RU2716421C2 - Доставка, применение и применения в терапии систем crispr-cas и композиций для целенаправленного воздействия на нарушения и заболевания с использованием вирусных компонентов
- Google Patents
Доставка, применение и применения в терапии систем crispr-cas и композиций для целенаправленного воздействия на нарушения и заболевания с использованием вирусных компонентов
Download PDF
Info
Publication number
RU2716421C2
RU2716421C2
RU2016101198A
RU2016101198A
RU2716421C2
RU 2716421 C2
RU2716421 C2
RU 2716421C2
RU 2016101198 A
RU2016101198 A
RU 2016101198A
RU 2016101198 A
RU2016101198 A
RU 2016101198A
RU 2716421 C2
RU2716421 C2
RU 2716421C2
Authority
RU
Russia
Prior art keywords
sequence
cas9
crispr
cells
target
Prior art date
2013-06-17
Application number
RU2016101198A
Other languages
English (en )
Other versions
RU2016101198A3
(ru
RU2016101198A
(ru
Inventor
Фэн ЧЖАН
Лэ ЦУН
Фэй ЖАНЬ
Маттиас ХАЙДЕНРАЙХ
Лукаш СУИЧ
Original Assignee
Те Брод Инститьют Инк. Массачусетс Инститьют Оф Текнолоджи Президент Энд Фэллоуз Оф Харвард Коллидж
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
2013-06-17
Filing date
2014-06-11
Publication date
2020-03-11
Family has litigation
Priority claimed from US201361836123P
external-priority
2013-12-12
Priority claimed from PCT/US2013/074667
external-priority
patent/WO2014093622A2/en
2014-06-11
Application filed by Те Брод Инститьют Инк., Массачусетс Инститьют Оф Текнолоджи, Президент Энд Фэллоуз Оф Харвард Коллидж
filed
Critical
Те Брод Инститьют Инк.
2019-03-27
Publication of RU2016101198A3
publication
Critical
patent/RU2016101198A3/ru
2019-03-27
Publication of RU2016101198A
publication
Critical
patent/RU2016101198A/ru
2020-03-11
Application granted
granted
Critical
2020-03-11
Publication of RU2716421C2
publication
Critical
patent/RU2716421C2/ru
2020-05-07
First worldwide family litigation filed
litigation
Critical
https://patents.darts-ip.com/?family=52105124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2716421(C2)
"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Links
239000000203
mixture
Substances
0.000
title
claims
abstract
description
135
201000010099
disease
Diseases
0.000
title
claims
abstract
description
37
238000002560
therapeutic procedure
Methods
0.000
title
description
5
210000000605
viral structures
Anatomy
0.000
title
description
2
230000003612
virological
Effects
0.000
claims
abstract
description
62
241000124008
Mammalia
Species
0.000
claims
abstract
description
15
108010077850
Nuclear Localization Signals
Proteins
0.000
claims
abstract
description
7
229920000033
CRISPR
Polymers
0.000
claims
description
459
108010082319
CRISPR-Associated Protein 9
Proteins
0.000
claims
description
262
238000010354
CRISPR gene editing
Methods
0.000
claims
description
236
230000014509
gene expression
Effects
0.000
claims
description
151
229920000023
polynucleotide
Polymers
0.000
claims
description
112
239000002157
polynucleotide
Substances
0.000
claims
description
112
229920000160
(ribonucleotides)n+m
Polymers
0.000
claims
description
110
229920003013
deoxyribonucleic acid
Polymers
0.000
claims
description
87
210000004556
Brain
Anatomy
0.000
claims
description
63
241000282414
Homo sapiens
Species
0.000
claims
description
58
230000027455
binding
Effects
0.000
claims
description
44
-1
DR2
Proteins
0.000
claims
description
41
230000004048
modification
Effects
0.000
claims
description
41
238000006011
modification reaction
Methods
0.000
claims
description
41
230000001105
regulatory
Effects
0.000
claims
description
40
238000009739
binding
Methods
0.000
claims
description
33
230000000051
modifying
Effects
0.000
claims
description
22
239000007924
injection
Substances
0.000
claims
description
20
238000002347
injection
Methods
0.000
claims
description
19
230000004807
localization
Effects
0.000
claims
description
19
210000004958
Brain cells
Anatomy
0.000
claims
description
18
230000002950
deficient
Effects
0.000
claims
description
17
241000193996
Streptococcus pyogenes
Species
0.000
claims
description
13
241000702423
Adeno-associated virus - 2
Species
0.000
claims
description
12
230000001629
suppression
Effects
0.000
claims
description
9
208000008581
Brain Disease
Diseases
0.000
claims
description
3
210000004602
germ cell
Anatomy
0.000
claims
description
3
230000001537
neural
Effects
0.000
claims
description
3
101710017796
SLC32A1
Proteins
0.000
claims
description
2
101700045413
DR1
Proteins
0.000
claims
1
101710008038
DR1R
Proteins
0.000
claims
1
102100012570
GFAP
Human genes
0.000
claims
1
101700069447
GFAP
Proteins
0.000
claims
1
101700052389
PRVM
Proteins
0.000
claims
1
101710033705
PVALB
Proteins
0.000
claims
1
102100020302
PVALB
Human genes
0.000
claims
1
210000003061
neural cell
Anatomy
0.000
claims
1
230000000694
effects
Effects
0.000
abstract
description
51
210000003527
eukaryotic cell
Anatomy
0.000
abstract
description
44
239000000126
substance
Substances
0.000
abstract
description
17
206010054938
Cerebral disease
Diseases
0.000
abstract
2
238000010453
CRISPR/Cas method
Methods
0.000
abstract
1
210000004027
cells
Anatomy
0.000
description
353
102000004190
Enzymes
Human genes
0.000
description
198
108090000790
Enzymes
Proteins
0.000
description
198
229940088598
Enzyme
Drugs
0.000
description
183
235000018102
proteins
Nutrition
0.000
description
89
102000004169
proteins and genes
Human genes
0.000
description
89
108090000623
proteins and genes
Proteins
0.000
description
89
210000004185
Liver
Anatomy
0.000
description
83
238000010356
CRISPR-Cas9 genome editing
Methods
0.000
description
79
230000035772
mutation
Effects
0.000
description
77
239000004055
small Interfering RNA
Substances
0.000
description
74
229920001985
Small interfering RNA
Polymers
0.000
description
72
150000002632
lipids
Chemical class
0.000
description
69
239000003814
drug
Substances
0.000
description
68
210000001519
tissues
Anatomy
0.000
description
64
210000002569
neurons
Anatomy
0.000
description
62
239000000047
product
Substances
0.000
description
55
239000002245
particle
Substances
0.000
description
53
HVYWMOMLDIMFJA-DPAQBDIFSA-N
(3β)-Cholest-5-en-3-ol
Chemical compound
C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2
HVYWMOMLDIMFJA-DPAQBDIFSA-N
0.000
description
48
210000001808
Exosomes
Anatomy
0.000
description
48
229940079593
drugs
Drugs
0.000
description
48
238000003776
cleavage reaction
Methods
0.000
description
46
239000002105
nanoparticle
Substances
0.000
description
46
LFQSCWFLJHTTHZ-UHFFFAOYSA-N
ethanol
Chemical compound
CCO
LFQSCWFLJHTTHZ-UHFFFAOYSA-N
0.000
description
45
108010043121
Green Fluorescent Proteins
Proteins
0.000
description
43
102000004144
Green Fluorescent Proteins
Human genes
0.000
description
42
239000002502
liposome
Substances
0.000
description
41
241000699666
Mus <mouse, genus>
Species
0.000
description
39
239000005090
green fluorescent protein
Substances
0.000
description
38
230000001404
mediated
Effects
0.000
description
38
101700085675
MESP2
Proteins
0.000
description
35
238000004458
analytical method
Methods
0.000
description
35
210000004940
Nucleus
Anatomy
0.000
description
34
238000003197
gene knockdown
Methods
0.000
description
34
241000196324
Embryophyta
Species
0.000
description
33
230000035897
transcription
Effects
0.000
description
33
238000001890
transfection
Methods
0.000
description
32
230000015572
biosynthetic process
Effects
0.000
description
31
241000699670
Mus sp.
