SI9012429B - Novi derivati kromana in tiokromana - Google Patents

Novi derivati kromana in tiokromana Download PDF

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Publication number
SI9012429B
SI9012429B SI9012429A SI9012429A SI9012429B SI 9012429 B SI9012429 B SI 9012429B SI 9012429 A SI9012429 A SI 9012429A SI 9012429 A SI9012429 A SI 9012429A SI 9012429 B SI9012429 B SI 9012429B
Authority
SI
Slovenia
Prior art keywords
alkyl
formula
alkenyl
compound
hydrogen
Prior art date
Application number
SI9012429A
Other languages
English (en)
Slovenian (sl)
Other versions
SI9012429A (en
Inventor
Lars-Gunnar Larsson
Rolf Noreen
Lucy Anna Renyi
Svante Bertil Ross
Daniel Dungan Sohn
Bjoern Eric Svensson
Seth Olov Thorberg
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of SI9012429A publication Critical patent/SI9012429A/sl
Publication of SI9012429B publication Critical patent/SI9012429B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Threshing Machine Elements (AREA)
  • Liquid Crystal Substances (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Harvester Elements (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Medicinal Preparation (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SI9012429A 1989-12-22 1990-12-21 Novi derivati kromana in tiokromana SI9012429B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8904361A SE8904361D0 (sv) 1989-12-22 1989-12-22 New chroman and thiochroman derivatives
YU242990A YU47936B (sh) 1989-12-22 1990-12-21 Derivati hromana i tiohromana i postupak za njihovo dobijanje

Publications (2)

Publication Number Publication Date
SI9012429A SI9012429A (en) 1997-12-31
SI9012429B true SI9012429B (sl) 1998-10-31

Family

ID=20377869

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9012429A SI9012429B (sl) 1989-12-22 1990-12-21 Novi derivati kromana in tiokromana

Country Status (42)

Country Link
EP (1) EP0460169B1 (member.php)
JP (1) JP2879972B2 (member.php)
KR (1) KR0178991B1 (member.php)
CN (1) CN1037438C (member.php)
AT (1) ATE138918T1 (member.php)
AU (1) AU641204B2 (member.php)
CA (1) CA2047237C (member.php)
CY (1) CY1991A (member.php)
CZ (1) CZ283630B6 (member.php)
DE (1) DE69027311T2 (member.php)
DK (1) DK0460169T3 (member.php)
DZ (1) DZ1469A1 (member.php)
EG (1) EG19749A (member.php)
ES (1) ES2087993T3 (member.php)
FI (1) FI102177B (member.php)
GR (1) GR3020497T3 (member.php)
HK (1) HK55897A (member.php)
HR (1) HRP920851B1 (member.php)
HU (1) HU211860A9 (member.php)
ID (1) ID945B (member.php)
IE (1) IE80753B1 (member.php)
IL (1) IL96712A (member.php)
IS (1) IS1665B (member.php)
LT (1) LT3967B (member.php)
LV (2) LV10449B (member.php)
MX (1) MX23889A (member.php)
NO (1) NO180336C (member.php)
NZ (1) NZ236407A (member.php)
PH (1) PH30797A (member.php)
PL (3) PL164592B1 (member.php)
PT (1) PT96304B (member.php)
RU (1) RU2092483C1 (member.php)
SA (1) SA90110186B1 (member.php)
SE (1) SE8904361D0 (member.php)
SG (1) SG48043A1 (member.php)
SI (1) SI9012429B (member.php)
SK (1) SK280261B6 (member.php)
TW (1) TW221056B (member.php)
UA (1) UA34416C2 (member.php)
WO (1) WO1991009853A1 (member.php)
YU (2) YU47936B (member.php)
ZA (1) ZA909708B (member.php)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
DE69124868T2 (de) * 1990-08-15 1997-07-10 Lilly Co Eli Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane
ES2102456T3 (es) * 1991-02-08 1997-08-01 Lilly Co Eli 3-amino-1,2,3,4-tetrahidronaftalenos sustituidos en el anillo.
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5434174A (en) * 1992-07-17 1995-07-18 Eli Lilly And Company Isoxazole derivatives for the treatment of irritable bowel syndrome
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
SE9703378D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
SE9703377D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
TW555757B (en) * 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
NZ526697A (en) 2001-01-16 2005-05-27 Astrazeneca Ab Therapeutic heterocyclic compounds
JP2004517129A (ja) 2001-01-16 2004-06-10 アストラゼネカ・アクチエボラーグ 治療用クロモン化合物
MXPA03006261A (es) * 2001-01-16 2003-09-22 Astrazeneca Ab Compuestos terapeuticos de cromano.
RU2193559C1 (ru) * 2001-05-16 2002-11-27 Пермская государственная фармацевтическая академия 2,4-ксилидид и м-фенетидид 2-ацетилиминокумарин-3-карбоновой кислоты, обладающие антикоагулянтной активностью
CA2453837C (en) 2001-07-20 2011-10-04 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder using eltoprazine and related compounds
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
US20080221193A1 (en) * 2006-12-22 2008-09-11 Wyeth 3-amino chromane derivatives
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CN101712672B (zh) * 2008-10-06 2013-02-06 中国中医科学院中药研究所 一种治疗心脑血管系统疾病新化合物及其制备方法、用途
DE102010041948A1 (de) 2010-10-04 2012-04-05 Mahle International Gmbh Filtereinrichtung
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
CN116655242A (zh) * 2023-05-10 2023-08-29 东北大学 一系列有机-无机杂化金属卤化物玻璃材料及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR862239B (en) * 1985-09-03 1986-12-31 Ciba Geigy Ag 3-amino-dihydro-(1)-benzopyrans and benzothiopyrans
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
US5258287A (en) * 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53

