SE506267C2 - Blandningar av polysackarider med låg molekylvikt samt framställning och användning av desamma - Google Patents

Blandningar av polysackarider med låg molekylvikt samt framställning och användning av desamma

Info

Publication number
SE506267C2
SE506267C2 SE9101957A SE9101957A SE506267C2 SE 506267 C2 SE506267 C2 SE 506267C2 SE 9101957 A SE9101957 A SE 9101957A SE 9101957 A SE9101957 A SE 9101957A SE 506267 C2 SE506267 C2 SE 506267C2
Authority
SE
Sweden
Prior art keywords
molecular weight
heparin
mixtures
daltons
average molecular
Prior art date
Application number
SE9101957A
Other languages
English (en)
Swedish (sv)
Other versions
SE9101957D0 (sv
SE9101957L (sv
Inventor
Roger Debrie
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9398013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE506267(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of SE9101957D0 publication Critical patent/SE9101957D0/xx
Publication of SE9101957L publication Critical patent/SE9101957L/
Publication of SE506267C2 publication Critical patent/SE506267C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9101957A 1990-06-26 1991-06-25 Blandningar av polysackarider med låg molekylvikt samt framställning och användning av desamma SE506267C2 (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9008013A FR2663639B1 (fr) 1990-06-26 1990-06-26 Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.

Publications (3)

Publication Number Publication Date
SE9101957D0 SE9101957D0 (sv) 1991-06-25
SE9101957L SE9101957L (sv) 1991-12-27
SE506267C2 true SE506267C2 (sv) 1997-11-24

Family

ID=9398013

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9101957A SE506267C2 (sv) 1990-06-26 1991-06-25 Blandningar av polysackarider med låg molekylvikt samt framställning och användning av desamma

Country Status (26)

