HUP0000728A2 - Naftiridinkarbonsavszármazék sója, eljárás előállítására és a vegyületet tartalmazó gyógyászati készítmény - Google Patents

Naftiridinkarbonsavszármazék sója, eljárás előállítására és a vegyületet tartalmazó gyógyászati készítmény

Info

Publication number
HUP0000728A2
HUP0000728A2 HU0000728A HUP0000728A HUP0000728A2 HU P0000728 A2 HUP0000728 A2 HU P0000728A2 HU 0000728 A HU0000728 A HU 0000728A HU P0000728 A HUP0000728 A HU P0000728A HU P0000728 A2 HUP0000728 A2 HU P0000728A2
Authority
HU
Hungary
Prior art keywords
salt
producing
carboxylic acid
pharmaceutical composition
composition containing
Prior art date
Application number
HU0000728A
Other languages
English (en)
Inventor
Jay Hyok Chang
Hoon Choi
Jong Ryoo Choi
Ae Ri Kim
Jin Hwa Lee
Tae Hee Lee
Do Hyun Nam
Ki Sook Park
Original Assignee
Lg Chemical Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd. filed Critical Lg Chemical Ltd.
Publication of HUP0000728A2 publication Critical patent/HUP0000728A2/hu
Publication of HUP0000728A3 publication Critical patent/HUP0000728A3/hu
Publication of HU225412B1 publication Critical patent/HU225412B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány racém 7-[3-(aminő-metil)-4-(metőxi-iminő)-pirrőlidin-1-il]-1-ciklőprőpil-6-flűőr-4-őxő-1,4-dihidrő-1,8-naftiridin-3-kar-bőnsav metánszűlfőnátsójára és hidrátjaira, valamint a vegyületekelőállítására vőnatkőzik. A találmány tárgyát képezik a vegyületekettartalmazó gyógyászati készítmények is. A találmány szerintivegyületek és gyógyászati készítmények baktériűmellenes terápiábanalkalmazhatók. ŕ
HU0000728A 1997-03-21 1998-03-20 Salt of naphthyridine carboxylic acid derivative HU225412B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970009840 1997-03-21
PCT/KR1998/000051 WO1998042705A1 (en) 1997-03-21 1998-03-20 Salt of naphthyridine carboxylic acid derivative

Publications (3)

Publication Number Publication Date
HUP0000728A2 true HUP0000728A2 (hu) 2000-09-28
HUP0000728A3 HUP0000728A3 (en) 2002-12-28
HU225412B1 HU225412B1 (en) 2006-11-28

Family

ID=19500439

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0000728A HU225412B1 (en) 1997-03-21 1998-03-20 Salt of naphthyridine carboxylic acid derivative
HU0600401A HU227536B1 (en) 1997-03-21 1998-03-20 Naphtyridine carboxylic acid derivative salt

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0600401A HU227536B1 (en) 1997-03-21 1998-03-20 Naphtyridine carboxylic acid derivative salt

Country Status (39)

Country Link
US (9) US7700617B2 (hu)
EP (2) EP1179533B1 (hu)
JP (3) JP3759962B2 (hu)
KR (1) KR100266499B1 (hu)
CN (1) CN1131229C (hu)
AP (1) AP1331A (hu)
AR (1) AR012125A1 (hu)
AT (2) ATE257836T1 (hu)
AU (1) AU726634B2 (hu)
BG (1) BG63972B1 (hu)
BR (1) BR9808290A (hu)
CA (1) CA2283671C (hu)
CZ (2) CZ288673B6 (hu)
DE (2) DE69814378T2 (hu)
DK (2) DK1179533T3 (hu)
DZ (1) DZ2448A1 (hu)
EA (1) EA001674B1 (hu)
ES (2) ES2198697T3 (hu)
HK (1) HK1026698A1 (hu)
HU (2) HU225412B1 (hu)
ID (1) ID22681A (hu)
IL (2) IL131812A0 (hu)
IN (1) IN188178B (hu)
IS (2) IS2093B (hu)
MA (1) MA24500A1 (hu)
MY (1) MY137653A (hu)
NO (1) NO312515B1 (hu)
NZ (1) NZ337748A (hu)
OA (1) OA11161A (hu)
PE (1) PE67999A1 (hu)
PL (1) PL191815B1 (hu)
PT (2) PT981527E (hu)
SA (1) SA98181055B1 (hu)
SI (2) SI1179533T1 (hu)
SK (1) SK284107B6 (hu)
TR (1) TR199902313T2 (hu)
UA (1) UA56218C2 (hu)
WO (1) WO1998042705A1 (hu)
ZA (1) ZA982335B (hu)

