DE69124868T2 - Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane - Google Patents

Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane

Info

Publication number
DE69124868T2
DE69124868T2 DE69124868T DE69124868T DE69124868T2 DE 69124868 T2 DE69124868 T2 DE 69124868T2 DE 69124868 T DE69124868 T DE 69124868T DE 69124868 T DE69124868 T DE 69124868T DE 69124868 T2 DE69124868 T2 DE 69124868T2
Authority
DE
Germany
Prior art keywords
alkyl
substituted
hydrogen
aryl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69124868T
Other languages
English (en)
Other versions
DE69124868D1 (de
Inventor
Craig Steven Hoechstetter
Diane Lynn Huser
Jr Charles Johnson Paget
John Mehnert Schaus
Robert Daniel Titus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69124868D1 publication Critical patent/DE69124868D1/de
Application granted granted Critical
Publication of DE69124868T2 publication Critical patent/DE69124868T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
DE69124868T 1990-08-15 1991-08-09 Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane Expired - Fee Related DE69124868T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56798590A 1990-08-15 1990-08-15

Publications (2)

Publication Number Publication Date
DE69124868D1 DE69124868D1 (de) 1997-04-10
DE69124868T2 true DE69124868T2 (de) 1997-07-10

Family

ID=24269428

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124868T Expired - Fee Related DE69124868T2 (de) 1990-08-15 1991-08-09 Ring-substituierte 2-Amino-1,2,3,4-tetra-hydronaphthaline, 3-Aminochromane und 3-Aminothiochromane

Country Status (25)

