SG164376A1 - Hcv ns3 protease inhibitors - Google Patents
Hcv ns3 protease inhibitorsInfo
- Publication number
- SG164376A1 SG164376A1 SG201005254-6A SG2010052546A SG164376A1 SG 164376 A1 SG164376 A1 SG 164376A1 SG 2010052546 A SG2010052546 A SG 2010052546A SG 164376 A1 SG164376 A1 SG 164376A1
- Authority
- SG
- Singapore
- Prior art keywords
- hcv
- protease inhibitors
- protease
- inhibitors
- hepatitis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70076405P | 2005-07-20 | 2005-07-20 | |
US72456605P | 2005-10-07 | 2005-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG164376A1 true SG164376A1 (en) | 2010-09-29 |
Family
ID=37467463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG201005254-6A SG164376A1 (en) | 2005-07-20 | 2006-07-14 | Hcv ns3 protease inhibitors |
Country Status (38)
Country | Link |
---|---|
US (2) | US7470664B2 (pt) |
EP (2) | EP1924593B9 (pt) |
JP (2) | JP4621282B2 (pt) |
KR (1) | KR101296095B1 (pt) |
AR (1) | AR057456A1 (pt) |
AT (1) | ATE443075T1 (pt) |
AU (1) | AU2006276189B9 (pt) |
BR (1) | BRPI0613633A2 (pt) |
CA (1) | CA2615022C (pt) |
CR (1) | CR9621A (pt) |
CY (1) | CY1109671T1 (pt) |
DE (1) | DE602006009280D1 (pt) |
DK (1) | DK1924593T3 (pt) |
DO (2) | DOP2006000171A (pt) |
EA (1) | EA013331B1 (pt) |
EC (1) | ECSP088107A (pt) |
ES (2) | ES2332821T3 (pt) |
GE (1) | GEP20115248B (pt) |
GT (1) | GT200600317A (pt) |
HK (1) | HK1121169A1 (pt) |
HN (1) | HN2008000087A (pt) |
HR (1) | HRP20090627T1 (pt) |
IL (1) | IL188618A0 (pt) |
JO (1) | JO2593B1 (pt) |
MA (1) | MA30198B1 (pt) |
MX (1) | MX2008000866A (pt) |
MY (1) | MY142240A (pt) |
NO (1) | NO20080879L (pt) |
NZ (1) | NZ565223A (pt) |
PE (1) | PE20070364A1 (pt) |
PL (1) | PL1924593T3 (pt) |
PT (1) | PT1924593E (pt) |
RS (1) | RS51101B (pt) |
SG (1) | SG164376A1 (pt) |
SI (1) | SI1924593T1 (pt) |
TN (1) | TNSN08033A1 (pt) |
TW (1) | TWI387603B (pt) |
WO (2) | WO2007015855A1 (pt) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003007697A (ja) * | 2001-06-21 | 2003-01-10 | Hitachi Kokusai Electric Inc | 半導体装置の製造方法、基板処理方法および基板処理装置 |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
US7879797B2 (en) * | 2005-05-02 | 2011-02-01 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
JP5406525B2 (ja) * | 2005-07-04 | 2014-02-05 | ツァナン・サイテック・カンパニー・リミテッド | ルテニウム錯体配位子、ルテニウム錯体、固定化ルテニウム錯体触媒及びその調製方法と用途 |
US7470664B2 (en) * | 2005-07-20 | 2008-12-30 | Merck & Co., Inc. | HCV NS3 protease inhibitors |
BRPI0613962A2 (pt) | 2005-07-25 | 2009-03-24 | Intermune Inc | inibidores macrocìclicos inovadores de replicação de vìrus da hepatite c |
WO2007016441A1 (en) * | 2005-08-01 | 2007-02-08 | Merck & Co., Inc. | Macrocyclic peptides as hcv ns3 protease inhibitors |
GEP20104956B (en) * | 2005-10-11 | 2010-04-12 | Array Biopharma Inc | Compounds for inhibiting hepatitis c viral replication and use thereof |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
GB0609492D0 (en) * | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
GB0612423D0 (en) * | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2079479B1 (en) * | 2006-10-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
EP2079480B1 (en) * | 2006-10-24 | 2013-06-05 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
