SK121896A3 - Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction - Google Patents
Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction Download PDFInfo
- Publication number
- SK121896A3 SK121896A3 SK1218-96A SK121896A SK121896A3 SK 121896 A3 SK121896 A3 SK 121896A3 SK 121896 A SK121896 A SK 121896A SK 121896 A3 SK121896 A3 SK 121896A3
- Authority
- SK
- Slovakia
- Prior art keywords
- endothelial
- compounds
- nitric oxide
- releasing
- dab
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4410997A DE4410997A1 (de) | 1994-03-30 | 1994-03-30 | Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen |
PCT/DE1995/000421 WO1995026725A1 (de) | 1994-03-30 | 1995-03-28 | Pharmazeutische zubereitingen und arzneistoffe zur prävention und behandlung endothelialer dysfunktion |
Publications (1)
Publication Number | Publication Date |
---|---|
SK121896A3 true SK121896A3 (en) | 1998-10-07 |
Family
ID=6514213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1218-96A SK121896A3 (en) | 1994-03-30 | 1995-03-28 | Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0752858A1 (lt) |
JP (1) | JPH09510979A (lt) |
CN (1) | CN1150387A (lt) |
BG (1) | BG63073B1 (lt) |
CA (1) | CA2186783A1 (lt) |
CZ (1) | CZ283696A3 (lt) |
DE (2) | DE4410997A1 (lt) |
EE (1) | EE9600139A (lt) |
FI (1) | FI963883A0 (lt) |
HU (1) | HU220165B (lt) |
IS (1) | IS4365A (lt) |
LT (1) | LT4310B (lt) |
LV (1) | LV11666B (lt) |
MX (1) | MX9604434A (lt) |
NO (1) | NO964102D0 (lt) |
PL (1) | PL316528A1 (lt) |
SI (1) | SI9520047A (lt) |
SK (1) | SK121896A3 (lt) |
WO (1) | WO1995026725A1 (lt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9423868D0 (en) * | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
DE19604361C2 (de) * | 1996-02-07 | 1999-01-14 | Sanol Arznei Schwarz Gmbh | Verwendung gasdichter Primärpackmittel für pharmazeutische Zusammensetzungen |
DE19654895C2 (de) * | 1996-02-07 | 2000-07-27 | Sanol Arznei Schwarz Gmbh | Detektionsverfahren |
DE19726812A1 (de) * | 1997-06-25 | 1999-01-07 | Isis Pharma Gmbh | Neue Derivate des Pentaerythrits, deren Herstellung und Verwendung sowie Intermediate zur Synthese derselben |
US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
ZA989356B (en) * | 1997-10-16 | 1998-11-16 | Isis Pharma Gmbh | Pharmaceutical preparations |
DE19745622A1 (de) * | 1997-10-16 | 1999-04-22 | Isis Pharma Gmbh | Neue Salpetersäureester des Pentaerythrits |
JP5187991B2 (ja) * | 1997-10-17 | 2013-04-24 | アーク・セラピューティックス・リミテッド | レニン−アンジオテンシン系の阻害剤の使用 |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
AU5503199A (en) * | 1998-06-24 | 2000-01-10 | Alpharma-Isis Gmbh And Co. Kg | Analytic substrates and antioxidative agents |
US6465463B1 (en) | 1999-09-08 | 2002-10-15 | Nitromed, Inc. | Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
AU780261B2 (en) | 1999-10-29 | 2005-03-10 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7537785B2 (en) | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
US7235237B2 (en) | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7708989B2 (en) | 1999-10-29 | 2010-05-04 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
WO2008124505A2 (en) * | 2007-04-05 | 2008-10-16 | Ironwood Pharmaceuticals,Inc. | Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders |
US9365574B2 (en) * | 2010-05-27 | 2016-06-14 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
RU2467748C1 (ru) * | 2011-08-08 | 2012-11-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" | Производное 3-(2,2,2-триметилгидразиний)пропионата - глицинат 3-(2,2,2-триметилгидразиний)пропионат калия, обладающее эндотелиопротекторной активностью |
