SI21026B - Stabilen, nasalno, oralno ali sublingvalno uporabljiv farmacevtski pripravek - Google Patents
Stabilen, nasalno, oralno ali sublingvalno uporabljiv farmacevtski pripravek Download PDFInfo
- Publication number
- SI21026B SI21026B SI200120009A SI200120009A SI21026B SI 21026 B SI21026 B SI 21026B SI 200120009 A SI200120009 A SI 200120009A SI 200120009 A SI200120009 A SI 200120009A SI 21026 B SI21026 B SI 21026B
- Authority
- SI
- Slovenia
- Prior art keywords
- preparation
- preparation according
- desmopressin
- available
- pharmaceutical composition
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract 3
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 claims abstract 9
- 229960004281 desmopressin Drugs 0.000 claims abstract 8
- NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 claims abstract 8
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical group OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract 6
- 239000001630 malic acid Substances 0.000 claims abstract 6
- 235000011090 malic acid Nutrition 0.000 claims abstract 6
- 239000007864 aqueous solution Substances 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 230000003204 osmotic effect Effects 0.000 claims 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- FIEYHAAMDAPVCH-UHFFFAOYSA-N 2-methyl-1h-quinazolin-4-one Chemical compound C1=CC=C2NC(C)=NC(=O)C2=C1 FIEYHAAMDAPVCH-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 208000019838 Blood disease Diseases 0.000 claims 1
- 208000008967 Enuresis Diseases 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 206010051077 Post procedural haemorrhage Diseases 0.000 claims 1
- SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 claims 1
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000002686 anti-diuretic effect Effects 0.000 claims 1
- 229940124538 antidiuretic agent Drugs 0.000 claims 1
- 239000003160 antidiuretic agent Substances 0.000 claims 1
- 229960002845 desmopressin acetate Drugs 0.000 claims 1
- 201000010064 diabetes insipidus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (20)
18 PATENTNI ZAHTEVKI 1. Stabilni, nasalno, oralno ali sublingvalno uporabljiv farmacevtski pripravek za uporabo pri pacientih, v obliki tekoče, zlasti vodne raztopine desmopresina kot učinkovine, pri čemer ta raztopina vsebuje osmotik in pufer, in pri katerem vrednost PH znaša med 4 in 6, prednostno 5, označen s tem, da je pufer za stabiliziranje desmopresina predstavlja jabolčna kislina.
2. Pripravek po zahtevku 1, označen s tem, da je jabolčna kislina na voljo v nizki koncentraciji, prednostno v območju 1 do 5 mM, še zlasti približno 2,5 mM.
3. Pripravek po zahtevku 1 ali 2, označen s tem, da je jabolčna kislina na voljo kot racemat.
4. Pripravek po enem od zahtevkov 1 do 3, označen s tem, da je desmopresin na voljo v nizki koncentraciji, zlasti v območju koncentracij od 0,005 do 2 mg/ml.
5. Pripravek po zahtevku 4, označen s tem, da je pri pripravku, primernem za oralno uporabo, desmopresin na voljo v koncentraciji od 0,005 do 0,04 mg/ml.
6. Pripravek po zahtevku 4, označen s tem, da je pri pripravku, primernem za nasalno uporabo, desmopresin na voljo v koncentraciji od 0,02 do 2,0 mg/ml, prednostno 0,08 do 1,0 mg/ml, zlasti 0,1 mg/ml.
7. Pripravek po zahtevku 4, označen s tem, da je pri pripravku, primernem za sublingualno uporabo, desmopresin na voljo v koncentraciji od 0,4 do 2,0 mg/ml.
8. Pripravek po enem od zahtevkov 1 do 7, označen s tem, daje za uravnavanje osmotskega tlaka uporabljen NaCl. 19
9. Pripravek po enem od zahtevkov 1 do 8, označen s tem, da je poleg jabolčne kisline uporabljen še nadaljnji pufer, npr. acetat/ocetna kislina.
10. Pripravek po enem od zahtevkov 1 do 9, označen s tem, daje brez konservansov.
11. Pripravek po enem od zahtevkov 1 do 9, označen s tem, da pripravek vsebuje 0,05 do 0,20 mg/ml benzalkonijevega klorida.
12. Pripravek po enem od zahtevkov 1 do 9, označen s tem, da pripravek vsebuje 1 do 2,5 mg/ml, zlasti 1 do 2 mg/ml metil-estra p-hidroksi-benzojeve kisline, po potrebi v kombinaciji z do 0,2 mg/ml, prednostno 0,1 do 0,2 mg/ml, zlasti 0,15 do 0,2 mg/ml propil-estra p-hidroksi-benzojeve kisline.
13. Pripravek po enem od zahtevkov 1 do 12, označen s tem, da vsebuje 0,1 mg/ml acetata desmopresina kot tudi DL-jabolčno kislino v koncentraciji 2,5 mM ter NaCl kot osmotik, po potrebi pa tudi 0,10 mg/ml benzalkonijevega klorida kot konservans, pri čemer je vrednost pH pripravka uravnana na približno 5.
14. Pripravek po enem od zahtevkov 1 do 13, označen s tem, da je jabolčna kislina na voljo v obliki soli, npr. natrijeve soli v raztopljenem stanju.
15. Postopek priprave pripravka po enem od zahtevkov 1 do 14, vsebujočega farmacevtski preparat, pri čemer se pripravek polni v steklene posode hidrolitiČnega razreda I ali II.
16. Nasalno uporabljiv farmacevtski preparat, vsebujoč pripravek po enem od zahtevkov 1 do 14.
17. Oralno uporabljiv farmacevtski preparat, vsebujoč pripravek po enem od zahtevkov 1 do 14. 20
18. Sublingvalno uporabljiv farmacevtski preparat, vsebujoč pripravek po enem od zahtevkov 1 do 14.
19. Uporaba farmacevtskega pripravka po enem od zahtevkov 1 do 14 za pripravo zdravila za zdravljenje pacientov z antidiuretičnimi obolenji, zlasti enuresis nocturna ali diabetes insipidus.
20. Uporaba farmacevtskega pripravka po enem od zahtevkov 1 do 14 za pripravo zdravila za zdravljenje pacientov s krvnimi obolenji, zlasti hemofilijo A, Willebrand-Jiirgensovim sindromom ali postoperativnimi krvavitvami.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0023300A AT409081B (de) | 2000-02-16 | 2000-02-16 | Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung |
| PCT/AT2001/000007 WO2001060394A1 (de) | 2000-02-16 | 2001-01-10 | Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI21026A SI21026A (sl) | 2003-04-30 |
| SI21026B true SI21026B (sl) | 2004-02-29 |
Family
ID=3669975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200120009A SI21026B (sl) | 2000-02-16 | 2001-01-10 | Stabilen, nasalno, oralno ali sublingvalno uporabljiv farmacevtski pripravek |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20030119728A1 (sl) |
| EP (1) | EP1255557B1 (sl) |
| JP (1) | JP2003529562A (sl) |
| AT (2) | AT409081B (sl) |
| AU (1) | AU771251B2 (sl) |
| CA (1) | CA2399822A1 (sl) |
| CZ (1) | CZ20022686A3 (sl) |
| DE (1) | DE50100958D1 (sl) |
| DK (1) | DK1255557T3 (sl) |
| ES (1) | ES2210121T3 (sl) |
| HU (1) | HU229961B1 (sl) |
| NO (1) | NO20023875L (sl) |
| NZ (1) | NZ520396A (sl) |
| PL (1) | PL357132A1 (sl) |
| PT (1) | PT1255557E (sl) |
| SI (1) | SI21026B (sl) |
| SK (1) | SK285374B6 (sl) |
| TR (1) | TR200400234T4 (sl) |
| WO (1) | WO2001060394A1 (sl) |
| ZA (1) | ZA200205868B (sl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| WO2003097080A1 (en) * | 2002-05-15 | 2003-11-27 | Sun Pharmaceutical Industries Limited | A stable aqueous composition of a peptide |