Country Link
US (1) US5389618A (de)
JP (1) JP3287363B2 (de)
KR (1) KR0185586B1 (de)
AT (1) AT398976B (de)
AU (1) AU643531B2 (de)
BE (1) BE1006827A3 (de)
CA (1) CA2045433C (de)
CH (1) CH682236A5 (de)
DK (1) DK176524B1 (de)
ES (1) ES2036922B9 (de)
FI (1) FI104490B (de)
FR (1) FR2663639B1 (de)
GB (1) GB2245898B (de)
GR (1) GR1000763B (de)
HU (1) HU210925B (de)
IE (1) IE66341B1 (de)
IL (1) IL98604A (de)
IT (1) IT1248557B (de)
LU (1) LU87957A1 (de)
MX (1) MX25829A (de)
NL (1) NL194947C (de)
NO (1) NO304991B1 (de)
NZ (1) NZ238691A (de)
PT (1) PT98102B (de)
SE (1) SE506267C2 (de)
ZA (1) ZA914869B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
FR2687158B1 (fr) * 1992-02-07 1995-06-30 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.
US5849721A (en) * 1992-02-07 1998-12-15 Rhone-Poulenc Rorer S.A. Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
HU219339B (en) * 1993-09-30 2001-03-28 Seikagaku Kogyo Co Ltd Dermatan sulphate with low heparin or heparane sulphate content and pharmaceutical compositions comprising them
WO2000065521A2 (en) * 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
MXPA02000142A (es) * 1999-06-30 2003-07-21 Hamilton Civic Hospitals Res Composiciones de heparina que inhiben los factores de coagulacion asociados con el coagulo.
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
AU1594801A (en) * 1999-11-12 2001-06-06 Emisphere Technologies, Inc. Liquid heparin formulation
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
JP2004507562A (ja) * 2000-09-08 2004-03-11 ハミルトン　シビック　ホスピタルズ　リサーチ　ディベロップメント　インコーポレイテッド 抗血栓性組成物
ES2238383T3 (es) 2000-12-16 2005-09-01 Aventis Pharma Deutschland Gmbh Uso de heparina de bajo peso molecular para el tratamiento de la osteoartrosis.
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
WO2003018032A1 (en) * 2001-08-28 2003-03-06 Leo Pharma A/S Antithrombotic compositions comprising low molecular weight heparin and low molecular weight dermatan sulphate
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
EP2402753A1 (de) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analyse von sulfatierten Polysacchariden
US20030236221A1 (en) * 2002-06-20 2003-12-25 Chemi Spa Process for the preparation of esters of heparin
DE60218642T2 (de) * 2002-06-20 2007-11-29 Chemi S.P.A., Cinisello Balsamo Verfahren zur Herstellung von Heparinestern
US20040265943A1 (en) * 2002-09-23 2004-12-30 Aventis Pharma S.A. Method for quantitatively determining specific groups constituting heparins or low molecular weight heparins
FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
AU2003299730B2 (en) * 2002-12-20 2009-04-02 Momenta Pharmaceuticals, Inc. Glycan markers for diagnosing and monitoring disease
EP1677831A1 (de) * 2003-06-05 2006-07-12 Gencell S.A. Fibroblastenwachstumsfaktor kodierenden plasmid zur behandlung von hypercholesterolemia oder diabetes erzeugten angiogenischen störungen
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050186679A1 (en) * 2004-02-24 2005-08-25 Christian Viskov Method for determining specific groups constituting heparins or low molecular weight heparins
EP1582531A1 (de) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
GB0509433D0 (en) * 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
CN100436483C (zh) * 2006-05-24 2008-11-26 杭州九源基因工程有限公司 一种依诺肝素钠的纯化生产方法
CA2652205A1 (en) 2006-05-25 2007-12-06 Mallik Sundaram Low molecular weight heparin composition and uses thereof
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
US7790466B1 (en) 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
AU2009250803A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
EP2233145A1 (de) 2009-03-19 2010-09-29 Sanofi-Aventis AVE5026-Dosis zur Behandlung von venöser Thromboembolie bei Patienten mit starker Nierenfunktionsstörung
EP2526122B1 (de) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Beurteilung von heparinzubereitungen
WO2012100733A1 (zh) 2011-01-28 2012-08-02 杭州九源基因工程有限公司 一种基于毛细管电泳的依诺肝素钠精细结构测定方法
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
AR085961A1 (es) 2011-04-11 2013-11-06 Sanofi Sa Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen
CN102603925B (zh) * 2012-03-21 2013-12-11 东营天东制药有限公司 一种由粗品肝素钠直接生产依诺肝素钠的方法
CN102603926B (zh) * 2012-03-27 2014-04-30 烟台东诚生化股份有限公司 一种高效价肝素钠制备新工艺
CN102633908A (zh) * 2012-05-02 2012-08-15 雷晓刚 一种高品质超低分子量肝素的制备方法
RU2512768C1 (ru) * 2012-12-18 2014-04-10 Федеральное бюджетное учреждение "Государственный институт кровезаменителей и медицинских препаратов (ФБУ "ГИКиМП") Способ получения низкомолекулярного гепарина
CN103145868B (zh) * 2013-01-07 2015-09-16 中国科学院昆明植物研究所 一种低分子量糖胺聚糖衍生物及其药物组合物和其制备方法与应用
CN103175925B (zh) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 依诺肝素钠生产过程中肝素苄基酯的酯化率的检测方法
CN103214591B (zh) * 2013-04-12 2015-11-04 中国科学院昆明植物研究所 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
WO2016118625A1 (en) * 2015-01-20 2016-07-28 Incarda Therapeutics, Inc. Unit aerosol doses for anticoagulation
CN109666086B (zh) * 2018-11-05 2020-12-22 上海宝维医药技术有限公司 一种高纯度肝素季铵盐的制备方法及其应用
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK108622C (da) * 1963-01-18 1968-01-15 Roussel Uclaf Fremgangsmåde til fremstilling af benzylheparinat eller dets alkalimetalsalte.
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
EP0066908B1 (de) * 1981-05-21 1985-08-28 Akzo N.V. Antithrombotikum auf Basis von Polysacchariden, Verfahren zur dessen Herstellung und medizinale Zusammensetzungen
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
DK196886D0 (da) * 1986-04-30 1986-04-30 Novo Industri As Fremstilling af polysaccharider
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
ES2006891A6 (es) * 1988-04-09 1989-05-16 Bioiberica Procedimiento de preparacion de fracciones de oligosacaridos por depolimerizacion quimica controlada de heparina.
EP0337327A1 (de) * 1988-04-09 1989-10-18 Bioiberica, S.A. Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina

Also Published As

Publication number Publication date
FI913101A (fi) 1991-12-27
JPH04226101A (ja) 1992-08-14
GB2245898A (en) 1992-01-15
HU210925B (en) 1995-09-28
GB9113589D0 (en) 1991-08-14
NZ238691A (en) 1992-07-28
ZA914869B (en) 1992-04-29
ES2036922A1 (es) 1993-06-01
JP3287363B2 (ja) 2002-06-04
SE9101957D0 (sv) 1991-06-25
GR1000763B (el) 1992-12-30
GR910100270A (en) 1992-08-25
CA2045433A1 (fr) 1991-12-27
NO912485D0 (no) 1991-06-25
CH682236A5 (de) 1993-08-13
FI913101A0 (fi) 1991-06-25
ATA128191A (de) 1994-07-15
AU7928891A (en) 1992-01-02
IT1248557B (it) 1995-01-19
ITMI911757A0 (it) 1991-06-26
NO304991B1 (no) 1999-03-15
FI104490B (fi) 2000-02-15
IL98604A0 (en) 1992-07-15
MX25829A (es) 1993-10-01
AU643531B2 (en) 1993-11-18
HUT57796A (en) 1991-12-30
NO912485L (no) 1991-12-27
DK124391A (da) 1991-12-27
ITMI911757A1 (it) 1992-12-26
FR2663639B1 (fr) 1994-03-18
BE1006827A3 (fr) 1995-01-03
DK176524B1 (da) 2008-07-14
LU87957A1 (fr) 1993-01-15
IE912216A1 (en) 1992-01-01
CA2045433C (fr) 2002-07-30
US5389618A (en) 1995-02-14
NL9101049A (nl) 1992-01-16
PT98102B (pt) 1998-11-30
PT98102A (pt) 1992-03-31
IE66341B1 (en) 1995-12-27
GB2245898B (en) 1993-10-06
ES2036922B9 (es) 2012-07-30
KR0185586B1 (ko) 1999-04-01
KR920000792A (ko) 1992-01-29
NL194947B (nl) 2003-04-01
NL194947C (nl) 2003-08-04
ES2036922B1 (es) 1994-03-01
AT398976B (de) 1995-02-27
IL98604A (en) 1998-08-15
DK124391D0 (da) 1991-06-25
SE9101957L (sv) 1991-12-27
FR2663639A1 (fr) 1991-12-27

Similar Documents

Publication Publication Date Title
SE506267C2 (sv) Blandningar av polysackarider med låg molekylvikt samt framställning och användning av desamma
USRE38743E1 (en) Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
Wu et al. Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase
DK173982B1 (da) Depolymeriserede heparinderivater, fremgangsmåde til fremstilling deraf og farmaceutisk præparat samt biologisk reagens med indhold heraf
US4981955A (en) Depolymerization method of heparin
US4303651A (en) Heparin fragments having selective anticoagulation activity
US4474770A (en) Oligosaccharides having anti-Xa activity, pharmaceutical compositions containing them and method of use
US4496550A (en) Oligosaccharides having selective anticoagulation activity
NZ197081A (en) Mixtures of sulphated polysaccharides
US6384021B1 (en) Heparin compositions of very low molecular weight
US5721357A (en) Preparation of sulfated polysaccharides for treatment or prevention of thromboses
WO1992002232A1 (en) Heparin fragment showing complement inhibition activity
US5849721A (en) Sulfated polysaccharides obtained from heparin, preparation process, pharmaceutical composition and use thereof
AU671817B2 (en) Sulphated polysaccharides, preparation thereof, pharmaceutical composition and use thereof
USRE35770E (en) Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
JP4051099B2 (ja) 低分子化ヘパリン、その製造法及び医薬組成物

Legal Events

Date Code Title Description
NUG Patent has lapsed