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GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
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US6331550B1 (en) 1999-06-29 2001-12-18 Smithkline Beecham Corporation Methods of use of quinolone compounds against anaerobic pathogenic bacteria
US6262071B1 (en) 1999-06-29 2001-07-17 Smithkline Beecham Corporation Methods of use of antimicrobial compounds against pathogenic amycoplasma bacteria
US6803376B1 (en) 1999-06-29 2004-10-12 Smithkline Beecham Corporation Method of use of quinolone compounds against pneumococcal and haemophilus bacteria
CA2282066C (en) 1999-06-29 2010-09-07 Smithkline Beecham Corporation Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
JP2001097864A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 呼吸管および尿路病原性細菌に対するフルオロキノリン化合物の使用方法
JP2001097863A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 嫌気性病原菌に対するフルオロキノロン化合物の使用法
EP1561465A3 (en) * 1999-09-22 2005-12-21 LG Life Sciences, Ltd. Methods of use of fluoroquinolone compounds against bacteria
GR1003520B (el) * 1999-09-22 2001-01-22 Smithkline Beecham Plc Μεθοδος χρησης ενωσεων φλουοροκινολονης εναντια σε νοσοκομειακα αρνητικα κατα gramμ παθογενων βακτηριδιων
JP2001097891A (ja) * 1999-09-24 2001-04-10 Smithkline Beecham Corp 呼吸器系病原菌に対するフルオロキノロン化合物の使用法
GR1003521B (el) * 1999-09-23 2001-01-22 Smithkline Beecham Plc Μεθοδοι χρησεως ενωσεων φλουοροκινολονης εναντια κατα gram θετικων παθογονων βακτηριδιων
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SI1412078T1 (sl) 2001-08-02 2009-04-30 Lg Life Sciences Ltd Lg Twin T Postopki za pripravo amino-zaščitenih derivatov 4-aminometilen-pirolidin-3-ona, gemifloksacina ali njegove soli
MXPA04005179A (es) * 2001-11-30 2004-08-11 Lg Life Sciences Ltd Un metodo para tratar infecciones bacterianas usando gemifloxacina o una sal de la misma y una antibiotico de (-lactama.
KR100517638B1 (ko) * 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
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US7834027B2 (en) 2005-06-15 2010-11-16 Hetero Drugs Limited Gemifloxacin process and polymorphs
KR101364900B1 (ko) * 2006-03-07 2014-02-19 욱크하트 리미티드 벤조퀴놀리진-2-카르복실산의 프로드러그
WO2010001408A2 (en) * 2008-06-06 2010-01-07 Matrix Laboratories Ltd. Novel polymorphic forms of gemifloxacin mesylate
WO2010146594A1 (en) * 2009-06-16 2010-12-23 Hetero Research Foundation Novel polymorphs of gemifloxacin mesylate
EP2491921A1 (en) * 2011-02-25 2012-08-29 Deva Holding Anonim Sirketi Conservation of anhydrous form of gemifloxacin
EP3254681B1 (en) * 2012-02-27 2019-06-19 Bristol-Myers Squibb Company N-(5s,6s,9r)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl-4-(2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate salt
CZ2016104A3 (cs) * 2016-02-24 2017-09-06 Zentiva, K.S. Krystalické modifikace solí methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}fenyl)amino](fenyl)methyliden}-2-oxo-2,3-dihydro-1H-indol-6-karboxylátu a způsoby jejich přípravy

