNSP-UHFFFAOYSA-N 3,3,4,4,5-pentafluorocyclopentene Chemical compound FC1C=CC(F)(F)C1(F)F GUHFVBYQXMBNSP-UHFFFAOYSA-N 0.000 description 1
- HLFSIQINPRVLNI-UHFFFAOYSA-N 3,3,4,4-tetrafluoro-1-(trifluoromethyl)cyclobutene Chemical compound FC(F)(F)C1=CC(F)(F)C1(F)F HLFSIQINPRVLNI-UHFFFAOYSA-N 0.000 description 1
- NQMSHLVISRYOFM-UHFFFAOYSA-N 3,3,4,4-tetrafluoro-1-methylcyclobutene Chemical compound CC1=CC(F)(F)C1(F)F NQMSHLVISRYOFM-UHFFFAOYSA-N 0.000 description 1
- XCXZHHIRCFEBSG-UHFFFAOYSA-N 3,3-difluoro-1-(1,1,2,2,2-pentafluoroethyl)cyclopropene Chemical compound FC(F)(F)C(F)(F)C1=CC1(F)F XCXZHHIRCFEBSG-UHFFFAOYSA-N 0.000 description 1
- PPWNCLVNXGCGAF-UHFFFAOYSA-N 3,3-dimethylbut-1-yne Chemical compound CC(C)(C)C#C PPWNCLVNXGCGAF-UHFFFAOYSA-N 0.000 description 1
- WZHHYIOUKQNLQM-UHFFFAOYSA-N 3,4,5,6-tetrachlorophthalic acid Chemical compound OC(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C(O)=O WZHHYIOUKQNLQM-UHFFFAOYSA-N 0.000 description 1
- HZNKQWVKCVCPKU-UHFFFAOYSA-N 3-(trifluoromethyl)cyclobutene Chemical compound FC(F)(F)C1CC=C1 HZNKQWVKCVCPKU-UHFFFAOYSA-N 0.000 description 1
- SPZXNEBFTNEDGH-UHFFFAOYSA-N 3-bromo-1,1,2,3,3-pentafluoroprop-1-ene Chemical compound FC(F)=C(F)C(F)(F)Br SPZXNEBFTNEDGH-UHFFFAOYSA-N 0.000 description 1
- MAUHKVNIHVSMSP-UHFFFAOYSA-N 3-bromopent-1-ene Chemical compound CCC(Br)C=C MAUHKVNIHVSMSP-UHFFFAOYSA-N 0.000 description 1
- IJTAKAGEJXIJPQ-UHFFFAOYSA-N 3-chloro-1,1,2,3,3-pentafluoroprop-1-ene Chemical compound FC(F)=C(F)C(F)(F)Cl IJTAKAGEJXIJPQ-UHFFFAOYSA-N 0.000 description 1
- PTJKNWOPCUOHJT-UHFFFAOYSA-N 3-fluoro-1-methylcyclobutene Chemical compound CC1=CC(F)C1 PTJKNWOPCUOHJT-UHFFFAOYSA-N 0.000 description 1
- QCMKXHXKNIOBBC-UHFFFAOYSA-N 3-fluoroprop-1-ene Chemical group FCC=C QCMKXHXKNIOBBC-UHFFFAOYSA-N 0.000 description 1
- FONJUXZYNZCFSE-UHFFFAOYSA-N 3-methylideneoxetane Chemical compound C=C1COC1 FONJUXZYNZCFSE-UHFFFAOYSA-N 0.000 description 1
- AJPJTQUKLOXNFS-UHFFFAOYSA-N 4,4,4-trifluorobutylsilane Chemical compound FC(F)(F)CCC[SiH3] AJPJTQUKLOXNFS-UHFFFAOYSA-N 0.000 description 1
- VHNNSNNVWSXSQQ-UHFFFAOYSA-N 4,4-difluorocyclopentene Chemical compound FC1(F)CC=CC1 VHNNSNNVWSXSQQ-UHFFFAOYSA-N 0.000 description 1
- UDIQNVMCHWHTBT-UHFFFAOYSA-N 5-phenylcyclohexa-2,4-dien-1-one Chemical compound C1(=CC=CC=C1)C1=CC=CC(C1)=O UDIQNVMCHWHTBT-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- JRLTTZUODKEYDH-UHFFFAOYSA-N 8-methylquinoline Chemical group C1=CN=C2C(C)=CC=CC2=C1 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 238000012371 Aseptic Filling Methods 0.000 description 1
- IPQLEWIXZJLSDV-UHFFFAOYSA-N BCCB Chemical compound BCCB IPQLEWIXZJLSDV-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 230000005653 Brownian motion process Effects 0.000 description 1
- VXGOWLCJKDHGBN-UHFFFAOYSA-N C12C3C1(C(F)(F)F)C32 Chemical compound C12C3C1(C(F)(F)F)C32 VXGOWLCJKDHGBN-UHFFFAOYSA-N 0.000 description 1
- HWVATTWTXDSOEO-UHFFFAOYSA-N C1=CC=CC1.FC1CCC1 Chemical compound C1=CC=CC1.FC1CCC1 HWVATTWTXDSOEO-UHFFFAOYSA-N 0.000 description 1
- BXPYOHUSBIOZRB-UHFFFAOYSA-N CCCCCCCCCCCC.C(CCCC)O Chemical compound CCCCCCCCCCCC.C(CCCC)O BXPYOHUSBIOZRB-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 description 1
- XWCDCDSDNJVCLO-UHFFFAOYSA-N Chlorofluoromethane Chemical compound FCCl XWCDCDSDNJVCLO-UHFFFAOYSA-N 0.000 description 1
- PNKTZJVUIDOSRY-UHFFFAOYSA-N ClC(S(=O)(=O)N)(F)Cl Chemical compound ClC(S(=O)(=O)N)(F)Cl PNKTZJVUIDOSRY-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000484025 Cuniculus Species 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000201862 Equus sp. Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- BCSXJSQFOLALIC-UHFFFAOYSA-N FC(=C)C1CC1 Chemical compound FC(=C)C1CC1 BCSXJSQFOLALIC-UHFFFAOYSA-N 0.000 description 1
- PWYGAAJLMCEVHQ-UHFFFAOYSA-N FC(F)(F)C(F)(F)C1CC1 Chemical compound FC(F)(F)C(F)(F)C1CC1 PWYGAAJLMCEVHQ-UHFFFAOYSA-N 0.000 description 1
- WRQNSSJUDLSULS-UHFFFAOYSA-N FC1=C(C=C(C1(F)F)F)F Chemical compound FC1=C(C=C(C1(F)F)F)F WRQNSSJUDLSULS-UHFFFAOYSA-N 0.000 description 1
- VVYCAVPYCGOBBV-UHFFFAOYSA-N FC1C(C12C(C2F)F)F Chemical compound FC1C(C12C(C2F)F)F VVYCAVPYCGOBBV-UHFFFAOYSA-N 0.000 description 1
- PFJNBGGXIABWAB-UHFFFAOYSA-N FC1C23C(C21C3)=O Chemical compound FC1C23C(C21C3)=O PFJNBGGXIABWAB-UHFFFAOYSA-N 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- 241000699672 Mesocricetus sp. Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 241000283900 Ovis sp. Species 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 241001504519 Papio ursinus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 108090000279 Peptidyltransferases Proteins 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 229920002048 Pluronic® L 92 Polymers 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 102000005686 Serum Globulins Human genes 0.000 description 1
- 108010045362 Serum Globulins Proteins 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 241000282890 Sus Species 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 1
- QFGXGNPYIYCZTP-UHFFFAOYSA-N [(dimethylphosphanylamino)-methylphosphanyl]methane Chemical compound CP(C)NP(C)C QFGXGNPYIYCZTP-UHFFFAOYSA-N 0.000 description 1
