SG10201914019YA - Antibody producing non-human mammals - Google Patents
Antibody producing non-human mammalsInfo
- Publication number
- SG10201914019YA SG10201914019YA SG10201914019YA SG10201914019YA SG10201914019YA SG 10201914019Y A SG10201914019Y A SG 10201914019YA SG 10201914019Y A SG10201914019Y A SG 10201914019YA SG 10201914019Y A SG10201914019Y A SG 10201914019YA SG 10201914019Y A SG10201914019Y A SG 10201914019YA
- Authority
- SG
- Singapore
- Prior art keywords
- human mammals
- antibody producing
- producing non
- mammals
- antibody
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2008050430 | 2008-06-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201914019YA true SG10201914019YA (en) | 2020-03-30 |
Family
ID=41280336
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201408500RA SG10201408500RA (en) | 2008-06-27 | 2009-06-29 | Antibody producing non-human mammals |
SG10201914027VA SG10201914027VA (en) | 2008-06-27 | 2009-06-29 | Antibody producing non-human mammals |
SG10201914019YA SG10201914019YA (en) | 2008-06-27 | 2009-06-29 | Antibody producing non-human mammals |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201408500RA SG10201408500RA (en) | 2008-06-27 | 2009-06-29 | Antibody producing non-human mammals |
SG10201914027VA SG10201914027VA (en) | 2008-06-27 | 2009-06-29 | Antibody producing non-human mammals |
Country Status (23)
Country | Link |
---|---|
EP (6) | EP3456190B1 (ru) |
JP (6) | JP5749161B2 (ru) |
KR (5) | KR101990228B1 (ru) |
CN (3) | CN105191863B (ru) |
AU (1) | AU2009263082C1 (ru) |
CA (1) | CA2729095C (ru) |
CY (2) | CY1114830T1 (ru) |
DK (3) | DK2556747T3 (ru) |
ES (3) | ES2445193T3 (ru) |
HK (1) | HK1154463A1 (ru) |
HR (2) | HRP20220205T1 (ru) |
HU (1) | HUE057994T2 (ru) |
LT (1) | LT3456190T (ru) |
MX (1) | MX2010014542A (ru) |
NZ (1) | NZ590118A (ru) |
PL (2) | PL3456190T3 (ru) |
PT (3) | PT2556747T (ru) |
RS (2) | RS53146B (ru) |
RU (2) | RU2559524C2 (ru) |
SG (3) | SG10201408500RA (ru) |
SI (2) | SI3456190T1 (ru) |
WO (1) | WO2009157771A2 (ru) |
ZA (1) | ZA201009312B (ru) |
Families Citing this family (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
DK1523496T3 (da) | 2002-07-18 | 2011-10-17 | Merus B V | Rekombinant fremstilling af blanding af antistoffer |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
EP3456190B1 (en) * | 2008-06-27 | 2021-11-24 | Merus N.V. | Antibody producing transgenic murine animal |
DK2346994T3 (da) | 2008-09-30 | 2022-02-28 | Ablexis Llc | Knock-in-mus til fremstilling af kimære antistoffer |
EP2421357B1 (en) | 2009-07-08 | 2013-01-23 | Kymab Limited | Animal models and therapeutic molecules |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
RU2724663C2 (ru) | 2010-02-08 | 2020-06-25 | Ридженерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
AU2013204019B2 (en) * | 2010-02-08 | 2014-02-27 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
AU2011234988B2 (en) | 2010-03-31 | 2014-10-30 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
CA2802591A1 (en) * | 2010-06-17 | 2011-12-22 | Kymab Limited | Animal models and therapeutic molecules |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10881084B2 (en) | 2010-07-26 | 2021-01-05 | Trianni, Inc | Transgenic animals and methods of use |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
