SI20008B - Improved meningococcal polysaccharide conjugate vaccine - Google Patents
Improved meningococcal polysaccharide conjugate vaccine Download PDFInfo
- Publication number
- SI20008B SI20008B SI9110243A SI9110243A SI20008B SI 20008 B SI20008 B SI 20008B SI 9110243 A SI9110243 A SI 9110243A SI 9110243 A SI9110243 A SI 9110243A SI 20008 B SI20008 B SI 20008B
- Authority
- SI
- Slovenia
- Prior art keywords
- group
- butanoyl
- polysaccharide
- pentanoyl
- modified polysaccharide
- Prior art date
Links
- 229920001282 polysaccharide Polymers 0.000 title claims abstract 19
- 239000005017 polysaccharide Substances 0.000 title claims abstract 19
- 150000004676 glycans Chemical class 0.000 title claims abstract 18
- 108010060123 Conjugate Vaccines Proteins 0.000 title 1
- 229940031670 conjugate vaccine Drugs 0.000 title 1
- 125000003047 N-acetyl group Chemical group 0.000 claims abstract 6
- 108090000623 proteins and genes Proteins 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 4
- 229960000814 tetanus toxoid Drugs 0.000 claims abstract 2
- -1 n-butanoyl Chemical group 0.000 claims 28
- 125000002252 acyl group Chemical group 0.000 claims 7
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 4
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 241000588650 Neisseria meningitidis Species 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 108010074605 gamma-Globulins Proteins 0.000 claims 2
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 108010077805 Bacterial Proteins Proteins 0.000 claims 1
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- BUACSMWVFUNQET-UHFFFAOYSA-H dialuminum;trisulfate;hydrate Chemical compound O.[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O BUACSMWVFUNQET-UHFFFAOYSA-H 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 125000000268 heptanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 241000617590 Escherichia coli K1 Species 0.000 abstract 2
- 241000588677 Neisseria meningitidis serogroup B Species 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 125000005629 sialic acid group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44819589A | 1989-12-14 | 1989-12-14 | |
| YU24391A YU24391A (sh) | 1989-12-14 | 1990-12-14 | Poboljšana meningokokna polisaharid kon-jugovana vakcina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI20008A SI20008A (sl) | 2000-02-29 |
| SI20008B true SI20008B (en) | 2001-02-28 |
Family
ID=23779371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9110243A SI20008B (en) | 1989-12-14 | 1990-12-14 | Improved meningococcal polysaccharide conjugate vaccine |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US5576002A (fr) |
| EP (1) | EP0504202B1 (fr) |
| JP (1) | JP2637845B2 (fr) |
| KR (1) | KR0158436B1 (fr) |
| CN (4) | CN1049223C (fr) |
| AR (1) | AR243934A1 (fr) |
| AT (1) | ATE121947T1 (fr) |
| AU (1) | AU641715B2 (fr) |
| BR (1) | BR9007917A (fr) |
| CA (1) | CA2071811C (fr) |
| CZ (1) | CZ283530B6 (fr) |
| DE (1) | DE69019164T2 (fr) |
| DK (1) | DK0504202T3 (fr) |
| ES (1) | ES2071288T3 (fr) |
| FI (2) | FI104539B (fr) |
| HR (1) | HRP920872A2 (fr) |
| HU (2) | HU218146B (fr) |
| IE (1) | IE68414B1 (fr) |
| IL (1) | IL96676A (fr) |
| IN (1) | IN171747B (fr) |
| NO (2) | NO305275B1 (fr) |
| NZ (1) | NZ236471A (fr) |
| PH (1) | PH30305A (fr) |
| PL (2) | PL166659B1 (fr) |
| RO (1) | RO111416B1 (fr) |
| RU (1) | RU2105568C1 (fr) |
| SI (1) | SI20008B (fr) |
| WO (1) | WO1991008772A1 (fr) |
| YU (1) | YU24391A (fr) |
| ZA (1) | ZA9010065B (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648241A (en) * | 1989-09-15 | 1997-07-15 | The General Hospital Corporation | Conjugate vaccine against group B streptococcus |
