ZA9010065B - Improved menigococcal polysaccharide conjugate vaccine - Google Patents

Improved menigococcal polysaccharide conjugate vaccine

Info

Publication number
ZA9010065B
ZA9010065B ZA9010065A ZA9010065A ZA9010065B ZA 9010065 B ZA9010065 B ZA 9010065B ZA 9010065 A ZA9010065 A ZA 9010065A ZA 9010065 A ZA9010065 A ZA 9010065A ZA 9010065 B ZA9010065 B ZA 9010065B
Authority
ZA
South Africa
Prior art keywords
menigococcal
improved
conjugate vaccine
polysaccharide conjugate
polysaccharide
Prior art date
Application number
ZA9010065A
Other languages
English (en)
Inventor
Harold J Jennings
Francis Michon
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Publication of ZA9010065B publication Critical patent/ZA9010065B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ZA9010065A 1989-12-14 1990-12-14 Improved menigococcal polysaccharide conjugate vaccine ZA9010065B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44819589A 1989-12-14 1989-12-14

Publications (1)

Publication Number Publication Date
ZA9010065B true ZA9010065B (en) 1992-02-26

Family

ID=23779371

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9010065A ZA9010065B (en) 1989-12-14 1990-12-14 Improved menigococcal polysaccharide conjugate vaccine

Country Status (30)

Country Link
US (3) US5576002A (fr)
EP (1) EP0504202B1 (fr)
JP (1) JP2637845B2 (fr)
KR (1) KR0158436B1 (fr)
CN (4) CN1049223C (fr)
AR (1) AR243934A1 (fr)
AT (1) ATE121947T1 (fr)
AU (1) AU641715B2 (fr)
BR (1) BR9007917A (fr)
CA (1) CA2071811C (fr)
CZ (1) CZ283530B6 (fr)
DE (1) DE69019164T2 (fr)
DK (1) DK0504202T3 (fr)
ES (1) ES2071288T3 (fr)
FI (2) FI104539B (fr)
HR (1) HRP920872A2 (fr)
HU (2) HU218146B (fr)
IE (1) IE68414B1 (fr)
IL (1) IL96676A (fr)
IN (1) IN171747B (fr)
NO (2) NO305275B1 (fr)
NZ (1) NZ236471A (fr)
PH (1) PH30305A (fr)
PL (2) PL166035B1 (fr)
RO (1) RO111416B1 (fr)
RU (1) RU2105568C1 (fr)
SI (1) SI20008B (fr)
WO (1) WO1991008772A1 (fr)
YU (1) YU24391A (fr)
ZA (1) ZA9010065B (fr)

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KR0158436B1 (ko) * 1989-12-14 1998-12-01 피에르 오. 페론 개선된 수막염균성 폴리사카라이드 결합체 백신
DE69330464T2 (de) * 1992-09-24 2001-11-08 Brigham And Women S Hospital B Gruppe b streptococcus typ ii und typ v polysaccharid-protein konjugate als impfstoffe
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5679654A (en) * 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5747287A (en) * 1995-04-28 1998-05-05 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
DE69637597D1 (de) * 1995-06-07 2008-08-21 Glaxosmithkline Biolog Sa Vakzine mit einem Polysaccharide Antigen-Trägerprotein Konjugat und freiem Trägerprotein
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
US5811102A (en) * 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
ZA97248B (en) * 1996-01-18 1997-07-18 Rohm & Haas Method for identifying and quantifying polymers utilizing immunoassay techniques
JP4150082B2 (ja) * 1996-08-27 2008-09-17 カイロン コーポレイション 独特の髄膜炎菌性ｂエピトープを規定するモノクローナル抗体およびワクチン組成物の調製におけるそれらの使用
JP4162267B2 (ja) * 1996-08-27 2008-10-08 カイロン コーポレイション Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ複合糖質およびその使用法
US6426074B1 (en) * 1997-03-19 2002-07-30 The Brigham And Women's Hospital Inc. Group B Streptococcus vaccine
EP0994723A1 (fr) 1997-06-24 2000-04-26 Chiron Corporation Procedes permettant d'immuniser des adultes grace a des compositions de vaccins anti-meningococcique
US6030619A (en) * 1997-08-27 2000-02-29 Chiron Corporation Molecular mimetics of meningococcal B epitopes
EP1051506B2 (fr) 1997-12-23 2019-08-21 Pfizer Ireland Pharmaceuticals Procedures permettant d'extraire et d'isoler des polysaccharides capsulaires bacteriens destines a etre utilises seuls, en tant que vaccins ou, lies a des proteines, en tant que vaccins conjugues
WO2000010599A2 (fr) * 1998-08-19 2000-03-02 North American Vaccine, Inc. Conjugue de proteine-polysaccharide immunogene a liaison beta-propionamido, utile comme vaccin etabli au moyen d'un polysaccharide n-acryloyle
US6436653B1 (en) 1998-12-15 2002-08-20 Exiqon A/S Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
US6518037B2 (en) * 1999-11-12 2003-02-11 University Of Iowa Research Foundation Two-component system that controls bacterial membrane synthesis
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
WO2002083711A2 (fr) 2001-04-17 2002-10-24 Chiron Corporation Mimetiques moleculaires d'epitopes b meningococciques qui elicitent des anticorps fonctionnellement actifs
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0121591D0 (en) * 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
PT1490409E (pt) * 2002-03-26 2009-04-03 Novartis Vaccines & Diagnostic Sacáridos modificados possuindo uma estabilidade melhorada em água
EP1638581A2 (fr) 2003-03-31 2006-03-29 The Brigham And Women's Hospital, Inc. Immunomodulateurs zwitterioniques destines au traitement de l'asthme et des allergies
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
ES2735809T3 (es) 2003-08-12 2019-12-20 Lipoxen Tech Limited Derivativos del ácido siálico para la derivatización y conjugación de proteínas
US8148335B2 (en) 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
BRPI0512413A (pt) 2004-06-23 2008-03-04 Childrens Hosp & Res Ct Oak derivados de polissacarìdeo e usos na indução de uma resposta imune
GB0428394D0 (en) * 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
HUE031380T2 (en) 2005-06-27 2017-07-28 Glaxosmithkline Biologicals Sa A method for producing vaccines
WO2007092451A2 (fr) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Polysaccharides zwitterioniques pour favoriser la maturation du système immunitaire et la santé
GB0611914D0 (en) 2006-06-15 2006-07-26 Teti Giuseppe Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide
EP1872791A1 (fr) 2006-06-30 2008-01-02 Institut Pasteur Utilisation de polysaccharides bactériens pour empêcher la formation d'un film biologique
CN101754773A (zh) * 2007-06-20 2010-06-23 巴克斯特国际有限公司 用于缀合疫苗的经过修饰的多糖
US8815253B2 (en) 2007-12-07 2014-08-26 Novartis Ag Compositions for inducing immune responses
WO2010083477A2 (fr) 2009-01-16 2010-07-22 University Of Maryland, Baltimore Vaccin à large spectre contre les salmonelles non typhoïdiques
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
EP2752403A1 (fr) * 2013-01-08 2014-07-09 Sika Technology AG Amine pour résines époxy à faibles émissions
CN108135167B (zh) 2015-08-19 2021-07-09 哈佛学院院长及董事 脂化psa组合物和方法
WO2018014012A1 (fr) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Compositions de glycolipide et procédés d'utilisation
JP7010961B2 (ja) * 2017-01-31 2022-02-10 ファイザー・インク 髄膜炎菌組成物およびその方法