Species
0.000
description
30
239000002585
base
Substances
0.000
description
29
150000007523
nucleic acids
Chemical group
0.000
description
29
108020004707
nucleic acids
Proteins
0.000
description
29
238000001415
gene therapy
Methods
0.000
description
28
230000001939
inductive effect
Effects
0.000
description
28
229920000642
polymer
Polymers
0.000
description
28
229940076185
Staphylococcus aureus
Drugs
0.000
description
26
241000191967
Staphylococcus aureus
Species
0.000
description
26
210000001947
Dentate Gyrus
Anatomy
0.000
description
25
230000001225
therapeutic
Effects
0.000
description
25
229940107161
Cholesterol
Drugs
0.000
description
24
235000012000
cholesterol
Nutrition
0.000
description
24
238000003780
insertion
Methods
0.000
description
24
210000003494
Hepatocytes
Anatomy
0.000
description
23
108020004999
Messenger RNA
Proteins
0.000
description
23
241000700605
Viruses
Species
0.000
description
23
150000001875
compounds
Chemical class
0.000
description
23
229920002106
messenger RNA
Polymers
0.000
description
23
238000000034
method
Methods
0.000
description
23
229920002168
Chimeric RNA
Polymers
0.000
description
22
239000011159
matrix material
Substances
0.000
description
22
241000713666
Lentivirus
Species
0.000
description
21
241001465754
Metazoa
Species
0.000
description
21
101700080605
NUC1
Proteins
0.000
description
21
238000005755
formation reaction
Methods
0.000
description
21
101700006494
nucA
Proteins
0.000
description
21
JCAIWDXKLCEQEO-LXOWHHAPSA-N
Copalyl diphosphate
Natural products
[P@@](=O)(OP(=O)(O)O)(OC/C=C(\CC[C@H]1C(=C)CC[C@H]2C(C)(C)CCC[C@@]12C)/C)O
JCAIWDXKLCEQEO-LXOWHHAPSA-N
0.000
description
20
210000003734
Kidney
Anatomy
0.000
description
20
210000000056
organs
Anatomy
0.000
description
20
NRJAVPSFFCBXDT-HUESYALOSA-N
1,2-distearoyl-sn-glycero-3-phosphocholine
Chemical compound
CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
NRJAVPSFFCBXDT-HUESYALOSA-N
0.000
description
18
102000018616
Apolipoproteins B
Human genes
0.000
description
18
108010027006
Apolipoproteins B
Proteins
0.000
description
18
101700070526
DNMT1
Proteins
0.000
description
18
102100018208
DNMT1
Human genes
0.000
description
18
229940090044
Injection
Drugs
0.000
description
18
238000002744
homologous recombination
Methods
0.000
description
18
102100006402
DNMT3A
Human genes
0.000
description
17
101710038368
DNMT3A
Proteins
0.000
description
17
125000002091
cationic group
Chemical group
0.000
description
17
229940110715
ENZYMES FOR TREATMENT OF WOUNDS AND ULCERS
Drugs
0.000
description
16
238000000692
Student's t-test
Methods
0.000
description
16
229940019336
antithrombotic Enzymes
Drugs
0.000
description
16
230000000295
complement
Effects
0.000
description
16
229940020899
hematological Enzymes
Drugs
0.000
description
16
238000000338
in vitro
Methods
0.000
description
16
239000000412
dendrimer
Substances
0.000
description
15
229920000736
dendritic polymer
Polymers
0.000
description
15
238000010362
genome editing
Methods
0.000
description
15
AVXURJPOCDRRFD-UHFFFAOYSA-N
hydroxylamine
Chemical compound
ON
AVXURJPOCDRRFD-UHFFFAOYSA-N
0.000
description
15
238000002513
implantation
Methods
0.000
description
15
229920001223
polyethylene glycol
Polymers
0.000
description
15
102100010474
GATA3
Human genes
0.000
description
14
235000001014
amino acid
Nutrition
0.000
description
14
108060004133
ispH
Proteins
0.000
description
14
239000002773
nucleotide
Substances
0.000
description
14
229920001405
Coding region
Polymers
0.000
description
13
206010028980
Neoplasm
Diseases
0.000
description
13
210000002220
Organoids
Anatomy
0.000
description
13
239000002202
Polyethylene glycol
Substances
0.000
description
13
201000011510
cancer
Diseases
0.000
description
13
239000003795
chemical substances by application
Substances
0.000
description
13
108091006028
chimera
Proteins
0.000
description
13
238000011161
development
Methods
0.000
description
13
230000018109
developmental process
Effects
0.000
description
13
239000000499
gel
Substances
0.000
description
13
230000001965
increased
Effects
0.000
description
13
210000003292
kidney cell
Anatomy
0.000
description
13
239000002609
media
Substances
0.000
description
13
102000004196
processed proteins & peptides
Human genes
0.000
description
13
108090000765
processed proteins & peptides
Proteins
0.000
description
13
241000701161
unidentified adenovirus
Species
0.000
description
13
238000001262
western blot
Methods
0.000
description
13
210000004379
Membranes
Anatomy
0.000
description
12
230000025458
RNA interference
Effects
0.000
description
12
230000004913
activation
Effects
0.000
description
12
210000003618
cortical neuron
Anatomy
0.000
description
12
239000012528
membrane
Substances
0.000
description
12
239000002953
phosphate buffered saline
Substances
0.000
description
12
238000011002
quantification
Methods
0.000
description
12
230000002987
rna-interference
Effects
0.000
description
12
108010051109
Cell-Penetrating Peptides
Proteins
0.000
description
11
102000019679
Cell-Penetrating Peptides
Human genes
0.000
description
11
FWBHETKCLVMNFS-UHFFFAOYSA-N
DATI
Chemical compound
C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1
FWBHETKCLVMNFS-UHFFFAOYSA-N
0.000
description
11
102100015153
DNMT3B
Human genes
0.000
description
11
101710038366
DNMT3B
Proteins
0.000
description
11
150000001413
amino acids
Chemical class
0.000
description
11
239000003446
ligand
Substances
0.000
description
11
125000003729
nucleotide group
Chemical group
0.000
description
11
238000010361
transduction
Methods
0.000
description
11
230000026683
transduction
Effects
0.000
description
11
241000282412
Homo
Species
0.000
description
10
229920002459
Intron
Polymers
0.000
description
10
101710011991
MYCBP2
Proteins
0.000
description
10
229920001850
Nucleic acid sequence
Polymers
0.000
description
10
102100001279
PAM
Human genes
0.000
description
10
101700040984
cctP
Proteins
0.000
description
10
230000000875
corresponding
Effects
0.000
description
10
230000002068
genetic
Effects
0.000
description
10
238000004519
manufacturing process
Methods
0.000
description
10
229920002401
polyacrylamide
Polymers
0.000
description
10
210000003855
Cell Nucleus
Anatomy
0.000
description
9
210000003027
Ear, Inner
Anatomy
0.000
description
9
229920002391
Guide RNA
Polymers
0.000
description
9
108020005004
Guide RNA
Proteins
0.000
description
9
108010071690
Prealbumin
Proteins
0.000
description
9
102000009190
Transthyretin
Human genes
0.000
description
9
239000000969
carrier
Substances
0.000
description
9
238000005516
engineering process
Methods
0.000
description
9
125000003700
epoxy group
Chemical group
0.000
description
9
238000001990
intravenous administration
Methods
0.000
description
9
238000002372
labelling
Methods
0.000
description
9
210000004962
mammalian cells
Anatomy
0.000
description
9
239000000463
material
Substances
0.000
description
9
238000004806
packaging method and process
Methods
0.000
description
9
230000001603
reducing
Effects
0.000
description
9
238000011160
research
Methods
0.000
description
9
239000000758
substrate
Substances
0.000
description
9
238000003786
synthesis reaction
Methods
0.000
description
9
230000002194
synthesizing
Effects
0.000
description
9
210000001320
Hippocampus
Anatomy
0.000
description
8
102000006890
Methyl-CpG-Binding Protein 2
Human genes
0.000
description
8
108010072388
Methyl-CpG-Binding Protein 2
Proteins
0.000
description
8
KHPCPRHQVVSZAH-HUOMCSJISA-N
Rosin
Natural products
O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1
KHPCPRHQVVSZAH-HUOMCSJISA-N
0.000
description
8
210000002966
Serum
Anatomy
0.000
description
8
102000001435
Synapsin
Human genes
0.000
description
8
108050009621
Synapsin
Proteins
0.000
description
8
101700081234
TTR
Proteins
0.000
description
8
102100016858
TTR
Human genes
0.000
description
8
238000004113
cell culture
Methods
0.000
description
8
108091009026
methyl-CpG binding proteins
Proteins
0.000
description
8
102000032065
methyl-CpG binding proteins
Human genes
0.000
description
8
210000000130
stem cell
Anatomy
0.000
description
8
239000003981
vehicle
Substances
0.000
description
8
102100015650
BACE1
Human genes
0.000
description
7
101700051112
BACE1
Proteins
0.000
description
7
210000004443
Dendritic Cells
Anatomy
0.000
description
7
101700072159
EMX1
Proteins
0.000
description
7
210000001508
Eye
Anatomy
0.000
description
7
102100005430
LNPK
Human genes
0.000
description
7
101710024851
LNPK
Proteins
0.000
description
7
101710011271
NUSAP1
Proteins
0.000
description
7
210000000633
Nuclear Envelope
Anatomy
0.000
description
7
210000002381
Plasma
Anatomy
0.000
description
7
102100013268
UTP4
Human genes
0.000
description
7
101700075834
UTP4
Proteins
0.000
description
7
238000006243
chemical reaction
Methods
0.000
description
7
230000000536
complexating
Effects
0.000
description
7
238000005520
cutting process
Methods
0.000
description
7
238000009826
distribution
Methods
0.000
description
7
238000004520
electroporation
Methods
0.000
description
7
230000001976
improved
Effects
0.000
description
7
230000001717
pathogenic
Effects
0.000
description
7
244000052769
pathogens
Species
0.000
description
7
230000001402
polyadenylating
Effects
0.000
description
7
238000000746
purification
Methods
0.000
description
7
230000002829
reduced
Effects
0.000
description
7
230000001743
silencing
Effects
0.000
description
7
238000003756
stirring
Methods
0.000
description
7
231100000419
toxicity
Toxicity
0.000
description
7
230000001988
toxicity
Effects
0.000
description
7
102100017796
APP
Human genes
0.000
description
6
108060000460
APP
Proteins
0.000
description
6
241000432074
Adeno-associated virus
Species
0.000
description
6
210000001163
Endosomes
Anatomy
0.000
description
6
108060002745
FAH
Proteins
0.000
description
6
102100008005
GPR180
Human genes
0.000
description
6
102100016995
HNF1A
Human genes
0.000
description
6
101700018864
HNF1A
Proteins
0.000
description
6
210000004072
Lung
Anatomy
0.000
description
6
102100006336
PDGFRL
Human genes
0.000
description
6
101710018288
PDGFRL
Proteins
0.000
description
6
101710037360
PRKCSH
Proteins
0.000
description
6
102100008062
PRKCSH
Human genes
0.000
description
6
241000700159
Rattus
Species
0.000
description
6
102100005424
SERPINA7
Human genes
0.000
description
6
101710037987
SERPINA7
Proteins
0.000
description
6
229940076156
Streptococcus pyogenes
Drugs
0.000
description
6
102100019730
TP53
Human genes
0.000
description
6
101710026335
TP53
Proteins
0.000
description
6
239000012190
activator
Substances
0.000
description
6
125000003277
amino group
Chemical group
0.000
description
6
230000003197
catalytic
Effects
0.000
description
6
238000010367
cloning
Methods
0.000
description
6
238000009792
diffusion process
Methods
0.000
description
6
238000005538
encapsulation
Methods
0.000
description
6
108020001507
fusion proteins
Proteins
0.000
description
6
102000037240
fusion proteins
Human genes
0.000
description
6
PCHJSUWPFVWCPO-UHFFFAOYSA-N
gold
Chemical compound
[Au]
PCHJSUWPFVWCPO-UHFFFAOYSA-N
0.000
description
6
238000001802
infusion
Methods
0.000
description
6
238000011068
load
Methods
0.000
description
6
238000005457
optimization
Methods
0.000
description
6
230000037361
pathway
Effects
0.000
description
6
229910052698
phosphorus
Inorganic materials
0.000
description
6
229920000333
poly(propyleneimine)
Polymers
0.000
description
6
229920000647
polyepoxide
Polymers
0.000
description
6
238000003559
rna-seq method
Methods
0.000
description
6
239000011780
sodium chloride
Substances
0.000
description
6
241000894007
species
Species
0.000
description
6
238000010186
staining
Methods
0.000
description
6
206010002022
Amyloidosis
Diseases
0.000
description
5
206010002023
Amyloidosis
Diseases
0.000
description
5
102100016401
EMX1
Human genes
0.000
description
5
241000206602
Eukaryota
Species
0.000
description
5
241000238631
Hexapoda
Species
0.000
description
5
206010061218
Inflammation
Diseases
0.000
description
5
229920002521
Macromolecule
Polymers
0.000
description
5
208000008589
Obesity
Diseases
0.000
description
5
229920000272
Oligonucleotide
Polymers
0.000
description
5
101710038792
PALG1
Proteins
0.000
description
5
101700032742
PROC
Proteins
0.000
description
5
210000000496
Pancreas
Anatomy
0.000
description
5
229920000320
RNA (poly(A))
Polymers
0.000
description
5
108020004412
RNA 3' Polyadenylation Signals
Proteins
0.000
description
5
241000283984
Rodentia
Species
0.000
description
5
101710043164
Segment-4
Proteins
0.000
description
5
241000194020
Streptococcus thermophilus
Species
0.000
description
5
210000000538
Tail
Anatomy
0.000
description
5
101700038759
VP1
Proteins
0.000
description
5
125000003275
alpha amino acid group
Chemical group
0.000
description
5
239000007864
aqueous solution
Substances
0.000
description
5
230000003542
behavioural
Effects
0.000
description
5
238000004166
bioassay
Methods
0.000
description
5
239000003153
chemical reaction reagent
Substances
0.000
description
5
201000003883
cystic fibrosis
Diseases
0.000
description
5
238000001514
detection method
Methods
0.000
description
5
201000009910
diseases by infectious agent
Diseases
0.000
description
5
238000001943
fluorescence-activated cell sorting
Methods
0.000
description
5
238000009472
formulation
Methods
0.000
description
5
230000030279
gene silencing
Effects
0.000
description
5
101700005460
hemA
Proteins
0.000
description
5
230000028993
immune response
Effects
0.000
description
5
230000004054
inflammatory process
Effects
0.000
description
5
230000002401
inhibitory effect
Effects
0.000
description
5
230000003993
interaction
Effects
0.000
description
5
230000000670
limiting
Effects
0.000
description
5
230000037356
lipid metabolism
Effects
0.000
description
5
230000000877
morphologic
Effects
0.000
description
5
231100000350
mutagenesis
Toxicity
0.000
description
5
230000001264
neutralization
Effects
0.000
description
5
229910052757
nitrogen
Inorganic materials
0.000
description
5
235000020824
obesity
Nutrition
0.000
description
5
239000011148
porous material
Substances
0.000
description
5
238000002360
preparation method
Methods
0.000
description
5
108060006962
recR
Proteins
0.000
description
5
239000000243
solution
Substances
0.000
description
5
238000006467
substitution reaction
Methods
0.000
description
5
241000701447
unidentified baculovirus
Species
0.000
description
5
KRKNYBCHXYNGOX-UHFFFAOYSA-K
2qpq
Chemical compound
[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O
KRKNYBCHXYNGOX-UHFFFAOYSA-K
0.000
description
4
101700082523
ABCC7
Proteins
0.000
description
4
102100003829
AGL
Human genes
0.000
description
4
101700023572
AGL
Proteins
0.000
description
4
210000001218
Blood-Brain Barrier
Anatomy
0.000
description
4
102100008990
CASP8
Human genes
0.000
description
4
101700075287
CASP8
Proteins
0.000
description
4
102100019896
CFTR
Human genes
0.000
description
4
101700035991
CFTR
Proteins
0.000
description
4
229920005681
CRISPR RNA
Polymers
0.000
description
4
102100002043
CTNNB1
Human genes
0.000
description
4
101710005974
CTNNB1
Proteins
0.000
description
4
229920000858
Cyclodextrin
Polymers
0.000
description
4
210000003520
Dendritic Spines
Anatomy
0.000
description
4
210000002744
Extracellular Matrix
Anatomy
0.000
description
4
102100014967
FAH
Human genes
0.000
description
4
101700032690
G6PC
Proteins
0.000
description
4
101710010865
HMGCR
Proteins
0.000
description
4
210000002216
Heart
Anatomy
0.000
description
4
102100013307
IGF2R
Human genes
0.000
description
4
101710032496
IGF2R
Proteins
0.000
description
4
102100014726
MECP2
Human genes
0.000
description
4
101700029603
MECP2
Proteins
0.000
description
4
OVRNDRQMDRJTHS-KEWYIRBNSA-N
N-[(3R,4R,5R,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
Chemical compound
CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O
OVRNDRQMDRJTHS-KEWYIRBNSA-N
0.000
description
4
101710004245
PDPK2P
Proteins
0.000
description
4
102100013257
PKD2
Human genes
0.000
description
4
102100005877
PKHD1
Human genes
0.000
description
4
101700007671
PKHD1
Proteins
0.000
description
4
102100006731
QDPR
Human genes
0.000
description
4
208000006289
Rett Syndrome
Diseases
0.000
description
4
101700003493
SCO1
Proteins
0.000
description
4
102100001849
SCO1
Human genes
0.000
description
4
102100001407
SLC17A8
Human genes
0.000
description
4
101710033963
SLC17A8
Proteins
0.000
description
4
102100001822
SLC2A2
Human genes
0.000
description
4
108091006279
SLC2A2
Proteins
0.000
description
4
102100013320
SLC37A4
Human genes
0.000
description
4
101710027247
SLC37A4
Proteins
0.000
description
4
102100013777
SYN1
Human genes
0.000
description
4
101700044490
SYN1
Proteins
0.000
description
4
241000251539
Vertebrata <Metazoa>
Species
0.000
description
4
NBIIXXVUZAFLBC-UHFFFAOYSA-K
[O-]P([O-])([O-])=O
Chemical compound
[O-]P([O-])([O-])=O
NBIIXXVUZAFLBC-UHFFFAOYSA-K
0.000
description
4
238000009825
accumulation
Methods
0.000
description
4
150000001412
amines
Chemical class
0.000
description
4
238000001574
biopsy
Methods
0.000
description
4
230000004186
co-expression
Effects
0.000
description
4
230000003247
decreasing
Effects
0.000
description
4
238000000502
dialysis
Methods
0.000
description
4
230000002708
enhancing
Effects
0.000
description
4
230000004927
fusion
Effects
0.000
description
4
PEDCQBHIVMGVHV-UHFFFAOYSA-N
glycerine
Chemical compound
OCC(O)CO
PEDCQBHIVMGVHV-UHFFFAOYSA-N
0.000
description
4
230000012010
growth
Effects
0.000
description
4
239000000185
hemagglutinin
Substances
0.000
description
4
230000002209
hydrophobic
Effects
0.000
description
4
238000010874
in vitro model
Methods
0.000
description
4
238000010253
intravenous injection
Methods
0.000
description
4
229920001427
mPEG
Polymers
0.000
description
4
238000009126
molecular therapy
Methods
0.000
description
4
IJGRMHOSHXDMSA-UHFFFAOYSA-N
nitrogen
Chemical compound
N#N
IJGRMHOSHXDMSA-UHFFFAOYSA-N
0.000
description
4
239000012071
phase
Substances
0.000
description
4
239000010452
phosphate
Substances
0.000
description
4
150000003904
phospholipids
Chemical class
0.000
description
4
230000000754
repressing
Effects
0.000
description
4
239000002924
silencing RNA
Substances
0.000
description
4
150000003384
small molecules
Chemical class
0.000
description
4
FAPWRFPIFSIZLT-UHFFFAOYSA-M
sodium chloride
Chemical compound
[Na+].[Cl-]
FAPWRFPIFSIZLT-UHFFFAOYSA-M
0.000
description
4
230000002103
transcriptional
Effects
0.000
description
4
239000012096
transfection reagent
Substances
0.000
description
4
238000005199
ultracentrifugation
Methods
0.000
description
4
238000005303
weighing
Methods
0.000
description
4
206010001897
Alzheimer's disease
Diseases
0.000
description
3
210000001130
Astrocytes
Anatomy
0.000
description
3
210000000988
Bone and Bones
Anatomy
0.000
description
3
210000003169
Central Nervous System
Anatomy
0.000
description
3
210000003483
Chromatin
Anatomy
0.000
description
3
108010077544
Chromatin
Proteins
0.000
description
3
108020004705
Codon
Proteins
0.000
description
3
102000031025
DNA-Binding Proteins
Human genes
0.000
description
3
108091000102
DNA-Binding Proteins
Proteins
0.000
description
3
KILNVBDSWZSGLL-KXQOOQHDSA-N
Dipalmitoylphosphatidylcholine
Chemical compound
CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC
KILNVBDSWZSGLL-KXQOOQHDSA-N
0.000
description
3
239000006144
Dulbecco’s modified Eagle's medium
Substances
0.000
description
3
239000004593
Epoxy
Substances
0.000
description
3
241000283073
Equus caballus
Species
0.000
description
3
208000006454
Hepatitis
Diseases
0.000
description
3
241000725303
Human immunodeficiency virus
Species
0.000
description
3
102000004889
Interleukin-6
Human genes
0.000
description
3
108090001005
Interleukin-6
Proteins
0.000
description
3
210000001503
Joints
Anatomy
0.000
description
3
210000001165
Lymph Nodes
Anatomy
0.000
description
3
210000003205
Muscles
Anatomy
0.000
description
3
210000000329
Myocytes, Smooth Muscle
Anatomy
0.000
description
3
102100007885
RBFOX3
Human genes
0.000
description
3
101710012983
RBFOX3
Proteins
0.000
description
3
102100007769
RIC8B
Human genes
0.000
description
3
101700025865
RIC8B
Proteins
0.000
description
3
240000004808
Saccharomyces cerevisiae
Species
0.000
description
3
101710026494
Saci_0459
Proteins
0.000
description
3
241000555745
Sciuridae
Species
0.000
description
3
102100000258
TAT
Human genes
0.000
description
3
210000003932
Urinary Bladder
Anatomy
0.000
description
3
102100015249
VEGFA
Human genes
0.000
description
3
108010073929
Vascular Endothelial Growth Factor A
Proteins
0.000
description
3
229920002533
WHP Posttrascriptional Response Element
Polymers
0.000
description
3
230000002159
abnormal effect
Effects
0.000
description
3
230000003213
activating
Effects
0.000
description
3
230000001058
adult
Effects
0.000
description
3
238000000137
annealing
Methods
0.000
description
3
230000000692
anti-sense
Effects
0.000
description
3
230000001580
bacterial
Effects
0.000
description
3
108010006025
bovine growth hormone
Proteins
0.000
description
3
UIIMBOGNXHQVGW-UHFFFAOYSA-M
buffer
Substances
[Na+].OC([O-])=O
UIIMBOGNXHQVGW-UHFFFAOYSA-M
0.000
description
3
201000009030
carcinoma
Diseases
0.000
description
3
108020001778
catalytic domains
Proteins
0.000
description
3
230000001684
chronic
Effects
0.000
description
3
230000001276
controlling effect
Effects
0.000
description
3
230000003412
degenerative
Effects
0.000
description
3
238000002296
dynamic light scattering
Methods
0.000
description
3
235000013601
eggs
Nutrition
0.000
description
3
230000012202
endocytosis
Effects
0.000
description
3
238000001125
extrusion
Methods
0.000
description
3
239000012530
fluid
Substances
0.000
description
3
125000000524
functional group
Chemical group
0.000
description
3
238000003209
gene knockout
Methods
0.000
description
3
231100000283
hepatitis
Toxicity
0.000
description
3
238000009396
hybridization
Methods
0.000
description
3
239000007943
implant
Substances
0.000
description
3
239000003112
inhibitor
Substances
0.000
description
3
238000001638
lipofection
Methods
0.000
description
3
231100000053
low toxicity
Toxicity
0.000
description
3
230000011987
methylation
Effects
0.000
description
3
238000007069
methylation reaction
Methods
0.000
description
3
239000000693
micelle
Substances
0.000
description
3
238000010172
mouse model
Methods
0.000
description
3
238000002703
mutagenesis
Methods
0.000
description
3
239000003921
oil
Substances
0.000
description
3
235000019198
oils
Nutrition
0.000
description
3
239000000546
pharmaceutic aid
Substances
0.000
description
3
WTJKGGKOPKCXLL-RRHRGVEJSA-N
phosphatidylcholine
Chemical compound
CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC
WTJKGGKOPKCXLL-RRHRGVEJSA-N
0.000
description
3
108060002324
polC
Proteins
0.000
description
3
229920000307
polymer substrate
Polymers
0.000
description
3
230000001124
posttranscriptional
Effects
0.000
description
3
125000002924
primary amino group
Chemical group
[H]N([H])*
0.000
description
3
210000001236
prokaryotic cell
Anatomy
0.000
description
3
102000005912
ran GTP-Binding Protein
Human genes
0.000
description
3
102000005962
receptors
Human genes
0.000
description
3
108020003175
receptors
Proteins
0.000
description
3
230000001718
repressive
Effects
0.000
description
3
230000004044
response
Effects
0.000
description
3
108091000053
retinol binding proteins
Proteins
0.000
description
3
102000030003
retinol binding proteins
Human genes
0.000
description
3
239000000523
sample
Substances
0.000
description
3
239000007787
solid
Substances
0.000
description
3
230000002269
spontaneous
Effects
0.000
description
3
230000000638
stimulation
Effects
0.000
description
3
239000006228
supernatant
Substances
0.000
description
3
238000002054
transplantation
Methods
0.000
description
3
238000002604
ultrasonography
Methods
0.000
description
3
230000002792
vascular
Effects
0.000
description
3
XLYOFNOQVPJJNP-UHFFFAOYSA-N
water
Substances
O
XLYOFNOQVPJJNP-UHFFFAOYSA-N
0.000
description
3
238000010146
3D printing
Methods
0.000
description
2
101710032100
ABCC10
Proteins
0.000
description
2
101710018486
AGAP007347
Proteins
0.000
description
2
101710027066
ALB
Proteins
0.000
description
2
102100001249
ALB
Human genes
0.000
description
2
102100011247
ANGPTL3
Human genes
0.000
description
2
101710043744
ANGPTL3
Proteins
0.000
description
2
102100007787
APOA1
Human genes
0.000
description
2
101700077954
APOA1
Proteins
0.000
description
2
101700053893
ATAT1
Proteins
0.000
description
2
102100019961
ATP7B
Human genes
0.000
description
2
101700032974
ATP7B
Proteins
0.000
description
2
102100006784
AXIN1
Human genes
0.000
description
2
101700062862
AXIN1
Proteins
0.000
description
2
210000000683
Abdominal Cavity
Anatomy
0.000
description
2
240000000800
Allium ursinum
Species
0.000
description
2
208000003808
Amyloid Neuropathy
Diseases
0.000
description
2
229940064005
Antibiotic throat preparations
Drugs
0.000
description
2
229940083879
Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Drugs
0.000
description
2
229940042052
Antibiotics for systemic use
Drugs
0.000
description
2
229940042786
Antitubercular Antibiotics
Drugs
0.000
description
2
206010003816
Autoimmune disease
Diseases
0.000
description
2
208000006112
Autosomal Recessive Hypercholesterolemia
Diseases
0.000
description
2
208000002814
Autosomal Recessive Polycystic Kidney
Diseases
0.000
description
2
108060001074
CACNA1S
Proteins
0.000
description
2
102100006400
CSF2
Human genes
0.000
description
2
102100009641
CXCL10
Human genes
0.000
description
2
101710032181
CXCL10
Proteins
0.000
description
2
210000000234
Capsid
Anatomy
0.000
description
2
210000000170
Cell Membrane
Anatomy
0.000
description
2
210000000349
Chromosomes
Anatomy
0.000
description
2
206010057668
Cognitive disease
Diseases
0.000
description
2
208000003322
Coinfection
Diseases
0.000
description
2
210000001072
Colon
Anatomy
0.000
description
2
229920002676
Complementary DNA
Polymers
0.000
description
2
KCYOZNARADAZIZ-PPBBKLJYSA-N
Cryptochrome
Natural products
O[C@@H]1CC(C)(C)C=2[C@@](C)(O[C@H](/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(\C)/[C@H]3O[C@@]4(C)C(C(C)(C)CCC4)=C3)/C)\C)/C)C=2)C1
KCYOZNARADAZIZ-PPBBKLJYSA-N
0.000
description
2
241000195493
Cryptophyta
Species
0.000
description
2
241000701022
Cytomegalovirus
Species
0.000
description
2
210000000805
Cytoplasm
Anatomy
0.000
description
2
230000004568
DNA-binding
Effects
0.000
description
2
210000001198
Duodenum
Anatomy
0.000
description
2
210000001671
Embryonic Stem Cells
Anatomy
0.000
description
2
241000713730
Equine infectious anemia virus
Species
0.000
description
2
241000588724
Escherichia coli
Species
0.000
description
2
102100009906
F7
Human genes
0.000
description
2
102100014538
FGA
Human genes
0.000
description
2
101710002408
FGA
Proteins
0.000
description
2
108010023321
Factor VII
Proteins
0.000
description
2
208000009760
Familial Amyloid Neuropathy
Diseases
0.000
description
2
241000611205
Fusarium oxysporum f. sp. lycopersici
Species
0.000
description
2
102100001511
G6PC
Human genes
0.000
description
2
102100011521
GBE1
Human genes
0.000
description
2
101710042188
GBE1
Proteins
0.000
description
2
229920002024
GDNA
Polymers
0.000
description
2
102100000375
GSN
Human genes
0.000
description
2
101710038984
GSN
Proteins
0.000
description
2
101700000288
GYS2
Proteins
0.000
description
2
102100013493
GYS2
Human genes
0.000
description
2
229940096919
Glycogen
Drugs
0.000
description
2
229920002527
Glycogen
Polymers
0.000
description
2
BYSGBSNPRWKUQH-UJDJLXLFSA-N
Glycogen
Chemical compound
O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)O1
BYSGBSNPRWKUQH-UJDJLXLFSA-N
0.000
description
2
108010017213
Granulocyte-Macrophage Colony-Stimulating Factor
Proteins
0.000
description
2
229940093922
Gynecological Antibiotics
Drugs
0.000
description
2
102100010498
HMGCR
Human genes
0.000
description
2
102100017125
HPD
Human genes
0.000
description
2
101710011863
HPD
Proteins
0.000
description
2
206010019663
Hepatic failure
Diseases
0.000
description
2
102000019267
Hepatic lipase
Human genes
0.000
description
2
108050006747
Hepatic lipase
Proteins
0.000
description
2
206010019695
Hepatic neoplasm
Diseases
0.000
description
2
208000006359
Hepatoblastoma
Diseases
0.000
description
2
206010019889
Hereditary neuropathic amyloidosis
Diseases
0.000
description
2
241000713772
Human immunodeficiency virus 1
Species
0.000
description
2
210000003405
Ileum
Anatomy
0.000
description
2
208000002336
Juvenile gout
Diseases
0.000
description
2
102100005748
KRT18
Human genes
0.000
description
2
101710026202
KRT18
Proteins
0.000
description
2
102100013423
KRT8
Human genes
0.000
description
2
101710005531
KRT8
Proteins
0.000
description
2
208000001083
Kidney Disease
Diseases
0.000
description
2
102100005969
LAMP2
Human genes
0.000
description
2
108010001831
LDL receptors
Proteins
0.000
description
2
102100012475
LDLR
Human genes
0.000
description
2
102100003515
LYZ
Human genes
0.000
description
2
101710010796
LYZ
Proteins
0.000
description
2
239000012097
Lipofectamine 2000
Substances
0.000
description
2
102000004895
Lipoproteins
Human genes
0.000
description
2
108090001030
Lipoproteins
Proteins
0.000
description
2
208000007903
Liver Failure
Diseases
0.000
description
2
210000004698
Lymphocytes
Anatomy
0.000
description
2
108010009491
Lysosomal-Associated Membrane Protein 2
Proteins
0.000
description
2
101700033811
MCH5
Proteins
0.000
description
2
101700010881
MES2
Proteins
0.000
description
2
101710005245
MRPL2
Proteins
0.000
description
2
101700048052
MUC15
Proteins
0.000
description
2
208000003331
Medullary Cystic Kidney Disease 2
Diseases
0.000
description
2
206010061284
Mental disease
Diseases
0.000
description
2
208000008466
Metabolic Disease
Diseases
0.000
description
2
206010027476
Metastasis
Diseases
0.000
description
2
210000001616
Monocytes
Anatomy
0.000
description
2
210000004165
Myocardium
Anatomy
0.000
description
2
LKQLRGMMMAHREN-YJFXYUILSA-N
N-stearoylsphingosine-1-phosphocholine
Chemical compound
CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)[C@H](O)\C=C\CCCCCCCCCCCCC
LKQLRGMMMAHREN-YJFXYUILSA-N
0.000
description
2
101700038846
NTT1
Proteins
0.000
description
2
206010029149
Nephropathy
Diseases
0.000
description
2
206010029151
Nephropathy
Diseases
0.000
description
2
208000009025
Nervous System Disease
Diseases
0.000
description
2
206010053643
Neurodegenerative disease
Diseases
0.000
description
2
238000000636
Northern blotting
Methods
0.000
description
2
239000012124
Opti-MEM
Substances
0.000
description
2
241000283973
Oryctolagus cuniculus
Species
0.000
description
2
101700086769
PER53
Proteins
0.000
description
2
102100008046
PFKM
Human genes
0.000
description
2
101710036302
PFKM
Proteins
0.000
description
2
102100013251
PKD1
Human genes
0.000
description
2
101710025003
PRKD2
Proteins
0.000
description
2
102100001856
PYGL
Human genes
0.000
description
2
101700026216
PYGL
Proteins
0.000
description
2
206010061536
Parkinson's disease
Diseases
0.000
description
2
WRMNZCZEMHIOCP-UHFFFAOYSA-N
Phenethyl alcohol
Chemical compound
OCCC1=CC=CC=C1
WRMNZCZEMHIOCP-UHFFFAOYSA-N
0.000
description
2
229940067631
Phospholipids
Drugs
0.000
description
2
208000009901
Polycystic Kidney Disease
Diseases
0.000
description
2
206010048834
Polycystic liver disease
Diseases
0.000
description
2
229920002873
Polyethylenimine
Polymers
0.000
description
2
108050006987
Poxvirus
Proteins
0.000
description
2
241000288906
Primates
Species
0.000
description
2
210000002307
Prostate
Anatomy
0.000
description
2
101710013392
QDPR
Proteins
0.000
description
2
101710004288
RRM2
Proteins
0.000
description
2
102100012115
RRM2
Human genes
0.000
description
2
235000011449
Rosa
Nutrition
0.000
description
2
102100009943
SEC63
Human genes
0.000
description
2
101700031842
SEC63
Proteins
0.000
description
2
102100011516
SERPINA1
Human genes
0.000
description
2
101710009148
SERPINA1
Proteins
0.000
description
2
102100018852
SNAI1
Human genes
0.000
description
2
229920000972
Sense strand
Polymers
0.000
description
2
210000002832
Shoulder
Anatomy
0.000
description
2
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Sirolimus
Chemical compound
C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1
QFJCIRLUMZQUOT-HPLJOQBZSA-N
0.000
description
2
210000003491
Skin
Anatomy
0.000
description
2
229920001891
Small hairpin RNA
Polymers
0.000
description
2
229920002924
Spherical nucleic acid
Polymers
0.000
description
2
210000000278
Spinal Cord
Anatomy
0.000
description
2
210000000952
Spleen
Anatomy
0.000
description
2
210000002784
Stomach
Anatomy
0.000
description
2
210000001744
T-Lymphocytes
Anatomy
0.000
description
2
101700074842
TAT
Proteins
0.000
description
2
101700059107
TCF7
Proteins
0.000
description
2
WDLRUFUQRNWCPK-UHFFFAOYSA-N
Tetraxetan
Chemical compound
OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1
WDLRUFUQRNWCPK-UHFFFAOYSA-N
0.000
description
2
229940024982
Topical Antifungal Antibiotics
Drugs
0.000
description
2
102000004338
Transferrin
Human genes
0.000
description
2
108090000901
Transferrin
Proteins
0.000
description
2
102000004243
Tubulin
Human genes
0.000
description
2
108090000704
Tubulin
Proteins
0.000
description
2
208000009682
Type 3 Maturity-Onset Diabetes of the Young
Diseases
0.000
description
2
102100006030
UMOD
Human genes
0.000
description
2
101710010582
UMOD
Proteins
0.000
description
2
210000000857
Visual Cortex
Anatomy
0.000
description
2
ZKSPKDDUPMUGBG-KWXKLSQISA-N
[(9Z,12Z)-octadeca-9,12-dienyl] 3-(dimethylamino)-2-[(9Z,12Z)-octadeca-9,12-dienoxy]propanoate
Chemical compound
CCCCC\C=C/C\C=C/CCCCCCCCOC(CN(C)C)C(=O)OCCCCCCCC\C=C/C\C=C/CCCCC
ZKSPKDDUPMUGBG-KWXKLSQISA-N
0.000
description
2
230000001133
acceleration
Effects
0.000
description
2
WEVYAHXRMPXWCK-UHFFFAOYSA-N
acetonitrile
Chemical compound
CC#N
WEVYAHXRMPXWCK-UHFFFAOYSA-N
0.000
description
2
239000000654
additive
Substances
0.000
description
2
230000002776
aggregation
Effects
0.000
description
2
238000004220
aggregation
Methods
0.000
description
2
229940050528
albumin
Drugs
0.000
description
2
150000001298
alcohols
Chemical class
0.000
description
2
230000003321
amplification
Effects
0.000
description
2
238000010171
animal model
Methods
0.000
description
2
239000003242
anti bacterial agent
Substances
0.000
description
2
230000001796
anti-degenerative
Effects
0.000
description
2
230000000259
anti-tumor
Effects
0.000
description
2
239000012062
aqueous buffer
Substances
0.000
description
2
230000006399
behavior
Effects
0.000
description
2
230000003115
biocidal
Effects
0.000
description
2
239000002551
biofuel
Substances
0.000
description
2
238000002725
brachytherapy
Methods
0.000
description
2
125000003917
carbamoyl group
Chemical group
[H]N([H])C(*)=O
0.000
description
2
150000001720
carbohydrates
Chemical class
0.000
description
2
235000014633
carbohydrates
Nutrition
0.000
description
2
230000022131
cell cycle
Effects
0.000
description
2
230000004663
cell proliferation
Effects
0.000
description
2
238000004140
cleaning
Methods
0.000
description
2
239000002299
complementary DNA
Substances
0.000
description
2
238000002856
computational phylogenetic analysis
Methods
0.000
description
2
230000001143
conditioned
Effects
0.000
description
2
238000010276
construction
Methods
0.000
description
2
239000002872
contrast media
Substances
0.000
description
2
238000001816
cooling
Methods
0.000
description
2
230000001054
cortical
Effects
0.000
description
2
238000010192
crystallographic characterization
Methods
0.000
description
2
239000012228
culture supernatant
Substances
0.000
description
2
210000004748
cultured cells
Anatomy
0.000
description
2
230000002354
daily
Effects
0.000
description
2
238000002716
delivery method
Methods
0.000
description
2
238000010586
diagram
Methods
0.000
description
2
210000002249
digestive system
Anatomy
0.000
description
2
239000000975
dye
Substances
0.000
description
2
210000002257
embryonic structures
Anatomy
0.000
description
2
230000003511
endothelial
Effects
0.000
description
2
108091005938
enhanced green fluorescent protein
Proteins
0.000
description
2
230000002255
enzymatic
Effects
0.000
description
2
230000004049
epigenetic modification
Effects
0.000
description
2
230000003628
erosive
Effects
0.000
description
2
150000002148
esters
Chemical class
0.000
description
2
238000002474
experimental method
Methods
0.000
description
2
238000000605
extraction
Methods
0.000
description
2
229940012413
factor VII
Drugs
0.000
description
2
239000012091
fetal bovine serum
Substances
0.000
description
2
239000000945
filler
Substances
0.000
description
2
238000001914
filtration
Methods
0.000
description
2
108091004535
flt3 ligand protein
Proteins
0.000
description
2
102000034387
fluorescent proteins
Human genes
0.000
description
2
108091006031
fluorescent proteins
Proteins
0.000
description
2
101700083876
frvX
Proteins
0.000
description
2
101700076357
fusA-1
Proteins
0.000
description
2
230000000799
fusogenic
Effects
0.000
description
2
238000001476
gene delivery
Methods
0.000
description
2
235000011187
glycerol
Nutrition
0.000
description
2
LYCAIKOWRPUZTN-UHFFFAOYSA-N
glycol
Chemical compound
OCCO
LYCAIKOWRPUZTN-UHFFFAOYSA-N
0.000
description
2
229910052737
gold
Inorganic materials
0.000
description
2
239000010931
gold
Substances
0.000
description
2
230000036541
health
Effects
0.000
description
2
238000010438
heat treatment
Methods
0.000
description
2
230000000971
hippocampal
Effects
0.000
description
2
229920001477
hydrophilic polymer
Polymers
0.000
description
2
210000002865
immune cell
Anatomy
0.000
description
2
238000010166
immunofluorescence
Methods
0.000
description
2
238000003125
immunofluorescent labeling
Methods
0.000
description
2
239000004615
ingredient
Substances
0.000
description
2
229940079866
intestinal antibiotics
Drugs
0.000
description
2
230000003834
intracellular
Effects
0.000
description
2
238000010255
intramuscular injection
Methods
0.000
description
2
239000007927
intramuscular injection
Substances
0.000
description
2
238000002955
isolation
Methods
0.000
description
2
239000010410
layer
Substances
0.000
description
2
230000013016
learning
Effects
0.000
description
2
230000004301
light adaptation
Effects
0.000
description
2
125000005647
linker group
Chemical group
0.000
description
2
239000007788
liquid
Substances
0.000
description
2
231100000845
liver adenoma
Toxicity
0.000
description
2
201000004044
liver cirrhosis
Diseases
0.000
description
2
231100000835
liver failure
Toxicity
0.000
description
2
101700002074
lly
Proteins
0.000
description
2
101700009216
malA
Proteins
0.000
description
2
201000001250
maturity-onset diabetes of the young type 3
Diseases
0.000
description
2
OKKJLVBELUTLKV-UHFFFAOYSA-N
methanol
Chemical compound
OC
OKKJLVBELUTLKV-UHFFFAOYSA-N
0.000
description
2
229920001239
microRNA
Polymers
0.000
description
2
239000002679
microRNA
Substances
0.000
description
2
244000005700
microbiome
Species
0.000
description
2
239000011859
microparticle
Substances
0.000
description
2
239000004005
microsphere
Substances
0.000
description
2
238000002156
mixing
Methods
0.000
description
2
239000003471
mutagenic agent
Substances
0.000
description
2
101700057694
mvaA
Proteins
0.000
description
2
238000003199
nucleic acid amplification method
Methods
0.000
description
2
229940005935
ophthalmologic Antibiotics
Drugs
0.000
description
2
230000036961
partial
Effects
0.000
description
2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N
phenol
Chemical compound
OC1=CC=CC=C1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N
0.000
description
2
201000011252
phenylketonuria
Diseases
0.000
description
2
239000000902
placebo
Substances
0.000
description
2
229940068196
placebo
Drugs
0.000
description
2
229920000768
polyamine
Polymers
0.000
description
2
108010059054
polycystic kidney disease 1 protein
Proteins
0.000
description
2
OZAIFHULBGXAKX-UHFFFAOYSA-N
precursor
Substances
N#CC(C)(C)N=NC(C)(C)C#N
OZAIFHULBGXAKX-UHFFFAOYSA-N
0.000
description
2
ATUOYWHBWRKTHZ-UHFFFAOYSA-N
propane
Chemical compound
CCC
ATUOYWHBWRKTHZ-UHFFFAOYSA-N
0.000
description
2
239000001294
propane
Substances
0.000
description
2
230000002633
protecting
Effects
0.000
description
2
201000004681
psoriasis
Diseases
0.000
description
2
108010059128
rabies virus glycoprotein peptide
Proteins
0.000
description
2
238000005215
recombination
Methods
0.000
description
2
230000008929
regeneration
Effects
0.000
description
2
238000011069
regeneration method
Methods
0.000
description
2
230000002207
retinal
Effects
0.000
description
2
230000001177
retroviral
Effects
0.000
description
2
239000010979
ruby
Substances
0.000
description
2
229910001750
ruby
Inorganic materials
0.000
description
2
125000000467
secondary amino group
Chemical group
[H]N([*:1])[*:2]
0.000
description
2
230000028327
secretion
Effects
0.000
description
2
231100000486
side effect
Toxicity
0.000
description
2
239000002356
single layer
Substances
0.000
description
2
VMHLLURERBWHNL-UHFFFAOYSA-M
sodium acetate
Chemical compound
[Na+].CC([O-])=O
VMHLLURERBWHNL-UHFFFAOYSA-M
0.000
description
2
239000001632
sodium acetate
Substances
0.000
description
2
235000017281
sodium acetate
Nutrition
0.000
description
2
238000001228
spectrum
Methods
0.000
description
2
238000007920
subcutaneous administration
Methods
0.000
description
2
QAOWNCQODCNURD-UHFFFAOYSA-L
sulfate
Chemical compound
[O-]S([O-])(=O)=O
QAOWNCQODCNURD-UHFFFAOYSA-L
0.000
description
2
RAHZWNYVWXNFOC-UHFFFAOYSA-N
sulphur dioxide
Chemical compound
