RU2766685C2 - Рнк-направляемая инженерия генома человека - Google Patents

Рнк-направляемая инженерия генома человека Download PDF

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RU2766685C2
RU2766685C2 RU2019127316A RU2019127316A RU2766685C2 RU 2766685 C2 RU2766685 C2 RU 2766685C2 RU 2019127316 A RU2019127316 A RU 2019127316A RU 2019127316 A RU2019127316 A RU 2019127316A RU 2766685 C2 RU2766685 C2 RU 2766685C2
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guide rna
nucleic acid
cell
rna
dna
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Джордж М. ЧЁРЧ
Прашант МАЛИ
Лухан ЯНГ
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Президент Энд Фэллоуз Оф Харвард Коллидж
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Wood Science & Technology (AREA)
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  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
RU2019127316A 2012-12-17 2013-12-16 Рнк-направляемая инженерия генома человека RU2766685C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261738355P 2012-12-17 2012-12-17
US61/738,355 2012-12-17
US201361779169P 2013-03-13 2013-03-13
US61/779,169 2013-03-13

Related Parent Applications (1)

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RU2015129018A Division RU2699523C2 (ru) 2012-12-17 2013-12-16 Рнк-направляемая инженерия генома человека

Publications (3)

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RU2019127316A RU2019127316A (ru) 2019-10-08
RU2019127316A3 RU2019127316A3 (https=) 2020-07-06
RU2766685C2 true RU2766685C2 (ru) 2022-03-15

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RU2019127316A RU2766685C2 (ru) 2012-12-17 2013-12-16 Рнк-направляемая инженерия генома человека
RU2015129018A RU2699523C2 (ru) 2012-12-17 2013-12-16 Рнк-направляемая инженерия генома человека

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US (19) US9970024B2 (https=)
EP (4) EP4282970A3 (https=)
JP (5) JP6700788B2 (https=)
KR (2) KR20220139433A (https=)
CN (3) CN121022900A (https=)
AU (5) AU2013363194B2 (https=)
CA (2) CA3081054A1 (https=)
DK (2) DK2931891T3 (https=)
ES (2) ES2741951T3 (https=)
IL (2) IL239326B2 (https=)
MX (3) MX383326B (https=)
MY (1) MY170059A (https=)
RU (2) RU2766685C2 (https=)
SG (3) SG10201912991WA (https=)
WO (2) WO2014099750A2 (https=)
ZA (2) ZA201504739B (https=)

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