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US4057685A (en) * 1972-02-02 1977-11-08 Abbott Laboratories Chemically modified endotoxin immunizing agent
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4644059A (en) * 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US4619828A (en) * 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4727136A (en) * 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
KR0158436B1 (ko) * 1989-12-14 1998-12-01 피에르 오. 페론 개선된 수막염균성 폴리사카라이드 결합체 백신

Also Published As

Publication number Publication date
CZ628490A3 (en) 1997-12-17
CA2071811C (fr) 2003-11-04
CN1100428A (zh) 1995-03-22
CN1049223C (zh) 2000-02-09
AR243934A1 (es) 1993-09-30
AU641715B2 (en) 1993-09-30
IN171747B (fr) 1992-12-26
PL166035B1 (pl) 1995-03-31
IE68414B1 (en) 1996-06-12
DE69019164D1 (de) 1995-06-08
NO305275B1 (no) 1999-05-03
NZ236471A (en) 1992-10-28
EP0504202B1 (fr) 1995-05-03
RU2105568C1 (ru) 1998-02-27
SI20008A (sl) 2000-02-29
HU9201966D0 (en) 1992-10-28
JPH05505392A (ja) 1993-08-12
US5683699A (en) 1997-11-04
PL288271A1 (en) 1991-12-16
CN1036522C (zh) 1997-11-26
IE904513A1 (en) 1991-06-19
FI104539B (fi) 2000-02-29
US5576002A (en) 1996-11-19
YU24391A (sh) 1995-12-04
IL96676A (en) 1996-09-12
CZ283530B6 (cs) 1998-04-15
CN1036504C (zh) 1997-11-26
EP0504202A1 (fr) 1992-09-23
IL96676A0 (en) 1991-09-16
NO973311D0 (no) 1997-07-17
SI20008B (en) 2001-02-28
ATE121947T1 (de) 1995-05-15
NO922316L (no) 1992-08-14
CN1100656A (zh) 1995-03-29
PL166659B1 (pl) 1995-06-30
DE69019164T2 (de) 1995-09-07
JP2637845B2 (ja) 1997-08-06
FI19991917A (fi) 1999-09-09
DK0504202T3 (da) 1995-10-02
NO922316D0 (no) 1992-06-12
AU6898791A (en) 1991-07-18
KR0158436B1 (ko) 1998-12-01
PH30305A (en) 1997-02-20
HUT64480A (en) 1994-01-28
RO111416B1 (ro) 1996-10-31
HRP920872A2 (en) 1997-06-30
HU218146B (hu) 2000-06-28
WO1991008772A1 (fr) 1991-06-27
ES2071288T3 (es) 1995-06-16
US5902586A (en) 1999-05-11
CN1072506C (zh) 2001-10-10
CN1055541A (zh) 1991-10-23
NO307835B1 (no) 2000-06-05
BR9007917A (pt) 1992-10-20
NO973311L (no) 1992-08-14
CN1096516A (zh) 1994-12-21
CA2071811A1 (fr) 1991-06-15
FI922737A0 (fi) 1992-06-12

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