| AT413078B (de) * | 2002-10-10 | 2005-11-15 | Gebro Pharma Gmbh | Verwendung eines puffers auf basis von apfelsäure für die herstellung einer nasal applizierbaren zubereitung |
| US7094545B2 (en) | 2003-04-30 | 2006-08-22 | Ferring Bv | Pharmaceutical composition as solid dosage form and method for manufacturing thereof |
| EP1500390B1 (en) | 2003-07-25 | 2005-08-17 | Ferring B.V. | Pharmaceutical desmopressin composition as solid dosage form and method for manufacturing thereof |
| DE60305043T2 (de) | 2003-11-13 | 2006-11-30 | Ferring B.V. | Blisterverpackung und feste Dosierungsform enthaltend Desmopressin |
| US7018653B2 (en) | 2003-12-29 | 2006-03-28 | Ferring B.V. | Method for preparing solid dosage form of desmopressin |
| JP5079257B2 (ja) * | 2005-05-16 | 2012-11-21 | 株式会社三和化学研究所 | Ｂｕｒｋｈｏｌｄｅｒｉａｃｅｐａｃｉａに対する保存剤 |
| SE0600482L (sv) * | 2006-03-02 | 2006-11-14 | Ferring Int Ct Sa | Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse |
| CA2988753A1 (en) | 2007-08-06 | 2009-02-12 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
| ES2319054B1 (es) * | 2007-08-06 | 2010-02-12 | Gp Pharm S.A. | Composicion farmaceutica oral de desmopresina. |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| ES2462465T5 (es) | 2008-05-21 | 2018-02-28 | Ferring B.V. | Desmopresina bucodispersable para aumentar el periodo inicial del sueño no alterado por nocturia |
| JO3400B1 (ar) | 2010-09-30 | 2019-10-20 | Ferring Bv | مركب صيدلاني من كاربيتوسين |
| JP2011116764A (ja) * | 2011-02-08 | 2011-06-16 | Fine Seymour H | 低用量デスモプレシンを含有する医薬組成物 |
| SG11201510647TA (en) | 2013-06-28 | 2016-01-28 | Amgen Inc | Stable liquid formulation of amg 416 (velcalcetide) |
| JP6341777B2 (ja) * | 2014-06-30 | 2018-06-13 | リプリーズ バイオファーマシューティクス，エルエルシー | 低用量デスモプレシンを含有する医薬組成物 |
| ES2923438T3 (es) * | 2014-11-20 | 2022-09-27 | Serenity Pharmaceuticals Llc | Composiciones que comprenden bajas dosis de desmopresina en combinación con un antagonista del receptor alfaadrenérgico |
| GB201721846D0 (en) * | 2017-12-22 | 2018-02-07 | Arecor Ltd | Novel composition |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61126014A (ja) * | 1984-11-22 | 1986-06-13 | Teijin Ltd | 経鼻投与用水性液剤 |
| JP2505430B2 (ja) * | 1986-11-04 | 1996-06-12 | 帝人株式会社 | 塩基性アミノ酸を含有する経鼻投与用粉末状組成物 |
| EP0432431B1 (en) * | 1989-11-16 | 1993-06-16 | PHIDEA S.p.A. | Liquid pharmaceutical composition for nasal administration containing a polypeptide as active ingredient |
| AU653026B2 (en) * | 1991-06-07 | 1994-09-15 | Teikoku Seiyaku Kabushiki Kaisha | Physiologically active polypeptide-containing pharmaceutical composition |
| JPH0640948A (ja) * | 1992-07-20 | 1994-02-15 | Kyowa Hakko Kogyo Co Ltd | イオントフォレシス用組成物 |
| JP3628713B2 (ja) * | 1993-06-07 | 2005-03-16 | 帝國製薬株式会社 | 生理学的に活性なペプチドを含有する膣投与製剤 |
| US5482931A (en) * | 1993-06-29 | 1996-01-09 | Ferring Ab | Stabilized pharmaceutical peptide compositions |
| US5674850A (en) * | 1993-12-23 | 1997-10-07 | Ferring Ab | High purity desmopressin produced in large single batches |