| HU218146B (hu) * | 1989-12-14 | 2000-06-28 | National Research Council Of Canada | Továbbfejlesztett meningokokkusz-poliszacharid-konjugátum vakcina |
| JP4163251B2 (ja) * | 1992-09-24 | 2008-10-08 | ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | グループｂストレプトコッカス・タイプ▲ｉｉ▼およびタイプ▲ｖ▼多糖−蛋白質接合ワクチン |
| US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| US6153406A (en) * | 1993-07-23 | 2000-11-28 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B |
| US5679654A (en) * | 1994-09-02 | 1997-10-21 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5700787A (en) * | 1994-09-02 | 1997-12-23 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5747287A (en) * | 1995-04-28 | 1998-05-05 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| HUP9802199A3 (en) * | 1995-06-07 | 1999-07-28 | Smithkline Beecham Biolog | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein and use of |
| US6284884B1 (en) | 1995-06-07 | 2001-09-04 | North American Vaccine, Inc. | Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof |
| US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
| ZA97248B (en) * | 1996-01-18 | 1997-07-18 | Rohm & Haas | Method for identifying and quantifying polymers utilizing immunoassay techniques |
| CA2264735C (fr) † | 1996-08-27 | 2008-01-29 | Chiron Corporation | Glycoconjugues du groupe serologique b de neisseria meningitidis et leurs procedes d'utilisation |
| ATE252602T1 (de) | 1996-08-27 | 2003-11-15 | Chiron Corp | Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen |
| US6426074B1 (en) | 1997-03-19 | 2002-07-30 | The Brigham And Women's Hospital Inc. | Group B Streptococcus vaccine |
| EP0994723A1 (fr) | 1997-06-24 | 2000-04-26 | Chiron Corporation | Procedes permettant d'immuniser des adultes grace a des compositions de vaccins anti-meningococcique |
| PT1007546E (pt) * | 1997-08-27 | 2009-04-24 | Childrens Hosp & Res Ct Oak | Compostos miméticos moleculares de epítopos de meningococos do serogrupo b |
| AU754256C (en) | 1997-12-23 | 2004-05-20 | Pfizer Ireland Pharmaceuticals | Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines |
| AU771330B2 (en) * | 1998-08-19 | 2004-03-18 | Baxter Healthcare Sa | Immunogenic beta-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an N-acryloylated polysaccharide |
| US6436653B1 (en) | 1998-12-15 | 2002-08-20 | Exiqon A/S | Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces |
| US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| US6518037B2 (en) * | 1999-11-12 | 2003-02-11 | University Of Iowa Research Foundation | Two-component system that controls bacterial membrane synthesis |
| GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| JP2004529643A (ja) | 2001-04-17 | 2004-09-30 | カイロン コーポレイション | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0121591D0 (en) * | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| PT1777236T (pt) * | 2002-03-26 | 2017-02-13 | Glaxosmithkline Biologicals Sa | Sacáridos modificados possuindo estabilidade melhorada em água para utilização como um medicamento |
| EP1638581A2 (fr) * | 2003-03-31 | 2006-03-29 | The Brigham And Women's Hospital, Inc. | Immunomodulateurs zwitterioniques destines au traitement de l'asthme et des allergies |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| WO2005016949A2 (fr) | 2003-08-12 | 2005-02-24 | Lipoxen Technologies Limited | Derives d'acide sialique |
| US8148335B2 (en) | 2004-06-23 | 2012-04-03 | Children's Hospital & Research Center Oakland | De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy |
| RU2404995C2 (ru) | 2004-06-23 | 2010-11-27 | Чилдрен'С Хоспитал Энд Рисерч Сентер Эт Окленд | Производные полисахаридов и их применение для индуцирования иммунной реакции |
| GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
| NZ564606A (en) | 2005-06-27 | 2010-10-29 | Glaxosmithkline Biolog Sa | Immunogenic composition comprising atleast two N. meningitidis capsular polysaccharides conjugated through a linker protein |
| WO2007092451A2 (fr) | 2006-02-06 | 2007-08-16 | The Brigham And Women's Hospital, Inc. | Polysaccharides zwitterioniques pour favoriser la maturation du système immunitaire et la santé |
| GB0611914D0 (en) | 2006-06-15 | 2006-07-26 | Teti Giuseppe | Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide |
| EP1872791A1 (fr) * | 2006-06-30 | 2008-01-02 | Institut Pasteur | Utilisation de polysaccharides bactériens pour empêcher la formation d'un film biologique |
| ES2621359T3 (es) * | 2007-06-20 | 2017-07-03 | Pfizer Ireland Pharmaceuticals | Polisacáridos modificados para vacunas conjugadas |
| EP3067048B1 (fr) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions d'induction des réponses immunitaires |
| WO2010083477A2 (fr) | 2009-01-16 | 2010-07-22 | University Of Maryland, Baltimore | Vaccin à large spectre contre les salmonelles non typhoïdiques |
| EP2731617A4 (fr) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | Compositions de psa contenant des lipides, procédés d'isolement et procédés pour les utiliser |
| EP2752403A1 (fr) * | 2013-01-08 | 2014-07-09 | Sika Technology AG | Amine pour résines époxy à faibles émissions |
| JP6918365B2 (ja) | 2015-08-19 | 2021-08-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 脂質化ｐｓａ組成物および方法 |
| CA3030974A1 (fr) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Compositions de glycolipide et procedes d'utilisation |
| CN118021947A (zh) * | 2017-01-31 | 2024-05-14 | 辉瑞大药厂 | 脑膜炎奈瑟菌组合物及其使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057685A (en) * | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4673574A (en) * | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4496538A (en) * | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
| US4619828A (en) * | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
| US4644059A (en) * | 1982-07-06 | 1987-02-17 | Connaught Laboratories, Inc. | Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| HU218146B (hu) * | 1989-12-14 | 2000-06-28 | National Research Council Of Canada | Továbbfejlesztett meningokokkusz-poliszacharid-konjugátum vakcina |
-
1990
- 1990-12-13 HU HU9201966A patent/HU218146B/hu unknown
- 1990-12-13 WO PCT/CA1990/000437 patent/WO1991008772A1/fr active IP Right Grant
- 1990-12-13 EP EP91900142A patent/EP0504202B1/fr not_active Expired - Lifetime
- 1990-12-13 DK DK91900142.0T patent/DK0504202T3/da active
- 1990-12-13 RO RO92-0789A patent/RO111416B1/ro unknown
- 1990-12-13 DE DE69019164T patent/DE69019164T2/de not_active Expired - Fee Related
- 1990-12-13 KR KR1019920701403A patent/KR0158436B1/ko not_active IP Right Cessation
- 1990-12-13 BR BR909007917A patent/BR9007917A/pt not_active Application Discontinuation
- 1990-12-13 JP JP3500908A patent/JP2637845B2/ja not_active Expired - Fee Related
- 1990-12-13 ES ES91900142T patent/ES2071288T3/es not_active Expired - Lifetime
- 1990-12-13 HU HU9201966A patent/HU9201966D0/hu unknown
- 1990-12-13 AT AT91900142T patent/ATE121947T1/de not_active IP Right Cessation
- 1990-12-13 CA CA002071811A patent/CA2071811C/fr not_active Expired - Fee Related
- 1990-12-13 AU AU68987/91A patent/AU641715B2/en not_active Ceased
- 1990-12-13 RU SU5052391A patent/RU2105568C1/ru active
- 1990-12-14 IE IE451390A patent/IE68414B1/en not_active IP Right Cessation
- 1990-12-14 YU YU24391A patent/YU24391A/sh unknown
- 1990-12-14 SI SI9110243A patent/SI20008B/sl not_active IP Right Cessation
- 1990-12-14 PL PL90302476A patent/PL166659B1/pl not_active IP Right Cessation
- 1990-12-14 IN IN1033/CAL/90A patent/IN171747B/en unknown
- 1990-12-14 PH PH41724A patent/PH30305A/en unknown
- 1990-12-14 NZ NZ236471A patent/NZ236471A/en unknown
- 1990-12-14 PL PL90288271A patent/PL166035B1/pl not_active IP Right Cessation
- 1990-12-14 CN CN90110444A patent/CN1049223C/zh not_active Expired - Fee Related
- 1990-12-14 ZA ZA9010065A patent/ZA9010065B/xx unknown
- 1990-12-14 CZ CS906284A patent/CZ283530B6/cs unknown
- 1990-12-14 IL IL9667690A patent/IL96676A/en not_active IP Right Cessation
- 1990-12-14 AR AR90318627A patent/AR243934A1/es active
-
1992
- 1992-06-12 FI FI922737A patent/FI104539B/fi active
- 1992-06-12 NO NO922316A patent/NO305275B1/no unknown
- 1992-10-02 HR HRP-243/91A patent/HRP920872A2/hr not_active Application Discontinuation
-
1993
- 1993-11-22 CN CN93114764A patent/CN1072506C/zh not_active Expired - Fee Related
- 1993-11-22 CN CN93119467A patent/CN1036504C/zh not_active Expired - Fee Related
- 1993-11-22 CN CN93114763A patent/CN1036522C/zh not_active Expired - Fee Related
-
1994
- 1994-05-05 US US08/238,600 patent/US5576002A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/485,623 patent/US5683699A/en not_active Expired - Lifetime
-
1997
- 1997-07-17 NO NO973311A patent/NO307835B1/no unknown
- 1997-10-17 US US08/953,771 patent/US5902586A/en not_active Expired - Fee Related
-
1999
- 1999-09-09 FI FI991917A patent/FI19991917A/fi unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI20008B (en) | Improved meningococcal polysaccharide conjugate vaccine | |
| US6531131B1 (en) | Conjugate vaccine for Neisseria meningitidis | |
| KR100593466B1 (ko) | 다당류-펩타이드접합체 | |
| EP0754055B1 (fr) | Compositions de polysaccharides de streptocoques du groupe a ayant des proprietes immunogenes et procedes associes | |
| NO320415B1 (no) | Multivalent vaksinesammensetning med blandet baerer | |
| JP2004505885A5 (fr) | ||
| IL119962A (en) | Process for making a pneumococcal polysaccharide - immunogenic protein conjugate | |
| ATE19734T1 (de) | Heamophilus influenzae b polysaccharid exotoxoid konjugat-impfstoff. | |
| RU2006114677A (ru) | Жидкие вакцины для множественных серогрупп менингококков | |
| US5192540A (en) | Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine | |
| EA199700419A1 (ru) | Вакцинная композиция, содержащая полирибозилрибитолфосфат, и способ ее получения | |
| ES2000140A6 (es) | Procedimiento para preparar vacunas conjugadas no toxicas contra infecciones por bacterias gram-negativas | |
| NZ299249A (en) | Use of an antigenic conjugate of a capsular polysaccharide from streptococcus and a protein component to immunise neonates | |
| EP0338265B1 (fr) | Vaccin à base d'un conjugat de protéine de membrane externe et de polysaccharide de type B d'haemophilus influenzae | |
| US6165468A (en) | Antigenic carbohydrate linked to an immunogenic carrier | |
| Devi et al. | Antibodies to poly (2 arrow right 8)- alpha-acetylneuraminic acid) and poly ((2 arrow right 9)- alpha-N-acetylneuraminic acid) are elicited by immunization of mice groups B and C meningococci and E. coli K 1. | |
| RU2023120100A (ru) | Пневмококковые полисахариды и их применение в иммуногенных конъюгатах полисахарид-белок-носитель | |
| KR20210092224A (ko) | 다가 당접합체 면역원성 조성물 | |
| RU2001107132A (ru) | Иммуногенный конъюгат бета-пропионамид-связанного полисахарида с белком, использующийся в качестве вакцины, который получают с помощью n-акрилоилированного полисахарида | |
| MXPA98007617A (es) | Conjugados de polisacaridos peptidos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20090910 |