EP2947151A1 (en) | 2010-08-02 | 2015-11-25 | Regeneron Pharmaceuticals, Inc. | Binding proteins comprising vl domains |
SI2739740T1 (sl) * | 2011-08-05 | 2019-12-31 | Regeneron Pharmaceuticals, Inc. | Humanizirane univerzalne lahkoverižne miši |
AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
EP2761008A1 (en) | 2011-09-26 | 2014-08-06 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
KR102280111B1 (ko) | 2011-12-22 | 2021-07-21 | 에프. 호프만-라 로슈 아게 | 발현 벡터 구성, 신규한 생산 세포 생성 방법 및 폴리펩티드의 재조합 생산을 위한 그의 용도 |
CN104202971B (zh) * | 2012-02-01 | 2016-07-06 | 瑞泽恩制药公司 | 表达包含vl结构域的重链的人源化啮齿动物的制备方法 |
GB2500113A (en) | 2012-03-05 | 2013-09-11 | Oxitec Ltd | Arthropod male germline gene expression system |
RU2683514C2 (ru) * | 2012-03-06 | 2019-03-28 | Регенерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
CA2865645A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing immunoglobulin sequences ph-sensitive for antigen building |
SI2883449T1 (en) | 2012-03-16 | 2018-05-31 | Regeneron Pharmaceuticals, Inc. | Light-chain modified antibodies with histidine and genetically modified rodents for their production |
US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
EP2825035A1 (en) | 2012-03-16 | 2015-01-21 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
GB2502127A (en) * | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
EP3594232A1 (en) | 2012-04-20 | 2020-01-15 | Merus N.V. | Methods and means for the production of ig-like molecules |
EP2854523A1 (en) * | 2012-06-05 | 2015-04-08 | Regeneron Pharmaceuticals, Inc. | Methods for making fully human bispecific antibodies using a common light chain |
EP2869845B1 (en) | 2012-07-06 | 2019-08-28 | Genmab B.V. | Dimeric protein with triple mutations |
CN103571872B (zh) * | 2012-08-09 | 2016-11-23 | 山东国际生物科技园发展有限公司 | 一种能够表达人抗体的转基因动物的制备方法 |
EP3470431A1 (en) | 2012-09-27 | 2019-04-17 | Merus N.V. | Bispecific igg antibodies as t cell engagers |
GB201303932D0 (en) | 2013-03-05 | 2013-04-17 | Oxitec Ltd | Muscle actin promoter |
SG11201506278RA (en) * | 2013-03-13 | 2015-09-29 | Regeneron Pharma | Mice expressing a limited immunoglobulin light chain repertoire |
MY174813A (en) | 2013-03-15 | 2020-05-16 | Zymeworks Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
TW201546284A (zh) | 2013-10-01 | 2015-12-16 | Kymab Ltd | 動物模式及治療分子 |
CN109090037B (zh) * | 2013-10-15 | 2021-05-28 | 瑞泽恩制药公司 | 人源化的il-15动物 |
CN106255513B (zh) | 2013-12-27 | 2022-01-14 | 酵活有限公司 | 用于药物偶联物的含磺酰胺连接系统 |
KR20240042540A (ko) | 2014-02-28 | 2024-04-02 | 메뤼스 엔.페. | ErbB-2와 ErbB-3에 결합하는 항체 |
JP6771385B2 (ja) | 2014-02-28 | 2020-10-21 | メルス ナムローゼ フェンノートシャップ | 二重特異性抗体および医薬組成物 |
ES2762640T3 (es) | 2014-03-21 | 2020-05-25 | Regeneron Pharma | Proteínas VL de unión a antígeno que exhiben diferentes características de unión |
WO2015143414A2 (en) | 2014-03-21 | 2015-09-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
GB2526867A (en) * | 2014-06-05 | 2015-12-09 | Oxitec Ltd | Gene expression system |
AU2015318556C1 (en) | 2014-09-17 | 2021-01-07 | Zymeworks Bc Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
AU2016232715A1 (en) | 2015-03-19 | 2017-09-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
RS57928B1 (sr) | 2015-07-10 | 2019-01-31 | Merus Nv | Antitela koja vezuju humani cd3 |
US20170058052A1 (en) | 2015-08-24 | 2017-03-02 | Trianni, Inc. | Enhanced production of immunoglobulins |
PL3365373T3 (pl) | 2015-10-23 | 2021-08-23 | Merus N.V. | Molekuły wiążące, które hamują wzrost nowotworu |
US10813346B2 (en) | 2015-12-03 | 2020-10-27 | Trianni, Inc. | Enhanced immunoglobulin diversity |
JP6929877B2 (ja) | 2016-02-04 | 2021-09-01 | トリアニ・インコーポレイテッドTrianni, Inc. | 免疫グロブリン産生の増強 |
PT3462853T (pt) | 2016-06-03 | 2023-04-21 | Regeneron Pharma | Animais não humanos que expressam desoxinucleotidiltransferase terminal exógena |
BR112019002771A2 (pt) | 2016-08-12 | 2019-05-14 | Oxitec Ltd | polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna. |
BR112019005895A2 (pt) | 2016-09-23 | 2019-06-11 | Merus N.V. | moléculas de ligação que modulam uma atividade biológica expressa por uma célula |
AU2018239320A1 (en) * | 2017-03-20 | 2019-11-07 | Washington University | Cells and methods of uses and making the same |
KR20190140944A (ko) | 2017-03-31 | 2019-12-20 | 메뤼스 엔.페. | ErbB-2, ErbB-2/ErbB-3 양성 종양을 가진 개체의 치료를 위한, ErbB-2 및 ErbB-3의 세포외 부분 상의 에피토프에 결합하는 항원-결합 부위를 가진 이중특이적 항체 및 ErbB-2 표적화제 |
CN110650752A (zh) | 2017-03-31 | 2020-01-03 | 美勒斯公司 | 用于治疗具有NRG1融合基因的细胞的ErbB-2和ErbB3结合双特异性抗体 |
MX2019013804A (es) | 2017-05-17 | 2020-02-24 | Merus Nv | Combinacion de un anticuerpo biespecifico de erbb-2/erbb-3 con terapia endocrina para cancer de mama. |
BR112020000209A8 (pt) | 2017-07-06 | 2020-08-11 | Merus Nv | moléculas de ligação que modulam uma atividade biológica expressa por uma célula |
EP3649155A1 (en) | 2017-07-06 | 2020-05-13 | Merus N.V. | Bispecific anti pd1-anti tim3 antibodies |
CN117964759A (zh) | 2017-07-06 | 2024-05-03 | 美勒斯公司 | 调节由细胞表达的生物活性的抗体 |
GB201710984D0 (en) * | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
CN111432838A (zh) | 2017-12-01 | 2020-07-17 | 美勒斯公司 | 使用双特异性抗体和il-15进行联合治疗 |
ES2928995T3 (es) * | 2017-12-05 | 2022-11-24 | Regeneron Pharma | Ratones que tienen una cadena ligera lambda de inmunoglobulina genomanipulada y usos de los mismos |
TWI804572B (zh) | 2018-02-09 | 2023-06-11 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
BR112020019026A2 (pt) | 2018-03-24 | 2020-12-29 | Regeneron Pharmaceuticals, Inc. | Animal não humano geneticamente modificado, métodos para produzir o animal não humano geneticamente modificado, para geração de uma proteína de ligação a antígeno, para obtenção de um ácido nucleico, e, para obtenção de uma célula que expressa um domínio variável de cadeia pesada de imunoglobulina humana e/ou um domínio variável de cadeia leve de imunoglobulina humana, método in vitro de produção de um domínio variável de imunoglobulina humana, ácido nucleico, célula hospedeira, célula isolada, e, domínio variável de cadeia pesada de imunoglobulina humana |
KR20200139189A (ko) | 2018-03-30 | 2020-12-11 | 메뤼스 엔.페. | 다가 항체 |
CN108624622A (zh) * | 2018-05-16 | 2018-10-09 | 湖南艾佳生物科技股份有限公司 | 一种基于CRISPR-Cas9系统构建的能分泌小鼠白细胞介素-6的基因工程细胞株 |
KR102480493B1 (ko) * | 2018-06-08 | 2022-12-21 | 크리스탈 바이오사이언스 주식회사 | 동일한 경쇄 i을 갖는 다양한 항체를 생산하기 위한 트랜스제닉 동물 |