O=S=O
RAHZWNYVWXNFOC-UHFFFAOYSA-N
0.000
description
2
230000020382
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I
Effects
0.000
description
2
239000004094
surface-active agent
Substances
0.000
description
2
239000000375
suspending agent
Substances
0.000
description
2
230000002459
sustained
Effects
0.000
description
2
150000003512
tertiary amines
Chemical class
0.000
description
2
101710036157
tfg3
Proteins
0.000
description
2
108091006090
transcriptional activators
Proteins
0.000
description
2
230000002463
transducing
Effects
0.000
description
2
230000001131
transforming
Effects
0.000
description
2
201000007905
transthyretin amyloidosis
Diseases
0.000
description
2
210000004881
tumor cells
Anatomy
0.000
description
2
201000011296
tyrosinemia
Diseases
0.000
description
2
241000712461
unidentified influenza virus
Species
0.000
description
2
201000011528
vascular disease
Diseases
0.000
description
2
230000003313
weakening
Effects
0.000
description
2
108091005946
yellow fluorescent protein
Proteins
0.000
description
2
MWRBNPKJOOWZPW-NYVOMTAGSA-N
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine zwitterion
Chemical compound
CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
MWRBNPKJOOWZPW-NYVOMTAGSA-N
0.000
description
1
AWWLEBBAQLFDFA-UHFFFAOYSA-N
1,4-bis(ethenyl)benzene;3-phenylpropanoic acid;styrene
Chemical compound
C=CC1=CC=CC=C1.C=CC1=CC=C(C=C)C=C1.OC(=O)CCC1=CC=CC=C1
AWWLEBBAQLFDFA-UHFFFAOYSA-N
0.000
description
1
LRFJOIPOPUJUMI-KWXKLSQISA-N
2-[2,2-bis[(9Z,12Z)-octadeca-9,12-dienyl]-1,3-dioxolan-4-yl]-N,N-dimethylethanamine
Chemical compound
CCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1
LRFJOIPOPUJUMI-KWXKLSQISA-N
0.000
description
1
WXNZTHHGJRFXKQ-UHFFFAOYSA-N
4-chlorophenol
Chemical compound
OC1=CC=C(Cl)C=C1
WXNZTHHGJRFXKQ-UHFFFAOYSA-N
0.000
description
1
101700075687
ACR
Proteins
0.000
description
1
102100018024
ANG
Human genes
0.000
description
1
206010000117
Abnormal behaviour
Diseases
0.000
description
1
229940022659
Acetaminophen
Drugs
0.000
description
1
229920001817
Agar
Polymers
0.000
description
1
206010064930
Age-related macular degeneration
Diseases
0.000
description
1
229920002287
Amplicon
Polymers
0.000
description
1
210000004727
Amygdala
Anatomy
0.000
description
1
102000013455
Amyloid beta-Peptides
Human genes
0.000
description
1
108010090849
Amyloid beta-Peptides
Proteins
0.000
description
1
108009000433
Amyotrophic lateral sclerosis (ALS)
Proteins
0.000
description
1
208000007502
Anemia
Diseases
0.000
description
1
102400000068
Angiostatin
Human genes
0.000
description
1
108010079709
Angiostatins
Proteins
0.000
description
1
108020004491
Antisense DNA
Proteins
0.000
description
1
108020000948
Antisense Oligonucleotides
Proteins
0.000
description
1
108020005544
Antisense RNA
Proteins
0.000
description
1
206010059512
Apoptosis
Diseases
0.000
description
1
239000004475
Arginine
Substances
0.000
description
1
206010003210
Arteriosclerosis
Diseases
0.000
description
1
241000238421
Arthropoda
Species
0.000
description
1
210000003926
Auditory Cortex
Anatomy
0.000
description
1
210000003719
B-Lymphocytes
Anatomy
0.000
description
1
101700004551
BRAF
Proteins
0.000
description
1
102100004328
BRAF
Human genes
0.000
description
1
APKFDSVGJQXUKY-INPOYWNPSA-N
BRL-49594
Chemical compound
O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1
APKFDSVGJQXUKY-INPOYWNPSA-N
0.000
description
1
208000008035
Back Pain
Diseases
0.000
description
1
210000004227
Basal Ganglia
Anatomy
0.000
description
1
210000003445
Biliary Tract
Anatomy
0.000
description
1
230000036912
Bioavailability
Effects
0.000
description
1
230000037177
Biodistribution
Effects
0.000
description
1
206010004938
Bipolar disease
Diseases
0.000
description
1
210000001124
Body Fluids
Anatomy
0.000
description
1
208000010392
Bone Fractures
Diseases
0.000
description
1
210000001185
Bone Marrow
Anatomy
0.000
description
1
240000002791
Brassica napus
Species
0.000
description
1
235000004977
Brassica sinapistrum
Nutrition
0.000
description
1
210000000481
Breast
Anatomy
0.000
description
1
210000004900
C-terminal fragment
Anatomy
0.000
description
1
108060001251
CD34
Proteins
0.000
description
1
102100016492
CD34
Human genes
0.000
description
1
102220446974
COMP P2A
Human genes
0.000
description
1
238000010455
CRISPR delivery
Methods
0.000
description
1
102100014050
CUL3
Human genes
0.000
description
1
101700002039
CUL3
Proteins
0.000
description
1
102000004657
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Human genes
0.000
description
1
108010003721
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Proteins
0.000
description
1
241000283707
Capra
Species
0.000
description
1
BVKZGUZCCUSVTD-UHFFFAOYSA-L
Carbonate dianion
Chemical compound
[O-]C([O-])=O
BVKZGUZCCUSVTD-UHFFFAOYSA-L
0.000
description
1
206010007509
Cardiac amyloidosis
Diseases
0.000
description
1
208000008787
Cardiovascular Disease
Diseases
0.000
description
1
108090000994
Catalytic RNA
Proteins
0.000
description
1
210000001638
Cerebellum
Anatomy
0.000
description
1
210000003679
Cervix Uteri
Anatomy
0.000
description
1
229960004926
Chlorobutanol
Drugs
0.000
description
1
OSASVXMJTNOKOY-UHFFFAOYSA-N
Chlorobutanol
Chemical compound
CC(C)(O)C(Cl)(Cl)Cl
OSASVXMJTNOKOY-UHFFFAOYSA-N
0.000
description
1
208000000094
Chronic Pain
Diseases
0.000
description
1
210000003952
Cochlear Nucleus
Anatomy
0.000
description
1
108020004635
Complementary DNA
Proteins
0.000
description
1
229920001972
Concatemer
Polymers
0.000
description
1
206010010356
Congenital anomaly
Diseases
0.000
description
1
210000004351
Coronary Vessels
Anatomy
0.000
description
1
102000011756
Cryptochromes
Human genes
0.000
description
1
108010037139
Cryptochromes
Proteins
0.000
description
1
102000004127
Cytokines
Human genes
0.000
description
1
108090000695
Cytokines
Proteins
0.000
description
1
WQZGKKKJIJFFOK-GASJEMHNSA-N
D-Glucose
Natural products
OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O
WQZGKKKJIJFFOK-GASJEMHNSA-N
0.000
description
1
125000000052
D-arginine group
Chemical group
[H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])N([H])C(N([H])[H])=N[H]
0.000
description
1
CZMRCDWAGMRECN-UGDNZRGBSA-N
D-sucrose
Chemical compound
O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1
CZMRCDWAGMRECN-UGDNZRGBSA-N
0.000
description
1
XCLDDDHMRBWEKC-UHFFFAOYSA-N
DAPI staining
Chemical compound
C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)[CH]C2=N1
XCLDDDHMRBWEKC-UHFFFAOYSA-N
0.000
description
1
238000000116
DAPI staining
Methods
0.000
description
1
102100000789
DES
Human genes
0.000
description
1
230000007067
DNA methylation
Effects
0.000
description
1
230000033616
DNA repair
Effects
0.000
description
1
206010011878
Deafness
Diseases
0.000
description
1
210000004207
Dermis
Anatomy
0.000
description
1
108010044052
Desmin
Proteins
0.000
description
1
UREBDLICKHMUKA-CXSFZGCWSA-N
Dexamethasone
Chemical compound
C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O
UREBDLICKHMUKA-CXSFZGCWSA-N
0.000
description
1
229960003957
Dexamethasone
Drugs
0.000
description
1
229920002307
Dextran
Polymers
0.000
description
1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N
Diphenhydramine
Chemical compound
C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1
ZZVUWRFHKOJYTH-UHFFFAOYSA-N
0.000
description
1
210000001956
EPC
Anatomy
0.000
description
1
102000033180
ERVK-6
Human genes
0.000
description
1
101710038044
ERVK-6
Proteins
0.000
description
1
101710024909
ERVPABLB-1
Proteins
0.000
description
1
102100001414
ERVPABLB-1
Human genes
0.000
description
1
101710027967
ERVW-1
Proteins
0.000
description
1
239000001692
EU approved anti-caking agent
Substances
0.000
description
1
108010079505
Endostatins
Proteins
0.000
description
1
210000002889
Endothelial Cells
Anatomy
0.000
description
1
241000283086
Equidae
Species
0.000
description
1
102000003951
Erythropoietin
Human genes
0.000
description
1
108090000394
Erythropoietin
Proteins
0.000
description
1
CBOQJANXLMLOSS-UHFFFAOYSA-N
Ethylvanillin
Chemical compound
CCOC1=CC(C=O)=CC=C1O
CBOQJANXLMLOSS-UHFFFAOYSA-N
0.000
description
1
208000009745
Eye Disease
Diseases
0.000
description
1
102100008658
FN1
Human genes
0.000
description
1
102000008857
Ferritin
Human genes
0.000
description
1
108050000784
Ferritin
Proteins