JP5360939B2 (ja) * | 2011-09-28 | 2013-12-04 | 国立大学法人徳島大学 | ニトロソニフェジピン誘導体を有効成分とする動脈硬化症治療剤 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR984523A (fr) * | 1949-02-10 | 1951-07-06 | Phosphate de trinitro-triéthanolamine et procédé de préparation | |
DE1695897C3 (de) * | 1966-07-04 | 1979-02-15 | Takeda Chemical Industries Ltd | N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US3886186A (en) * | 1971-04-29 | 1975-05-27 | American Home Prod | Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol |
GB1356374A (en) * | 1971-04-29 | 1974-06-12 | American Home Prod | Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol |
DE2532124C3 (de) * | 1975-07-18 | 1979-04-19 | Cassella Ag, 6000 Frankfurt | Verfahren zur Herstellung von 4-Amino-morpholin |
US4200640A (en) * | 1976-04-02 | 1980-04-29 | Chugai Seiyaku Kabushiki Kaisha | Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use |
DE2623800C3 (de) * | 1976-05-28 | 1978-11-23 | Sanol Schwarz-Monheim Gmbh, 4000 Duesseldorf | Obersättigte wässerige Isosorbiddinitrat-Lösung, Herstellungsverfahren und Verwendung |
US4065488A (en) * | 1977-02-24 | 1977-12-27 | American Home Products Corporation | Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate |
DE2903927C2 (de) * | 1979-02-02 | 1981-03-12 | Sanol Schwarz-Monheim Gmbh, 4019 Monheim | Verfahren zur selektiven Herstellung von Isosorbid-5-nitrat |
DE3028873C2 (de) * | 1980-07-30 | 1983-10-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Herstellung von 1,4 zu 3,6-Dianhydro-D-glucit-5-nitrat (Isosorbid-5-nitrat) |
DE3102947A1 (de) * | 1981-01-29 | 1982-09-02 | Heinrich Mack Nachf., 7918 Illertissen | Verfahren zur herstellung von isosorbid-5-nitrat |
FR2500835A1 (fr) * | 1981-02-27 | 1982-09-03 | Poudres & Explosifs Ste Nale | Procede de synthese des mononitrates d'isosorbide |
DE3117612A1 (de) * | 1981-05-05 | 1982-11-25 | Cassella Ag, 6000 Frankfurt | Verfahren zur herstellung von isosorbid-5-nitrat |
DE3124410A1 (de) * | 1981-06-22 | 1983-01-05 | Heinrich Mack Nachf., 7918 Illertissen | Verfahren zur herstellung von isosorbid-2-nitrat |
JPS5910513A (ja) * | 1982-07-12 | 1984-01-20 | Nitto Electric Ind Co Ltd | 医薬製剤 |
DE3325652A1 (de) * | 1983-07-15 | 1985-01-24 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Feste, stabile isosorbid-5-mononitrat enthaltende arzneimittelzubereitungen und verfahren zu ihrer herstellung |
DE3328094A1 (de) * | 1983-08-04 | 1985-02-21 | H. Trommsdorff GmbH & Co, 5110 Alsdorf | Phlegmatisierte pharmazeutische zubereitung von explosionsfaehigen salpetersaeureestern |
DE3479800D1 (en) * | 1983-11-25 | 1989-10-26 | Toshin Chemical Co | A method for the preparation of isosorbide-5-nitrate and sodium isosorbide-5-nitrate hydrate as a precursor thereof |
DD244980A1 (de) * | 1985-12-18 | 1987-04-22 | Isis Chemie Zwickau Veb | Verfahren zur herstellung von n-morpholinoaminoacetonitril und dessen hydrochlorid |
DD293492A5 (de) * | 1987-11-26 | 1991-09-05 | Isis-Chemie Gmbh,De | Verfahren zur herstellung einer glyceroltrinitrat-arzneiform mit gleichmaessig verzoegerter arzneistofffreisetzung |
US5284872A (en) * | 1989-09-12 | 1994-02-08 | Schwarz Pharma Ag | Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof |
DE4007705C1 (lt) * | 1990-03-10 | 1991-09-26 | G. Pohl-Boskamp Gmbh & Co. Chemisch-Pharmazeutische Fabrik, 2214 Hohenlockstedt, De | |
DE4038203A1 (de) * | 1990-11-30 | 1992-06-04 | Kali Chemie Pharma Gmbh | Pharmazeutische spray-zubereitungen mit coronaraktiven wirkstoffen |
US5385937A (en) * | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
-
1994
- 1994-03-30 DE DE4410997A patent/DE4410997A1/de not_active Withdrawn
-
1995
- 1995-03-28 WO PCT/DE1995/000421 patent/WO1995026725A1/de not_active Application Discontinuation
