ES2060184T3 - Moleculas anfifilicas conteniendo fluor y fosforo con propiedades tensoactivas. - Google Patents

Moleculas anfifilicas conteniendo fluor y fosforo con propiedades tensoactivas.

Info

Publication number
ES2060184T3
ES2060184T3 ES90910640T ES90910640T ES2060184T3 ES 2060184 T3 ES2060184 T3 ES 2060184T3 ES 90910640 T ES90910640 T ES 90910640T ES 90910640 T ES90910640 T ES 90910640T ES 2060184 T3 ES2060184 T3 ES 2060184T3
Authority
ES
Spain
Prior art keywords
amphyphilic
phosphorus
containing fluorine
molecules containing
tensoactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90910640T
Other languages
English (en)
Inventor
Jean Riess
Francois Jeanneaux
Marie-Pierre Krafft
Catherine Santaella
Pierre Vierling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATTA
Original Assignee
ATTA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ATTA filed Critical ATTA
Application granted granted Critical
Publication of ES2060184T3 publication Critical patent/ES2060184T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings

Abstract

SE DESCRIBEN UNOS COMPUESTOS DE FORMULA GENERAL (I) O (II) QUE SON UTILES COMO REVESTIMIENTOS EN LA PREPARACION DE EMULSIONES DE FLUORCARBON, QUE PUEDEN SER UTILIZADAS COMO SUSTITUTOS DE LA SANGRE, PORTADORES DE OXIGENO, Y PARA MUCHAS OTRAS APLICACIONES TERAPEUTICAS Y DE DIAGNOSIS. TAMBIEN SON UTILES EN FORMULACIONES LIPSOMALES QUE SON A SU VEZ AGENTES TERAPEUTICOS O SUMINISTRADORES DE UN VEHICULO PARA DICHOS AGENTES.
ES90910640T 1989-06-22 1990-06-21 Moleculas anfifilicas conteniendo fluor y fosforo con propiedades tensoactivas. Expired - Lifetime ES2060184T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89401777 1989-06-22

Publications (1)

Publication Number Publication Date
ES2060184T3 true ES2060184T3 (es) 1994-11-16

Family

ID=8202964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90910640T Expired - Lifetime ES2060184T3 (es) 1989-06-22 1990-06-21 Moleculas anfifilicas conteniendo fluor y fosforo con propiedades tensoactivas.

Country Status (10)

Country Link
US (1) US5344930A (es)
EP (1) EP0478686B1 (es)
JP (1) JP2849471B2 (es)
AT (1) ATE92931T1 (es)
AU (1) AU639008B2 (es)
CA (1) CA2059288C (es)
DE (1) DE69002767T2 (es)
DK (1) DK0478686T3 (es)
ES (1) ES2060184T3 (es)
WO (1) WO1990015807A1 (es)

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Also Published As

Publication number Publication date
ATE92931T1 (de) 1993-08-15
CA2059288C (en) 2001-02-13
EP0478686A1 (en) 1992-04-08
AU6037790A (en) 1991-01-08
DE69002767D1 (de) 1993-09-16
AU639008B2 (en) 1993-07-15
JPH05501861A (ja) 1993-04-08
WO1990015807A1 (en) 1990-12-27
DK0478686T3 (da) 1993-11-29
JP2849471B2 (ja) 1999-01-20
CA2059288A1 (en) 1990-12-23
US5344930A (en) 1994-09-06
EP0478686B1 (en) 1993-08-11
DE69002767T2 (de) 1994-03-17

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