SE443980B - Forfarande for framstellning av 2-penem-3-karboxylsyraforeningar - Google Patents

Forfarande for framstellning av 2-penem-3-karboxylsyraforeningar

Info

Publication number
SE443980B
SE443980B SE7805217A SE7805217A SE443980B SE 443980 B SE443980 B SE 443980B SE 7805217 A SE7805217 A SE 7805217A SE 7805217 A SE7805217 A SE 7805217A SE 443980 B SE443980 B SE 443980B
Authority
SE
Sweden
Prior art keywords
acid
penem
group
carboxylic acid
lower alkyl
Prior art date
Application number
SE7805217A
Other languages
English (en)
Swedish (sv)
Other versions
SE7805217L (sv
Inventor
J Gosteli
I Ernest
R B Woodward
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of SE7805217L publication Critical patent/SE7805217L/xx
Publication of SE443980B publication Critical patent/SE443980B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SE7805217A 1977-05-09 1978-05-08 Forfarande for framstellning av 2-penem-3-karboxylsyraforeningar SE443980B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77306A LU77306A1 (zh) 1977-05-09 1977-05-09

Publications (2)

Publication Number Publication Date
SE7805217L SE7805217L (sv) 1978-11-10
SE443980B true SE443980B (sv) 1986-03-17

Family

ID=19728568

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7805217A SE443980B (sv) 1977-05-09 1978-05-08 Forfarande for framstellning av 2-penem-3-karboxylsyraforeningar
SE8305299A SE8305299L (sv) 1977-05-09 1983-09-29 Tiaazaforeningar med -laktamer

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8305299A SE8305299L (sv) 1977-05-09 1983-09-29 Tiaazaforeningar med -laktamer

Country Status (13)

Country Link
US (5) US4331676A (zh)
JP (1) JPS53137951A (zh)
AU (1) AU527917B2 (zh)
BE (1) BE866845A (zh)
CH (1) CH646173A5 (zh)
DE (1) DE2819655A1 (zh)
DK (1) DK200578A (zh)
ES (1) ES469568A1 (zh)
FR (8) FR2405949A1 (zh)
GB (4) GB1604751A (zh)
LU (1) LU77306A1 (zh)
NL (1) NL7804974A (zh)
SE (2) SE443980B (zh)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055573A (en) * 1976-11-19 1991-10-08 Merck & Co., Inc. Process for preparing 1-carba-2-penem-3-carboxylic acid
IN149747B (zh) * 1977-06-07 1982-04-03 Pfizer
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
IT1162268B (it) * 1978-02-16 1987-03-25 Glaxo Group Ltd Composti beta-lattamici procedimento per produrli composizioni che li contengono e intermedi per prepararli
EP0010358A1 (en) * 1978-09-20 1980-04-30 Glaxo Group Limited Beta-lactam compounds, processes for their preparation, compositions containing them, intermediates of use in their preparation and methods for the production thereof
US4290948A (en) 1978-11-22 1981-09-22 Beecham Group Limited Process for their preparation of β-lactam antibacterial agents
AT365594B (de) * 1978-11-24 1982-01-25 Erba Farmitalia Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
EP0061205B1 (en) * 1979-01-10 1986-03-12 Schering Corporation 2-penem compounds; a method for their preparation and pharmaceutical compositions comprising them
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
AT368506B (de) * 1979-02-24 1982-10-25 Erba Farmitalia Verfahren zur herstellung von neuen penemcarbonsaeuren und deren salzen
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4683226A (en) * 1979-08-01 1987-07-28 Schering Corporation 6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids
US4406834A (en) 1979-09-21 1983-09-27 Bristol-Myers Company 2,6 Disubstituted penems and intermediates therefor
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
DE3069524D1 (en) * 1979-12-20 1984-11-29 Hoechst Uk Ltd Penem derivatives
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS56142283A (en) * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
JPS56142282A (en) * 1980-03-10 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
EP0176064A1 (en) * 1980-11-06 1986-04-02 Hoechst Uk Limited Intermediates for the production of 7-oxo-4-thia-1-aza[3,2,0]heptane and 7-oxo-4-thia-1-aza[3,2,0]hept-2-ene derivatives
ES8305366A1 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
DE3274982D1 (en) * 1981-07-08 1987-02-12 Hoechst Uk Ltd Antibacterial penem derivatives
JPS58116487A (ja) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
JPS5946289A (ja) * 1982-09-08 1984-03-15 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
JPS60243064A (ja) * 1984-05-17 1985-12-03 Taiho Yakuhin Kogyo Kk アゼチジノンジスルフイド誘導体
EP0379281A3 (en) * 1989-01-19 1991-03-20 Cosmopolitan Textile Company Limited Web inspecting method and apparatus
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
CA2147129A1 (en) * 1992-10-27 1994-05-11 James B. Doherty New substituted azetidinones as anti-inflammatory and antidegenerative agents
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
WO2004039776A2 (en) * 2002-11-01 2004-05-13 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of benzyl 2-oxo-4- (heteroaryl) dithio-alpha-isoprenyl-1- azetidineazetate derivatives
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
JP2015518854A (ja) * 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
EP3790843A1 (de) * 2018-05-07 2021-03-17 Covestro Intellectual Property GmbH & Co. KG Speichermedium und verfahren für die abtrennung, die speicherung und den transport von chlor aus chlor enthaltenden gasen
CN114720591B (zh) * 2022-03-22 2022-12-30 北京安胜瑞力科技有限公司 一种工业废水中dmac的定量分析方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE648188A (zh) 1963-05-29 1964-09-16
BE755940A (fr) * 1969-09-09 1971-03-09 Hoechst Ag Azetidinones-2 portant des substituants en position 4 et leur preparation
GB1368074A (en) * 1971-02-04 1974-09-25 Beecham Group Ltd Substituted beta-lactams and their preparation
DE2265798C2 (de) * 1971-06-24 1985-09-26 Fujisawa Pharmaceutical Co., Ltd., Osaka Verfahren zur Herstellung von Oxoazetidin-Derivaten
JPS4854056A (zh) * 1971-11-12 1973-07-30
US4070477A (en) * 1975-12-08 1978-01-24 Ciba-Geigy Corporation 2-Penem compounds
IN149747B (zh) * 1977-06-07 1982-04-03 Pfizer
GB2005246A (en) * 1977-07-13 1979-04-19 Glaxo Group Ltd beta -Lactam compounds and processes for their preparation
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4169833A (en) * 1977-12-14 1979-10-02 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4192801A (en) * 1978-04-27 1980-03-11 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates

Also Published As

Publication number Publication date
GB1604751A (en) 1981-12-16
FR2422637B1 (zh) 1982-04-23
FR2405946B1 (zh) 1983-09-30
AU3588478A (en) 1979-11-15
FR2405950A1 (fr) 1979-05-11
FR2411179B1 (zh) 1982-04-23
FR2405950B1 (zh) 1981-07-31
SE8305299D0 (sv) 1983-09-29
GB1604754A (en) 1981-12-16
FR2405949B1 (zh) 1980-10-24
NL7804974A (nl) 1978-11-13
US4515717A (en) 1985-05-07
FR2411179A1 (fr) 1979-07-06
FR2405945A1 (fr) 1979-05-11
CH646173A5 (de) 1984-11-15
US4524028A (en) 1985-06-18
FR2405946A1 (fr) 1979-05-11
FR2405945B1 (zh) 1982-04-09
FR2422637A1 (fr) 1979-11-09
US4331676A (en) 1982-05-25
BE866845A (fr) 1978-11-09
JPS53137951A (en) 1978-12-01
US4518533A (en) 1985-05-21
FR2405955B1 (zh) 1981-07-31
FR2405934A1 (fr) 1979-05-11
GB1604753A (en) 1981-12-16
SE8305299L (sv) 1983-09-29
DE2819655A1 (de) 1978-11-23
ES469568A1 (es) 1980-01-01
US4447360A (en) 1984-05-08
DK200578A (da) 1978-11-10
SE7805217L (sv) 1978-11-10
FR2405934B1 (zh) 1980-09-05
AU527917B2 (en) 1983-03-31
LU77306A1 (zh) 1979-01-18
FR2405955A1 (fr) 1979-05-11
GB1604752A (en) 1981-12-16
FR2405949A1 (fr) 1979-05-11

Similar Documents

Publication Publication Date Title
SE443980B (sv) Forfarande for framstellning av 2-penem-3-karboxylsyraforeningar
EP0003960B1 (de) 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
SE449489B (sv) Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet
EP0000636A1 (en) Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation
SE460791B (sv) Nya karbapenemderivat och foerfarande foer framstaellning daerav
KR930005332B1 (ko) 카르바페넴 화합물의 제조방법
KR880002512B1 (ko) 페넴 화합물 및 이의 제조방법
EP0074599A1 (en) 5,6-cis-Carbapenem derivatives, their production and use
US4500457A (en) Process for preparing thia-aza compounds with a beta-lactam ring
NO834189L (no) Fremgangsmaate til fremstilling av 6-hydroksy-laverealkyl-penem-forbindelser
EP0517065A1 (de) Tetrazyklische beta-Lactam Antibiotika und Verfahren zur ihrer Darstellung
SE449103B (sv) Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
IT8322230A1 (it) Carbapenem-derivati fluoroalchilati
NO834191L (no) Fremgangsmaate til fremstilling av heterocykliske forbindelser
EP0199675A1 (de) Heterocyclyl-penem-Verbindungen
NO841788L (no) Heterocyklyl-lavalkyl-penem-forbindelser, fremgangsmaate til deres fremstilling, farmasoeytiske preparater, inneholdende disse forbindelser og anvendelse av sistnevnte
FI81584C (fi) Foerfarande foer framstaellning av antibakteriella 6-alfa-hydroxietyl-2-substituerad-2-penem-3-karboxylsyror.
US4540580A (en) 2-[(1'R)-1'-Aminoalkyl]penems
US4505905A (en) Cyclobutanone antibacterials
NO824067L (no) Aminobutylforbindelser.
NO845277L (no) Fremgangsmaate til fremstilling av nye optisk aktive penemforbindelser.
JPS62129281A (ja) アゼチジン−２−オン誘導体及びその製造方法
EP0211236A1 (en) 7-Oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives
IE48777B1 (en) 3,4-disubstituted azetidin-2-one compounds and processes for their preparation
NO871934L (no) 7-okso-4-tia-1-azabicyklo(3,2,0)hept-2-en-derivater.