SG11202003828WA - Process for the purification of a sialic acid from a fermentation broth - Google Patents
Process for the purification of a sialic acid from a fermentation brothInfo
- Publication number
- SG11202003828WA SG11202003828WA SG11202003828WA SG11202003828WA SG11202003828WA SG 11202003828W A SG11202003828W A SG 11202003828WA SG 11202003828W A SG11202003828W A SG 11202003828WA SG 11202003828W A SG11202003828W A SG 11202003828WA SG 11202003828W A SG11202003828W A SG 11202003828WA
- Authority
- SG
- Singapore
- Prior art keywords
- purification
- sialic acid
- fermentation broth
- broth
- fermentation
- Prior art date
Links
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title 1
- 238000000855 fermentation Methods 0.000 title 1
- 230000004151 fermentation Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/08—Deoxysugars; Unsaturated sugars; Osones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pediatric Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17202833.4A EP3486326A1 (en) | 2017-11-21 | 2017-11-21 | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| PCT/EP2018/079908 WO2019101489A1 (en) | 2017-11-21 | 2018-10-31 | Process for the purification of a sialic acid from a fermentation broth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003828WA true SG11202003828WA (en) | 2020-06-29 |
Family
ID=60654618
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003828WA SG11202003828WA (en) | 2017-11-21 | 2018-10-31 | Process for the purification of a sialic acid from a fermentation broth |
| SG10202011764WA SG10202011764WA (en) | 2017-11-21 | 2018-10-31 | Process for the purification of a sialic acid from a fermentation broth |
| SG10202011765RA SG10202011765RA (en) | 2017-11-21 | 2018-11-15 | Process for the purification of l-fucose from a fermentation broth |
| SG11202003843PA SG11202003843PA (en) | 2017-11-21 | 2018-11-15 | Process for the purification of l-fucose from a fermentation broth |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202011764WA SG10202011764WA (en) | 2017-11-21 | 2018-10-31 | Process for the purification of a sialic acid from a fermentation broth |
| SG10202011765RA SG10202011765RA (en) | 2017-11-21 | 2018-11-15 | Process for the purification of l-fucose from a fermentation broth |
| SG11202003843PA SG11202003843PA (en) | 2017-11-21 | 2018-11-15 | Process for the purification of l-fucose from a fermentation broth |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11834691B2 (zh) |
| EP (3) | EP3486326A1 (zh) |
| JP (2) | JP7285256B2 (zh) |
| KR (2) | KR20200088818A (zh) |
| CN (4) | CN117958431A (zh) |
| AU (2) | AU2018373415B2 (zh) |
| BR (2) | BR112020009969A2 (zh) |
| DK (1) | DK3714060T3 (zh) |
| MX (2) | MX2020005161A (zh) |
| PH (2) | PH12020550671A1 (zh) |
| SG (4) | SG11202003828WA (zh) |
| WO (2) | WO2019101489A1 (zh) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3486326A1 (en) * | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| EP3524067A1 (en) | 2018-02-08 | 2019-08-14 | Jennewein Biotechnologie GmbH | Spray-dried mixture of human milk oligosaccharides |
| JP2021505171A (ja) | 2017-12-08 | 2021-02-18 | イェンネワイン バイオテクノロジー ゲーエムベーハーＪｅｎｎｅｗｅｉｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅ ＧｍｂＨ | 噴霧乾燥シアリルラクトース |
| WO2021064629A1 (en) * | 2019-10-01 | 2021-04-08 | Glycom A/S | Separation of neutral oligosaccharides from fermentation broth |
| EP3821717A1 (en) * | 2019-11-15 | 2021-05-19 | Jennewein Biotechnologie GmbH | A method for drying human milk oligosaccharides |