- SOKUDFNQQPERMT-UHFFFAOYSA-N [3,3,3-trifluoro-2-(trifluoromethyl)propyl]silane Chemical compound FC(F)(F)C(C[SiH3])C(F)(F)F SOKUDFNQQPERMT-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- JUCMRTZQCZRJDC-UHFFFAOYSA-N acetyl fluoride Chemical compound CC(F)=O JUCMRTZQCZRJDC-UHFFFAOYSA-N 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001345 alkine derivatives Chemical class 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000002473 artificial blood Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- YOALFLHFSFEMLP-UHFFFAOYSA-N azane;2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoic acid Chemical compound [NH4+].[O-]C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F YOALFLHFSFEMLP-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- JTRPLRMCBJSBJV-UHFFFAOYSA-N benzonaphthacene Natural products C1=CC=C2C3=CC4=CC5=CC=CC=C5C=C4C=C3C=CC2=C1 JTRPLRMCBJSBJV-UHFFFAOYSA-N 0.000 description 1
- JAPMJSVZDUYFKL-UHFFFAOYSA-N bicyclo[3.1.0]hexane Chemical compound C1CCC2CC21 JAPMJSVZDUYFKL-UHFFFAOYSA-N 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000012455 biphasic mixture Substances 0.000 description 1
- RHNWJNBJQDKCLG-UHFFFAOYSA-N bis(difluoromethyl)-bis(fluoromethyl)silane Chemical compound FC[Si](CF)(C(F)F)C(F)F RHNWJNBJQDKCLG-UHFFFAOYSA-N 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 239000003633 blood substitute Substances 0.000 description 1
- 229910000085 borane Inorganic materials 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- RUEKPBLTWGFBOD-UHFFFAOYSA-N bromoethyne Chemical class BrC#C RUEKPBLTWGFBOD-UHFFFAOYSA-N 0.000 description 1
- LHMHCLYDBQOYTO-UHFFFAOYSA-N bromofluoromethane Chemical compound FCBr LHMHCLYDBQOYTO-UHFFFAOYSA-N 0.000 description 1
- 238000005537 brownian motion Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- PEMNHBDEZYBANS-UHFFFAOYSA-N butan-2-yl(trifluoro)silane Chemical compound CCC(C)[Si](F)(F)F PEMNHBDEZYBANS-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- GNEVIACKFGQMHB-UHFFFAOYSA-N carbon suboxide Chemical compound O=C=C=C=O GNEVIACKFGQMHB-UHFFFAOYSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000012754 cardiac puncture Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 1
- 125000004775 chlorodifluoromethyl group Chemical group FC(F)(Cl)* 0.000 description 1
- YGHUUVGIRWMJGE-UHFFFAOYSA-N chlorodimethylsilane Chemical compound C[SiH](C)Cl YGHUUVGIRWMJGE-UHFFFAOYSA-N 0.000 description 1
- DIWKDXFZXXCDLF-UHFFFAOYSA-N chloroethyne Chemical group ClC#C DIWKDXFZXXCDLF-UHFFFAOYSA-N 0.000 description 1
- 235000019406 chloropentafluoroethane Nutrition 0.000 description 1
- IAQRGUVFOMOMEM-ARJAWSKDSA-N cis-but-2-ene Chemical compound C\C=C/C IAQRGUVFOMOMEM-ARJAWSKDSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- NKKMVIVFRUYPLQ-NSCUHMNNSA-N crotononitrile Chemical compound C\C=C\C#N NKKMVIVFRUYPLQ-NSCUHMNNSA-N 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 150000001924 cycloalkanes Chemical class 0.000 description 1
- 150000001925 cycloalkenes Chemical class 0.000 description 1
- FQAOIEUHEDESAK-UHFFFAOYSA-N cyclopenta-1,3-diene Chemical compound C1C=CC=C1.C1C=CC=C1 FQAOIEUHEDESAK-UHFFFAOYSA-N 0.000 description 1
- 150000001940 cyclopentanes Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- AZSZCFSOHXEJQE-UHFFFAOYSA-N dibromodifluoromethane Chemical compound FC(F)(Br)Br AZSZCFSOHXEJQE-UHFFFAOYSA-N 0.000 description 1
- QDGONURINHVBEW-UHFFFAOYSA-N dichlorodifluoroethylene Chemical group FC(F)=C(Cl)Cl QDGONURINHVBEW-UHFFFAOYSA-N 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- YSLFMGDEEXOKHF-UHFFFAOYSA-N difluoro(iodo)methane Chemical compound FC(F)I YSLFMGDEEXOKHF-UHFFFAOYSA-N 0.000 description 1
- KPDQCLCQVBNKFB-UHFFFAOYSA-N difluoromethyl-(fluoromethyl)-dimethylsilane Chemical compound FC[Si](C)(C)C(F)F KPDQCLCQVBNKFB-UHFFFAOYSA-N 0.000 description 1
- ANMGQFVSOFHYSE-UHFFFAOYSA-N difluoromethyl-(fluoromethyl)-methyl-(trifluoromethyl)silane Chemical compound FC[Si](C)(C(F)F)C(F)(F)F ANMGQFVSOFHYSE-UHFFFAOYSA-N 0.000 description 1
- IDQODARIHQOMBG-UHFFFAOYSA-N difluoromethylidenecyclobutane Chemical compound FC(F)=C1CCC1 IDQODARIHQOMBG-UHFFFAOYSA-N 0.000 description 1
- ZLTVJTLCEBCPRC-UHFFFAOYSA-N difluorophosphoryloxymethane Chemical compound COP(F)(F)=O ZLTVJTLCEBCPRC-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- YQGOWXYZDLJBFL-UHFFFAOYSA-N dimethoxysilane Chemical compound CO[SiH2]OC YQGOWXYZDLJBFL-UHFFFAOYSA-N 0.000 description 1
- UBHZUDXTHNMNLD-UHFFFAOYSA-N dimethylsilane Chemical compound C[SiH2]C UBHZUDXTHNMNLD-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002592 echocardiography Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- IQSBKDJPSOMMRZ-UHFFFAOYSA-N ethenyl(methyl)silane Chemical compound C[SiH2]C=C IQSBKDJPSOMMRZ-UHFFFAOYSA-N 0.000 description 1
- LIWAQLJGPBVORC-UHFFFAOYSA-N ethylmethylamine Chemical compound CCNC LIWAQLJGPBVORC-UHFFFAOYSA-N 0.000 description 1
- CXKWXYISKZVUBR-UHFFFAOYSA-N ethynoxyethene Chemical compound C=COC#C CXKWXYISKZVUBR-UHFFFAOYSA-N 0.000 description 1
- AOZJZWCWZVENEF-UHFFFAOYSA-N ethynylgermane Chemical compound [GeH3]C#C AOZJZWCWZVENEF-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- BSSAVAPAZUPJLX-UHFFFAOYSA-N fluoro(methoxy)methane Chemical compound COCF BSSAVAPAZUPJLX-UHFFFAOYSA-N 0.000 description 1
