SE436874B - N-substituerade moranolinderivat - Google Patents
N-substituerade moranolinderivatInfo
- Publication number
- SE436874B SE436874B SE7903817A SE7903817A SE436874B SE 436874 B SE436874 B SE 436874B SE 7903817 A SE7903817 A SE 7903817A SE 7903817 A SE7903817 A SE 7903817A SE 436874 B SE436874 B SE 436874B
- Authority
- SE
- Sweden
- Prior art keywords
- water
- substituted
- moranoline derivatives
- derivatives
- substituted moranoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53053603A JPS5943947B2 (ja) | 1978-05-03 | 1978-05-03 | N−置換モラノリン誘導体 |
JP8260678A JPS5943948B2 (ja) | 1978-07-06 | 1978-07-06 | 置換モラノリン誘導体 |
JP12066178A JPS5943949B2 (ja) | 1978-09-29 | 1978-09-29 | モラノリンのn−置換誘導体 |
JP571479A JPS6026387B2 (ja) | 1979-01-20 | 1979-01-20 | シンナミルモラノリン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7903817L SE7903817L (sv) | 1979-11-04 |
SE436874B true SE436874B (sv) | 1985-01-28 |
Family
ID=27454348
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7903817A SE436874B (sv) | 1978-05-03 | 1979-05-02 | N-substituerade moranolinderivat |
SE8402550A SE451016B (sv) | 1978-05-03 | 1984-05-11 | N-substituerade derivat av moranolin |
SE8402549A SE451015B (sv) | 1978-05-03 | 1984-05-11 | Substituerade moranolinderivat |
SE8402551A SE451017B (sv) | 1978-05-03 | 1984-05-11 | Cinnamylmoranolin-derivat |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8402550A SE451016B (sv) | 1978-05-03 | 1984-05-11 | N-substituerade derivat av moranolin |
SE8402549A SE451015B (sv) | 1978-05-03 | 1984-05-11 | Substituerade moranolinderivat |
SE8402551A SE451017B (sv) | 1978-05-03 | 1984-05-11 | Cinnamylmoranolin-derivat |
Country Status (9)
Country | Link |
---|---|
US (1) | US4533668A (de) |
CH (1) | CH642629A5 (de) |
DE (1) | DE2915037C3 (de) |
DK (1) | DK151623C (de) |
FR (1) | FR2424910A1 (de) |
GB (1) | GB2020278B (de) |
IT (1) | IT1116820B (de) |
NL (1) | NL175820C (de) |
SE (4) | SE436874B (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
DE2925943A1 (de) * | 1979-06-27 | 1981-01-29 | Bayer Ag | 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE2942365A1 (de) * | 1979-10-19 | 1981-05-14 | Bayer Ag, 5090 Leverkusen | 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
JP2504000B2 (ja) * | 1986-09-02 | 1996-06-05 | 日本新薬株式会社 | グルコシルモラノリン誘導体 |
JPS6461459A (en) * | 1987-08-28 | 1989-03-08 | Nippon Shinyaku Co Ltd | Moranoline derivative |
GB8827701D0 (en) * | 1987-12-09 | 1988-12-29 | Nippon Shinyaku Co Ltd | Thrombolytic &c compositions |
US5192772A (en) * | 1987-12-09 | 1993-03-09 | Nippon Shinyaku Co. Ltd. | Therapeutic agents |
US4985445A (en) * | 1988-02-12 | 1991-01-15 | Meiji Seika Kaisha, Ltd. | Cancer cell metastasis inhibitors and novel compounds |
EP0350012A3 (de) * | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antivirale Zusammensetzung |
US5216168A (en) * | 1992-04-01 | 1993-06-01 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
US5268482A (en) * | 1992-04-01 | 1993-12-07 | G. D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
US5342951A (en) * | 1992-04-01 | 1994-08-30 | G.D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
ES2095032T3 (es) * | 1992-04-01 | 1997-02-01 | Searle & Co | Derivados 2- y 3-amino y azido de 1,5-iminoazucares como compuestos antivirales. |
US5258518A (en) * | 1992-04-01 | 1993-11-02 | G. D. Searle & Co. | 2-substituted tertiary carbinol derivatives of deoxynojirimycin |
US5331096A (en) * | 1992-04-01 | 1994-07-19 | G. D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
US6291657B1 (en) | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
MY122499A (en) | 1997-11-10 | 2006-04-29 | Searle & Co | Use of alkylated iminosugars to treat multidrug resistance |
US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
BR9907882A (pt) | 1998-02-12 | 2000-10-17 | Searle & Co | Uso de compostos de 1,5-didesóxi-1,5-imino-d-glucitol n-substituìdos para o tratamento de infecções de vìrus de hepatite |