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GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process

Also Published As

Publication number Publication date
MA24500A1 (fr) 1998-10-01
SK123699A3 (en) 2000-08-14
JP4781614B2 (ja) 2011-09-28
AP9901649A0 (en) 1999-09-30
BG63972B1 (bg) 2003-08-29
ZA982335B (en) 1999-11-23
DE69814378D1 (de) 2003-06-12
SI0981527T1 (en) 2003-10-31
UA56218C2 (uk) 2003-05-15
PT1179533E (pt) 2004-05-31
HU0600401D0 (en) 2006-07-28
AR012125A1 (es) 2000-09-27
US20150291585A1 (en) 2015-10-15
HUP0600401A3 (en) 2010-05-28
US20170253588A1 (en) 2017-09-07
KR100266499B1 (ko) 2000-12-01
ATE257836T1 (de) 2004-01-15
WO1998042705A1 (en) 1998-10-01
DK1179533T3 (da) 2004-05-03
NZ337748A (en) 2001-03-30
US20090182006A1 (en) 2009-07-16
OA11161A (en) 2003-04-25
EP1179533A3 (en) 2002-03-20
US20160264569A1 (en) 2016-09-15
IS7952A (is) 2005-07-21
DZ2448A1 (fr) 2003-01-11
HK1026698A1 (en) 2000-12-22
CA2283671C (en) 2003-09-16
US20080039488A1 (en) 2008-02-14
HU227536B1 (en) 2011-08-29
JP2009051851A (ja) 2009-03-12
US20110312987A1 (en) 2011-12-22
JP3759962B2 (ja) 2006-03-29
NO994595L (no) 1999-09-21
PE67999A1 (es) 1999-09-30
US20140187576A1 (en) 2014-07-03
ES2198697T3 (es) 2004-02-01
US20130065917A1 (en) 2013-03-14
AP1331A (en) 2004-11-26
AU6636698A (en) 1998-10-20
BR9808290A (pt) 2000-05-16
PT981527E (pt) 2003-09-30
ES2213669T3 (es) 2004-09-01
PL191815B1 (pl) 2006-07-31
EP1179533B1 (en) 2004-01-14
IL131812A (en) 2006-04-10
AU726634B2 (en) 2000-11-16
IN188178B (hu) 2002-08-31
NO994595D0 (no) 1999-09-21
JP2004002413A (ja) 2004-01-08
EA199900855A1 (ru) 2000-04-24
CZ288715B6 (cs) 2001-08-15
BG103750A (en) 2000-06-30
DE69821147D1 (de) 2004-02-19
EA001674B1 (ru) 2001-06-25
IS2093B (is) 2006-04-12
DE69821147T2 (de) 2004-11-11
EP1179533A2 (en) 2002-02-13
ATE239724T1 (de) 2003-05-15
US20100240694A1 (en) 2010-09-23
SK284107B6 (sk) 2004-09-08
HUP0000728A3 (en) 2002-12-28
CN1251101A (zh) 2000-04-19
ID22681A (id) 1999-12-09
IS5181A (is) 1999-09-14
CA2283671A1 (en) 1998-10-01
TR199902313T2 (xx) 1999-12-21
HU225412B1 (en) 2006-11-28
DE69814378T2 (de) 2004-02-26
DK0981527T3 (da) 2003-09-01
PL335812A1 (en) 2000-05-22
KR19980080504A (ko) 1998-11-25
NO312515B1 (no) 2002-05-21
IS2095B (is) 2006-04-12
MY137653A (en) 2009-02-27
JP2000510484A (ja) 2000-08-15
EP0981527B1 (en) 2003-05-07
IL131812A0 (en) 2001-03-19
CZ328299A3 (cs) 2000-02-16
SI1179533T1 (en) 2004-04-30
EP0981527A1 (en) 2000-03-01
CN1131229C (zh) 2003-12-17
CZ288673B6 (cs) 2001-08-15
SA98181055B1 (ar) 2006-10-11
US7700617B2 (en) 2010-04-20

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