CY1108812T1 - Διαδικασιες για την παρασκευη amino - προστατευμενων παραγωγων της 4-αμινομεθυλενο-πυρρολιδιν-3-ονης, γεμιφλοξακινης ή ενος αλατος αυτης - Google Patents

Διαδικασιες για την παρασκευη amino - προστατευμενων παραγωγων της 4-αμινομεθυλενο-πυρρολιδιν-3-ονης, γεμιφλοξακινης ή ενος αλατος αυτης

Info

Publication number
CY1108812T1
CY1108812T1 CY20091100007T CY091100007T CY1108812T1 CY 1108812 T1 CY1108812 T1 CY 1108812T1 CY 20091100007 T CY20091100007 T CY 20091100007T CY 091100007 T CY091100007 T CY 091100007T CY 1108812 T1 CY1108812 T1 CY 1108812T1
Authority
CY
Cyprus
Prior art keywords
compound
production
sub
formula
provides
Prior art date
Application number
CY20091100007T
Other languages
English (en)
Inventor
Clemens Michael Helmut Brechtelsbauer
Stephen Thomas Carpenter
Trevor John Grinter
Michael Anthony Harris
Yeongdae Kim
Youngwoon Kwon
Dongchul Lee
François Xavier Ricard
Richard Neville Saunders
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0118938A external-priority patent/GB0118938D0/en
Priority claimed from GB0217637A external-priority patent/GB0217637D0/en
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of CY1108812T1 publication Critical patent/CY1108812T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • B01F25/4314—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles
    • B01F25/43141—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles composed of consecutive sections of helical formed elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/242—Tubular reactors in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/32—Packing elements in the form of grids or built-up elements for forming a unit or module inside the apparatus for mass or heat transfer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00164—Controlling or regulating processes controlling the flow
    • B01J2219/00166—Controlling or regulating processes controlling the flow controlling the residence time inside the reactor vessel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/32—Details relating to packing elements in the form of grids or built-up elements for forming a unit of module inside the apparatus for mass or heat transfer
    • B01J2219/322—Basic shape of the elements
    • B01J2219/32203—Sheets
    • B01J2219/3221—Corrugated sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/32—Details relating to packing elements in the form of grids or built-up elements for forming a unit of module inside the apparatus for mass or heat transfer
    • B01J2219/322—Basic shape of the elements
    • B01J2219/32203—Sheets
    • B01J2219/32213—Plurality of essentially parallel sheets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Η εφεύρεση παρέχει μια διαδικασία για την παρασκευή μιας ένωσης του τύπου (I): όπου R1 και R2 τα οποία μπορεί να είναι τα ίδια ή διαφορετικά, είναι αμινοπροστατευτικές ομάδες, η οποία διαδικασία περιλαμβάνει την προστασία μιας ένωσης του τύπου (II) με μέθοδο συνεχούς λειτουργίας σε φάση διαλύματος. Αυτό προσφέρει πλεονεκτήματα σε σχέση με τη λειτουργία κατά παρτίδες. Η διαδικασία πραγματοποιείται συνήθως σε εξοπλισμό της αντίδρασης διαμορφωμένο για χρήση σε μέθοδο συνεχούς διεργασίας, για παράδειγμα που περιλαμβάνει έναν ή περισσότερους στατικούς ανάμεικτες ή έναν αντιδραστήρα εμβολικής ροής. Κατά προτίμηση, ο αντιδραστήρας εμβολικής ροής περιλαμβάνει έναν επενδεδυμένο αυλωτό αντιδραστήρα εξοπλισμένο στο εσωτερικό με εσωτερικά αναμεικτικά στοιχεία τα οποία συνεχώς διαχωρίζουν και επαναμειγνύουν τα ρεύματα της αντίδρασης ενισχύοντας τη μεταφορά μάζας και θερμότητας, οπότε επιτυγχάνεται ομοιόμορφο προφίλ εμβολικής ροής με στροβιλώδη ροή του ρευστού. Η εφεύρεση παρέχει επίσης μια διαδικασία για την παρασκευή της αντιβακτηριακής ένωσης γεμιφλοξακίνης ή ενός φαρμακευτικώς αποδεκτού άλατος και/ή ένυδρης μορφής αυτής, η οποία περιλαμβάνει μετατροπή μιας ένωσης του τύπου (I). Η εφεύρεση παρέχει επίσης μια διαδικασία για την παρασκευή μιας ένωσης του τύπου (VIIIα).
CY20091100007T 2001-08-02 2009-01-08 Διαδικασιες για την παρασκευη amino - προστατευμενων παραγωγων της 4-αμινομεθυλενο-πυρρολιδιν-3-ονης, γεμιφλοξακινης ή ενος αλατος αυτης CY1108812T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0118938A GB0118938D0 (en) 2001-08-02 2001-08-02 Novel process
GB0217637A GB0217637D0 (en) 2002-07-30 2002-07-30 Novel processes
EP02755123A EP1412078B1 (en) 2001-08-02 2002-08-02 Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one, gemifloxacin or a salt thereof

Publications (1)

Publication Number Publication Date
CY1108812T1 true CY1108812T1 (el) 2014-04-09

Family

ID=26246399

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100007T CY1108812T1 (el) 2001-08-02 2009-01-08 Διαδικασιες για την παρασκευη amino - προστατευμενων παραγωγων της 4-αμινομεθυλενο-πυρρολιδιν-3-ονης, γεμιφλοξακινης ή ενος αλατος αυτης

Country Status (12)

Country Link
US (1) US7199242B2 (el)
EP (1) EP1412078B1 (el)
JP (1) JP2005500350A (el)
KR (1) KR100892864B1 (el)
AT (1) ATE410225T1 (el)
CY (1) CY1108812T1 (el)
DE (1) DE60229255D1 (el)
DK (1) DK1412078T3 (el)
ES (1) ES2314082T3 (el)
PT (1) PT1412078E (el)
SI (1) SI1412078T1 (el)
WO (1) WO2003011450A1 (el)

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Also Published As

Publication number Publication date
ATE410225T1 (de) 2008-10-15
WO2003011450A1 (en) 2003-02-13
KR20040058170A (ko) 2004-07-03
ES2314082T3 (es) 2009-03-16
US7199242B2 (en) 2007-04-03
JP2005500350A (ja) 2005-01-06
US20050043546A1 (en) 2005-02-24
EP1412078B1 (en) 2008-10-08
KR100892864B1 (ko) 2009-04-15
DE60229255D1 (de) 2008-11-20
EP1412078A1 (en) 2004-04-28
PT1412078E (pt) 2009-01-08
DK1412078T3 (da) 2009-02-02
SI1412078T1 (sl) 2009-04-30

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