YU48695B - Supstituisani u prstenu 2-amino-1,2,3,4-tetrahidronaftaleni, 3-aminohromani i postupak za njihovo dobijanje - Google Patents

Supstituisani u prstenu 2-amino-1,2,3,4-tetrahidronaftaleni, 3-aminohromani i postupak za njihovo dobijanje

Info

Publication number
YU48695B
YU48695B YU140291A YU140291A YU48695B YU 48695 B YU48695 B YU 48695B YU 140291 A YU140291 A YU 140291A YU 140291 A YU140291 A YU 140291A YU 48695 B YU48695 B YU 48695B
Authority
YU
Yugoslavia
Prior art keywords
alkyl
substituted
hydrogen
aryl
cycloalkyl
Prior art date
Application number
YU140291A
Other languages
English (en)
Other versions
YU140291A (sh
Inventor
Craig Steven Hoechstetter
Diane Lynn Huser
Charles Johnson Paget Jr.
John Mehnert Schaus
Robert Daniel Titus
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU140291A publication Critical patent/YU140291A/sh
Publication of YU48695B publication Critical patent/YU48695B/sh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pregnancy & Childbirth (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Lubricants (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Supstiuisani u prstenu 2-amin-1,2,3,4-tetrahidronaftaleni, 3-aminohromani i 3-aminotiohromani formule i njihove soli, naznaceni time, sto R je C1-C4 alkil, C3-C4 alkenil, ili ciklopropilmetil; R1 je vodonik, C1-C4 alkil, C3-C4 alkenil, ciklopropilmetil, aril(C1-C4-alkil), -COR4, -(CH2)nS(C1-C4 alkil) ili -(CH2)nCONR5R6; n je ceo broj od 1 do 4; R4 je vodonik, C1-C4 alkil, C1-C4 alkoksi, ili fenil; R5 i R6 su nezavisno vodonik, C1-C4 alkil, ili C3-C7 cikloalkil pod uslovom sto kada jedan od R5 ili R6 je cikloalkil tada drugi je vodonik; X je -CH2-, -O-, -S-, A je ili R2 je C1-C8 alkil, C1-C8 alkil supstituisan sa C1-C3 alkoksi, halo, hidroksi ili C1-C3 alkiltio, C2-C4 alkenil, aril, aril supstituisan sa C1-C3 alkoksi, halo, hidroksi, C1-C3 alkiltio, C1-C3 alkil ili trifluorometil, aril(C1-C4 - alkil), aril(C1-C4 alkil) supstituisan sa C1-C3 alkoksi, halo, hidroksi, C1-C3 alkiltio, C1-C3 alkil ili trifluorometil, C3-C7 cikloalkil-supstituisani metil, ili C3-C7 cikloalkil, pod uslovom da je: i) kada je A > C(O) i R1 je C3-C4 alkenil, R je C3-C4 alkenil takode; i ii) kada je A > C(O) i R1 je vodonik, C1-C4 alkil, 0 ciklopropilmetil, aril(C1-C4 alkil), -(CH2)nS(C1-C4 alkil) ili -(CH2)nCONR5R6 gde je aril(C1-C4 alkil) je nesto drugo, a nije naftil(C1-C4 alkil), zatim R2 je C7-C8 alkil, C1-C8 alkil supstituisan sa C1-C3 alkoksi, halo, hidroksi ili C1-C3alkiltio, C2-C4 alkenil, aril supstituisan sa hidroksi ili C1-C3 alkiltio, aril(C1-C4 alkil), aril(C1-C4 alkil)supstituisan sa C1-C3 alkoksi, halo, hidroksi, C1-C3 alkiltio, C1-C3 alkil ili trifluorometil, C6-C7 cikloalkil supstituisan metilom ili cikloheptilom. - Prijava sadrzi jos 1 nezavisan i 8 zavisnih zahteva.
YU140291A 1990-08-15 1991-08-14 Supstituisani u prstenu 2-amino-1,2,3,4-tetrahidronaftaleni, 3-aminohromani i postupak za njihovo dobijanje YU48695B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56798590A 1990-08-15 1990-08-15

Publications (2)