| WO2021155157A1 (en) * | 2020-01-29 | 2021-08-05 | Dsm Ip Assets B.V. | Process for recovering & purifying human milk oligosaccharides |
| US11618902B2 (en) * | 2020-03-30 | 2023-04-04 | Jiangnan University | Bacillus subtilis for producing N-acetylneuraminic acid and application thereof |
| CN114487255A (zh) * | 2020-10-23 | 2022-05-13 | 内蒙古伊利实业集团股份有限公司 | 一种乳粉或乳清粉中唾液酸含量的检测方法 |
| CN112526022A (zh) * | 2020-11-27 | 2021-03-19 | 内蒙古伊利实业集团股份有限公司 | 一种乳中母乳低聚糖的检测方法 |
| CN113005161B (zh) * | 2021-02-19 | 2023-04-28 | 中国科学院合肥物质科学研究院 | 一种聚唾液酸的制备方法及聚唾液酸制品 |
| US20230354867A1 (en) * | 2021-03-10 | 2023-11-09 | Synlait Milk Limited | Nutritional compositions and methods related thereto |
| KR20220168579A (ko) * | 2021-06-16 | 2022-12-23 | 지에스칼텍스 주식회사 | 발효액으로부터 목적한 화합물을 수득하는 방법 |
| CN113607903B (zh) * | 2021-07-30 | 2024-03-15 | 振德医疗用品股份有限公司 | 一种检测含有正电荷聚合物细菌内毒素的方法 |
| CN113956304B (zh) * | 2021-09-27 | 2023-10-20 | 嘉必优生物技术（武汉）股份有限公司 | 一种n-乙酰神经氨酸的制备方法 |
| CN114539333B (zh) * | 2022-03-01 | 2023-12-22 | 德元堂(上海)健康科技发展有限公司 | 一种唾液酸的循环生产工艺 |
| CN116042562B (zh) * | 2022-03-11 | 2023-10-20 | 山东恒鲁生物科技有限公司 | 重组酵母菌及其应用 |
| CN114878705B (zh) * | 2022-04-20 | 2023-10-27 | 中轻食品检验认证有限公司 | 一种测定燕窝制品中唾液酸稳定碳同位素比值的方法 |
| CN114773408B (zh) * | 2022-04-26 | 2023-09-29 | 山东润德生物科技有限公司 | 一种从发酵液中制取唾液酸的方法 |
| CN115246864A (zh) * | 2022-07-15 | 2022-10-28 | 山东润德生物科技有限公司 | 一种制备唾液酸的方法 |
| CN115232178A (zh) * | 2022-08-18 | 2022-10-25 | 山东润德生物科技有限公司 | 一种从发酵液中提取唾液酸的工艺及该工艺的应用 |
| KR20240081664A (ko) * | 2022-11-30 | 2024-06-10 | 씨제이제일제당 (주) | 발효 제품 제조 공정 및 제조 장치 |
| CN116496330B (zh) * | 2023-06-28 | 2023-09-19 | 山东福洋生物制造工程研究院 | 一种唾液酸的提取方法及其提取的唾液酸 |
| CN117088923B (zh) * | 2023-10-20 | 2024-02-13 | 山东星光首创生物科技有限公司 | 一种高流动性2’-岩藻糖基乳糖的生产方法 |
| CN117646048A (zh) * | 2023-12-08 | 2024-03-05 | 重庆智合生物医药有限公司 | 一种缩短岩藻多糖发酵时间的生产方法 |
| CN117683832B (zh) * | 2024-02-04 | 2024-05-14 | 山东润德生物科技有限公司 | 一种聚唾液酸发酵培养基及其应用 |
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| RU2571274C2 (ru) | 2013-09-24 | 2015-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВПО "ВГУИТ") | Способ получения фукозы и фукозосодержащих гидролизатов из биомассы бурых водорослей |
| MX2016006220A (es) | 2013-11-15 | 2016-08-08 | Nestec Sa | Composiciones para usar en la prevencion o tratamiento de la enterocolitis necrotizante en infantes y niños pequeños nacidos por cesarea. |
| MX2016006060A (es) | 2013-11-15 | 2016-08-03 | Nestec Sa | Composiciones para usar en la prevencion o tratamiento de la enterocolitis necrotizante en infantes y niños pequeños. |
| EP2896628B1 (en) * | 2014-01-20 | 2018-09-19 | Jennewein Biotechnologie GmbH | Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation |
| CN104072533B (zh) | 2014-06-10 | 2016-05-11 | 中国科学院广州能源研究所 | 一类含低聚氧化乙烯单元的硅腈类化合物及其制备方法、在锂电池中的应用 |
| CN115350200A (zh) | 2014-12-08 | 2022-11-18 | 格礼卡姆股份公司 | 用于治疗代谢障碍的合成组合物 |
| EP3050973A1 (en) | 2015-01-30 | 2016-08-03 | Jennewein Biotechnologie GmbH | Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars |
| CN104628794B (zh) * | 2015-03-10 | 2017-05-10 | 武汉中科光谷绿色生物技术有限公司 | 一种对微生物发酵法生产的n‑乙酰神经氨酸进行分离提纯的方法 |
| DK3274465T3 (da) | 2015-03-26 | 2022-10-24 | Basf Se | Biokatalytisk fremstilling af l-fucose |
| CN106929461B (zh) | 2017-04-25 | 2020-11-03 | 江南大学 | 一种提高n-乙酰神经氨酸产量的重组枯草芽孢杆菌 |
| EP3473644A1 (en) * | 2017-10-17 | 2019-04-24 | Jennewein Biotechnologie GmbH | Fermentative production of n-acetylneuraminic acid |
| EP3486326A1 (en) | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
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