EP2076278B1 (en) * | 2006-10-24 | 2015-05-06 | Merck Sharp & Dohme Corp. | Macrocyclic HCV NS3 protease inhibitors |
CN101568346B (zh) * | 2006-10-27 | 2015-11-25 | 默沙东公司 | Hcv ns3蛋白酶抑制剂 |
MX2009004556A (es) * | 2006-10-27 | 2009-07-10 | Merck & Co Inc | Inhibidores de la proteasa ns3 del hcv. |
US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
GB0625345D0 (en) * | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
CN103224506A (zh) * | 2006-12-20 | 2013-07-31 | P.安杰莱蒂分子生物学研究所 | 抗病毒的吲哚 |
GB0625349D0 (en) * | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
WO2008112108A1 (en) | 2007-03-09 | 2008-09-18 | Merck & Co., Inc. | In vivo hcv resistance to anti-viral inhibitors |
AU2008240834B2 (en) * | 2007-04-24 | 2012-08-23 | F. Hoffmann-La Roche Ag | Process for HCV protease inhibitor intermediate |
NZ581606A (en) * | 2007-05-03 | 2012-06-29 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
AU2008251425A1 (en) | 2007-05-10 | 2008-11-20 | Array Biopharma, Inc. | Novel peptide inhibitors of hepatitis C virus replication |
AU2008277440A1 (en) * | 2007-07-17 | 2009-01-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic indole derivatives for the treatment of hepatitis C infections |
US8927569B2 (en) * | 2007-07-19 | 2015-01-06 | Merck Sharp & Dohme Corp. | Macrocyclic compounds as antiviral agents |
US8383583B2 (en) * | 2007-10-26 | 2013-02-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors |
CL2008003384A1 (es) | 2007-11-14 | 2009-12-11 | Enanta Pharm Inc | Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
MX2010005261A (es) * | 2007-11-14 | 2010-10-15 | Enanta Pharm Inc | Inhibidores macrocíclicos de proteasa de serina de hepatitis c de tetrazolilo. |
WO2009079353A1 (en) | 2007-12-14 | 2009-06-25 | Enanta Pharmaceuticals, Inc. | Triazole-containing macrocyclic hcv serine protease inhibitors |
JP2011506472A (ja) | 2007-12-14 | 2011-03-03 | エナンタ ファーマシューティカルズ インコーポレイテッド | 大環状オキシミルc型肝炎セリンプロテアーゼ阻害剤 |
JP5623289B2 (ja) | 2007-12-19 | 2014-11-12 | ベーリンガーインゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
WO2009085978A1 (en) | 2007-12-20 | 2009-07-09 | Enanta Pharceuticals, Inc. | Bridged carbocyclic oxime hepatitis c virus serine protease inhibitors |
US8293705B2 (en) | 2007-12-21 | 2012-10-23 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
TW201546079A (zh) | 2007-12-21 | 2015-12-16 | Celgene Avilomics Res Inc | Hcv蛋白酶抑制劑及其用途(一) |
AU2015224437B2 (en) * | 2007-12-21 | 2017-05-25 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
US8309685B2 (en) * | 2007-12-21 | 2012-11-13 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
CN101951770B (zh) | 2007-12-21 | 2014-12-31 | 阿维拉制药公司 | Hcv蛋白酶抑制剂和其用途 |
MX2010008523A (es) * | 2008-02-04 | 2010-08-31 | Idenix Pharmaceuticals Inc | Inhibidores macrociclicos de serina proteasa. |
AU2009217551B2 (en) * | 2008-02-25 | 2014-07-31 | Msd Italia S.R.L. | Therapeutic compounds |
JP5490778B2 (ja) * | 2008-03-20 | 2014-05-14 | エナンタ ファーマシューティカルズ インコーポレイテッド | C型肝炎ウイルス阻害剤としてのフッ素化大環状化合物 |
AP2010005416A0 (en) * | 2008-04-15 | 2010-10-31 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication. |
US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8461107B2 (en) * | 2008-04-28 | 2013-06-11 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