Country Link
US (5) US5286753A (de)
EP (1) EP0471515B1 (de)
JP (1) JPH04244050A (de)
KR (1) KR920004331A (de)
CN (1) CN1039967C (de)
AT (1) ATE149480T1 (de)
AU (1) AU652569B2 (de)
CA (1) CA2048846A1 (de)
CZ (1) CZ281137B6 (de)
DE (1) DE69124868T2 (de)
DK (1) DK0471515T3 (de)
ES (1) ES2100211T3 (de)
FI (1) FI913833A (de)
GR (1) GR3023409T3 (de)
HU (1) HU218668B (de)
IE (1) IE912880A1 (de)
IL (1) IL99175A (de)
MX (1) MX9100675A (de)
MY (1) MY110619A (de)
NO (1) NO176094C (de)
NZ (1) NZ239371A (de)
PT (1) PT98641B (de)
RU (1) RU2060245C1 (de)
YU (1) YU48695B (de)
ZA (1) ZA916425B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0389425T3 (da) * 1989-03-22 1995-05-22 Ciba Geigy Ag Benzothiopyranylaminer
US5616610A (en) * 1989-12-22 1997-04-01 Astra Aktiebolag (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
US5340838A (en) * 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
ES2100211T3 (es) * 1990-08-15 1997-06-16 Lilly Co Eli 2-amino-1,2,3,4-tetrahidronaftalenos, 3-aminocromanos y 3-aminotiocromanos sustituidos en el anillo.
NZ241495A (en) * 1991-02-08 1994-10-26 Lilly Co Eli 2-amino-1,2,3,4-tetrahydronaphthalene and 3-aminochromane derivative, preparation and pharmaceutical compositions thereof
AU654573B2 (en) * 1991-08-21 1994-11-10 Eli Lilly And Company Benzo(f)quinolinones
FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1994022495A1 (en) * 1993-03-31 1994-10-13 The Trustees Of The University Of Pennsylvania Dopamine d-3 and serotonin (5-ht1a) receptor ligands and imaging agents
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
FR2717175B1 (fr) * 1994-03-11 1996-06-14 Adir Nouveaux composés alkylaminoindanes, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
US5482942A (en) * 1994-06-28 1996-01-09 American Home Products Corporation (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
CA2288897A1 (en) * 1997-04-30 1998-11-05 Clint Duane Walker Aminotetralins as 5-ht1d.alpha. agonists
US6355674B1 (en) 1997-04-30 2002-03-12 Eli Lilly And Company Aminotetralins as 5-HT1D α Agonists
US5962488A (en) * 1998-04-08 1999-10-05 Roberts Laboratories, Inc. Stable pharmaceutical formulations for treating internal bowel syndrome containing isoxazole derivatives
FR2792529B1 (fr) * 1999-04-26 2001-09-28 Sod Conseils Rech Applic Nouvelles compositions pharmaceutiques comprenant des derives de 2-isoxazole-8-aminotetralines
US7060847B2 (en) * 2003-07-18 2006-06-13 Roche Diagnostics Operations, Inc. Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637740A (en) * 1969-04-21 1972-01-25 Pfizer Aminobenzocycloalkane compounds
US3930022A (en) * 1972-07-03 1975-12-30 Squibb & Sons Inc Certain tetrahydronaphthalenes used in the treatment of cardiac arrhythmia
EP0026848B1 (de) * 1979-09-14 1983-05-04 Sandoz Ag Tetralinderivate, ihre Herstellung und Heilmittel, welche diese Verbindungen enthalten
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
JPS5970653A (ja) * 1982-10-15 1984-04-21 Takeda Chem Ind Ltd 眼圧低下剤
US4520030A (en) * 1983-12-12 1985-05-28 Synthelabo Anti-ulcer agents
US4975461A (en) * 1986-06-19 1990-12-04 E. R. Squibb & Sons, Inc. P-aminophenols, derivatives thereof and method of use
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
DE3719924A1 (de) * 1986-12-22 1988-06-30 Bayer Ag 8-substituierte 2-aminotetraline
CA1331191C (en) * 1988-03-25 1994-08-02 Bengt Ronny Andersson Therapeutically useful tetralin derivatives
CA1335591C (en) * 1988-05-23 1995-05-16 James Arthur Nixon Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
US4873265A (en) * 1988-07-14 1989-10-10 Thomes Pharmacal Co., Inc. Anti-infective methods and compositions
IL114715A (en) * 1989-02-27 1997-01-10 Lilly Co Eli Intermediate compounds for ring-substituted 2-amino-1, 2, 3, 4-tetrahydronaphthalenes and 3-aminochromanes
CA1335106C (en) * 1989-02-27 1995-04-04 John Mehnert Schaus Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
WO1990012795A1 (en) * 1989-04-27 1990-11-01 The Upjohn Company Substituted 3-amino chromans
US5306830A (en) * 1989-04-27 1994-04-26 The Upjohn Company Substituted 3-amino chromans
BE1004067A6 (fr) * 1989-05-23 1992-09-15 Cockerill Sambre Sa Dispositif d'arret d'urgence pour installation industrielle.
SE8901889D0 (sv) * 1989-05-26 1989-05-26 Astra Ab Novel 8-substituted-2-aminotetralines
EP0476016B1 (de) * 1989-05-31 1998-10-28 PHARMACIA & UPJOHN COMPANY ZNS-wirksame 8-Heterocyclyl-2-aminotetralin Derivate
SE8904361D0 (sv) * 1989-12-22 1989-12-22 Astra Ab New chroman and thiochroman derivatives
ES2100211T3 (es) * 1990-08-15 1997-06-16 Lilly Co Eli 2-amino-1,2,3,4-tetrahidronaftalenos, 3-aminocromanos y 3-aminotiocromanos sustituidos en el anillo.
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
NZ241495A (en) * 1991-02-08 1994-10-26 Lilly Co Eli 2-amino-1,2,3,4-tetrahydronaphthalene and 3-aminochromane derivative, preparation and pharmaceutical compositions thereof
FR2689509B1 (fr) * 1992-04-01 1994-06-03 Adir Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
DE69124868D1 (de) 1997-04-10
NO176094C (no) 1995-02-01
IE912880A1 (en) 1992-02-26
CN1059903A (zh) 1992-04-01
NO913175D0 (no) 1991-08-14
CZ281137B6 (cs) 1996-06-12
RU2060245C1 (ru) 1996-05-20
US5552444A (en) 1996-09-03
ES2100211T3 (es) 1997-06-16
IL99175A (en) 1998-06-15
JPH04244050A (ja) 1992-09-01
IL99175A0 (en) 1992-07-15
US5286753A (en) 1994-02-15
NZ239371A (en) 1993-01-27
PT98641A (pt) 1992-06-30
GR3023409T3 (en) 1997-08-29
KR920004331A (ko) 1992-03-27
MY110619A (en) 1998-09-30
HU912708D0 (en) 1992-01-28
NO176094B (no) 1994-10-24
YU140291A (sh) 1994-01-20
EP0471515A1 (de) 1992-02-19
CS249391A3 (en) 1992-03-18
ZA916425B (en) 1993-04-28
FI913833A0 (fi) 1991-08-13
AU652569B2 (en) 1994-09-01
US5466709A (en) 1995-11-14
PT98641B (pt) 1999-01-29
US5426229A (en) 1995-06-20
FI913833A (fi) 1992-02-16
HU218668B (hu) 2000-10-28
EP0471515B1 (de) 1997-03-05
YU48695B (sh) 1999-07-28
CN1039967C (zh) 1998-09-30
MX9100675A (es) 1992-04-01
NO913175L (no) 1992-02-17
AU8240391A (en) 1992-02-20
ATE149480T1 (de) 1997-03-15
DK0471515T3 (da) 1997-07-21
CA2048846A1 (en) 1992-02-16
HUT61965A (en) 1993-03-29
US5470977A (en) 1995-11-28

Similar Documents

Publication Publication Date Title
ATE149480T1 (de) Ring-substituierte 2-amino-1,2,3,4-tetra- hydronaphthaline, 3-aminochromane und 3- aminothiochromane
ATE80617T1 (de) Mittel zur ortsspezifischen alkylierung.
KR930703319A (ko) 키산틴 유도체
ES2065478T3 (es) 2-amino-1,2,3,4-tetrahidronaftalenos y 3-aminocromanos sustituidos en el anillo.
ATE87921T1 (de) Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen.
DK0585116T3 (da) 1-alkoxy-naphthalen-2-carboxamidderivater med høj affinitet for serotonin 5HT1A receptoren
ATE33980T1 (de) Benzaldoxim-carbamat-derivate.
IE882107L (en) Pyrimidones
IL107389A (en) N-substituted carbonyloxyalkyl- pyrroles and insecticidal, acaricidal and molluscicidal compositions containing them
ATE123378T1 (de) Schädlingsbekämpfungsmittel.
AU5127996A (en) Substituted 6-r-1,3,4-thiadiazine-2-amines, the use thereof as anaesthetising, cardiovascular and hypometabolic agents, and a pharmaceutical composition containing them
SE7902264L (sv) N,n'-bis(fenylkarbamoylmetyl)amidiner och sett for framstellning derav

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee