SG10201902598VA - Peptidomimetic macrocycles and formulations thereof - Google Patents

Peptidomimetic macrocycles and formulations thereof

Info

Publication number
SG10201902598VA
SG10201902598VA SG10201902598VA SG10201902598VA SG10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA
Authority
SG
Singapore
Prior art keywords
formulations
disclosed
peptidomimetic macrocycles
peptidomimetic
aqueous pharmaceutical
Prior art date
Application number
SG10201902598VA
Other languages
English (en)
Inventor
David Allen Annis
Krzysztof Darlak
Chris Rhodes
Sonoko Kanai
Joerg Hoernschemeyer
Michaela Grass
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of SG10201902598VA publication Critical patent/SG10201902598VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SG10201902598VA 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof SG10201902598VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462054842P 2014-09-24 2014-09-24

Publications (1)

Publication Number Publication Date
SG10201902598VA true SG10201902598VA (en) 2019-04-29

Family

ID=55582019

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201902598VA SG10201902598VA (en) 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof
SG11201702175YA SG11201702175YA (en) 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201702175YA SG11201702175YA (en) 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof

Country Status (12)

Country Link
US (3) US10905739B2 (he)
EP (1) EP3197477A4 (he)
JP (3) JP2018503595A (he)
KR (1) KR102570210B1 (he)
CN (2) CN107106642B (he)
AU (1) AU2015320545C1 (he)
BR (1) BR112017005736A2 (he)
CA (1) CA2961029A1 (he)
IL (1) IL251122B (he)
MX (1) MX2017003819A (he)
SG (2) SG10201902598VA (he)
WO (1) WO2016049355A1 (he)

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WO2008076904A1 (en) 2006-12-14 2008-06-26 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CN104086641A (zh) 2007-02-23 2014-10-08 爱勒让治疗公司 三唑大环系统
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US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2480565A4 (en) 2009-09-22 2014-01-01 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
DK2603600T3 (da) 2010-08-13 2019-03-04 Aileron Therapeutics Inc Peptidomimetiske makrocyklusser
CA2852468A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6971970B2 (ja) * 2015-09-03 2021-11-24 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics, Inc. ペプチド模倣大環状分子およびその使用
US11306130B2 (en) 2016-04-01 2022-04-19 Arizona Board Of Regents On Behalf Of The University Of Arizona PAR3 mimetic peptides and uses thereof
WO2017205786A1 (en) * 2016-05-27 2017-11-30 Aileron Therapeutics, Inc. Cell permeable peptidomimetic macrocycles
WO2017218949A2 (en) * 2016-06-17 2017-12-21 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2018098534A1 (en) * 2016-12-02 2018-06-07 Garvan Institute Of Medical Research Methods of treating cancer and reagents thereof
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
KR20210118810A (ko) * 2018-10-24 2021-10-01 알리스타 파마슈티컬즈, 인크. 아디포넥틴 펩티드모방체 제제
WO2020190742A1 (en) * 2019-03-15 2020-09-24 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP4121113A1 (en) * 2020-03-20 2023-01-25 Techfields Inc. Method for improving the stability of a pharmaceutical composition comprising a high penetration drug, and the pharmaceutical composition obtained therefrom
CA3193261A1 (en) * 2020-10-14 2022-04-21 Dana-Farber Cancer Institute, Inc. Chimeric conjugates for degradation of viral and host proteins and methods of use

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