US7964560B2 (en) | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2300491B1 (en) | 2008-05-29 | 2016-01-06 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
SI2310095T1 (sl) * | 2008-07-22 | 2013-01-31 | Merck Sharp & Dohme Corp. | Makrocikliäśne kuinoksalinske spojine kot hcv ns3 proteazni inhibitorji |
US8188137B2 (en) | 2008-08-15 | 2012-05-29 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
US8044087B2 (en) | 2008-09-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8563505B2 (en) | 2008-09-29 | 2013-10-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
AU2009335904A1 (en) * | 2008-12-19 | 2011-08-04 | Gilead Sciences, Inc. | HCV NS3 protease inhibitors |
AU2010203656A1 (en) | 2009-01-07 | 2011-07-21 | Scynexis, Inc. | Cyclosporine derivative for use in the treatment of HCV and HIV infection |
WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
WO2010118078A1 (en) | 2009-04-08 | 2010-10-14 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
CA2761650C (en) * | 2009-05-13 | 2015-05-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis c virus inhibitors |
EP2432318A4 (en) * | 2009-05-22 | 2012-11-21 | Sequoia Pharmaceuticals Inc | NS3 PROTEASE INHIBITORS OF BIPACROCYCLIC HEPATITIS C VIRUS |
EP2459582B1 (en) | 2009-07-30 | 2015-05-27 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
US8637449B2 (en) * | 2009-08-27 | 2014-01-28 | Merck Sharp & Dohme Corp. | Processes for preparing protease inhibitors of hepatitis C virus |
CN102741270B (zh) * | 2009-09-28 | 2015-07-22 | 英特穆恩公司 | C型肝炎病毒复制的环肽抑制剂 |
WO2011049908A2 (en) | 2009-10-19 | 2011-04-28 | Enanta Pharmaceuticals, Inc. | Bismacrokyclic compounds as hepatitis c virus inhibitors |
US8653025B2 (en) | 2010-01-27 | 2014-02-18 | AB Pharma Ltd. | Polyheterocyclic compounds highly potent as HCV inhibitors |
IN2012MN02896A (pt) | 2010-06-24 | 2015-06-12 | Panmed Ltd | |
KR101990279B1 (ko) | 2010-09-21 | 2019-06-19 | 이난타 파마슈티칼스, 인코포레이티드 | 매크로사이클릭 프롤린 유도된 hcv 세린 프로테아제 억제제 |
CN103328466B (zh) | 2010-11-01 | 2016-08-03 | Rfs制药公司 | Hcv ns3蛋白酶抑制剂 |
JP6034802B2 (ja) * | 2010-12-14 | 2016-11-30 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 大環状ラクタムの調製のための方法および中間体 |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
AU2012269643A1 (en) * | 2011-06-16 | 2014-02-06 | AB Pharma Ltd. | Macrocyclic heterocyclic compound for inhibiting hepatitis C virus and preparation and use thereof |
US8912141B2 (en) | 2011-06-23 | 2014-12-16 | Panmed Ltd. | Treatment of hepatitis C virus |
BR112014003798A2 (pt) | 2011-08-19 | 2017-03-01 | Merck Sharp & Dohme | método para fabricar um composto, e, composto |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
DK2583680T1 (da) | 2011-10-21 | 2015-01-19 | Abbvie Inc | Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
CN104383541A (zh) | 2011-10-21 | 2015-03-04 | 艾伯维公司 | 用于治疗hcv的包含至少两种直接抗病毒剂和利巴韦林但无干扰素的方法 |
KR20140098759A (ko) * | 2011-10-31 | 2014-08-08 | 머크 샤프 앤드 돔 코포레이션 | 바이러스성 질환의 치료에 유용한 조성물 |
CN107964006A (zh) * | 2012-01-11 | 2018-04-27 | 艾伯维公司 | 用于制备hcv蛋白酶抑制剂的方法 |
CA2858814A1 (en) | 2012-01-12 | 2013-07-18 | Rfs Pharma, Llc | Hcv ns3 protease inhibitors |
CN102617705B (zh) | 2012-02-16 | 2014-12-31 | 上海纬诺医药科技有限公司 | 抑制丙肝病毒复制的大环类化合物 |
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
