DK151623C - Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number
DK151623C
DK151623C DK178379A DK178379A DK151623C DK 151623 C DK151623 C DK 151623C DK 178379 A DK178379 A DK 178379A DK 178379 A DK178379 A DK 178379A DK 151623 C DK151623 C DK 151623C
Authority
DK
Denmark
Prior art keywords
analogue
preparation
acid addition
addition salts
acceptable acid
Prior art date
Application number
DK178379A
Other languages
Danish (da)
English (en)
Other versions
DK151623B (da
DK178379A (da
Inventor
Shingo Matsumura
Hiroshi Enomoto
Yoshiaki Aoyagi
Yoshiaki Yoshikuni
Kohei Kura
Masahiro Yagi
Ichiro Shirahase
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP53053603A external-priority patent/JPS5943947B2/ja
Priority claimed from JP8260678A external-priority patent/JPS5943948B2/ja
Priority claimed from JP12066178A external-priority patent/JPS5943949B2/ja
Priority claimed from JP571479A external-priority patent/JPS6026387B2/ja
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of DK178379A publication Critical patent/DK178379A/da
Publication of DK151623B publication Critical patent/DK151623B/da
Application granted granted Critical
Publication of DK151623C publication Critical patent/DK151623C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK178379A 1978-05-03 1979-05-01 Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf DK151623C (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP5360378 1978-05-03
JP53053603A JPS5943947B2 (ja) 1978-05-03 1978-05-03 Ｎ−置換モラノリン誘導体
JP8260678 1978-07-06
JP8260678A JPS5943948B2 (ja) 1978-07-06 1978-07-06 置換モラノリン誘導体
JP12066178A JPS5943949B2 (ja) 1978-09-29 1978-09-29 モラノリンのｎ−置換誘導体
JP12066178 1978-09-29
JP571479A JPS6026387B2 (ja) 1979-01-20 1979-01-20 シンナミルモラノリン誘導体
JP571479 1979-01-20

Publications (3)

Publication Number Publication Date
DK178379A DK178379A (da) 1979-11-04
DK151623B DK151623B (da) 1987-12-21
DK151623C true DK151623C (da) 1988-07-18

Family

ID=27454348

Family Applications (1)

Application Number Title Priority Date Filing Date
DK178379A DK151623C (da) 1978-05-03 1979-05-01 Analogifremgangsmaade til fremstilling af n-substituerede moranolinderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (9)

Country Link
US (1) US4533668A (de)
CH (1) CH642629A5 (de)
DE (1) DE2915037C3 (de)
DK (1) DK151623C (de)
FR (1) FR2424910A1 (de)
GB (1) GB2020278B (de)
IT (1) IT1116820B (de)
NL (1) NL175820C (de)
SE (4) SE436874B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2925943A1 (de) * 1979-06-27 1981-01-29 Bayer Ag 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
JP2504000B2 (ja) * 1986-09-02 1996-06-05 日本新薬株式会社 グルコシルモラノリン誘導体
JPS6461459A (en) * 1987-08-28 1989-03-08 Nippon Shinyaku Co Ltd Moranoline derivative
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
GB8827701D0 (en) * 1987-12-09 1988-12-29 Nippon Shinyaku Co Ltd Thrombolytic &c compositions
US4985445A (en) * 1988-02-12 1991-01-15 Meiji Seika Kaisha, Ltd. Cancer cell metastasis inhibitors and novel compounds
EP0350012A3 (de) * 1988-07-08 1990-09-05 Meiji Seika Kaisha Ltd. Antivirale Zusammensetzung
US5216168A (en) * 1992-04-01 1993-06-01 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5268482A (en) * 1992-04-01 1993-12-07 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
DE69304393T2 (de) * 1992-04-01 1997-03-20 Searle & Co 2- und 3-Amino und Azidoderivate von 1,5-Iminozuckern als antivirale Arzneimittel
US5206251A (en) * 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
US5331096A (en) * 1992-04-01 1994-07-19 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5399567A (en) * 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
DE69821520T2 (de) * 1997-11-10 2004-12-16 G.D. Searle & Co., Chicago Verwendung von alkylierten iminozuckern zur behandlung von multipler medikamentenresistenz
DE69932154T2 (de) 1998-02-12 2007-05-31 G.D. Searle Llc, Chicago Verwendung von n-substituirten-1,5-dideoxy-1,5-imino-d-glucitolen zur behandlung von hepatitis infektionen
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
JP2003505501A (ja) 1999-02-12 2003-02-12 ジー・ディー・サール・アンド・カンパニー 肝炎ウィルス感染の処置のためのグルカミン化合物
ES2311921T3 (es) 1999-02-12 2009-02-16 United Therapeutics Corporation N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
WO2001060366A1 (en) * 2000-02-14 2001-08-23 Pharmacia Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
CA2586761A1 (en) * 2004-11-10 2006-05-18 Genzyme Corporation Methods of treating diabetes mellitus
AT502145B1 (de) * 2005-03-24 2012-01-15 Univ Graz Tech Glycosidase-hemmendes iminoalditol
PT2032134E (pt) * 2006-05-09 2015-10-07 Genzyme Corp Métodos de tratamento da doença do fígado gorduroso
CN104876855A (zh) * 2006-05-24 2015-09-02 联合治疗公司 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
WO2008150486A2 (en) 2007-05-31 2008-12-11 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
MX337396B (es) 2007-10-05 2016-03-02 Genzyme Corp Metodo para el tratamiento de enfermedades del riñon poliquisticas con derivados de ceramica.
EP2320886B1 (de) 2008-07-28 2017-06-28 Genzyme Corporation Glucosylceramid-synthase-hemmung zur behandlung von kollabierender glomerulopathie und anderen glomerulären erkrankungen
CN107935983A (zh) * 2008-10-03 2018-04-20 简詹姆公司 2‑酰胺基丙醇型葡糖神经酰胺合酶抑制剂
WO2017192599A1 (en) 2016-05-02 2017-11-09 Florida State University Research Foundation, Inc. Treatment of zika virus infections using alpha-glucosidase inhibitors
US11369592B2 (en) 2020-02-21 2022-06-28 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors
PE20231424A1 (es) * 2020-05-07 2023-09-13 Alectos Therapeutics Inc Inhibidores de glucosilceramidasa no lisosomal y los usos de los mismos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5282710A (en) * 1975-12-29 1977-07-11 Nippon Shinyaku Co Ltd Extraction of effective drug component from mulberry
DE2735316C3 (de) * 1977-08-05 1981-01-29 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von nadeiförmigen, ferrimagnetischen Eisenoxiden

Also Published As

Publication number Publication date
SE436874B (sv) 1985-01-28
SE8402550L (sv) 1984-05-11
FR2424910A1 (fr) 1979-11-30
DK151623B (da) 1987-12-21
SE451016B (sv) 1987-08-24
DE2915037A1 (de) 1979-11-08
US4533668A (en) 1985-08-06
GB2020278A (en) 1979-11-14
NL175820C (nl) 1985-01-02
SE8402549D0 (sv) 1984-05-11
DK178379A (da) 1979-11-04
DE2915037C3 (de) 1981-11-05
SE7903817L (sv) 1979-11-04
GB2020278B (en) 1983-02-23
CH642629A5 (de) 1984-04-30
FR2424910B1 (de) 1981-12-11
NL175820B (nl) 1984-08-01
SE8402551L (sv) 1984-05-11
SE8402551D0 (sv) 1984-05-11
SE8402549L (sv) 1984-05-11
IT1116820B (it) 1986-02-10
NL7903421A (nl) 1979-11-06
SE451017B (sv) 1987-08-24
DE2915037B2 (de) 1981-01-29
IT7948904A0 (it) 1979-05-02
SE8402550D0 (sv) 1984-05-11
SE451015B (sv) 1987-08-24

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