- YHYNFMGKZFOMAG-UHFFFAOYSA-N fluorocyclopentane Chemical compound FC1CCCC1 YHYNFMGKZFOMAG-UHFFFAOYSA-N 0.000 description 1
- UHCBBWUQDAVSMS-UHFFFAOYSA-N fluoroethane Chemical compound CCF UHCBBWUQDAVSMS-UHFFFAOYSA-N 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 238000011194 good manufacturing practice Methods 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- WBCLXFIDEDJGCC-UHFFFAOYSA-N hexafluoro-2-butyne Chemical compound FC(F)(F)C#CC(F)(F)F WBCLXFIDEDJGCC-UHFFFAOYSA-N 0.000 description 1
- VBZWSGALLODQNC-UHFFFAOYSA-N hexafluoroacetone Chemical compound FC(F)(F)C(=O)C(F)(F)F VBZWSGALLODQNC-UHFFFAOYSA-N 0.000 description 1
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- RNYJXPUAFDFIQJ-UHFFFAOYSA-N hydron;octadecan-1-amine;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[NH3+] RNYJXPUAFDFIQJ-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007914 intraventricular administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 229960000824 iopentol Drugs 0.000 description 1
- IUNJANQVIJDFTQ-UHFFFAOYSA-N iopentol Chemical compound COCC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I IUNJANQVIJDFTQ-UHFFFAOYSA-N 0.000 description 1
- 229960004537 ioversol Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229910052743 krypton Inorganic materials 0.000 description 1
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- XZFDPQVQHKDPHP-UHFFFAOYSA-N methanedithione;methanol;methyl acetate Chemical compound OC.S=C=S.COC(C)=O XZFDPQVQHKDPHP-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- DDCYYCUMAFYDDU-UHFFFAOYSA-N methyl thiohypochlorite Chemical compound CSCl DDCYYCUMAFYDDU-UHFFFAOYSA-N 0.000 description 1
- HUWNGKVNXAXAMN-UHFFFAOYSA-N methyl(3,3,3-trifluoropropyl)silane Chemical compound C[SiH2]CCC(F)(F)F HUWNGKVNXAXAMN-UHFFFAOYSA-N 0.000 description 1
- BDRSUPBVZTWBIS-UHFFFAOYSA-N methyl-tris(trifluoromethyl)silane Chemical compound FC(F)(F)[Si](C)(C(F)(F)F)C(F)(F)F BDRSUPBVZTWBIS-UHFFFAOYSA-N 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 210000002346 musculoskeletal system Anatomy 0.000 description 1
- JWDVRIOQNXFNES-UHFFFAOYSA-N n,1,1,1-tetrafluoro-n-(trifluoromethyl)methanamine Chemical compound FC(F)(F)N(F)C(F)(F)F JWDVRIOQNXFNES-UHFFFAOYSA-N 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- PQTWNYIRLGTLFQ-UHFFFAOYSA-N non-1-en-3-yne Chemical compound CCCCCC#CC=C PQTWNYIRLGTLFQ-UHFFFAOYSA-N 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- IOQPZZOEVPZRBK-UHFFFAOYSA-N octan-1-amine Chemical compound CCCCCCCCN IOQPZZOEVPZRBK-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- GTLACDSXYULKMZ-UHFFFAOYSA-N pentafluoroethane Chemical compound FC(F)C(F)(F)F GTLACDSXYULKMZ-UHFFFAOYSA-N 0.000 description 1
- XNLICIUVMPYHGG-UHFFFAOYSA-N pentan-2-one Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 description 1
- 229960004065 perflutren Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- PMJHHCWVYXUKFD-UHFFFAOYSA-N piperylene Natural products CC=CC=C PMJHHCWVYXUKFD-UHFFFAOYSA-N 0.000 description 1
- 210000004224 pleura Anatomy 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000006308 propyl amino group Chemical group 0.000 description 1
- UIDUKLCLJMXFEO-UHFFFAOYSA-N propylsilane Chemical compound CCC[SiH3] UIDUKLCLJMXFEO-UHFFFAOYSA-N 0.000 description 1
- MWWATHDPGQKSAR-UHFFFAOYSA-N propyne Chemical compound CC#C MWWATHDPGQKSAR-UHFFFAOYSA-N 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- MHQHHBYRYFICDV-UHFFFAOYSA-M sodium;pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].O=C1CC(=O)[N-]C(=O)N1 MHQHHBYRYFICDV-UHFFFAOYSA-M 0.000 description 1
- 239000008137 solubility enhancer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910052717 sulfur Chemical group 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- OBTWBSRJZRCYQV-UHFFFAOYSA-N sulfuryl difluoride Chemical compound FS(F)(=O)=O OBTWBSRJZRCYQV-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- UNWUYTNKSRTDDC-UHFFFAOYSA-N tert-butylsilane Chemical compound CC(C)(C)[SiH3] UNWUYTNKSRTDDC-UHFFFAOYSA-N 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- FJIKXKJQWYEOJC-UHFFFAOYSA-N tetrakis(trifluoromethyl)silane Chemical compound FC(F)(F)[Si](C(F)(F)F)(C(F)(F)F)C(F)(F)F FJIKXKJQWYEOJC-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- XNVSISPDLQXINP-UHFFFAOYSA-N trifluoro(1,1,2,2,3,3,4,4,4-nonafluorobutyl)silane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)[Si](F)(F)F XNVSISPDLQXINP-UHFFFAOYSA-N 0.000 description 1
- JPFXZNHCKMVEJJ-UHFFFAOYSA-N trifluoro(2-methylpropyl)silane Chemical compound CC(C)C[Si](F)(F)F JPFXZNHCKMVEJJ-UHFFFAOYSA-N 0.000 description 1
- GEGIENATMYITAP-UHFFFAOYSA-N trifluoro(nitro)methane Chemical compound [O-][N+](=O)C(F)(F)F GEGIENATMYITAP-UHFFFAOYSA-N 0.000 description 1
- PGOMVYSURVZIIW-UHFFFAOYSA-N trifluoro(nitroso)methane Chemical compound FC(F)(F)N=O PGOMVYSURVZIIW-UHFFFAOYSA-N 0.000 description 1
- OFHCXWMZXQBQMH-UHFFFAOYSA-N trifluoro(trifluoromethylsulfanyl)methane Chemical compound FC(F)(F)SC(F)(F)F OFHCXWMZXQBQMH-UHFFFAOYSA-N 0.000 description 1
- CGMFFOXAQVRUAZ-UHFFFAOYSA-N trifluoro-(trifluoromethyldisulfanyl)methane Chemical compound FC(F)(F)SSC(F)(F)F CGMFFOXAQVRUAZ-UHFFFAOYSA-N 0.000 description 1
- MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 description 1
- UORVGPXVDQYIDP-UHFFFAOYSA-N trihydridoboron Substances B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- OBFAQTLODKWTNI-UHFFFAOYSA-N tris(trifluoromethyl) phosphite Chemical compound FC(F)(F)OP(OC(F)(F)F)OC(F)(F)F OBFAQTLODKWTNI-UHFFFAOYSA-N 0.000 description 1
- NXHILIPIEUBEPD-UHFFFAOYSA-H tungsten hexafluoride Chemical compound F[W](F)(F)(F)(F)F NXHILIPIEUBEPD-UHFFFAOYSA-H 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/008,172 US5558855A (en) | 1993-01-25 | 1993-01-25 | Phase shift colloids as ultrasound contrast agents |
US08/148,284 US5595723A (en) | 1993-01-25 | 1993-11-08 | Method for preparing storage stable colloids |
PCT/US1994/000422 WO1994016739A1 (en) | 1993-01-25 | 1994-01-19 | Phase shift colloids as ultrasound contrast agents |
Publications (2)
Publication Number | Publication Date |
---|---|
SK93095A3 SK93095A3 (en) | 1995-11-08 |
SK281535B6 true SK281535B6 (sk) | 2001-04-09 |
Family
ID=26677890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK930-95A SK281535B6 (sk) | 1993-01-25 | 1994-01-19 | Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy |
Country Status (18)
Country | Link |
---|---|
US (3) | US5558853A (zh) |
EP (1) | EP0680341B1 (zh) |
JP (1) | JP3621413B2 (zh) |
CN (1) | CN1068230C (zh) |
AT (1) | ATE200985T1 (zh) |
BR (1) | BR9405667A (zh) |
CA (1) | CA2154590C (zh) |
CZ (1) | CZ191695A3 (zh) |
DE (1) | DE69427185T2 (zh) |
ES (1) | ES2158892T3 (zh) |
FI (1) | FI953546A (zh) |
HU (1) | HUT72323A (zh) |
NO (1) | NO952819L (zh) |
NZ (1) | NZ262237A (zh) |
PL (1) | PL176116B1 (zh) |
SG (1) | SG52198A1 (zh) |
SK (1) | SK281535B6 (zh) |
WO (1) | WO1994016739A1 (zh) |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5656211A (en) | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5305757A (en) | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
WO1993000933A1 (en) * | 1991-07-05 | 1993-01-21 | University Of Rochester | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
IL108416A (en) * | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
US5695740A (en) * | 1993-05-12 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide |
US5701899A (en) * | 1993-05-12 | 1997-12-30 | The Board Of Regents Of The University Of Nebraska | Perfluorobutane ultrasound contrast agent and methods for its manufacture and use |
US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
US5855865A (en) * | 1993-07-02 | 1999-01-05 | Molecular Biosystems, Inc. | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
US5605673A (en) | 1993-07-30 | 1997-02-25 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
NZ276167A (en) | 1993-12-15 | 1996-11-26 | Bracco Research Sa | Ultrasound contrast medium comprising two gases in aqueous suspension |
US5736121A (en) | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
US5730955A (en) * | 1994-08-02 | 1998-03-24 | Molecular Biosystems, Inc. | Process for making gas-filled microspheres containing a liquid hydrophobic barrier |
US5965109A (en) * | 1994-08-02 | 1999-10-12 | Molecular Biosystems, Inc. | Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
EP0727225A3 (en) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
JP4215820B2 (ja) * | 1995-06-07 | 2009-01-28 | イマアーレクス・フアーマシユーチカル・コーポレーシヨン | 診断的および治療的使用のための新規な標的化組成物 |
US5674469A (en) * | 1995-06-07 | 1997-10-07 | Molecular Biosystems, Inc. | Gas-exchange method of making gas-filled microspheres |
US5897851A (en) * | 1995-06-07 | 1999-04-27 | Sonus Pharmaceuticals, Inc. | Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging |
US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US6521211B1 (en) * | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US6183497B1 (en) | 1998-05-01 | 2001-02-06 | Sub-Q, Inc. | Absorbable sponge with contrasting agent |
US6162192A (en) * | 1998-05-01 | 2000-12-19 | Sub Q, Inc. | System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge |
US6071301A (en) | 1998-05-01 | 2000-06-06 | Sub Q., Inc. | Device and method for facilitating hemostasis of a biopsy tract |
US5648098A (en) * | 1995-10-17 | 1997-07-15 | The Board Of Regents Of The University Of Nebraska | Thrombolytic agents and methods of treatment for thrombosis |
US5611344A (en) * | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
US6245747B1 (en) | 1996-03-12 | 2001-06-12 | The Board Of Regents Of The University Of Nebraska | Targeted site specific antisense oligodeoxynucleotide delivery method |
AU736301B2 (en) | 1996-05-01 | 2001-07-26 | Imarx Therapeutics, Inc. | Methods for delivering compounds into a cell |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US5976501A (en) * | 1996-06-07 | 1999-11-02 | Molecular Biosystems, Inc. | Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion |
US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
GB9617811D0 (en) | 1996-08-27 | 1996-10-09 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
ES2189974T3 (es) | 1996-09-11 | 2003-07-16 | Imarx Pharmaceutical Corp | Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador. |
PL332820A1 (en) | 1996-10-21 | 1999-10-11 | Nycomed Imaging As | Improved contrast media |
US6106473A (en) * | 1996-11-06 | 2000-08-22 | Sts Biopolymers, Inc. | Echogenic coatings |
US7229413B2 (en) | 1996-11-06 | 2007-06-12 | Angiotech Biocoatings Corp. | Echogenic coatings with overcoat |
BR9714181A (pt) * | 1996-12-24 | 2000-02-29 | Rhone Poulenc Agrochimie | Processo para controlar insetos por meio de aplicação de um ingrediente inseticidamente ativo, composições pesticida e afidicida, composto, e, processo para preparar o mesmo. |
DE19704398A1 (de) * | 1997-02-06 | 1998-08-13 | Mwo Ges Zur Herstellung Von Ch | Füllmasse |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6537246B1 (en) * | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
GB9708240D0 (en) * | 1997-04-23 | 1997-06-11 | Nycomed Imaging As | Improvements in or relating to contrast agents |
ES2296332T3 (es) * | 1997-04-30 | 2008-04-16 | Point Biomedical Corporation | Microparticulas que son utilizadas como agentes de contraste para la liberacion de medicamentos en el flujo sanguineo. |
US20050019266A1 (en) * | 1997-05-06 | 2005-01-27 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
AU7702798A (en) | 1997-05-30 | 1998-12-30 | Alliance Pharmaceutical Corporation | Methods and apparatus for monitoring and quantifying the movement of fluid |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US6205352B1 (en) | 1997-11-19 | 2001-03-20 | Oncology Innovations, Inc. | Sentinel node identification using non-isotope means |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US6200328B1 (en) | 1998-05-01 | 2001-03-13 | Sub Q, Incorporated | Device and method for facilitating hemostasis of a biopsy tract |
US20010045575A1 (en) | 1998-05-01 | 2001-11-29 | Mark Ashby | Device and method for facilitating hemostasis of a biopsy tract |
US6610026B2 (en) | 1998-05-01 | 2003-08-26 | Sub-Q, Inc. | Method of hydrating a sponge material for delivery to a body |
US6315753B1 (en) | 1998-05-01 | 2001-11-13 | Sub-Q, Inc. | System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge |
AU3101000A (en) * | 1998-11-25 | 2000-06-13 | Procter & Gamble Company, The | Improved uncomplexed cyclodextrin compositions for odor control |
US6127430A (en) * | 1998-12-16 | 2000-10-03 | 3M Innovative Properties Company | Microemulsions containing water and hydrofluroethers |
US6159917A (en) * | 1998-12-16 | 2000-12-12 | 3M Innovative Properties Company | Dry cleaning compositions containing hydrofluoroether |
US6444192B1 (en) | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
JP4271375B2 (ja) | 1999-02-10 | 2009-06-03 | サブ−キュー・インコーポレーテッド | 生検管路の止血を容易とするためのデバイスおよび方法 |
EP1202671A4 (en) | 1999-08-13 | 2004-11-10 | Point Biomedical Corp | MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM |
US7695492B1 (en) | 1999-09-23 | 2010-04-13 | Boston Scientific Scimed, Inc. | Enhanced bleed back system |
US6540735B1 (en) | 2000-05-12 | 2003-04-01 | Sub-Q, Inc. | System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge |
US6923525B2 (en) * | 2000-05-22 | 2005-08-02 | Seiko Epson Corporation | Head member ink repellence treating method and treating device |
WO2002005865A2 (en) * | 2000-07-14 | 2002-01-24 | Sub-Q, Inc. | Sheath-mounted arterial plug delivery device |
US7201725B1 (en) | 2000-09-25 | 2007-04-10 | Sub-Q, Inc. | Device and method for determining a depth of an incision |
NO20010234D0 (no) * | 2001-01-12 | 2001-01-12 | Nycomed Imaging As | Perfusjon avbildningsbilde |
US8187625B2 (en) | 2001-03-12 | 2012-05-29 | Boston Scientific Scimed, Inc. | Cross-linked gelatin composition comprising a wetting agent |
WO2002087636A1 (en) * | 2001-03-12 | 2002-11-07 | Sub-Q, Inc. | Methods for sterilizing cross-linked gelatin compositions |
DE10119522A1 (de) * | 2001-04-20 | 2002-12-05 | Innovacell Biotechnologie Gmbh | Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel |
US7029489B1 (en) | 2001-05-18 | 2006-04-18 | Sub-Q, Inc. | System and method for delivering hemostasis promoting material to a blood vessel puncture site |
US7037322B1 (en) | 2001-11-08 | 2006-05-02 | Sub-Q, Inc. | System and method for delivering hemostasis promoting material to a blood vessel puncture with a staging tube |
US20040126400A1 (en) * | 2002-05-03 | 2004-07-01 | Iversen Patrick L. | Delivery of therapeutic compounds via microparticles or microbubbles |
US6776995B1 (en) | 2002-05-28 | 2004-08-17 | Rina Revivo | Souffle facial and body scrub |
US20040102730A1 (en) * | 2002-10-22 | 2004-05-27 | Davis Thomas P. | System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge |
US7955353B1 (en) | 2002-11-04 | 2011-06-07 | Sub-Q, Inc. | Dissolvable closure device |
US7455680B1 (en) | 2002-11-04 | 2008-11-25 | Boston Scientific Scimed, Inc. | Apparatus and method for inhibiting blood loss |
US8317821B1 (en) | 2002-11-04 | 2012-11-27 | Boston Scientific Scimed, Inc. | Release mechanism |
US7875043B1 (en) | 2003-12-09 | 2011-01-25 | Sub-Q, Inc. | Cinching loop |
US7101578B1 (en) | 2004-03-01 | 2006-09-05 | Spa De Soleil, Inc. | Salt sorbet facial and body scrub |
JP2008510870A (ja) * | 2004-08-25 | 2008-04-10 | ハム,ヨーンシク | R502、r12またはr22代替用の混合冷媒及びそれを用いた冷凍システム |
EP1814559A1 (en) * | 2004-10-19 | 2007-08-08 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Methods and compositions for protecting cells from ultrasound-mediated cytolysis |