TW201408669A (zh) | 2012-08-08 | 2014-03-01 | Merck Sharp & Dohme | Hcv ns3蛋白酶抑制劑 |
RS55592B1 (sr) | 2012-10-19 | 2017-06-30 | Bristol Myers Squibb Co | 9-metil supstituisani heksadekahidrociklopropa(e)pirolo(1,2-a)(1,4)diazaciklopentadecinil karbamat derivati kao nestrukturalni 3 (ns3) proteazni inhibitori za lečenje infekcijavirusom hepatitisa c |
WO2014070964A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
WO2014071007A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
WO2014121417A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
WO2014121418A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
WO2014137869A1 (en) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
US20140316154A1 (en) * | 2013-03-15 | 2014-10-23 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
CN105073758B (zh) | 2013-03-15 | 2017-08-11 | 吉利德科学公司 | 丙型肝炎病毒抑制剂 |
US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
EP3057926A4 (en) | 2013-10-18 | 2017-07-12 | Merck Sharp & Dohme Corp. | Methods and intermediates for preparing macrolactams |
CA3022119A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3480613A (en) * | 1967-07-03 | 1969-11-25 | Merck & Co Inc | 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof |
FR2722210B1 (fr) * | 1994-07-08 | 1996-08-14 | Rhone Poulenc Rorer Sa | Nouvelles streptogramines et procede de preparation de streptogramines par mutasynthese |
US6128582A (en) | 1996-04-30 | 2000-10-03 | Vertex Pharmaceuticals Incorporated | Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
GB9707659D0 (en) | 1997-04-16 | 1997-06-04 | Peptide Therapeutics Ltd | Hepatitis C NS3 Protease inhibitors |
NZ503263A (en) | 1997-08-11 | 2002-10-25 | Boehringer Ingelheim Ca Ltd | Hepatitis C NS3 protease inhibitor peptides and peptide analogues |
ES2241157T3 (es) | 1997-08-11 | 2005-10-16 | Boehringer Ingelheim (Canada) Ltd. | Peptidos inhibidores de la hepatitis c. |
IT1299134B1 (it) | 1998-02-02 | 2000-02-29 | Angeletti P Ist Richerche Bio | Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi |
BR9908270A (pt) | 1998-02-25 | 2004-06-29 | Univ Emory | 2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos |
GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
AU3376699A (en) | 1998-03-31 | 1999-10-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
EP1106626B1 (en) | 1998-08-10 | 2003-05-28 | Hokkaido Electric Power Company, Incorporated | Process for the preparation of regular glycopeptides |
US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
JP2002528499A (ja) | 1998-10-29 | 2002-09-03 | ブリストル−マイヤーズ スクイブ カンパニー | Impdh酵素のインヒビターであるアミノ核誘導化合物 |
US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
UA74546C2 (en) | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
EP1196414B1 (en) | 1999-06-25 | 2003-09-03 | Vertex Pharmaceuticals Incorporated | Prodrugs of carbamate inhibitors of impdh |
AU763356C (en) | 1999-12-27 | 2004-08-26 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
US6455508B1 (en) | 2000-02-15 | 2002-09-24 | Kanda S. Ramasamy | Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides |
US6495677B1 (en) | 2000-02-15 | 2002-12-17 | Kanda S. Ramasamy | Nucleoside compounds |
KR20030005197A (ko) * | 2000-02-18 | 2003-01-17 | 샤이어 바이오켐 인코포레이티드 | 뉴클레오시드유도체를 이용한 플라비바이러스 감염의 치료또는 예방 방법 |