| CA2329004C (en) * | 1998-06-30 | 2009-04-14 | Takeda Chemical Industries, Ltd. | Combination of insulin sensitizer with anorectic for treating or preventing diabetes |
| EP1185710A2 (en) * | 1999-04-16 | 2002-03-13 | Zymetx, Inc. | Viral detection method using viral encoded enzymes and chemiluminescent substrates |
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| WO2003097080A1 (en) * | 2002-05-15 | 2003-11-27 | Sun Pharmaceutical Industries Limited | A stable aqueous composition of a peptide |
-
2000
- 2000-02-16 AT AT0023300A patent/AT409081B/de active
-
2001
- 2001-01-10 NZ NZ520396A patent/NZ520396A/en unknown
- 2001-01-10 HU HU0204550A patent/HU229961B1/hu not_active IP Right Cessation
- 2001-01-10 ES ES01901008T patent/ES2210121T3/es not_active Expired - Lifetime
- 2001-01-10 DK DK01901008T patent/DK1255557T3/da active
- 2001-01-10 CA CA002399822A patent/CA2399822A1/en not_active Abandoned
- 2001-01-10 EP EP01901008A patent/EP1255557B1/de not_active Expired - Lifetime
- 2001-01-10 SI SI200120009A patent/SI21026B/sl not_active IP Right Cessation
- 2001-01-10 US US10/203,614 patent/US20030119728A1/en not_active Abandoned
- 2001-01-10 DE DE50100958T patent/DE50100958D1/de not_active Expired - Lifetime
- 2001-01-10 WO PCT/AT2001/000007 patent/WO2001060394A1/de active IP Right Grant
- 2001-01-10 TR TR2004/00234T patent/TR200400234T4/xx unknown
- 2001-01-10 AT AT01901008T patent/ATE253928T1/de active
- 2001-01-10 PT PT01901008T patent/PT1255557E/pt unknown
- 2001-01-10 JP JP2001559490A patent/JP2003529562A/ja not_active Ceased
- 2001-01-10 CZ CZ20022686A patent/CZ20022686A3/cs unknown
- 2001-01-10 AU AU26520/01A patent/AU771251B2/en not_active Ceased
- 2001-01-10 PL PL01357132A patent/PL357132A1/xx not_active IP Right Cessation
-
2002
- 2002-01-10 SK SK1049-2002A patent/SK285374B6/sk unknown
- 2002-07-23 ZA ZA200205868A patent/ZA200205868B/en unknown
- 2002-08-15 NO NO20023875A patent/NO20023875L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA2332000A (de) | 2001-10-15 |
| HUP0204550A3 (en) | 2004-12-28 |
| EP1255557B1 (de) | 2003-11-12 |
| NZ520396A (en) | 2004-05-28 |
| SK285374B6 (sk) | 2006-12-07 |
| AU771251B2 (en) | 2004-03-18 |
| DK1255557T3 (da) | 2004-03-22 |
| HU229961B1 (hu) | 2015-03-30 |
| SK10492002A3 (sk) | 2003-02-04 |
| AU2652001A (en) | 2001-08-27 |
| HUP0204550A2 (en) | 2003-05-28 |
| CZ20022686A3 (cs) | 2003-01-15 |
| JP2003529562A (ja) | 2003-10-07 |
| NO20023875L (no) | 2002-10-11 |
| SI21026A (sl) | 2003-04-30 |
| PL357132A1 (en) | 2004-07-12 |
| NO20023875D0 (no) | 2002-08-15 |
| TR200400234T4 (tr) | 2004-03-22 |
| WO2001060394A1 (de) | 2001-08-23 |
| US20030119728A1 (en) | 2003-06-26 |
| ES2210121T3 (es) | 2004-07-01 |
| DE50100958D1 (de) | 2003-12-18 |
| ATE253928T1 (de) | 2003-11-15 |
| ZA200205868B (en) | 2004-02-10 |
| CA2399822A1 (en) | 2001-08-23 |
| AT409081B (de) | 2002-05-27 |
| EP1255557A1 (de) | 2002-11-13 |
| PT1255557E (pt) | 2004-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20090820 |