Also Published As

Publication number Publication date
ATE138918T1 (de) 1996-06-15
HRP920851A2 (en) 1995-10-31
PL164592B1 (pl) 1994-08-31
JP2879972B2 (ja) 1999-04-05
CA2047237C (en) 2003-02-11
IL96712A0 (en) 1991-09-16
GR3020497T3 (en) 1996-10-31
MX23889A (es) 1993-10-01
FI913943A0 (fi) 1991-08-21
EP0460169A1 (en) 1991-12-11
SI9012429A (en) 1997-12-31
IS3662A7 (is) 1991-06-23
AU6977091A (en) 1991-07-24
DE69027311D1 (en) 1996-07-11
CZ283630B6 (cs) 1998-05-13
LT3967B (en) 1996-05-27
HK55897A (en) 1997-05-09
LV10449B (en) 1995-10-20
IS1665B (is) 1997-07-04
TW221056B (member.php) 1994-02-11
NO913273L (no) 1991-10-08
SG48043A1 (en) 1998-04-17
SE8904361D0 (sv) 1989-12-22
JPH04503682A (ja) 1992-07-02
CN1052669A (zh) 1991-07-03
IL96712A (en) 1995-08-31
HRP920851B1 (en) 2000-02-29
LV10449A (lv) 1995-02-20
EP0460169B1 (en) 1996-06-05
IE80753B1 (en) 1999-01-13
SK657890A3 (en) 1999-10-08
YU47936B (sh) 1996-05-20
PL293066A1 (en) 1992-08-10
NO180336C (no) 1997-04-02
UA34416C2 (uk) 2001-03-15
FI102177B1 (fi) 1998-10-30
YU72191A (sh) 1995-01-31
IE904535A1 (en) 1991-07-03
YU242990A (sh) 1993-10-20
CA2047237A1 (en) 1991-06-23
PH30797A (en) 1997-10-17
ZA909708B (en) 1991-08-28
PL164608B1 (pl) 1994-08-31
RU2092483C1 (ru) 1997-10-10
LTIP1730A (en) 1995-08-25
AU641204B2 (en) 1993-09-16
CZ657890A3 (cs) 1998-02-18
PT96304B (pt) 1998-09-30
LV11894A (lv) 1997-12-20
SK280261B6 (sk) 1999-10-08
FI102177B (fi) 1998-10-30
HU211860A9 (en) 1995-12-28
LV11894B (en) 1998-05-20
ES2087993T3 (es) 1996-08-01
PL164609B1 (en) 1994-08-31
NO913273D0 (no) 1991-08-21
CN1037438C (zh) 1998-02-18
NZ236407A (en) 1993-08-26
SA90110186B1 (ar) 2001-11-11
PT96304A (pt) 1991-09-30
YU47923B (sh) 1996-05-20
EG19749A (en) 1996-01-31
ID945B (id) 1996-09-20
KR0178991B1 (ko) 1999-03-20
KR920701193A (ko) 1992-08-11
PL293065A1 (en) 1992-08-10
DK0460169T3 (da) 1996-09-23
DE69027311T2 (de) 1996-10-24
DZ1469A1 (fr) 2004-09-13
NO180336B (no) 1996-12-23
WO1991009853A1 (en) 1991-07-11
CY1991A (en) 1997-09-05

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