WO2001077091A2 (en) | 2000-04-05 | 2001-10-18 | Tularik Inc. | Ns5b hcv polymerase inhibitors |
PL359359A1 (en) | 2000-04-05 | 2004-08-23 | Schering Corporation | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties |
DE60136620D1 (de) | 2000-04-13 | 2009-01-02 | Pharmasset Inc | 3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
EP1313559B2 (en) * | 2000-08-10 | 2012-10-24 | Trustees of Boston College | Recyclable metathesis catalysts |
US6955174B2 (en) * | 2000-08-18 | 2005-10-18 | Uryovascular Systems, Inc. | Cryotherapy method for detecting and treating vulnerable plaque |
US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
US6809101B2 (en) | 2000-09-01 | 2004-10-26 | Shionogi & Co., Ltd. | Compounds having anti-hepatitis C virus effect |
CN1646141B (zh) | 2000-10-18 | 2014-06-25 | 吉利德制药有限责任公司 | 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物 |
ES2324594T3 (es) | 2000-12-12 | 2009-08-11 | Schering Corporation | Diaril peptidicos utilizados como inhibidores de la serina proteasa ns3 del virus de la hepatitis c. |
WO2002048116A2 (en) | 2000-12-13 | 2002-06-20 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
AU2002232660A1 (en) | 2000-12-15 | 2002-06-24 | Pharmasset Ltd. | Antiviral agents for treatment of flaviviridae infections |
CA2437209A1 (en) | 2000-12-26 | 2002-07-04 | Mitsubishi Pharma Corporation | Remedies for hepatitis c |
MXPA03006514A (es) * | 2001-01-22 | 2004-12-02 | Merck & Co Inc | Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico. |
GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
US7544374B2 (en) | 2001-08-14 | 2009-06-09 | Tel Aviv University Future Technology Development L.P. | Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy |
WO2003026675A1 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
AU2002330154A1 (en) | 2001-09-28 | 2003-04-07 | Centre National De La Recherche Scientifique | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US7282512B2 (en) | 2002-01-17 | 2007-10-16 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors |
GB0201179D0 (en) | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
CA2369711A1 (en) * | 2002-01-30 | 2003-07-30 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis c virus |
US6828301B2 (en) | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
CA2474563C (en) | 2002-02-13 | 2010-11-09 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
EP1501850A2 (en) | 2002-05-06 | 2005-02-02 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
AU2003269890A1 (en) | 2002-06-21 | 2004-01-06 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
AU2003269892A1 (en) | 2002-06-27 | 2004-01-19 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
WO2004002999A2 (en) | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections |
PL374792A1 (en) | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | 2' and 3'-nucleoside prodrugs for treating flaviviridae infections |
AU2003269902A1 (en) | 2002-07-16 | 2004-02-02 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
CN1671727A (zh) | 2002-07-25 | 2005-09-21 | 麦克洛基克斯生物技术有限公司 | 抗病毒7-脱氮-d-核苷及其用途 |
CA2494340C (en) | 2002-08-01 | 2012-01-24 | Pharmasset Inc. | Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