MX2020013652A (es) | 2018-06-14 | 2022-04-21 | Regeneron Pharma | Animales no humanos con capacidad de reordenamiento dh-dh en las secuencias codificantes de la cadena pesada de inmunoglobulina. |
JP2022521036A (ja) | 2018-12-20 | 2022-04-05 | メルス ナムローゼ フェンノートシャップ | CLEC12AxCD3二重特異性抗体及び疾患の治療方法 |
EP3897117A1 (en) | 2018-12-21 | 2021-10-27 | Compass Therapeutics LLC | Transgenic mouse expressing common human light chain |
BR112021013009A2 (pt) | 2018-12-31 | 2021-09-14 | Merus N.V. | Domínios de ligação mistos |
JP7440516B2 (ja) | 2018-12-31 | 2024-02-28 | メルス ナムローゼ フェンノートシャップ | 切断多価多量体 |
WO2020154293A1 (en) | 2019-01-22 | 2020-07-30 | Bristol-Myers Squibb Company | Antibodies against il-7r alpha subunit and uses thereof |
JP2022520649A (ja) | 2019-02-14 | 2022-03-31 | メルス ナムローゼ フェンノートシャップ | Egfr、her2及びher3に結合する結合部分の組み合わせ |
US20220127375A1 (en) | 2019-02-14 | 2022-04-28 | Merus N.V. | Producing compositions comprising two or more antibodies |
CA3125380A1 (en) | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
TW202039578A (zh) | 2019-03-29 | 2020-11-01 | 荷蘭商美勒斯公司 | Cd3結合分子 |
TW202102544A (zh) * | 2019-04-04 | 2021-01-16 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
SG11202112399PA (en) | 2019-05-09 | 2021-12-30 | Merus Nv | Variant domains for multimerizing proteins and separation thereof |
CN114502725A (zh) * | 2019-07-01 | 2022-05-13 | 特里安尼公司 | 转基因哺乳动物及使用方法 |
EP3998081A4 (en) * | 2019-07-05 | 2023-07-12 | Ono Pharmaceutical Co., Ltd. | TREATMENT OF BLOOD CANCER WITH PD-1/CD3 DUAL SPECIFICITY PROTEIN |
WO2021020416A1 (ja) * | 2019-07-30 | 2021-02-04 | 小野薬品工業株式会社 | 二重特異性抗体 |
EP3772518A1 (en) | 2019-08-07 | 2021-02-10 | Merus N.V. | Modified human variable domains |
CN114555115A (zh) | 2019-08-19 | 2022-05-27 | 美勒斯公司 | 用结合lgr5和egfr的抗体与拓扑异构酶i抑制剂的组合治疗癌症 |
GB201912008D0 (en) | 2019-08-21 | 2019-10-02 | Cambridge Entpr Ltd | Antibody |
EP4069722A1 (en) | 2019-12-02 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
IL294181A (en) | 2019-12-24 | 2022-08-01 | Merus Nv | tgf-beta-rii binding proteins |
CA3166407A1 (en) | 2020-01-29 | 2021-08-05 | Merus N.V. | Means and method for modulating fimmune cell engaging effects |
CA3176186A1 (en) | 2020-04-24 | 2021-10-28 | Ernesto Isaac WASSERMAN | Treatment of cancers with an antibody that binds lgr5 and egfr |
CN115667532A (zh) * | 2020-06-02 | 2023-01-31 | 百奥赛图(北京)医药科技股份有限公司 | 具有共有轻链免疫球蛋白基因座的经遗传修饰的非人动物 |
TW202229328A (zh) | 2020-09-11 | 2022-08-01 | 美商再生元醫藥公司 | 抗原特異性抗體之鑑定及產生 |
CN117624324A (zh) | 2020-12-15 | 2024-03-01 | 美勒斯公司 | 利用结合lgr5和egfr的抗体治疗癌症 |
CN116710486A (zh) | 2020-12-16 | 2023-09-05 | 美勒斯公司 | 用于治疗癌症的多特异性抗体 |
AU2021400584A1 (en) | 2020-12-16 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
EP4262867A1 (en) | 2020-12-18 | 2023-10-25 | Merus N.V. | Antibody composition |
MX2023007401A (es) | 2020-12-23 | 2023-07-06 | Regeneron Pharma | Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos. |
WO2023059191A1 (en) | 2021-10-06 | 2023-04-13 | Merus N.V. | Treatment of immune checkpoint inhibitor-treated cancers with high egfr expression using an antibody that binds at least egfr |
WO2023146394A1 (en) | 2022-01-25 | 2023-08-03 | Merus N.V. | Combination therapy for the treatment of cancer |
WO2023172134A1 (en) | 2022-03-07 | 2023-09-14 | Merus N.V. | Treatment with an antibody that binds egfr and cmet. |