WO2006043359A1 (ja) * | 2004-10-22 | 2006-04-27 | Hitachi Medical Corporation | 超音波造影剤 |
US8540639B2 (en) * | 2009-04-23 | 2013-09-24 | Roberto Kusminsky | Ultrasonographic identification of a sentinel lymph node |
CA2773181C (en) | 2009-09-04 | 2018-02-27 | The University Of North Carolina At Chapel Hill | Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics |
US9427410B2 (en) | 2010-10-08 | 2016-08-30 | The University Of North Carolina At Chapel Hill | Formulation of acoustically activatable particles having low vaporization energy and methods for using same |
CA2829017C (en) | 2011-03-04 | 2020-08-25 | The Board Of Trustees Of The University Of Arkansas | Dodecafluoropentane emulsion as a stroke and ischemia therapy |
US8822549B2 (en) * | 2011-10-13 | 2014-09-02 | Jennifer L. Johnson | Buffered oxygen therapeutic |
US9700523B2 (en) | 2011-10-13 | 2017-07-11 | Nuvox Pharma Llc | Buffered oxygen therapeutic |
US9982290B2 (en) | 2012-10-04 | 2018-05-29 | The University Of North Carolina At Chapel Hill | Methods and systems for using encapsulated microbubbles to process biological samples |
US10052394B2 (en) | 2014-11-21 | 2018-08-21 | General Electric Company | Microbubble tether for diagnostic and therapeutic applications |
EP4154915A1 (en) | 2014-12-31 | 2023-03-29 | Lantheus Medical Imaging, Inc. | Lipid-encapsulated gas microsphere compositions and related methods |
CN105374266B (zh) * | 2015-12-16 | 2018-11-13 | 中山大学附属第三医院 | 一种用于模拟肿瘤超声造影的仿体模型 |
MX2018013409A (es) | 2016-05-04 | 2019-07-08 | Lantheus Medical Imaging Inc | Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido. |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
US11406722B2 (en) | 2017-03-16 | 2022-08-09 | The Board Of Regents Of The University Of Texas System | Nanodroplets with improved properties |
CN113640405A (zh) * | 2021-07-13 | 2021-11-12 | 南方电网科学研究院有限责任公司 | 一种电气设备的故障检测方法 |
Family Cites Families (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE410470C (de) * | 1921-02-15 | 1925-03-10 | Hermann Oehme Dr | Verfahren zur Extraktion des Nitrierungsproduktes des AEthylens aus Abfallsaeure |
US3898843A (en) * | 1973-05-22 | 1975-08-12 | Methven & Co Limited G | On-off flow control device and irrigation system incorporating same |
US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4265251A (en) * | 1979-06-28 | 1981-05-05 | Rasor Associates, Inc. | Method of determining pressure within liquid containing vessel |
US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
US4442843A (en) * | 1980-11-17 | 1984-04-17 | Schering, Ag | Microbubble precursors and methods for their production and use |
US4681119A (en) * | 1980-11-17 | 1987-07-21 | Schering Aktiengesellschaft | Method of production and use of microbubble precursors |
US4361979A (en) * | 1981-04-07 | 1982-12-07 | Brio Toy Ab | Connection element for making assemblies of toy units |
US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
CH664654A5 (fr) * | 1981-12-18 | 1988-03-15 | Cerac Inst Sa | Procede et dispositif pour la commande d'un moteur a courant alternatif sans balai. |
JPS5967229A (ja) * | 1982-10-08 | 1984-04-16 | Green Cross Corp:The | 超音波診断造影剤 |
US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
US4572203A (en) * | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
DE3834705A1 (de) * | 1988-10-07 | 1990-04-12 | Schering Ag | Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln |
US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5618514A (en) * | 1983-12-21 | 1997-04-08 | Nycomed Imaging As | Diagnostic and contrast agent |
US4767610A (en) * | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
DE3529195A1 (de) * | 1985-08-14 | 1987-02-26 | Max Planck Gesellschaft | Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung |
AU6621586A (en) * | 1985-11-18 | 1987-06-02 | University Of Texas System, The | Polychelating agents for image and spectral enhancement (and spectral shift) |
US5080885A (en) * | 1986-01-14 | 1992-01-14 | Alliance Pharmaceutical Corp. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
US4865836A (en) * | 1986-01-14 | 1989-09-12 | Fluoromed Pharmaceutical, Inc. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US4927623A (en) * | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
US5284645A (en) * | 1987-08-05 | 1994-02-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems |
EP0231091B1 (en) * | 1986-01-24 | 1993-03-31 | Children's Hospital Medical Center | Stable emulsions of highly fluorinated organic compound |
EP0245019A3 (en) * | 1986-04-30 | 1989-05-10 | Michael A. Davis | Low density contrast medium for diagnosis of pathologic conditions |
FR2602774B1 (fr) * | 1986-07-29 | 1990-10-19 | Atta | Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives |
JPS6360943A (ja) * | 1986-09-01 | 1988-03-17 | Green Cross Corp:The | 超音波診断造影剤 |
US5219538A (en) * | 1987-03-13 | 1993-06-15 | Micro-Pak, Inc. | Gas and oxygen carrying lipid vesicles |
US4895876A (en) * | 1987-03-20 | 1990-01-23 | Air Products And Chemicals, Inc. | Concentrated stable fluorochemical aqueous emulsions containing triglycerides |
US5354549A (en) * | 1987-07-24 | 1994-10-11 | Nycomed Imaging As | Iodinated esters |
CN1013830B (zh) * | 1987-08-26 | 1991-09-11 | 宋振才 | B超胃肠造影剂的制造工艺 |
US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
IE61591B1 (en) * | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
US5425366A (en) * | 1988-02-05 | 1995-06-20 | Schering Aktiengesellschaft | Ultrasonic contrast agents for color Doppler imaging |
ATE109663T1 (de) * | 1988-02-05 | 1994-08-15 | Schering Ag | Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika. |
US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
SU1641280A1 (ru) * | 1988-08-10 | 1991-04-15 | Научно-исследовательский институт кардиологии | Способ эхокардиографии |
US4993415A (en) * | 1988-08-19 | 1991-02-19 | Alliance Pharmaceutical Corp. | Magnetic resonance imaging with perfluorocarbon hydrides |
DE3828905A1 (de) * | 1988-08-23 | 1990-03-15 | Schering Ag | Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel |
US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
GB8900376D0 (en) * | 1989-01-09 | 1989-03-08 | Nycomed As | Iodinated esters |
US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
ES2060184T3 (es) * | 1989-06-22 | 1994-11-16 | Atta | Moleculas anfifilicas conteniendo fluor y fosforo con propiedades tensoactivas. |
JP2918063B2 (ja) * | 1989-08-30 | 1999-07-12 | カリーヒエミー アクチエンゲゼルシヤフト | 化合物aと化合物bとの混合物の分離法 |
JPH062134B2 (ja) * | 1989-09-08 | 1994-01-12 | 株式会社東芝 | 超音波診断装置 |
JPH02196730A (ja) * | 1989-12-15 | 1990-08-03 | Green Cross Corp:The | 超音波診断造影剤 |
US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5228446A (en) * | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5230882A (en) * | 1989-12-22 | 1993-07-27 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
GB9003821D0 (en) * | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
SU1718798A1 (ru) * | 1990-02-21 | 1992-03-15 | Институт медицинской радиологии АМН СССР | Способ исследовани суставов |
IN172208B (zh) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5578292A (en) * | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US5556610A (en) * | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
DE59107006D1 (de) * | 1990-04-25 | 1996-01-18 | Hoechst Ag | Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff. |
US5137928A (en) * | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
DK0531421T3 (da) * | 1990-06-01 | 1998-01-12 | Imarx Pharmaceutical Corp | Kontrastmedier til ultralydsimagografi |
US5215680A (en) * | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
FR2665705B1 (fr) * | 1990-08-09 | 1993-07-30 | Atta | Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical. |
US5310540A (en) * | 1990-10-05 | 1994-05-10 | Sintetica Sa | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
US5487390A (en) * | 1990-10-05 | 1996-01-30 | Massachusetts Institute Of Technology | Gas-filled polymeric microbubbles for ultrasound imaging |
US5236693A (en) * | 1990-11-14 | 1993-08-17 | Brigham And Women's Hospital | Medical ultrasound contrast agent and method of using same |
DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
US5107842A (en) * | 1991-02-22 | 1992-04-28 | Molecular Biosystems, Inc. | Method of ultrasound imaging of the gastrointestinal tract |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5496535A (en) * | 1991-04-12 | 1996-03-05 | Alliance Pharmaceutical Corp. | Fluorocarbon contrast media for use with MRI and radiographic imaging |
SE470086B (sv) * | 1991-04-23 | 1993-11-08 | Kabi Pharmacia Ab | Organspecifik emulsion |
US5147631A (en) * | 1991-04-30 | 1992-09-15 | Du Pont Merck Pharmaceutical Company | Porous inorganic ultrasound contrast agents |
EP0586524B2 (en) * | 1991-06-03 | 2000-11-02 | Nycomed Imaging As | Improvements in or relating to contrast agents |
WO1993000933A1 (en) * | 1991-07-05 | 1993-01-21 | University Of Rochester | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
IE80926B1 (en) * | 1991-07-05 | 1999-06-30 | Nycomed Imaging As | Improvements in or relating to contrast agents |
FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
DE4127442C2 (de) * | 1991-08-17 | 1996-08-22 | Udo Dr Gros | Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
AU679428C (en) * | 1991-09-17 | 2006-07-13 | Ge Healthcare As | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
WO1993006869A1 (en) * | 1991-10-04 | 1993-04-15 | Mallinckrodt Medical, Inc. | Gaseous ultrasound contrast agents |
US5344640A (en) * | 1991-10-22 | 1994-09-06 | Mallinckrodt Medical, Inc. | Preparation of apatite particles for medical diagnostic imaging |
US5264220A (en) * | 1991-11-12 | 1993-11-23 | Long David M Jr | Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents |
US5559523A (en) * | 1991-11-15 | 1996-09-24 | Northern Telecom Limited | Layered antenna |
US5403575A (en) * | 1991-12-12 | 1995-04-04 | Hemagen/Pfc | Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them |
GB9200387D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
PL174114B1 (pl) * | 1992-03-06 | 1998-06-30 | Nycomed Imaging As | Środek kontrastujący |
US5362478A (en) * | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5401493A (en) * | 1993-03-26 | 1995-03-28 | Molecular Biosystems, Inc. | Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same |
US5567415A (en) * | 1993-05-12 | 1996-10-22 | The Board Of Regents Of The University Of Nebraska | Ultrasound contrast agents and methods for their manufacture and use |
US5578291A (en) * | 1993-05-14 | 1996-11-26 | The Board Of Regents Of The University Of Nebraska | Method and composition for optimizing left ventricular videointensity in echocardiography |
US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
IL110185A (en) * | 1993-07-02 | 1999-05-09 | Molecular Biosystems Inc | Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas |
US5605673A (en) * | 1993-07-30 | 1997-02-25 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
US5385147A (en) * | 1993-09-22 | 1995-01-31 | Molecular Biosystems, Inc. | Method of ultrasonic imaging of the gastrointestinal tract and upper abdominal organs using an orally administered negative contrast medium |
US5406950A (en) * | 1993-12-23 | 1995-04-18 | Mallinckrodt Medical, Inc. | Inhalable contrast agent |
US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US5560364A (en) * | 1995-05-12 | 1996-10-01 | The Board Of Regents Of The University Of Nebraska | Suspended ultra-sound induced microbubble cavitation imaging |
US5606973A (en) * | 1995-06-07 | 1997-03-04 | Molecular Biosystems, Inc. | Liquid core microdroplets for ultrasound imaging |
US5611344A (en) * | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
-
1994
- 1994-01-19 US US08/182,024 patent/US5558853A/en not_active Expired - Lifetime
- 1994-01-19 DE DE69427185T patent/DE69427185T2/de not_active Expired - Fee Related
- 1994-01-19 WO PCT/US1994/000422 patent/WO1994016739A1/en not_active Application Discontinuation
- 1994-01-19 CN CN94191564A patent/CN1068230C/zh not_active Expired - Fee Related
- 1994-01-19 AT AT94908587T patent/ATE200985T1/de active
- 1994-01-19 CA CA002154590A patent/CA2154590C/en not_active Expired - Fee Related
- 1994-01-19 PL PL94309986A patent/PL176116B1/pl unknown
- 1994-01-19 JP JP51708494A patent/JP3621413B2/ja not_active Expired - Fee Related
- 1994-01-19 ES ES94908587T patent/ES2158892T3/es not_active Expired - Lifetime
- 1994-01-19 HU HU9502163A patent/HUT72323A/hu unknown
- 1994-01-19 SG SG1995002382A patent/SG52198A1/en unknown
- 1994-01-19 NZ NZ262237A patent/NZ262237A/en unknown
- 1994-01-19 SK SK930-95A patent/SK281535B6/sk unknown
- 1994-01-19 CZ CZ951916A patent/CZ191695A3/cs unknown
- 1994-01-19 EP EP94908587A patent/EP0680341B1/en not_active Expired - Lifetime
- 1994-01-19 BR BR9405667A patent/BR9405667A/pt not_active Application Discontinuation
-
1995
- 1995-06-06 US US08/469,472 patent/US5707607A/en not_active Expired - Fee Related
- 1995-07-17 NO NO952819A patent/NO952819L/no not_active Application Discontinuation
- 1995-07-24 FI FI953546A patent/FI953546A/fi unknown
-
1996
- 1996-04-18 US US08/634,654 patent/US5876696A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1068230C (zh) | 2001-07-11 |
NO952819D0 (no) | 1995-07-17 |
CA2154590C (en) | 2001-06-12 |
ES2158892T3 (es) | 2001-09-16 |
JPH08508977A (ja) | 1996-09-24 |
HU9502163D0 (en) | 1995-09-28 |
SG52198A1 (en) | 1998-09-28 |
DE69427185D1 (de) | 2001-06-13 |
ATE200985T1 (de) | 2001-05-15 |
NO952819L (no) | 1995-09-22 |
PL176116B1 (pl) | 1999-04-30 |
SK93095A3 (en) | 1995-11-08 |
EP0680341B1 (en) | 2001-05-09 |
AU680652B2 (en) | 1997-08-07 |
CZ191695A3 (en) | 1996-05-15 |
BR9405667A (pt) | 1995-11-21 |
US5558853A (en) | 1996-09-24 |
CA2154590A1 (en) | 1994-08-04 |
WO1994016739A1 (en) | 1994-08-04 |
AU6162494A (en) | 1994-08-15 |
FI953546A0 (fi) | 1995-07-24 |
US5707607A (en) | 1998-01-13 |
US5876696A (en) | 1999-03-02 |
FI953546A (fi) | 1995-09-22 |
HUT72323A (en) | 1996-04-29 |
DE69427185T2 (de) | 2001-12-06 |
PL309986A1 (en) | 1995-11-13 |
CN1119831A (zh) | 1996-04-03 |
NZ262237A (en) | 1997-06-24 |
EP0680341A1 (en) | 1995-11-08 |
JP3621413B2 (ja) | 2005-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK281535B6 (sk) | Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy | |
RU2131744C1 (ru) | Биосовместимое контрастное средство, стабильная биосовместимая коллоидная дисперсия, способ получения ультразвукового изображения животного, способы получения стабильного при хранении контрастного средства | |
CA2119129C (en) | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media | |
JP4317270B2 (ja) | 投与性組成物および磁気共鳴画像法 | |
DE69720979T2 (de) | Thermostabilisiertes kontrastmittel | |
DE69721331T2 (de) | Verbesserungen für oder in bezug auf kontrastmitteln in ultraschallbilddarstellung | |
KR100401429B1 (ko) | 오스트발드계수가낮은플루오로화에테르로안정화된기체에멀젼 | |
PL182223B1 (pl) | Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL | |
US6569404B1 (en) | Phase shift colloids as ultrasound contrast agents | |
DE60111917T2 (de) | Lyophilisierbares Kontrastmittel, gasgefüllte Mikrobläschen enthaltend | |
JPH08507786A (ja) | 肺における気体捕獲特性が低減されたフルオロカーボンエマルジョン | |
US20030032879A1 (en) | Microbubble formation using ultrasound | |
DE60006683T2 (de) | Methode um ein gasenthaltendes konstrastmittel mit einer spülflüssigkeit zu mischen vor der verabrechnung in einer kontinuierlichen infustion | |
AU710508B2 (en) | Phase shift colloids as ultrasound contrast agents | |
US20050053552A1 (en) | Phase shift colloids as ultrasound contrast agents | |
AU680652C (en) | Phase shift colloids as ultrasound contrast agents | |
US20040131547A1 (en) | Contrast agents |