SE9301916D0 - New peptides derivatives - Google Patents
New peptides derivativesInfo
- Publication number
- SE9301916D0 SE9301916D0 SE19939301916A SE9301916A SE9301916D0 SE 9301916 D0 SE9301916 D0 SE 9301916D0 SE 19939301916 A SE19939301916 A SE 19939301916A SE 9301916 A SE9301916 A SE 9301916A SE 9301916 D0 SE9301916 D0 SE 9301916D0
- Authority
- SE
- Sweden
- Prior art keywords
- new peptides
- peptides derivatives
- derivatives
- new
- therapy
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (59)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19939301916A SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | New peptides derivatives |
UA95115078A UA65518C2 (en) | 1993-06-03 | 1994-02-06 | Peptide derivatives |
TW083104085A TW403731B (en) | 1993-06-03 | 1994-05-05 | New peptides derivatives |
IL123996A IL123996A (en) | 1993-06-03 | 1994-05-12 | Use of compounds as starting materials in synthesis of a serine protease inhibitor |
IL10963494A IL109634A (en) | 1993-06-03 | 1994-05-12 | Peptide derivatives their preparation and pharmaceutical compositions containing them |
IL12399594A IL123995A (en) | 1993-06-03 | 1994-05-12 | Peptide derivatives, their preparation and pharmaceutical compositions comprising them |
IS4166A IS1805B (is) | 1993-06-03 | 1994-05-16 | Aðferð til að framleiða nýjar peptíðafleiður sem eru þrombíntálmar |
HR940311A HRP940311B1 (en) | 1993-06-03 | 1994-05-17 | New peptide derivatives |
MX9404114A MX9404114A (es) | 1993-06-03 | 1994-06-01 | Nuevos derivados de peptidos. |
EG32494A EG20671A (en) | 1993-06-03 | 1994-06-02 | New peptides derivatives |
PT94918636T PT701568E (pt) | 1993-06-03 | 1994-06-02 | Novos derivados de peptidos |
ES94918636T ES2128277T3 (es) | 1993-06-03 | 1994-06-02 | Nuevos derivados de peptidos. |
AU69869/94A AU684086C (en) | 1993-06-03 | 1994-06-02 | New peptide derivatives |
EP94918636A EP0701568B1 (fr) | 1993-06-03 | 1994-06-02 | Nouveaux derives peptidiques |
DK94918636T DK0701568T3 (da) | 1993-06-03 | 1994-06-02 | Nye peptidderivater |
KR1019950705448A KR100339456B1 (ko) | 1993-06-03 | 1994-06-02 | 신규펩티드유도체 |
PCT/SE1994/000535 WO1994029336A1 (fr) | 1993-06-03 | 1994-06-02 | Nouveaux derives peptidiques |
RU96101161A RU2142469C1 (ru) | 1993-06-03 | 1994-06-02 | Пептидные производные, их стереоизомеры или физиологически приемлемые соли, обладающие противотромбозной, противосвертывающей или противовоспалительной активностью, способ их получения, фармацевтическая композиция, способ подавления тромбина, способ подавления кининогеназ, применение соединений в качестве исходных в синтезе ингибитора тромбина |
SK1454-95A SK283150B6 (sk) | 1993-06-03 | 1994-06-02 | Peptidové deriváty, spôsob ich prípravy, farmaceutický prípravok s ich obsahom a ich použitie |
SG1996006171A SG48013A1 (en) | 1993-06-03 | 1994-06-02 | New peptide derivatives |
CA002162900A CA2162900C (fr) | 1993-06-03 | 1994-06-02 | Nouveaux derives de peptides |
EP00121659A EP1067136A1 (fr) | 1993-06-03 | 1994-06-02 | Nouveaux dérivés peptidiques |
DE0701568T DE701568T1 (de) | 1993-06-03 | 1994-06-02 | Neuartige peptidderivate |
NZ267534A NZ267534A (en) | 1993-06-03 | 1994-06-02 | Trypsin-like serine protease inhibitors and compositions thereof, and precursor reagents |
JP50166595A JP3205558B2 (ja) | 1993-06-03 | 1994-06-02 | 新規ペプチド誘導体 |
CZ19953020A CZ290104B6 (cs) | 1993-06-03 | 1994-06-02 | Peptidový derivát, způsob jeho přípravy a použitía farmaceutický přípravek s jeho obsahem |
CN94192799A CN1099425C (zh) | 1993-06-03 | 1994-06-02 | 新的肽衍生物 |
DE69427150T DE69427150T2 (de) | 1993-06-03 | 1994-06-02 | Neuartige peptidderivate |
SI9430365T SI0701568T1 (en) | 1993-06-03 | 1994-06-02 | New peptide derivatives |
HU0103039A HU0103039D0 (en) | 1993-06-03 | 1994-06-02 | Use of para-amidinobenzylamine for the synthesis of peptide like serine protease inhibitors, and protected derivatives thereof |
MYPI94001423A MY119155A (en) | 1993-06-03 | 1994-06-02 | New peptide derivatives |
BR9406746A BR9406746A (pt) | 1993-06-03 | 1994-06-02 | Composto processo para sua preparaçao preparado farmacêutico uso de um composto processo para a obtençao da inibiçao de trombina em um organismo humano ou animale fragmento estrutural |
AT94918636T ATE200783T1 (de) | 1993-06-03 | 1994-06-02 | Neuartige peptidderivate |
PL94311819A PL181968B1 (pl) | 1993-06-03 | 1994-06-02 | Nowe pochodne peptydowe, sposób wytwarzania pochodnych peptydowych oraz kompozycje farmaceutyczne zawierajace pochodne peptydowe PL |
DE122004000045C DE122004000045I2 (de) | 1993-06-03 | 1994-06-02 | Neuartige peptidderivate |
HU9503445A HU226825B1 (en) | 1993-06-03 | 1994-06-02 | Peptide derivatives, process for prepearing them, pharmaceutical compositions containing them and use of them |
LTIP1947A LT3768B (en) | 1993-06-03 | 1994-06-03 | Novel peptides derivatives, process for their preparation, pharmaceutical compositions and use starting materials in synthesis of a serine protease inhibitors |
YUP-336/94A RS49576B (sr) | 1993-06-03 | 1994-06-03 | Novi derivati peptida |
SA94150051A SA94150051B1 (ar) | 1993-06-03 | 1994-07-03 | مشتقات ببتيد جديدة |
EE9400456A EE03264B1 (et) | 1993-06-03 | 1994-11-23 | Peptiidi derivaadid, nende saamise protsess, neid sisaldavad ravimpreparaadid ja nende kasutamine |
US08/468,046 US5602253A (en) | 1993-06-03 | 1995-06-06 | Peptides derivatives |
US08/470,277 US5723444A (en) | 1993-06-03 | 1995-06-06 | Starting materials in the synthesis of thrombin and kinogenase inhibitors |
US08/470,258 US5783563A (en) | 1993-06-03 | 1995-06-06 | Method for treatment or prophylaxis of venous thrombosis |
US08/465,916 US5780631A (en) | 1993-06-03 | 1995-06-06 | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
US08/484,427 US5856307A (en) | 1993-06-03 | 1995-06-07 | Peptide derivatives as kininogenase inhibitors |
US08/481,811 US5939392A (en) | 1993-06-03 | 1995-06-07 | Method of thrombin inhibition |
NO19954873A NO314406B1 (no) | 1993-06-03 | 1995-11-30 | Nye peptidderivater, farmasöytisk preparat inneholdende slike derivater, deres anvendelse, fremgangsmåter for deres fremstilling, ogmellomprodukter |
FI955828A FI119812B (fi) | 1993-06-03 | 1995-12-04 | Menetelmä uusien, terapeuttisesti käyttökelpoisten peptidijohdannaisten valmistamiseksi |
CNB991248597A CN1178905C (zh) | 1993-06-03 | 1999-11-15 | 新的肽衍生物 |
US09/566,403 US6984627B1 (en) | 1993-06-03 | 2000-05-08 | Peptide derivatives |
JP2001091958A JP2001322974A (ja) | 1993-06-03 | 2001-03-28 | 4−アミノメチル−1−アミジノベンゼン化合物 |
HK01102259A HK1031375A1 (en) | 1993-06-03 | 2001-03-28 | New peptide derivatives. |
JP2001158596A JP2002047264A (ja) | 1993-06-03 | 2001-05-28 | アミノアルキルベンゼン化合物 |
GR20010401107T GR3036258T3 (en) | 1993-06-03 | 2001-07-24 | New peptide derivatives |
NO2004009C NO2004009I1 (no) | 1993-06-03 | 2004-12-13 | Melagatran, stereoisomerer derav eller fysiologisksalter eller estrer derav |
NL300178C NL300178I2 (nl) | 1993-06-03 | 2005-03-03 | Nieuwe peptidederivaten. |
US11/090,786 US20050222395A1 (en) | 1993-06-03 | 2005-03-25 | New peptide derivatives |
LU91173C LU91173I2 (fr) | 1993-06-03 | 2005-05-11 | Ximelagatran, et les sels pharmaceutiquement acceptables de celui-ci (exanta). |
US12/222,604 US20090192137A1 (en) | 1993-06-03 | 2008-08-12 | Dialysis method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19939301916A SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | New peptides derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9301916D0 true SE9301916D0 (sv) | 1993-06-03 |
Family
ID=20390165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE19939301916A SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | New peptides derivatives |
Country Status (40)
Country | Link |
---|---|
US (4) | US5723444A (fr) |
EP (2) | EP0701568B1 (fr) |
JP (3) | JP3205558B2 (fr) |
KR (1) | KR100339456B1 (fr) |
CN (2) | CN1099425C (fr) |
AT (1) | ATE200783T1 (fr) |
BR (1) | BR9406746A (fr) |
CA (1) | CA2162900C (fr) |
CZ (1) | CZ290104B6 (fr) |
DE (3) | DE69427150T2 (fr) |
DK (1) | DK0701568T3 (fr) |
EE (1) | EE03264B1 (fr) |
EG (1) | EG20671A (fr) |
ES (1) | ES2128277T3 (fr) |
FI (1) | FI119812B (fr) |
GR (1) | GR3036258T3 (fr) |
HK (1) | HK1031375A1 (fr) |
HR (1) | HRP940311B1 (fr) |
HU (2) | HU226825B1 (fr) |
IL (2) | IL123996A (fr) |
IS (1) | IS1805B (fr) |
LT (1) | LT3768B (fr) |
LU (1) | LU91173I2 (fr) |
MX (1) | MX9404114A (fr) |
MY (1) | MY119155A (fr) |
NL (1) | NL300178I2 (fr) |
NO (2) | NO314406B1 (fr) |
NZ (1) | NZ267534A (fr) |
PL (1) | PL181968B1 (fr) |
PT (1) | PT701568E (fr) |
RS (1) | RS49576B (fr) |
RU (1) | RU2142469C1 (fr) |
SA (1) | SA94150051B1 (fr) |
SE (1) | SE9301916D0 (fr) |
SG (1) | SG48013A1 (fr) |
SI (1) | SI0701568T1 (fr) |
SK (1) | SK283150B6 (fr) |
TW (1) | TW403731B (fr) |
UA (1) | UA65518C2 (fr) |
WO (1) | WO1994029336A1 (fr) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US6984627B1 (en) * | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
SE9900043D0 (sv) * | 1999-01-11 | 1999-01-11 | Astra Ab | New use |
RU2136661C1 (ru) * | 1993-10-21 | 1999-09-10 | Джи Ди Сирл энд Ко. | Амидинопроизводные, их применение и фармацевтическая композиция |
JP4561696B2 (ja) * | 1994-01-27 | 2010-10-13 | 三菱化学株式会社 | プロリンアミド誘導体 |
US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
CA2143533A1 (fr) * | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Agents antithrombotiques |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
US6090786A (en) * | 1994-06-10 | 2000-07-18 | Fondatech Benelux N.V. | Serine proteases, their activity and their synthetic inhibitors |
DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
DE4443390A1 (de) * | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
CN1173872A (zh) * | 1995-02-10 | 1998-02-18 | 巴斯福股份公司 | 凝血酶抑制剂 |
NZ302649A (en) * | 1995-02-17 | 2000-01-28 | Basf Ag | Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US5629324A (en) * | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
US5610308A (en) * | 1995-05-18 | 1997-03-11 | Bristol-Myers Squibb Company | Process for preparing intermediates for thrombin inhibitors |
SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
US6239150B1 (en) | 1995-07-26 | 2001-05-29 | Mitsubishi Chemical Corporation | Penicillaminamide derivatives |
JP2008024720A (ja) * | 1995-07-26 | 2008-02-07 | Mitsubishi Chemicals Corp | ペニシラミンアミド誘導体 |
DE69627184D1 (de) * | 1995-12-09 | 2003-05-08 | Akzo Nobel Nv | 3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften |
GB9526273D0 (en) * | 1995-12-21 | 1996-02-21 | Astra Ab | New prodrugs |
TW541316B (en) * | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
SE9600216D0 (sv) * | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
CN1212706A (zh) * | 1996-02-13 | 1999-03-31 | 阿克佐诺贝尔公司 | 丝氨酸蛋白酶抑制剂 |
IL120310A (en) | 1996-03-01 | 2002-02-10 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
TW523513B (en) * | 1996-03-01 | 2003-03-11 | Akzo Nobel Nv | Serine protease inhibitors |
US5811402A (en) * | 1996-03-22 | 1998-09-22 | Eli Lilly And Company | Antithrombotic diamides |
SE9602145D0 (sv) * | 1996-05-31 | 1996-05-31 | Astra Ab | New improved formulation for treatment of thromboembolism |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
CA2258915A1 (fr) | 1996-06-25 | 1997-12-31 | Michael Robert Wiley | Agents anticoagulants |
US6200967B1 (en) | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
US6756389B2 (en) * | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
US5792761A (en) * | 1996-08-12 | 1998-08-11 | Merck & Co., Inc. | Thrombin inhibitors |
DE19632772A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
DE19632773A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
IL121474A0 (en) * | 1996-08-23 | 1998-02-08 | Akzo Nobel Nv | Thrombin inhibitors |
SE9603724D0 (sv) * | 1996-10-11 | 1996-10-11 | Astra Ab | New pharmaceutical parenteral formulation of a thrombin inhibitor |
US5798377A (en) * | 1996-10-21 | 1998-08-25 | Merck & Co., Inc. | Thrombin inhibitors |
US5869487A (en) * | 1996-10-24 | 1999-02-09 | Merck & Co., Inc. | Pyrido 3,4-B!pyrazines for use as thrombin inhibitors |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
US6262069B1 (en) * | 1997-08-29 | 2001-07-17 | Protherics Molecular Design Limited | 1-amino-7-isoquinoline derivatives as serine protease inhibitors |
US6087373A (en) * | 1997-09-23 | 2000-07-11 | Merck & Co., Inc. | Thrombin inhibitors |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
DE19755682A1 (de) * | 1997-12-15 | 1999-06-17 | Knoll Ag | Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren |
WO1999037611A1 (fr) * | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Amidines heterocycliques utilisees comme inhibiteurs de la kallicreine |
EP1051431A1 (fr) | 1998-01-26 | 2000-11-15 | Basf Aktiengesellschaft | Inhibiteurs de la thrombine |
NZ508005A (en) | 1998-04-24 | 2003-05-30 | Dimensional Pharm Inc | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines useful as serine protease inhibitors |
SE9802938D0 (sv) | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
SE9802939D0 (sv) | 1998-09-01 | 1998-09-01 | Astra Ab | New process |
SE9802973D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
SE9802974D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
EP0987274A1 (fr) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Inhibiteurs du facteur VIIa |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
KR20000047461A (ko) * | 1998-12-29 | 2000-07-25 | 성재갑 | 트롬빈 억제제 |
SE9900070D0 (sv) | 1999-01-13 | 1999-01-13 | Astra Ab | New use |
EP1150996B1 (fr) | 1999-01-13 | 2007-11-21 | AstraZeneca AB | Nouveaux derives d'amidinobenzylamine et leur utilisation comme inhibiteurs de thrombine |
JP4489976B2 (ja) | 1999-04-09 | 2010-06-23 | ビーエーエスエフ ソシエタス・ヨーロピア | 補体プロテアーゼの低分子インヒビター |
AR023510A1 (es) * | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
US6239132B1 (en) | 1999-04-23 | 2001-05-29 | Merck & Co., Inc. | Thrombin inhibitors |
AR023819A1 (es) * | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
ATE279435T1 (de) | 1999-05-10 | 2004-10-15 | Abbott Gmbh & Co Kg | Salze von thrombininhibitoren |
EP1189618A4 (fr) | 1999-06-04 | 2002-06-19 | Merck & Co Inc | Inhibiteurs de la thrombine |
EP1059302A1 (fr) * | 1999-06-08 | 2000-12-13 | Aventis Pharma Deutschland GmbH | Inhibiteurs de factor VIIa |
SE9902550D0 (sv) * | 1999-07-02 | 1999-07-02 | Astra Ab | New crystalline forms |
EP1210433A2 (fr) * | 1999-08-31 | 2002-06-05 | The Board Of Regents, The University Of Texas System | Methodes et compositions d'un nouvel inhibiteur de serine protease |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
DE10029015A1 (de) * | 2000-06-15 | 2001-12-20 | Curacyte Ag | Hemmstoffe für den Gerinnungsfaktor Xa |
DE10029014A1 (de) | 2000-06-15 | 2001-12-20 | Univ Schiller Jena | Urokinase-Hemmstoffe |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
WO2002028411A1 (fr) | 2000-10-06 | 2002-04-11 | Xenoport, Inc. | Composes permettant une liberation prolongee de medicaments oraux |
DE10049937A1 (de) * | 2000-10-06 | 2002-04-11 | Knoll Ag | Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten |
US6462021B1 (en) | 2000-11-06 | 2002-10-08 | Astrazeneca Ab | Use of low molecular weight thrombin inhibitor |
US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
WO2002050056A1 (fr) | 2000-12-18 | 2002-06-27 | Merck & Co., Inc. | Derives de benzylamine et leur utilisation comme inhibiteurs de thrombine |
US6528503B2 (en) | 2000-12-18 | 2003-03-04 | Merck & Co., Inc. | Thrombin inhibitors |
US7144899B2 (en) | 2001-02-09 | 2006-12-05 | Merck & Co., Inc. | Thrombin inhibitors |
DE10117730A1 (de) | 2001-04-09 | 2002-10-10 | Basf Ag | Umsetzung von (Di)Aminen in Gegenwart einer Lysinoxidase und eines Reduktionsmittels |
AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
DE10133786A1 (de) * | 2001-07-16 | 2003-02-06 | Boehringer Ingelheim Pharma | Verwendung von Thrombin-Inhibitoren zur Behandlung von Arthritis |
SE0103590D0 (sv) | 2001-10-26 | 2001-10-26 | Astrazeneca Ab | New Combination |
SE0200198D0 (sv) | 2002-01-23 | 2002-01-23 | Astrazeneca Ab | New use |
DE50310038D1 (de) | 2002-03-11 | 2008-08-07 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
DE10210590A1 (de) * | 2002-03-11 | 2003-10-02 | Curacyte Ag | Hemmstoffe des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
US7084134B2 (en) | 2002-05-02 | 2006-08-01 | Merk & Co., Inc. | Thrombin inhibitors |
US7754216B2 (en) | 2002-05-21 | 2010-07-13 | Mayo Foundation For Medical Education And Research | Method of treating multiple sclerosis with anti-K6 antibody |
SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
SE0301879D0 (sv) * | 2003-06-25 | 2003-06-25 | Astrazeneca Ab | New process |
DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
FR2867780B1 (fr) * | 2004-03-19 | 2006-05-19 | Servier Lab | Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP4775259B2 (ja) | 2004-03-31 | 2011-09-21 | 味の素株式会社 | アニリン誘導体 |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
US20060194325A1 (en) * | 2005-02-14 | 2006-08-31 | Gable Jennifer H | Fluid handling cassette with a fluid control interface |
WO2006117358A1 (fr) * | 2005-05-03 | 2006-11-09 | Bayer Cropscience Sa | Nouveaux derives d'heterocyclylethylamide |
US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
JP2009528843A (ja) * | 2006-03-06 | 2009-08-13 | ヒューマジーン・インコーポレイテッド | 組換えヒトトロンビンおよびフィブリノゲンの調製法 |
DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
GB0807828D0 (en) * | 2008-04-29 | 2008-06-04 | Vantia Ltd | Aminopyridine derivatives |
CN102924567B (zh) * | 2008-10-28 | 2014-06-04 | 上海医药工业研究院 | 一类肽化合物、其制备方法及用途 |
TWI419700B (zh) * | 2010-01-06 | 2013-12-21 | Academia Sinica | 甘藷胰蛋白酶抑制因子用於治療發炎及痛敏感之用途 |
US8921319B2 (en) | 2010-07-07 | 2014-12-30 | The Medicines Company (Leipzig) Gmbh | Serine protease inhibitors |
CN102464701B (zh) | 2010-11-08 | 2015-10-21 | 上海医药工业研究院 | 一类新型化合物、其制备方法及用途 |
WO2012075287A2 (fr) * | 2010-12-01 | 2012-06-07 | The University Of Mississippi | Nouveaux inhibiteurs sélectifs de la prolylcarboxypeptidase |
DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
US11584714B2 (en) | 2018-05-29 | 2023-02-21 | Omeros Corporation | MASP-2 inhibitors and methods of use |
SG11202010925UA (en) * | 2018-05-29 | 2020-12-30 | Omeros Corp | Masp-2 inhibitors and methods of use |