Publication Number Publication Date
YU140291A YU140291A (sh) 1994-01-20
YU48695B true YU48695B (sh) 1999-07-28

Family

ID=24269428

Family Applications (1)

Application Number Title Priority Date Filing Date
YU140291A YU48695B (sh) 1990-08-15 1991-08-14 Supstituisani u prstenu 2-amino-1,2,3,4-tetrahidronaftaleni, 3-aminohromani i postupak za njihovo dobijanje

Country Status (25)

Country Link
US (5) US5286753A (sh)
EP (1) EP0471515B1 (sh)
JP (1) JPH04244050A (sh)
KR (1) KR920004331A (sh)
CN (1) CN1039967C (sh)
AT (1) ATE149480T1 (sh)
AU (1) AU652569B2 (sh)
CA (1) CA2048846A1 (sh)
CZ (1) CZ281137B6 (sh)
DE (1) DE69124868T2 (sh)
DK (1) DK0471515T3 (sh)
ES (1) ES2100211T3 (sh)
FI (1) FI913833A (sh)
GR (1) GR3023409T3 (sh)
HU (1) HU218668B (sh)
IE (1) IE912880A1 (sh)
IL (1) IL99175A (sh)
MX (1) MX9100675A (sh)
MY (1) MY110619A (sh)
NO (1) NO176094C (sh)
NZ (1) NZ239371A (sh)
PT (1) PT98641B (sh)
RU (1) RU2060245C1 (sh)
YU (1) YU48695B (sh)
ZA (1) ZA916425B (sh)

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FR2691149B1 (fr) * 1992-05-18 1994-07-08 Adir Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
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FR2717175B1 (fr) * 1994-03-11 1996-06-14 Adir Nouveaux composés alkylaminoindanes, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
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US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
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CA2288897A1 (en) * 1997-04-30 1998-11-05 Clint Duane Walker Aminotetralins as 5-ht1d.alpha. agonists
US6355674B1 (en) 1997-04-30 2002-03-12 Eli Lilly And Company Aminotetralins as 5-HT1D α Agonists
US5962488A (en) 1998-04-08 1999-10-05 Roberts Laboratories, Inc. Stable pharmaceutical formulations for treating internal bowel syndrome containing isoxazole derivatives
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Also Published As

Publication number Publication date
YU140291A (sh) 1994-01-20
CN1039967C (zh) 1998-09-30
EP0471515A1 (en) 1992-02-19
ES2100211T3 (es) 1997-06-16
DE69124868T2 (de) 1997-07-10
NO176094B (no) 1994-10-24
US5286753A (en) 1994-02-15
IL99175A (en) 1998-06-15
IE912880A1 (en) 1992-02-26
IL99175A0 (en) 1992-07-15
ZA916425B (en) 1993-04-28
FI913833A (fi) 1992-02-16
FI913833A0 (fi) 1991-08-13
NO176094C (no) 1995-02-01
RU2060245C1 (ru) 1996-05-20
HU218668B (hu) 2000-10-28
US5552444A (en) 1996-09-03
CN1059903A (zh) 1992-04-01
PT98641A (pt) 1992-06-30
MY110619A (en) 1998-09-30
CZ281137B6 (cs) 1996-06-12
US5426229A (en) 1995-06-20
HU912708D0 (en) 1992-01-28
HUT61965A (en) 1993-03-29
KR920004331A (ko) 1992-03-27
DE69124868D1 (de) 1997-04-10
JPH04244050A (ja) 1992-09-01
NZ239371A (en) 1993-01-27
CS249391A3 (en) 1992-03-18
AU652569B2 (en) 1994-09-01
MX9100675A (es) 1992-04-01
AU8240391A (en) 1992-02-20
ATE149480T1 (de) 1997-03-15
EP0471515B1 (en) 1997-03-05
CA2048846A1 (en) 1992-02-16
GR3023409T3 (en) 1997-08-29
DK0471515T3 (da) 1997-07-21
US5466709A (en) 1995-11-14
NO913175L (no) 1992-02-17
PT98641B (pt) 1999-01-29
NO913175D0 (no) 1991-08-14
US5470977A (en) 1995-11-28

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