- 1995-03-28 MX MX9604434A patent/MX9604434A/es not_active IP Right Cessation
- 1995-03-28 HU HU9602671A patent/HU220165B/hu not_active IP Right Cessation
- 1995-03-28 CA CA002186783A patent/CA2186783A1/en not_active Abandoned
- 1995-03-28 SK SK1218-96A patent/SK121896A3/sk unknown
- 1995-03-28 EP EP95914275A patent/EP0752858A1/de not_active Withdrawn
- 1995-03-28 JP JP7525343A patent/JPH09510979A/ja active Pending
- 1995-03-28 DE DE19580261T patent/DE19580261D2/de not_active Expired - Lifetime
- 1995-03-28 EE EE9600139A patent/EE9600139A/xx unknown
- 1995-03-28 CZ CZ962836A patent/CZ283696A3/cs unknown
- 1995-03-28 CN CN95193401A patent/CN1150387A/zh active Pending
- 1995-03-28 SI SI9520047A patent/SI9520047A/sl unknown
- 1995-03-28 PL PL95316528A patent/PL316528A1/xx unknown
-
1996
- 1996-09-19 LV LVP-96-378A patent/LV11666B/lv unknown
- 1996-09-25 IS IS4365A patent/IS4365A/is unknown
- 1996-09-27 NO NO964102A patent/NO964102D0/no not_active Application Discontinuation
- 1996-09-27 FI FI963883A patent/FI963883A0/fi unknown
- 1996-10-22 LT LT96-148A patent/LT4310B/lt not_active IP Right Cessation
- 1996-10-22 BG BG100930A patent/BG63073B1/bg unknown
Also Published As
Publication number | Publication date |
---|---|
IS4365A (is) | 1996-09-25 |
LT4310B (lt) | 1998-03-25 |
LV11666A (lv) | 1997-02-20 |
CA2186783A1 (en) | 1995-10-12 |
NO964102L (no) | 1996-09-27 |
JPH09510979A (ja) | 1997-11-04 |
LV11666B (en) | 1997-06-20 |
PL316528A1 (en) | 1997-01-20 |
HU220165B (hu) | 2001-11-28 |
HU9602671D0 (en) | 1996-11-28 |
AU698359B2 (en) | 1998-10-29 |
AU2134595A (en) | 1995-10-23 |
FI963883A (fi) | 1996-09-27 |
HUT76676A (en) | 1997-10-28 |
DE4410997A1 (de) | 1995-10-26 |
CN1150387A (zh) | 1997-05-21 |
BG63073B1 (bg) | 2001-03-30 |
LT96148A (en) | 1997-12-29 |
DE19580261D2 (de) | 1997-05-28 |
BG100930A (en) | 1997-07-31 |
MX9604434A (es) | 1997-12-31 |
EE9600139A (et) | 1997-04-15 |
FI963883A0 (fi) | 1996-09-27 |
CZ283696A3 (cs) | 1998-03-18 |
NO964102D0 (no) | 1996-09-27 |
EP0752858A1 (de) | 1997-01-15 |
WO1995026725A1 (de) | 1995-10-12 |
SI9520047A (en) | 1997-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK121896A3 (en) | Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction | |
US5973011A (en) | Pharmaceutical preparations and medicaments for the prevention and treatment of endothelial dysfunction | |
US7244749B2 (en) | Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases | |
EP0930076B1 (en) | Pharmaceutical compositions comprising CS-866 and insulin resistance improving agents and their use for the treatment of arteriosclerosis and xanthoma | |
EP1303304A2 (en) | Pharmaceutical combinations for treatment and prevention of diabetes mellitus | |
AU2002211452A1 (en) | Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases | |
CZ20012343A3 (cs) | Kombinace inhibitorů transportu ľlučové kyseliny v ileu a derivátů kyseliny nikotinové pro kardiovaskulární indikace | |
AU2003258909A1 (en) | Dosage forms and related therapies | |
WO1994016740A1 (en) | The use of nitric oxide-delivering compounds for the treatment or prevention of alcoholic liver injury | |
US20220265776A1 (en) | Combination | |
CA2355645A1 (en) | Increasing brain glucose utilization | |
JPH0296537A (ja) | プロタミンの使用における有害作用の予防または減少用組成物 | |
CA2501717C (en) | Use of epothilone derivatives for the treatment of hyperparathyroidism | |
Bennett et al. | Coronary sinus diverticulum containing posteroseptal accessory pathway | |
Morris et al. | Small molecule approaches to the prevention of restenosis | |
JP2008094852A (ja) | 医薬 | |
JPS63201125A (ja) | 胃十二指腸潰瘍の治療に対する相乗的抗分泌作用を有する薬剤組成物 | |
NZ539695A (en) | Dosage forms and related therapies |