IL293550A (en) | 2019-12-04 | 2022-08-01 | Omeros Corp | 2-masp inhibitor compounds, preparations containing them and their uses |
JP2023504542A (ja) | 2019-12-04 | 2023-02-03 | オメロス コーポレーション | Masp-2阻害剤および使用方法 |
EP4070658A1 (fr) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Utilisation de composés anticoagulants comme rodenticides |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2748295A1 (de) * | 1977-10-27 | 1979-05-03 | Bayer Ag | Neue derivate des bpti |
HU178398B (en) * | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
US4568636A (en) * | 1981-03-25 | 1986-02-04 | Pentapharm Ag | Tripeptide derivatives |
US4395401A (en) * | 1981-09-09 | 1983-07-26 | Smithkline Beckman Corporation | Renally active dipeptides |
HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
CA1341029C (fr) | 1985-02-04 | 2000-06-20 | Michael Kolb | Inhibiteurs de la peptidase |
DE3505555A1 (de) * | 1985-02-18 | 1986-09-11 | Behringwerke Ag, 3550 Marburg | Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
PT84170B (pt) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas |
DE3606480A1 (de) * | 1986-02-28 | 1987-09-03 | Behringwerke Ag | Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung |
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0362002B1 (fr) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | Inhibiteurs de protease HIV |
ZA897515B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
US5273982A (en) * | 1990-03-09 | 1993-12-28 | Hoffmann-La Roche Inc. | Acetic acid derivatives |
US5110812A (en) * | 1990-06-04 | 1992-05-05 | Bristol-Myers Squibb Co. | Azetidin-2-one derivatives as serine protease inhibitors |
US5037819A (en) * | 1990-06-04 | 1991-08-06 | Bristol-Myers Squibb Company | Azetidin-2-one derivatives as serine protease inhibitors |
TW201303B (fr) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
GB9019558D0 (en) | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
NZ239876A (en) * | 1990-09-27 | 1993-12-23 | Merck & Co Inc | Glycyl-b-alanine derivatives and pharmaceutical compositions thereof. |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
CA2073776A1 (fr) * | 1990-11-15 | 1992-05-16 | Joerg Stuerzebecher | Derives meta-substitues de la phenylalanine |
DE4115468A1 (de) * | 1991-05-11 | 1992-11-12 | Behringwerke Ag | Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien |
SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
ZA928581B (en) * | 1991-11-12 | 1994-05-06 | Lilly Co Eli | Antithrombotic agents |
SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
US5783563A (en) * | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
AU1025795A (en) * | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
SE504185C2 (sv) * | 1994-11-08 | 1996-12-02 | Astra Ab | Lagringsstabil vattenlösning för infusion av trombininhibitorer |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
TW541316B (en) * | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
-
1993
- 1993-06-03 SE SE19939301916A patent/SE9301916D0/xx unknown
-
1994
- 1994-02-06 UA UA95115078A patent/UA65518C2/uk unknown
- 1994-05-05 TW TW083104085A patent/TW403731B/zh active
- 1994-05-12 IL IL123996A patent/IL123996A/en not_active IP Right Cessation
- 1994-05-12 IL IL10963494A patent/IL109634A/xx not_active IP Right Cessation
- 1994-05-16 IS IS4166A patent/IS1805B/is unknown
- 1994-05-17 HR HR940311A patent/HRP940311B1/xx not_active IP Right Cessation
- 1994-06-01 MX MX9404114A patent/MX9404114A/es not_active IP Right Cessation
- 1994-06-02 DE DE69427150T patent/DE69427150T2/de not_active Expired - Lifetime
- 1994-06-02 DE DE0701568T patent/DE701568T1/de active Pending
- 1994-06-02 MY MYPI94001423A patent/MY119155A/en unknown
- 1994-06-02 ES ES94918636T patent/ES2128277T3/es not_active Expired - Lifetime
- 1994-06-02 SI SI9430365T patent/SI0701568T1/xx unknown
- 1994-06-02 EP EP94918636A patent/EP0701568B1/fr not_active Expired - Lifetime
- 1994-06-02 HU HU9503445A patent/HU226825B1/hu not_active IP Right Cessation
- 1994-06-02 DE DE122004000045C patent/DE122004000045I2/de active Active
- 1994-06-02 EP EP00121659A patent/EP1067136A1/fr not_active Withdrawn
- 1994-06-02 PT PT94918636T patent/PT701568E/pt unknown
- 1994-06-02 EG EG32494A patent/EG20671A/xx active
- 1994-06-02 DK DK94918636T patent/DK0701568T3/da active
- 1994-06-02 JP JP50166595A patent/JP3205558B2/ja not_active Expired - Fee Related
- 1994-06-02 WO PCT/SE1994/000535 patent/WO1994029336A1/fr active IP Right Grant
- 1994-06-02 KR KR1019950705448A patent/KR100339456B1/ko not_active IP Right Cessation
- 1994-06-02 CZ CZ19953020A patent/CZ290104B6/cs not_active IP Right Cessation
- 1994-06-02 HU HU0103039A patent/HU0103039D0/hu not_active Application Discontinuation
- 1994-06-02 SK SK1454-95A patent/SK283150B6/sk not_active IP Right Cessation
- 1994-06-02 PL PL94311819A patent/PL181968B1/pl not_active IP Right Cessation
- 1994-06-02 SG SG1996006171A patent/SG48013A1/en unknown
- 1994-06-02 AT AT94918636T patent/ATE200783T1/de active
- 1994-06-02 CN CN94192799A patent/CN1099425C/zh not_active Expired - Fee Related
- 1994-06-02 NZ NZ267534A patent/NZ267534A/xx not_active IP Right Cessation
- 1994-06-02 RU RU96101161A patent/RU2142469C1/ru not_active IP Right Cessation
- 1994-06-02 BR BR9406746A patent/BR9406746A/pt not_active Application Discontinuation
- 1994-06-02 CA CA002162900A patent/CA2162900C/fr not_active Expired - Fee Related
- 1994-06-03 RS YUP-336/94A patent/RS49576B/sr unknown
- 1994-06-03 LT LTIP1947A patent/LT3768B/lt not_active IP Right Cessation
- 1994-07-03 SA SA94150051A patent/SA94150051B1/ar unknown
- 1994-11-23 EE EE9400456A patent/EE03264B1/xx not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/470,277 patent/US5723444A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,046 patent/US5602253A/en not_active Expired - Lifetime
- 1995-06-07 US US08/481,811 patent/US5939392A/en not_active Expired - Lifetime
- 1995-11-30 NO NO19954873A patent/NO314406B1/no not_active IP Right Cessation
- 1995-12-04 FI FI955828A patent/FI119812B/fi active IP Right Grant
-
1999
- 1999-11-15 CN CNB991248597A patent/CN1178905C/zh not_active Expired - Fee Related
-
2001
- 2001-03-28 JP JP2001091958A patent/JP2001322974A/ja active Pending
- 2001-03-28 HK HK01102259A patent/HK1031375A1/xx not_active IP Right Cessation
- 2001-05-28 JP JP2001158596A patent/JP2002047264A/ja active Pending
- 2001-07-24 GR GR20010401107T patent/GR3036258T3/el unknown
-
2004
- 2004-12-13 NO NO2004009C patent/NO2004009I1/no unknown
-
2005
- 2005-03-03 NL NL300178C patent/NL300178I2/nl unknown
- 2005-03-25 US US11/090,786 patent/US20050222395A1/en not_active Abandoned
- 2005-05-11 LU LU91173C patent/LU91173I2/fr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE9301916D0 (sv) | New peptides derivatives | |
NO943232L (no) | Aromatiske karboksylsyrederivater | |
FI862132A (fi) | Cytostatiskt verksamma titanocenkomplex. | |
DK0617959T3 (da) | Lægemiddel til behandling af hudsygdomme | |
DE69101755T2 (de) | Verwendung von Phosphomycin pharmazeutisch akzeptierbare Salze als topisches Wundheilungsmittel. | |
IT1251202B (it) | 6-amminochinoloni, sintesi ed impiego come antibatterici | |
ATE119394T1 (de) | Verwendung von myricetin-3-0-beta-d-glucuronid als arzneimittel. | |
DE69314573T2 (de) | 2-Thiazolylpyrroleakrylate mit fungizider Wirkung |