WO2001008672A2 (en) | 1999-02-12 | 2001-02-08 | G.D. Searle & Co. | Glucamine compounds for treating hepatitis virus infections |
US6545021B1 (en) | 1999-02-12 | 2003-04-08 | G.D. Searle & Co. | Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
CN1422156A (zh) * | 2000-02-14 | 2003-06-04 | 法马西亚公司 | N-取代的-1,5-二脱氧-1,5-亚氨基-d-葡萄糖醇化合物在治疗肝炎病毒感染中的用途 |
US8003617B2 (en) * | 2004-11-10 | 2011-08-23 | Genzyme Corporation | Methods of treating diabetes mellitus |
AT502145B1 (de) * | 2005-03-24 | 2012-01-15 | Univ Graz Tech | Glycosidase-hemmendes iminoalditol |
PT2032134E (pt) | 2006-05-09 | 2015-10-07 | Genzyme Corp | Métodos de tratamento da doença do fígado gorduroso |
CN104876855A (zh) * | 2006-05-24 | 2015-09-02 | 联合治疗公司 | 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法 |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
EP2594565B1 (de) * | 2007-05-31 | 2018-10-24 | Genzyme Corporation | Glukosylceramid-Synthase-Hemmer vom 2-Acylaminpropanol-Typ |
EP2209473B1 (de) | 2007-10-05 | 2017-11-22 | Genzyme Corporation | Verfahren zur behandlung von polyzystischer nierenerkrankung mit ceramid-derivaten |
US8389517B2 (en) | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
MX2011003517A (es) | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
WO2017192599A1 (en) | 2016-05-02 | 2017-11-09 | Florida State University Research Foundation, Inc. | Treatment of zika virus infections using alpha-glucosidase inhibitors |
EP4106752A4 (de) | 2020-02-21 | 2024-03-20 | Florida State University Research Foundation, Inc. | Behandlung von infektionen mit dem humanen coronavirus unter verwendung von alpha-glucosidase-glykoprotein-prozessierungsinhibitoren |
US20230174486A1 (en) * | 2020-05-07 | 2023-06-08 | ALECTOS THERAPEUTICS lNC. | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5282710A (en) * | 1975-12-29 | 1977-07-11 | Nippon Shinyaku Co Ltd | Extraction of effective drug component from mulberry |
DE2735316C3 (de) * | 1977-08-05 | 1981-01-29 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von nadeiförmigen, ferrimagnetischen Eisenoxiden |
-
1979
- 1979-03-21 GB GB7909865A patent/GB2020278B/en not_active Expired
- 1979-04-12 DE DE2915037A patent/DE2915037C3/de not_active Expired
- 1979-04-25 FR FR7910559A patent/FR2424910A1/fr active Granted
- 1979-04-27 US US06/033,839 patent/US4533668A/en not_active Expired - Lifetime
- 1979-05-01 DK DK178379A patent/DK151623C/da not_active IP Right Cessation
- 1979-05-02 IT IT48904/79A patent/IT1116820B/it active
- 1979-05-02 NL NLAANVRAGE7903421,A patent/NL175820C/xx not_active IP Right Cessation
- 1979-05-02 SE SE7903817A patent/SE436874B/sv not_active IP Right Cessation
- 1979-05-03 CH CH415879A patent/CH642629A5/de not_active IP Right Cessation
-
1984
- 1984-05-11 SE SE8402550A patent/SE451016B/sv not_active IP Right Cessation
- 1984-05-11 SE SE8402549A patent/SE451015B/sv not_active IP Right Cessation
- 1984-05-11 SE SE8402551A patent/SE451017B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SE8402549D0 (sv) | 1984-05-11 |
NL7903421A (nl) | 1979-11-06 |
FR2424910A1 (fr) | 1979-11-30 |
IT7948904A0 (it) | 1979-05-02 |
DE2915037C3 (de) | 1981-11-05 |
SE8402549L (sv) | 1984-05-11 |
GB2020278B (en) | 1983-02-23 |
DK151623C (da) | 1988-07-18 |
SE8402551L (sv) | 1984-05-11 |
DK151623B (da) | 1987-12-21 |
DK178379A (da) | 1979-11-04 |
SE451017B (sv) | 1987-08-24 |
FR2424910B1 (de) | 1981-12-11 |
SE451016B (sv) | 1987-08-24 |
GB2020278A (en) | 1979-11-14 |
DE2915037A1 (de) | 1979-11-08 |
DE2915037B2 (de) | 1981-01-29 |
NL175820B (nl) | 1984-08-01 |
SE8402550D0 (sv) | 1984-05-11 |
CH642629A5 (de) | 1984-04-30 |
IT1116820B (it) | 1986-02-10 |
US4533668A (en) | 1985-08-06 |
SE451015B (sv) | 1987-08-24 |
SE8402551D0 (sv) | 1984-05-11 |
SE7903817L (sv) | 1979-11-04 |
SE8402550L (sv) | 1984-05-11 |
NL175820C (nl) | 1985-01-02 |
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