KR920004331A - 고리-치환된 2-아미노-1, 2, 3, 4-테트라하이드로나프탈렌, 3-아미노크로만, 및 3-아미노 티오크로만 - Google Patents

고리-치환된 2-아미노-1, 2, 3, 4-테트라하이드로나프탈렌, 3-아미노크로만, 및 3-아미노 티오크로만 Download PDF

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KR920004331A
KR920004331A KR1019910014065A KR910014065A KR920004331A KR 920004331 A KR920004331 A KR 920004331A KR 1019910014065 A KR1019910014065 A KR 1019910014065A KR 910014065 A KR910014065 A KR 910014065A KR 920004331 A KR920004331 A KR 920004331A
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South Korea
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alkyl
substituted
compound
hydrogen
aryl
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KR1019910014065A
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스티븐 훽스테터 크레이그
린 허서 다이안
쥬니어 챨스 존슨 파겟
메너트 샤우스 존
다니엘 티터스 로버트
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원본미기재
일라이 릴리 앤드 캄파니
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Publication of KR920004331A publication Critical patent/KR920004331A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Abstract

내용 없음

Description

고리-치환된 2-아미노-1, 2, 3, 4-테트라하이드로나프탈렌, 3-아미노크로만, 및 3-아미노티오크로만
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅰ)의 화합물 및 그의 약학적으로 허용되는 산 부가염 :
    상기 식에서,R 이 C1-C4알킬, C3-C4알케닐 또는 사이클로프로필메틸이고, R3은 수소이거나 또는 R 및 R3가 함께는 구조식 -CH2CH2CH2-의 이가 그룹을 나타내고, R1은 수소, C1-C4알킬, C3-C4알케닐, 사이클로프로필메틸, 아릴(C1-C4-알킬), -COR4, -(CH2)nS(C1-C4-알킬)또는 -(CH2)nCONR5R6이고, n은 1 내지 4의 정수이고, R4는 수소, C1-C4알킬,C1-C4알콕시 또는 페닐이고, R5및 R6는 독립적으로 수소, C1-C4알킬, 또는 C3-C7-사이클로알킬이고, 단, R5및 R6중 하나가 사이클로알킬일 때, 다른 하나는 수소이고, X는 -CH2-, -O-, -S-,〉SO, 또는〉SO2이고, A는＞C(0) 또는 〉CHOH이고, R2는 C1-C3알킬, 치환된 C1-C8알킬, C2-C4알케닐, 아릴, 치환된 아릴, 아릴(C1-C4-알킬), 치환된 아릴(C1-C4알킬), C3-C7사이클로알킬-치환된 메틸, 또는 C3-C7사이클로알킬이다.
  2. 제1항에 있어서, A가 ＞C(0)인 화합물.
  3. 제1항 또는 제2 항에 있어서, R 및 R3가 함께 결합하여 구조식 -CH2CH2CH2-의 이가 그룹을 나타내는 화합물.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, X가 -CH2-인 화합물.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, R2가 C1내지 C8알킬인 화합물.
  6. 제5항에 있어서, R2가 C1내지 C5알킬인 화합물.
  7. 제1항 내지 제6항중 어느 한 항에 있어서, R 및 R1이 모두 C1내지 C4알킬인 화합물.
  8. 제7항에 있어서, R 및 R1이 모두 n-프로필인 화합물.
  9. 제1항 내지 제8항중 어느 한 항에 있어서, R2가 3급-부틸인 화합물.
  10. 제1항 내지 제8항중 어느 한 항에 있어서, R2가 이소프로필인 화합물.
  11. 활성 성분으로서 A가＞C(0)인 제1항 및 제3항 내지 제10항중 어느 한 항에 청구된 화합물을 그의 하나 이상의 약학적으로 허용되는 담체, 부형제 또는 희석제와 함께 포함하는 5-HT1A작용활성을 갖는 제형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910014065A 1990-08-15 1991-08-14 고리-치환된 2-아미노-1, 2, 3, 4-테트라하이드로나프탈렌, 3-아미노크로만, 및 3-아미노 티오크로만 KR920004331A (ko)

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US56798590A 1990-08-15 1990-08-15
US07/567,985 1990-08-15

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KR920004331A true KR920004331A (ko) 1992-03-27

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US (5) US5286753A (ko)
EP (1) EP0471515B1 (ko)
JP (1) JPH04244050A (ko)
KR (1) KR920004331A (ko)
CN (1) CN1039967C (ko)
AT (1) ATE149480T1 (ko)
AU (1) AU652569B2 (ko)
CA (1) CA2048846A1 (ko)
CZ (1) CZ281137B6 (ko)
DE (1) DE69124868T2 (ko)
DK (1) DK0471515T3 (ko)
ES (1) ES2100211T3 (ko)
FI (1) FI913833A (ko)
GR (1) GR3023409T3 (ko)
HU (1) HU218668B (ko)
IE (1) IE912880A1 (ko)
IL (1) IL99175A (ko)
MX (1) MX9100675A (ko)
MY (1) MY110619A (ko)
NO (1) NO176094C (ko)
NZ (1) NZ239371A (ko)
PT (1) PT98641B (ko)
RU (1) RU2060245C1 (ko)
YU (1) YU48695B (ko)
ZA (1) ZA916425B (ko)

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Also Published As

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YU140291A (sh) 1994-01-20
CN1039967C (zh) 1998-09-30
YU48695B (sh) 1999-07-28
EP0471515A1 (en) 1992-02-19
ES2100211T3 (es) 1997-06-16
DE69124868T2 (de) 1997-07-10
NO176094B (no) 1994-10-24
US5286753A (en) 1994-02-15
IL99175A (en) 1998-06-15
IE912880A1 (en) 1992-02-26
IL99175A0 (en) 1992-07-15
ZA916425B (en) 1993-04-28
FI913833A (fi) 1992-02-16
FI913833A0 (fi) 1991-08-13
NO176094C (no) 1995-02-01
RU2060245C1 (ru) 1996-05-20
HU218668B (hu) 2000-10-28
US5552444A (en) 1996-09-03
CN1059903A (zh) 1992-04-01
PT98641A (pt) 1992-06-30
MY110619A (en) 1998-09-30
CZ281137B6 (cs) 1996-06-12
US5426229A (en) 1995-06-20
HU912708D0 (en) 1992-01-28
HUT61965A (en) 1993-03-29
DE69124868D1 (de) 1997-04-10
JPH04244050A (ja) 1992-09-01
NZ239371A (en) 1993-01-27
CS249391A3 (en) 1992-03-18
AU652569B2 (en) 1994-09-01
MX9100675A (es) 1992-04-01
AU8240391A (en) 1992-02-20
ATE149480T1 (de) 1997-03-15
EP0471515B1 (en) 1997-03-05
CA2048846A1 (en) 1992-02-16
GR3023409T3 (en) 1997-08-29
DK0471515T3 (da) 1997-07-21
US5466709A (en) 1995-11-14
NO913175L (no) 1992-02-17
PT98641B (pt) 1999-01-29
NO913175D0 (no) 1991-08-14
US5470977A (en) 1995-11-28

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WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid