SI9012379B - Antraciklinski glikozidi in postopek za njihovo pripravo - Google Patents
Antraciklinski glikozidi in postopek za njihovo pripravo Download PDFInfo
- Publication number
- SI9012379B SI9012379B SI9012379A SI9012379A SI9012379B SI 9012379 B SI9012379 B SI 9012379B SI 9012379 A SI9012379 A SI 9012379A SI 9012379 A SI9012379 A SI 9012379A SI 9012379 B SI9012379 B SI 9012379B
- Authority
- SI
- Slovenia
- Prior art keywords
- formula
- compound
- preparation
- derivative
- antracycline
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 229930182470 glycoside Natural products 0.000 title 1
- 150000002338 glycosides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 4
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 claims 2
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical class N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 101000837626 Homo sapiens Thyroid hormone receptor alpha Proteins 0.000 claims 1
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 claims 1
- 102100028702 Thyroid hormone receptor alpha Human genes 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 1
- 230000026045 iodination Effects 0.000 claims 1
- 238000006192 iodination reaction Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 238000006277 sulfonation reaction Methods 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229960004679 doxorubicin Drugs 0.000 abstract 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N doxorubicine Natural products O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/313—Compounds having groups containing halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898928654A GB8928654D0 (en) | 1989-12-19 | 1989-12-19 | Preparation of 2-methoxy-4-morpholinyl anthracyclines |
| GB909007513A GB9007513D0 (en) | 1990-04-03 | 1990-04-03 | Morpholinyl derivatives of doxorubicin and process for their preparation |
| YU237990A YU48136B (sh) | 1989-12-19 | 1990-12-17 | Morfolinil derivati doksorubicina i postupak za njihovo dobijanje |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9012379A SI9012379A (en) | 1997-12-31 |
| SI9012379B true SI9012379B (sl) | 2000-02-29 |
Family
ID=26296395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9012379A SI9012379B (sl) | 1989-12-19 | 1990-12-17 | Antraciklinski glikozidi in postopek za njihovo pripravo |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0434960B1 (cs) |
| JP (1) | JP3300342B2 (cs) |
| KR (1) | KR0183033B1 (cs) |
| CN (2) | CN1024922C (cs) |
| AT (1) | ATE143023T1 (cs) |
| AU (1) | AU636429B2 (cs) |
| CA (1) | CA2046857C (cs) |
| CZ (1) | CZ281949B6 (cs) |
| DE (1) | DE69028610T2 (cs) |
| DK (1) | DK0434960T3 (cs) |
| ES (1) | ES2094136T3 (cs) |
| FI (1) | FI97389C (cs) |
| GR (1) | GR3021557T3 (cs) |
| HR (1) | HRP921226B1 (cs) |
| HU (2) | HU209433B (cs) |
| IE (1) | IE81174B1 (cs) |
| IL (3) | IL96643A (cs) |
| MY (1) | MY119192A (cs) |
| NO (2) | NO175533C (cs) |
| NZ (1) | NZ243695A (cs) |
| PT (1) | PT96226B (cs) |
| RU (1) | RU2100366C1 (cs) |
| SI (1) | SI9012379B (cs) |
| SK (1) | SK278994B6 (cs) |
| TW (1) | TW208019B (cs) |
| UA (1) | UA27108A1 (cs) |
| WO (1) | WO1991009046A1 (cs) |
| YU (1) | YU48136B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| ATE344801T1 (de) * | 1999-12-29 | 2006-11-15 | Immunogen Inc | Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung |
| ES2369640T3 (es) | 2002-05-24 | 2011-12-02 | Angiotech International Ag | Composiciones y métodos para revestir implantes médicos. |
| MXPA05003183A (es) | 2002-09-26 | 2005-06-08 | Angiotech Int Ag | Evolturas perivasculares. |
| DE60331367D1 (de) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| EP1605951A1 (en) * | 2003-03-18 | 2005-12-21 | Pharmacia Italia S.p.A. | Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor |
| WO2008006720A2 (en) * | 2006-07-12 | 2008-01-17 | Nerviano Medical Sciences S.R.L. | Crystalline nemorubicin hydrochloride |
| CN101555264B (zh) * | 2008-04-11 | 2014-09-03 | 天津和美生物技术有限公司 | 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用 |
| CN101353361B (zh) * | 2008-08-08 | 2011-06-01 | 中国人民解放军第四军医大学 | 一种阿霉素前体药物的制备方法及其应用 |
| EP2646456B1 (en) * | 2010-12-02 | 2015-01-21 | Nerviano Medical Sciences S.r.l. | Process for the preparation of morpholinyl anthracycline derivatives |
| US9828405B2 (en) | 2013-04-29 | 2017-11-28 | Nerviano Medical Sciences S.R.L. | Morpholinyl anthracycline derivatives |
| JP2017502950A (ja) | 2013-12-11 | 2017-01-26 | ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ | サルモネラＴ３ＳＳエフェクタータンパク質（ＳｉｐＡ）を使用した疾患を治療するための組成物および方法 |
| RU2715902C2 (ru) | 2014-11-05 | 2020-03-04 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Функционализированные производные морфолинилантрациклина |
| CN115043895A (zh) * | 2022-07-15 | 2022-09-13 | 戊言医药科技（上海）有限公司 | 一种pnu-159682及其中间体的制备方法 |
| EP4572798A1 (en) * | 2022-08-15 | 2025-06-25 | Synaffix B.V. | Anthracyclins and conjugates thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2883443A (en) * | 1956-07-13 | 1959-04-21 | Ruetschi Karl | Lead-acid storage battery |
| US4423123A (en) * | 1980-04-17 | 1983-12-27 | Shin-Kobe Electric Machinery Co., Ltd. | Electric storage battery and a method of making the same |
| JPS57163393A (en) * | 1981-03-27 | 1982-10-07 | Microbial Chem Res Found | Novel anthracyclin derivative and its preparation |
| US4363857A (en) * | 1981-10-16 | 1982-12-14 | General Motors Corporation | Laminated metal-plastic battery grid |
| US4710564A (en) * | 1985-01-18 | 1987-12-01 | Microbial Chemistry Research Foundation | Anthracycline compounds |
| GB2172594B (en) * | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
| JPS6215323A (ja) * | 1986-02-14 | 1987-01-23 | Dainippon Ink & Chem Inc | 微多孔中空繊維の製造法 |
| US4861836A (en) * | 1986-12-23 | 1989-08-29 | Daikin Industries Ltd. | Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same |
-
1990
- 1990-11-15 DE DE69028610T patent/DE69028610T2/de not_active Expired - Fee Related
- 1990-11-15 DK DK90121905.5T patent/DK0434960T3/da active
- 1990-11-15 AT AT90121905T patent/ATE143023T1/de not_active IP Right Cessation
- 1990-11-15 ES ES90121905T patent/ES2094136T3/es not_active Expired - Lifetime
- 1990-11-15 EP EP90121905A patent/EP0434960B1/en not_active Expired - Lifetime
- 1990-12-12 IL IL9664390A patent/IL96643A/en not_active IP Right Cessation
- 1990-12-12 NZ NZ243695A patent/NZ243695A/xx unknown
- 1990-12-12 CZ CS906219A patent/CZ281949B6/cs not_active IP Right Cessation
- 1990-12-12 SK SK6219-90A patent/SK278994B6/sk unknown
- 1990-12-12 IL IL111527A patent/IL111527A/en not_active IP Right Cessation
- 1990-12-14 TW TW079110518A patent/TW208019B/zh active
- 1990-12-17 IE IE454390A patent/IE81174B1/en not_active IP Right Cessation
- 1990-12-17 PT PT96226A patent/PT96226B/pt not_active IP Right Cessation
- 1990-12-17 MY MYPI94001426A patent/MY119192A/en unknown
- 1990-12-17 SI SI9012379A patent/SI9012379B/sl not_active IP Right Cessation
- 1990-12-17 YU YU237990A patent/YU48136B/sh unknown
- 1990-12-18 RU SU915001540A patent/RU2100366C1/ru not_active IP Right Cessation
- 1990-12-18 HU HU9200656A patent/HU209433B/hu unknown
- 1990-12-18 CA CA002046857A patent/CA2046857C/en not_active Expired - Fee Related
- 1990-12-18 AU AU69194/91A patent/AU636429B2/en not_active Ceased
- 1990-12-18 WO PCT/EP1990/002229 patent/WO1991009046A1/en not_active Ceased
- 1990-12-18 UA UA5001540A patent/UA27108A1/uk unknown
- 1990-12-18 HU HU912994A patent/HU208148B/hu not_active IP Right Cessation
- 1990-12-18 CN CN90110144A patent/CN1024922C/zh not_active Expired - Fee Related
- 1990-12-18 JP JP50124491A patent/JP3300342B2/ja not_active Expired - Fee Related
- 1990-12-18 KR KR1019910700930A patent/KR0183033B1/ko not_active Expired - Fee Related
-
1991
- 1991-08-14 NO NO913176A patent/NO175533C/no unknown
- 1991-08-16 FI FI913887A patent/FI97389C/fi active
-
1992
- 1992-11-11 HR HRP-2379/90A patent/HRP921226B1/xx not_active IP Right Cessation
-
1993
- 1993-03-05 CN CN93102413A patent/CN1039708C/zh not_active Expired - Fee Related
-
1994
- 1994-03-09 NO NO940831A patent/NO176911C/no unknown
- 1994-11-04 IL IL11152794A patent/IL111527A0/xx unknown
-
1996
- 1996-11-06 GR GR960402934T patent/GR3021557T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20090819 |