RU99117921A - Аминосоединение для получения новых производных пиридонкарбоновой кислоты или их солей - Google Patents
Аминосоединение для получения новых производных пиридонкарбоновой кислоты или их солейInfo
- Publication number
- RU99117921A RU99117921A RU99117921/04A RU99117921A RU99117921A RU 99117921 A RU99117921 A RU 99117921A RU 99117921/04 A RU99117921/04 A RU 99117921/04A RU 99117921 A RU99117921 A RU 99117921A RU 99117921 A RU99117921 A RU 99117921A
- Authority
- RU
- Russia
- Prior art keywords
- amino compound
- salts
- new
- production
- acid derivatives
- Prior art date
Links
- -1 AMINO COMPOUND Chemical class 0.000 title claims 8
- 239000002253 acid Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000011780 sodium chloride Substances 0.000 title 1
- 125000003277 amino group Chemical group 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
Claims (5)
1. Аминосоединение общей формулы (С)
в которой Х представляет атом азота;
Y - представляет -СН= или CR7=, (где R7 является низшим алкилом галогена);
Z - представляет -СН=;
R2a - представляет необязательно замещенную аминогруппу или защищенную аминогруппу;
R3 - представляет атом водорода или галогена.
2. Аминосоединение по п.1, в котором R3 представляет атом фтора или хлора.
3. Аминосоединение по п.1 или 2, в котором Y представляет СН= или CR7=, (где R7 является метилом, атомом фтора или хлора).
4. Аминосоединение по любому из пп.1, 2 и 3, в котором указанная замещенная аминогруппа или защищенная аминогруппа в определении R2a представляет метиламино, изо-пропиламино, трет-бутиламино, бензиламино, п-метоксибензиламино или 1,1,3,3-тетраметилбутиламино.
5. Аминосоединение по любому из пп.1, 2 и 3, в котором R2a является незамещенной аминогруппой.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26928095 | 1995-09-22 | ||
| JP7-269280 | 1995-09-22 | ||
| JP17846296 | 1996-06-19 | ||
| JP8-178462 | 1996-06-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98107259/04A Division RU2167873C2 (ru) | 1995-09-22 | 1996-09-20 | Производные пиридонкарбоновой кислоты или их соли и антибактериальное средство |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2171252C2 RU2171252C2 (ru) | 2001-07-27 |
| RU99117921A true RU99117921A (ru) | 2004-06-20 |
Family
ID=26498637
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98107259/04A RU2167873C2 (ru) | 1995-09-22 | 1996-09-20 | Производные пиридонкарбоновой кислоты или их соли и антибактериальное средство |
| RU99117921/04A RU2171252C2 (ru) | 1995-09-22 | 1996-09-20 | Аминосоединение для получения новых производных пиридонкарбоновой кислоты или их солей |
| RU2000113595/04A RU2177945C1 (ru) | 1995-09-22 | 1996-09-20 | Производное пиридонкарбоновой кислоты или его соль |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98107259/04A RU2167873C2 (ru) | 1995-09-22 | 1996-09-20 | Производные пиридонкарбоновой кислоты или их соли и антибактериальное средство |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000113595/04A RU2177945C1 (ru) | 1995-09-22 | 1996-09-20 | Производное пиридонкарбоновой кислоты или его соль |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US5998436A (ru) |
| EP (3) | EP0952151B1 (ru) |
| JP (3) | JP3103380B2 (ru) |
| KR (2) | KR100299430B1 (ru) |
| CN (3) | CN1105715C (ru) |
| AT (3) | ATE241601T1 (ru) |
| AU (1) | AU721805B2 (ru) |
| BR (2) | BR9612862B8 (ru) |
| CA (3) | CA2290712C (ru) |
| DE (3) | DE69617750T2 (ru) |
| DK (3) | DK0992501T3 (ru) |
| ES (3) | ES2200439T3 (ru) |
| HK (2) | HK1016602A1 (ru) |
| HU (3) | HUP9904390A3 (ru) |
| PT (3) | PT911327E (ru) |
| RU (3) | RU2167873C2 (ru) |
| WO (1) | WO1997011068A1 (ru) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2469026C2 (ru) * | 2006-11-24 | 2012-12-10 | Ац Иммуне Са | Новые соединения для лечения заболеваний, связанных с амилоидом или амилоидподобными белками |
| US8916590B2 (en) | 2009-10-15 | 2014-12-23 | Ac Immune Sa | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system |
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| ATE248162T1 (de) * | 1999-07-01 | 2003-09-15 | Wakunaga Pharma Co Ltd | Quinolincarbonsäure-derivate oder salze davon |
| US6586420B1 (en) | 1999-09-02 | 2003-07-01 | Wakunaga Pharmaceutical Co., Ltd. | Quinolinecarboxylic acid derivative or its salt |
| JP2005097116A (ja) * | 1999-11-11 | 2005-04-14 | Wakunaga Pharmaceut Co Ltd | キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法 |
| JP2005232000A (ja) * | 2000-03-10 | 2005-09-02 | Dainippon Pharmaceut Co Ltd | ピリドンカルボン酸誘導体又はその塩 |
| KR100777149B1 (ko) * | 2000-11-20 | 2007-11-19 | 다이이찌 세이야꾸 가부시기가이샤 | 데할로게노 화합물 |
| JP2004535370A (ja) | 2001-03-05 | 2004-11-25 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 味をマスクした液体製薬学的組成物 |
| WO2003031443A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| CA2529347C (en) | 2003-04-30 | 2011-09-06 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| WO2005026145A2 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| WO2005058888A2 (en) | 2003-12-18 | 2005-06-30 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| US8158797B2 (en) * | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| EP2100892B1 (en) * | 2004-07-30 | 2014-04-23 | AbbVie Inc. | Preparation of pyridonecarboxylic acid antibacterials |
| US7576216B2 (en) | 2004-07-30 | 2009-08-18 | Abbott Laboratories | Preparation of pyridonecarboxylic acid antibacterials |
| US20090156577A1 (en) * | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| WO2006034474A2 (en) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
| PT3056492T (pt) | 2004-10-08 | 2021-12-27 | Abbvie Inc | Sal de meglumina e formas cristalinas do mesmo de um fármaco (delafloxacina) |
| ZA200704862B (en) | 2004-11-17 | 2008-12-31 | Wakunaga Pharma Co Ltd | Novel pyridonecarboxylic acid derivatives or salts thereof |
| JP2008523139A (ja) * | 2004-12-14 | 2008-07-03 | アストラゼネカ・アクチエボラーグ | 置換アミノピリジン類及びその使用 |
| WO2006082588A2 (en) * | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| ME02003B (me) * | 2005-04-11 | 2012-12-31 | Abbott Lab | Farmaceutske smeše koje imaju unapređene profile rastvaranja za lekove koji su slabo rastvorljivi |
| JP2009530288A (ja) * | 2006-03-16 | 2009-08-27 | ノバルティス アクチエンゲゼルシャフト | 特に黒色腫の処置のためのヘテロ環式有機化合物 |
| US7902227B2 (en) | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
| ES2966093T3 (es) | 2008-09-24 | 2024-04-18 | Melinta Subsidiary Corp | Formulación farmacéutica que contiene un derivado de quinolona |
| NZ593345A (en) | 2008-11-15 | 2013-04-26 | Rib X Pharmaceuticals Inc | Antimicrobial composition comprising a quinolone carboxylic acid derivative and a cyclodextrin |
| DE102009021535B8 (de) | 2009-05-15 | 2012-12-13 | Stabilo International Gmbh | Verschlusskappe |
| CA2785668A1 (en) * | 2009-12-25 | 2011-06-30 | Ube Industries, Ltd. | Aminopyridine compound |
| CN103936718B (zh) * | 2013-01-22 | 2016-06-29 | 上海医药工业研究院 | 一种高纯度delafloxacin的制备方法 |
| CN103936717B (zh) * | 2013-01-22 | 2016-08-10 | 上海医药工业研究院 | 一种delafloxacin中间体及其制备方法 |
| CN104098548B (zh) * | 2013-04-11 | 2017-07-18 | 上海医药工业研究院 | 一种Delafloxacin的精制方法 |
| TW201609652A (zh) * | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程（三） |
| CN104876911A (zh) * | 2014-02-27 | 2015-09-02 | 南京工业大学 | 一种简易的方法合成德拉沙星 |
| TWI705814B (zh) | 2014-06-20 | 2020-10-01 | 美商梅琳塔有限責任公司 | 醫藥組成物及其用途 |
| UY36402A (es) | 2014-11-14 | 2016-06-30 | Melinta Therapeutics Inc | Método para tratar, prevenir, o reducir el riesgo de infección cutánea |
| US9845325B2 (en) * | 2016-02-19 | 2017-12-19 | Novartis Ag | Tetracyclic pyridone compounds as antivirals |
| CN108084161A (zh) * | 2017-12-28 | 2018-05-29 | 北京沃邦医药科技有限公司 | 德拉沙星及其中间体的制备方法 |
| CN108033948A (zh) * | 2017-12-28 | 2018-05-15 | 北京沃邦医药科技有限公司 | 一种德拉沙星及其中间体的制备 |
| CN114507230B (zh) * | 2020-11-17 | 2023-07-21 | 西华大学 | 一种双环吡啶酮类衍生物、其合成方法及其用途 |
| CN114539213A (zh) * | 2021-08-18 | 2022-05-27 | 广东工业大学 | 一种氟喹诺酮类化合物及其制备方法和应用 |
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| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
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| WO1996023775A1 (fr) * | 1995-01-30 | 1996-08-08 | Wakunaga Seiyaku Kabushiki Kaisha | Nouveaux derives d'acide pyridonecarboxylique ou de ses sels et agent antibacterien contenant ces derives en tant qu'ingredient actif |
| NL1000360C2 (nl) * | 1995-05-15 | 1996-11-18 | Akzo Nobel Nv | Werkwijze ter bereiding van pyridine-2, 6-diamines |
-
1996
- 1996-09-20 BR BRPI9612862-3B8D patent/BR9612862B8/pt not_active IP Right Cessation
- 1996-09-20 DK DK99124494T patent/DK0992501T3/da active
- 1996-09-20 DE DE69617750T patent/DE69617750T2/de not_active Expired - Lifetime
- 1996-09-20 PT PT96931264T patent/PT911327E/pt unknown
- 1996-09-20 ES ES99111114T patent/ES2200439T3/es not_active Expired - Lifetime
- 1996-09-20 RU RU98107259/04A patent/RU2167873C2/ru active
- 1996-09-20 HU HU9904390A patent/HUP9904390A3/hu unknown
- 1996-09-20 RU RU99117921/04A patent/RU2171252C2/ru not_active IP Right Cessation
- 1996-09-20 ES ES96931264T patent/ES2169811T3/es not_active Expired - Lifetime
- 1996-09-20 AT AT99111114T patent/ATE241601T1/de active
- 1996-09-20 RU RU2000113595/04A patent/RU2177945C1/ru active
- 1996-09-20 EP EP99111114A patent/EP0952151B1/en not_active Expired - Lifetime
- 1996-09-20 KR KR1019980702128A patent/KR100299430B1/ko not_active IP Right Cessation
- 1996-09-20 DE DE69628466T patent/DE69628466T2/de not_active Expired - Lifetime
- 1996-09-20 AT AT96931264T patent/ATE210129T1/de active
- 1996-09-20 AT AT99124494T patent/ATE222906T1/de active
- 1996-09-20 HU HU9902714A patent/HU225224B1/hu unknown
- 1996-09-20 US US09/043,472 patent/US5998436A/en not_active Expired - Lifetime
- 1996-09-20 DE DE69623358T patent/DE69623358T2/de not_active Expired - Lifetime
- 1996-09-20 CA CA002290712A patent/CA2290712C/en not_active Expired - Lifetime
- 1996-09-20 CN CN96198104A patent/CN1105715C/zh not_active Expired - Lifetime
- 1996-09-20 BR BRPI9610485-6B8A patent/BR9610485B8/pt not_active IP Right Cessation
- 1996-09-20 CA CA002290709A patent/CA2290709C/en not_active Expired - Fee Related
- 1996-09-20 DK DK99111114T patent/DK0952151T3/da active
- 1996-09-20 EP EP96931264A patent/EP0911327B1/en not_active Expired - Lifetime
- 1996-09-20 PT PT99124494T patent/PT992501E/pt unknown
- 1996-09-20 EP EP99124494A patent/EP0992501B1/en not_active Expired - Lifetime
- 1996-09-20 PT PT99111114T patent/PT952151E/pt unknown
- 1996-09-20 ES ES99124494T patent/ES2183473T3/es not_active Expired - Lifetime
- 1996-09-20 WO PCT/JP1996/002710 patent/WO1997011068A1/ja active IP Right Grant
- 1996-09-20 DK DK96931264T patent/DK0911327T3/da active
- 1996-09-20 JP JP09512602A patent/JP3103380B2/ja not_active Expired - Lifetime
- 1996-09-20 CA CA002232728A patent/CA2232728C/en not_active Expired - Lifetime
- 1996-09-20 HU HU9904389A patent/HU225225B1/hu unknown
- 1996-09-20 KR KR1020007009581A patent/KR100343331B1/ko not_active IP Right Cessation
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1999
- 1999-04-15 JP JP10767199A patent/JP3304311B2/ja not_active Expired - Lifetime
- 1999-04-21 HK HK99101731A patent/HK1016602A1/xx not_active IP Right Cessation
- 1999-05-24 AU AU31227/99A patent/AU721805B2/en not_active Ceased
- 1999-06-10 US US09/329,336 patent/US6156903A/en not_active Expired - Lifetime
- 1999-06-10 US US09/329,246 patent/US6133284A/en not_active Expired - Lifetime
- 1999-10-06 JP JP28523599A patent/JP3187795B2/ja not_active Expired - Lifetime
- 1999-10-22 CN CNB991233107A patent/CN1196683C/zh not_active Expired - Fee Related
- 1999-10-22 CN CNB991233115A patent/CN1136216C/zh not_active Expired - Lifetime
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2000
- 2000-11-17 HK HK00107356A patent/HK1028032A1/xx not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2469026C2 (ru) * | 2006-11-24 | 2012-12-10 | Ац Иммуне Са | Новые соединения для лечения заболеваний, связанных с амилоидом или амилоидподобными белками |
| US8673940B2 (en) | 2006-11-24 | 2014-03-18 | Ac Immune Sa | Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
| US8916590B2 (en) | 2009-10-15 | 2014-12-23 | Ac Immune Sa | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system |
| US9701660B2 (en) | 2009-10-15 | 2017-07-11 | Ac Immune S.A. | 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system |
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