WO2005051904A3 - Novel processes for the synthesis of cyclopropyl compounds - Google Patents

Novel processes for the synthesis of cyclopropyl compounds Download PDF

Info

Publication number
WO2005051904A3
WO2005051904A3 PCT/US2004/034943 US2004034943W WO2005051904A3 WO 2005051904 A3 WO2005051904 A3 WO 2005051904A3 US 2004034943 W US2004034943 W US 2004034943W WO 2005051904 A3 WO2005051904 A3 WO 2005051904A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
novel processes
cyclopropyl compounds
group
cyclopropyl
Prior art date
Application number
PCT/US2004/034943
Other languages
French (fr)
Other versions
WO2005051904A2 (en
Inventor
Srinivasan Raj Nagarajan
Hwang-Fun Lu
Original Assignee
Pharmacia Corp
Srinivasan Raj Nagarajan
Hwang-Fun Lu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp, Srinivasan Raj Nagarajan, Hwang-Fun Lu filed Critical Pharmacia Corp
Publication of WO2005051904A2 publication Critical patent/WO2005051904A2/en
Publication of WO2005051904A3 publication Critical patent/WO2005051904A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention relates to processes for the preparation of cyclopropyl compounds of Formula: (I) wherein: x is an integer selected from the group consisting of 0, 1 and 2; R1 and R2 are independently selected from the group consisting of H, C1-C6 alkyl, and halo; and R3, R4, R5, R6 and R7 are independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, and halo.
PCT/US2004/034943 2003-10-23 2004-10-22 Novel processes for the synthesis of cyclopropyl compounds WO2005051904A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51374303P 2003-10-23 2003-10-23
US60/513,743 2003-10-23

Publications (2)

Publication Number Publication Date
WO2005051904A2 WO2005051904A2 (en) 2005-06-09
WO2005051904A3 true WO2005051904A3 (en) 2005-08-25

Family

ID=34632742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/034943 WO2005051904A2 (en) 2003-10-23 2004-10-22 Novel processes for the synthesis of cyclopropyl compounds

Country Status (1)

Country Link
WO (1) WO2005051904A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2588474A4 (en) * 2010-07-01 2014-07-23 Yuhan Corp Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NEWCOMB, M. ET AL.: "Picosecond radical kinetics. Rate constants for ring openings of 2-aryl-substituted cyclopropylcarbinyl radicals.", CA. J.CHEM., vol. 77, no. 5/6, 1999, pages 1123 - 1135, XP008050187 *
RODRIQUES, K.E.: "A Novel route to Cycloüropyl Ketones, Aldehydes, and Carboxylic acids.", TETRAHED. LETT., vol. 32, no. 10, 1991, pages 1275 - 1278, XP002987399 *

Also Published As

Publication number Publication date
WO2005051904A2 (en) 2005-06-09

Similar Documents

Publication Publication Date Title
WO2005061458A3 (en) Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
WO2004082822A3 (en) Methods for isolating crystalline form i of 5-azacytidine
TW200519088A (en) Aryl or heteroaryl amide compounds
GB0129476D0 (en) Organic compounds
YU57603A (en) Phosphodiesterase 4 inhibitors
NO20065830L (en) Substituted 2-quinolyloxazoles useful as PDE4 inhibitors.
WO2005092858A3 (en) Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist
EP1775289A4 (en) Novel imidazolidine derivatives
IL175940A0 (en) Prostaglandin synthesis
HRP20050082A2 (en) 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
MY145819A (en) Process and intermediates useful in the preparation of pharmaceutical compounds as fulvestrant
WO2005060693A3 (en) 9-desoxoerythromycin compounds as prokinetic agents
HK1096548A1 (en) Imidazopyridine-derivatives as inductible no-synthase inhibitors
WO2003042169A3 (en) Process for synthesizing aspartic and glutamic acid derivatives and diazoketone intermediates thereof
TW200619201A (en) Process for the preparation of pyrazoles
DE602004003948D1 (en) PREPARATION OF 2-18F-2-DESOXY-D-GLUCOSE BY SOLID PHASE SYNTHESIS
MY139404A (en) Preparation process of some halogeno-substituted monosulfides and their hydroxymonosulfide or isothiouronium bromide equivalents as intermediates
EP1555261A4 (en) Valerolactone compounds and perfume composition
WO2002079753A3 (en) 2-aminobenzoxazole derivatives and combinatorial libraries thereof
TW200626533A (en) Hydroxy-aromatic compound, process for the preparation thereof, and use of the compound
GB0327323D0 (en) Novel pharmaceuticals
WO2003024400A3 (en) Process for the preparation of 1,5-diarylpyrazoles
WO2005051904A3 (en) Novel processes for the synthesis of cyclopropyl compounds
WO2003024958A3 (en) Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles
MXPA04005151A (en) Therapeutic compounds.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
122 Ep: pct application non-entry in european phase