SI1412078T1 - Postopki za pripravo amino-zaščitenih derivatov 4-aminometilen-pirolidin-3-ona, gemifloksacina ali njegove soli - Google Patents

Postopki za pripravo amino-zaščitenih derivatov 4-aminometilen-pirolidin-3-ona, gemifloksacina ali njegove soli

Info

Publication number
SI1412078T1
SI1412078T1 SI200230778T SI200230778T SI1412078T1 SI 1412078 T1 SI1412078 T1 SI 1412078T1 SI 200230778 T SI200230778 T SI 200230778T SI 200230778 T SI200230778 T SI 200230778T SI 1412078 T1 SI1412078 T1 SI 1412078T1
Authority
SI
Slovenia
Prior art keywords
compound
production
sub
formula
provides
Prior art date
Application number
SI200230778T
Other languages
English (en)
Inventor
Clemens Michael Helmut Brechtelsbauer
Stephen Thomas Carpenter
Trevor John Grinter
Michael Anthony Harris
Yeongdae Kim
Youngwoon Kwon
Dongchul Lee
Francois Xavier Ricard
Richard Neville Saunders
Original Assignee
Lg Life Sciences Ltd Lg Twin T
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0118938A external-priority patent/GB0118938D0/en
Priority claimed from GB0217637A external-priority patent/GB0217637D0/en
Application filed by Lg Life Sciences Ltd Lg Twin T filed Critical Lg Life Sciences Ltd Lg Twin T
Publication of SI1412078T1 publication Critical patent/SI1412078T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4314—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles
    • B01F25/43141—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles composed of consecutive sections of helical formed elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/242—Tubular reactors in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/32—Packing elements in the form of grids or built-up elements for forming a unit or module inside the apparatus for mass or heat transfer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00164—Controlling or regulating processes controlling the flow
    • B01J2219/00166—Controlling or regulating processes controlling the flow controlling the residence time inside the reactor vessel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/32—Details relating to packing elements in the form of grids or built-up elements for forming a unit of module inside the apparatus for mass or heat transfer
    • B01J2219/322—Basic shape of the elements
    • B01J2219/32203—Sheets
    • B01J2219/3221—Corrugated sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/32—Details relating to packing elements in the form of grids or built-up elements for forming a unit of module inside the apparatus for mass or heat transfer
    • B01J2219/322—Basic shape of the elements
    • B01J2219/32203—Sheets
    • B01J2219/32213—Plurality of essentially parallel sheets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
SI200230778T 2001-08-02 2002-08-02 Postopki za pripravo amino-zaščitenih derivatov 4-aminometilen-pirolidin-3-ona, gemifloksacina ali njegove soli SI1412078T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0118938A GB0118938D0 (en) 2001-08-02 2001-08-02 Novel process
GB0217637A GB0217637D0 (en) 2002-07-30 2002-07-30 Novel processes
EP02755123A EP1412078B1 (en) 2001-08-02 2002-08-02 Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one, gemifloxacin or a salt thereof
PCT/GB2002/003585 WO2003011450A1 (en) 2001-08-02 2002-08-02 Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof

Publications (1)

Publication Number Publication Date
SI1412078T1 true SI1412078T1 (sl) 2009-04-30

Family

ID=26246399

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200230778T SI1412078T1 (sl) 2001-08-02 2002-08-02 Postopki za pripravo amino-zaščitenih derivatov 4-aminometilen-pirolidin-3-ona, gemifloksacina ali njegove soli

Country Status (12)

Country Link
US (1) US7199242B2 (sl)
EP (1) EP1412078B1 (sl)
JP (1) JP2005500350A (sl)
KR (1) KR100892864B1 (sl)
AT (1) ATE410225T1 (sl)
CY (1) CY1108812T1 (sl)
DE (1) DE60229255D1 (sl)
DK (1) DK1412078T3 (sl)
ES (1) ES2314082T3 (sl)
PT (1) PT1412078E (sl)
SI (1) SI1412078T1 (sl)
WO (1) WO2003011450A1 (sl)

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KR100653334B1 (ko) 2003-03-07 2006-12-04 주식회사 엘지생명과학 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법
WO2006030952A1 (ja) * 2004-09-17 2006-03-23 Ebara Corporation 流体混合器
US7834027B2 (en) * 2005-06-15 2010-11-16 Hetero Drugs Limited Gemifloxacin process and polymorphs
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
KR100894889B1 (ko) * 2007-12-17 2009-04-30 삼성전기주식회사 교반 기능을 갖는 토출 장치
JP5604038B2 (ja) * 2008-08-25 2014-10-08 株式会社日立製作所 反応装置及び反応プラント
CN104693088B (zh) * 2013-12-06 2018-01-05 常州市勇毅生物药业有限公司 一种吉米沙星侧链的制备方法
US10159953B2 (en) 2015-11-12 2018-12-25 Uop Llc Reactor for use with an ionic liquid catalyst
EP3960282B1 (en) * 2019-04-25 2024-04-17 JGC Japan Corporation Fluid mixing unit and fluid mixing method
JP7542067B2 (ja) * 2019-12-19 2024-08-29 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション ハロゲン化アルコキシエタンの調製
CN113773240B (zh) * 2021-10-12 2022-05-31 北京阳光诺和药物研究股份有限公司 吉米沙星侧链化合物的制备方法
CN114349676B (zh) * 2022-03-21 2022-09-02 凯莱英生命科学技术(天津)有限公司 N-Boc-2,5-二氢吡咯连续合成的方法

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EP0478497B1 (de) 1990-09-19 1994-03-30 Sulzer Chemtech AG Statischer Mischer mit rohrartigem Gehäuse
JP2851454B2 (ja) 1991-06-18 1999-01-27 三井化学株式会社 フェノキシアミン類の製造方法
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Also Published As

Publication number Publication date
ATE410225T1 (de) 2008-10-15
WO2003011450A1 (en) 2003-02-13
KR20040058170A (ko) 2004-07-03
ES2314082T3 (es) 2009-03-16
US7199242B2 (en) 2007-04-03
JP2005500350A (ja) 2005-01-06
US20050043546A1 (en) 2005-02-24
CY1108812T1 (el) 2014-04-09
EP1412078B1 (en) 2008-10-08
KR100892864B1 (ko) 2009-04-15
DE60229255D1 (de) 2008-11-20
EP1412078A1 (en) 2004-04-28
PT1412078E (pt) 2009-01-08
DK1412078T3 (da) 2009-02-02

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