WO2004072243A2 (en) * | 2003-02-07 | 2004-08-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis c serine protease inhibitors |
US20040254159A1 (en) * | 2003-02-27 | 2004-12-16 | Hasvold Lisa A. | Heterocyclic kinase inhibitors |
EP1601685A1 (en) * | 2003-03-05 | 2005-12-07 | Boehringer Ingelheim International GmbH | Hepatitis c inhibiting compounds |
US7157424B2 (en) * | 2003-04-02 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
ES2386161T3 (es) * | 2003-04-16 | 2012-08-10 | Bristol-Myers Squibb Company | Proceso para separar una mezcla de enantiómeros de éster alquílico usando una enzima |
US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
AR044129A1 (es) | 2003-05-06 | 2005-08-24 | Altana Pharma Ag | Compuestos intermedios de imidazopiridina. proceso de preparacion. |
CN1791599A (zh) * | 2003-05-21 | 2006-06-21 | 贝林格尔.英格海姆国际有限公司 | 丙型肝炎抑制剂化合物 |
US6955184B2 (en) | 2003-05-29 | 2005-10-18 | Honeywell International, Inc. | Pneumatic generator system for simulating operating conditions of an aircraft |
EP1644395B1 (en) * | 2003-06-19 | 2006-11-22 | F. Hoffmann-La Roche Ag | Processes for preparing 4'azido nucleoside derivatives |
US7125845B2 (en) | 2003-07-03 | 2006-10-24 | Enanta Pharmaceuticals, Inc. | Aza-peptide macrocyclic hepatitis C serine protease inhibitors |
EA012389B1 (ru) | 2004-03-30 | 2009-10-30 | Интермун, Инк. | Макроциклические соединения в качестве ингибиторов вирусной репликации |
US7470664B2 (en) * | 2005-07-20 | 2008-12-30 | Merck & Co., Inc. | HCV NS3 protease inhibitors |
GB0519797D0 (en) | 2005-09-29 | 2005-11-09 | Istituto Di Ricerche D Biolog | Therapeutic agents |
GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
WO2008019303A2 (en) | 2006-08-04 | 2008-02-14 | Enanta Pharmaceuticals, Inc. | Pyridazinonyl macrocyclic hepatitis c serine protease inhibitors |
CN101568346B (zh) | 2006-10-27 | 2015-11-25 | 默沙东公司 | Hcv ns3蛋白酶抑制剂 |
CL2008003384A1 (es) | 2007-11-14 | 2009-12-11 | Enanta Pharm Inc | Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
MX2010005261A (es) | 2007-11-14 | 2010-10-15 | Enanta Pharm Inc | Inhibidores macrocíclicos de proteasa de serina de hepatitis c de tetrazolilo. |
-
2006
- 2006-07-12 US US11/484,925 patent/US7470664B2/en active Active
- 2006-07-12 TW TW095125510A patent/TWI387603B/zh not_active IP Right Cessation
- 2006-07-12 AR ARP060102995A patent/AR057456A1/es active IP Right Grant
- 2006-07-14 PL PL06787475T patent/PL1924593T3/pl unknown
- 2006-07-14 NZ NZ565223A patent/NZ565223A/en not_active IP Right Cessation
- 2006-07-14 EP EP06787475A patent/EP1924593B9/en active Active
- 2006-07-14 JP JP2008522888A patent/JP4621282B2/ja active Active
- 2006-07-14 WO PCT/US2006/027831 patent/WO2007015855A1/en active Application Filing
- 2006-07-14 ES ES06787475T patent/ES2332821T3/es active Active
- 2006-07-14 BR BRPI0613633-8A patent/BRPI0613633A2/pt not_active IP Right Cessation
- 2006-07-14 DE DE602006009280T patent/DE602006009280D1/de active Active
- 2006-07-14 PT PT06787475T patent/PT1924593E/pt unknown
- 2006-07-14 WO PCT/US2006/027573 patent/WO2007015787A1/en active Application Filing
- 2006-07-14 AT AT06787475T patent/ATE443075T1/de active
- 2006-07-14 AU AU2006276189A patent/AU2006276189B9/en not_active Ceased
- 2006-07-14 ES ES06787698.7T patent/ES2446015T3/es active Active