TW202337909A (zh) | 2022-03-07 | 2023-10-01 | 荷蘭商美勒斯公司 | 包括結合EGFR及cMET之抗體的組合療法 |
GB202216503D0 (en) | 2022-11-05 | 2022-12-21 | Quadrucept Bio Ltd | Non-human vertebrates & cells |
GB202217978D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
WO2024136658A1 (en) | 2022-12-23 | 2024-06-27 | Merus N.V. | Combination treatment of cancers using an antibody that binds at least egfr and an immune checkpoint inhibitor |
WO2024144401A1 (en) | 2022-12-28 | 2024-07-04 | Merus N.V. | Treatment of cancer with a combination of an antibody that binds egfr and cytotoxic drugs |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4531078A (en) | 1983-10-27 | 1985-07-23 | Polaroid Corporation | Control circuit for electronic flash |
GB8909218D0 (en) | 1989-04-22 | 1989-06-07 | Medical Res Council | Improvements in or relating to enhancers |
US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
EP0546073B1 (en) * | 1990-08-29 | 1997-09-10 | GenPharm International, Inc. | production and use of transgenic non-human animals capable of producing heterologous antibodies |
US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
AU3328493A (en) * | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
JPH08140528A (ja) * | 1993-12-03 | 1996-06-04 | Genpharm Internatl Inc | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
US5885827A (en) * | 1996-01-23 | 1999-03-23 | The Regents Of The Universtiy Of California | Eukaryotic high rate mutagenesis system |
ATE299938T1 (de) | 1997-05-02 | 2005-08-15 | Genentech Inc | Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
JP2002512624A (ja) | 1997-05-21 | 2002-04-23 | バイオベーション リミテッド | 非免疫原性タンパク質の製造方法 |
IL138579A0 (en) * | 1998-03-30 | 2001-10-31 | Res Dev Foundation | Corticotropin releasing factor receptor 1-deficient mice |
US20020028488A1 (en) | 2000-06-19 | 2002-03-07 | Sujay Singh | Transgenic avian species for making human and chimeric antibodies |
US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
DK1523496T3 (da) * | 2002-07-18 | 2011-10-17 | Merus B V | Rekombinant fremstilling af blanding af antistoffer |
EP1439234A1 (en) * | 2003-01-08 | 2004-07-21 | ARTEMIS Pharmaceuticals GmbH | Targeted transgenesis using the rosa26 locus |
ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
WO2005068622A2 (en) | 2004-01-20 | 2005-07-28 | Merus B.V. | Mixtures of binding proteins |
JP4487068B2 (ja) * | 2004-10-12 | 2010-06-23 | 国立大学法人 岡山大学 | 細胞の遺伝子変異機能の制御による変異タンパク質の作製方法 |
CA2604440A1 (en) * | 2005-04-29 | 2006-11-09 | Inserm (Institut De La Sante Et De La Recherche Medicale) | Transgenic animals and methods of making recombinant antibodies |
WO2007117410A2 (en) * | 2006-03-31 | 2007-10-18 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
MX2009003393A (es) | 2006-10-02 | 2009-05-11 | Regeneron Pharma | Anticuerpos humanos de alta afinidad para el receptor de il-4 humano. |
NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
EP3456190B1 (en) * | 2008-06-27 | 2021-11-24 | Merus N.V. | Antibody producing transgenic murine animal |
RU2724663C2 (ru) * | 2010-02-08 | 2020-06-25 | Ридженерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
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