- 2006-07-14 DK DK06787475.0T patent/DK1924593T3/da active
- 2006-07-14 EA EA200800371A patent/EA013331B1/ru not_active IP Right Cessation
- 2006-07-14 SG SG201005254-6A patent/SG164376A1/en unknown
- 2006-07-14 CA CA2615022A patent/CA2615022C/en not_active Expired - Fee Related
- 2006-07-14 SI SI200630496T patent/SI1924593T1/sl unknown
- 2006-07-14 KR KR1020087001532A patent/KR101296095B1/ko not_active IP Right Cessation
- 2006-07-14 MX MX2008000866A patent/MX2008000866A/es active IP Right Grant
- 2006-07-14 GE GEAP200610513A patent/GEP20115248B/en unknown
- 2006-07-14 EP EP06787698.7A patent/EP1910404B9/en not_active Not-in-force
- 2006-07-14 RS RSP-2009/0548A patent/RS51101B/sr unknown
- 2006-07-17 GT GT200600317A patent/GT200600317A/es unknown
- 2006-07-17 JO JO2006229A patent/JO2593B1/en active
- 2006-07-18 PE PE2006000864A patent/PE20070364A1/es not_active Application Discontinuation
- 2006-07-19 MY MYPI20063431A patent/MY142240A/en unknown
- 2006-07-19 DO DO2006000171A patent/DOP2006000171A/es unknown
-
2007
- 2007-12-20 CR CR9621A patent/CR9621A/es unknown
-
2008
- 2008-01-06 IL IL188618A patent/IL188618A0/en unknown
- 2008-01-14 EC EC2008008107A patent/ECSP088107A/es unknown
- 2008-01-21 TN TNP2008000033A patent/TNSN08033A1/en unknown
- 2008-01-21 HN HN2008000087A patent/HN2008000087A/es unknown
- 2008-02-18 MA MA30655A patent/MA30198B1/fr unknown
- 2008-02-19 NO NO20080879A patent/NO20080879L/no not_active Application Discontinuation
- 2008-11-20 HK HK08112711.5A patent/HK1121169A1/xx not_active IP Right Cessation
- 2008-12-01 US US12/325,965 patent/US8216999B2/en active Active
-
2009
- 2009-04-27 DO DO2009000094A patent/DOP2009000094A/es unknown
- 2009-11-24 HR HR20090627T patent/HRP20090627T1/hr unknown
- 2009-12-14 CY CY20091101328T patent/CY1109671T1/el unknown
-
2010
- 2010-10-07 JP JP2010227222A patent/JP5345117B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG164376A1 (en) | Hcv ns3 protease inhibitors | |
MY164469A (en) | Hcv ns3 protease inhibitors | |
WO2006119061A3 (en) | Hcv ns3 protease inhibitors | |
WO2008057208A3 (en) | Hcv ns3 protease inhibitors | |
WO2008051514A3 (en) | Hcv ns3 protease inhibitors | |
WO2008051475A3 (en) | Hcv ns3 protease inhibitors | |
WO2008051477A3 (en) | Hcv ns3 protease inhibitors | |
MY152070A (en) | Macrocyclic quinxaline compounds as hcv ns3 protease inhibitors | |
MX2011006631A (es) | Inhibidores de proteasa ns3 del virus hcv. | |
NO20081086L (no) | Makrosykliske peptider som HCV NS3-proteaseinhibitorer | |
TW200639169A (en) | Bicyclic heteroaryl derivatives for treating viruses | |
WO2013074386A3 (en) | Hcv ns3 protease inhibitors | |
MX2009008872A (es) | Compuestos macrociclicos como inhibidores de proteasa ns3 del virus de hepatitis c. | |
PL1987038T3 (pl) | Inhibitory HCV NS5B | |
TW200745120A (en) | Indolobenzazepine HCV NS5B inhibitors | |
ATE469155T1 (de) | Cyclopropyl-fusionierte indolbenzazepin-hcv-ns5b- hemmer | |
TW200720285A (en) | Nucleoside compounds for treating viral infections | |
MX2011009644A (es) | Inhibidores del virus de la hepatitis c. | |
UA90909C2 (en) | Hcv ns3 protease inhibitors | |
UA95990C2 (en) | Hcv ns3 protease inhibitors | |
MY142331A (en) | Bicyclic heteroaryl derivatives for treating viruses |