0.000
description
1
238000008416
Ferritin
Methods
0.000
description
1
108010067306
Fibronectins
Proteins
0.000
description
1
206010016654
Fibrosis
Diseases
0.000
description
1
108090000217
Frataxin
Proteins
0.000
description
1
102000003869
Frataxin
Human genes
0.000
description
1
206010017533
Fungal infection
Diseases
0.000
description
1
241000233866
Fungi
Species
0.000
description
1
241000223221
Fusarium oxysporum
Species
0.000
description
1
210000001222
GABA-ergic neuron
Anatomy
0.000
description
1
101700047102
GAD1
Proteins
0.000
description
1
102100010054
GAD1
Human genes
0.000
description
1
101710009965
GAD2
Proteins
0.000
description
1
102100015189
GAD2
Human genes
0.000
description
1
101710008404
GAPDH
Proteins
0.000
description
1
102100006425
GAPDH
Human genes
0.000
description
1
101700014779
GLB1
Proteins
0.000
description
1
108010010803
Gelatin
Proteins
0.000
description
1
108060003199
Glucagon
Proteins
0.000
description
1
229960004666
Glucagon
Drugs
0.000
description
1
MASNOZXLGMXCHN-ZLPAWPGGSA-N
Glucagonum
Chemical compound
C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1
MASNOZXLGMXCHN-ZLPAWPGGSA-N
0.000
description
1
229960002743
Glutamine
Drugs
0.000
description
1
VEXZGXHMUGYJMC-UHFFFAOYSA-N
HCl
Chemical compound
Cl
VEXZGXHMUGYJMC-UHFFFAOYSA-N
0.000
description
1
WZUVPPKBWHMQCE-VYIIXAMBSA-N
Haematoxylin
Chemical compound
C12=CC(O)=C(O)C=C2C[C@@]2(O)C1C1=CC=C(O)C(O)=C1OC2
WZUVPPKBWHMQCE-VYIIXAMBSA-N
0.000
description
1
229920001941
Hammerhead ribozyme
Polymers
0.000
description
1
208000004559
Hearing Loss
Diseases
0.000
description
1
206010011879
Hearing loss
Diseases
0.000
description
1
229960002897
Heparin
Drugs
0.000
description
1
ZFGMDIBRIDKWMY-PASTXAENSA-N
Heparin
Chemical compound
CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O
ZFGMDIBRIDKWMY-PASTXAENSA-N
0.000
description
1
206010019851
Hepatotoxicity
Diseases
0.000
description
1
208000009889
Herpes Simplex
Diseases
0.000
description
1
229920001681
Heteroduplex
Polymers
0.000
description
1
108010033040
Histones
Proteins
0.000
description
1
102000006947
Histones
Human genes
0.000
description
1
208000006572
Human Influenza
Diseases
0.000
description
1
201000001971
Huntington's disease
Diseases
0.000
description
1
210000003016
Hypothalamus
Anatomy
0.000
description
1
101700035976
ICAM2
Proteins
0.000
description
1
101700046422
IFNA
Proteins
0.000
description
1
101700011451
IFNB1
Proteins
0.000
description
1
102100015720
IFNB1
Human genes
0.000
description
1
210000000987
Immune System
Anatomy
0.000
description
1
210000004969
Inflammatory Cells
Anatomy
0.000
description
1
206010022004
Influenza like illness
Diseases
0.000
description
1
RCINICONZNJXQF-MZXODVADSA-N
Intaxel
Chemical compound
O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1
RCINICONZNJXQF-MZXODVADSA-N
0.000
description
1
241001527806
Iti
Species
0.000
description
1
210000003127
Knee
Anatomy
0.000
description
1
125000000010
L-asparaginyl group
Chemical group
O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H]
0.000
description
1
ZDXPYRJPNDTMRX-VKHMYHEASA-N
L-glutamine
Chemical compound
OC(=O)[C@@H](N)CCC(N)=O
ZDXPYRJPNDTMRX-VKHMYHEASA-N
0.000
description
1
KDXKERNSBIXSRK-YFKPBYRVSA-N
L-lysine
Chemical compound
NCCCC[C@H](N)C(O)=O
KDXKERNSBIXSRK-YFKPBYRVSA-N
0.000
description
1
238000008214
LDL Cholesterol
Methods
0.000
description
1
102000000909
LEM domain
Human genes
0.000
description
1
108050007943
LEM domain
Proteins
0.000
description
1
GUBGYTABKSRVRQ-UUNJERMWSA-N
Lactose
Natural products
O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1
GUBGYTABKSRVRQ-UUNJERMWSA-N
0.000
description
1
229920000126
Latex
Polymers
0.000
description
1
208000008456
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Diseases
0.000
description
1
210000000265
Leukocytes
Anatomy
0.000
description
1
239000000232
Lipid Bilayer
Substances
0.000
description
1
210000000210
Loop of Henle
Anatomy
0.000
description
1
244000276497
Lycopersicon esculentum
Species
0.000
description
1
235000007688
Lycopersicon esculentum
Nutrition
0.000
description
1
239000004472
Lysine
Substances
0.000
description
1
101700064880
MBD2
Proteins
0.000
description
1
102100008691
MBD2
Human genes
0.000
description
1
102100008740
MED12
Human genes
0.000
description
1
101700000875
MED12
Proteins
0.000
description
1
102100002229
MYO1G
Human genes
0.000
description
1
101700002128
MYO1G
Proteins
0.000
description
1
210000002540
Macrophages
Anatomy
0.000
description
1
208000002780
Macular Degeneration
Diseases
0.000
description
1
206010025650
Malignant melanoma
Diseases
0.000
description
1
210000002264
Mammary Glands, Animal
Anatomy
0.000
description
1
210000004293
Mammary Glands, Human
Anatomy
0.000
description
1
210000000138
Mast Cells
Anatomy
0.000
description
1
210000001595
Mastoid
Anatomy
0.000
description
1
238000007476
Maximum Likelihood
Methods
0.000
description
1
102000018697
Membrane Proteins
Human genes
0.000
description
1
108010052285
Membrane Proteins
Proteins
0.000
description
1
230000036740
Metabolism
Effects
0.000
description
1
206010027480
Metastatic malignant melanoma
Diseases
0.000
description
1
INQOMBQAUSQDDS-UHFFFAOYSA-N
Methyl iodide
Chemical compound
IC
INQOMBQAUSQDDS-UHFFFAOYSA-N
0.000
description
1
229920000168
Microcrystalline cellulose
Polymers
0.000
description
1
210000000274
Microglia
Anatomy
0.000
description
1
210000000110
Microvilli
Anatomy
0.000
description
1
241000699660
Mus musculus
Species
0.000
description
1
210000002027
Muscle, Skeletal
Anatomy
0.000
description
1
210000002460
Muscle, Smooth
Anatomy
0.000
description
1
210000003699
Muscle, Striated
Anatomy
0.000
description
1
NFQBIAXADRDUGK-KWXKLSQISA-N
N,N-dimethyl-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine
Chemical class
CCCCC\C=C/C\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/C\C=C/CCCCC
NFQBIAXADRDUGK-KWXKLSQISA-N
0.000
description
1
210000004898
N-terminal fragment
Anatomy
0.000
description
1
102100018369
NF1
Human genes
0.000
description
1
102100010499
NF2
Human genes
0.000
description
1
101700071070
NF2
Proteins
0.000
description
1
241000244206
Nematoda
Species
0.000
description
1
210000001577
Neostriatum
Anatomy
0.000
description
1
206010029113
Neovascularisation
Diseases
0.000
description
1
210000000944
Nerve Tissue
Anatomy
0.000
description
1
108010085793
Neurofibromin 1
Proteins
0.000
description
1
206010029333
Neurosis
Diseases
0.000
description
1
210000002445
Nipples
Anatomy
0.000
description
1
210000001331
Nose
Anatomy
0.000
description
1
210000000956
Olfactory Bulb
Anatomy
0.000
description
1
210000004248
Oligodendroglia
Anatomy
0.000
description
1
210000003463
Organelles
Anatomy
0.000
description
1
206010031252
Osteomyelitis
Diseases
0.000
description
1
206010033128
Ovarian cancer
Diseases
0.000
description
1
241000283898
Ovis
Species
0.000
description
1
101700044345
PDE7A
Proteins
0.000
description
1
101710041867
PHGDH
Proteins
0.000
description
1
102100016617
PHGDH
Human genes
0.000
description
1
102100019197
PPP1R12C
Human genes
0.000
description
1
101710002259
PPP1R12C
Proteins
0.000
description
1
102100005499
PTPRC
Human genes
0.000
description
1
101700059076
PTPRC
Proteins
0.000
description
1
239000002033
PVDF binder
Substances
0.000
description
1
229960001592
Paclitaxel
Drugs
0.000
description
1
208000002193
Pain
Diseases
0.000
description
1
208000009608
Papillomavirus Infections
Diseases
0.000
description
1
206010034636
Peripheral vascular disease
Diseases
0.000
description
1
229940067107
Phenylethyl Alcohol
Drugs
0.000
description
1
NMHMNPHRMNGLLB-UHFFFAOYSA-N
Phloretic acid
Chemical compound
OC(=O)CCC1=CC=C(O)C=C1
NMHMNPHRMNGLLB-UHFFFAOYSA-N
0.000
description
1
210000000557
Podocytes
Anatomy
0.000
description
1
229920000795
Polyadenylation
Polymers
0.000
description
1
229940068968
Polysorbate 80
Drugs
0.000
description
1
229940069338
Potassium Sorbate
Drugs
0.000
description
1
CHHHXKFHOYLYRE-STWYSWDKSA-M
Potassium sorbate
Chemical compound
[K+].C\C=C\C=C\C([O-])=O
CHHHXKFHOYLYRE-STWYSWDKSA-M
0.000
description
1
210000002442
Prefrontal Cortex
Anatomy
0.000
description
1
210000000976
Primary motor cortex
Anatomy
0.000
description
1
208000003991
Primitive Neuroectodermal Tumors
Diseases
0.000
description
1
229940075579
Propyl Gallate
Drugs
0.000
description
1
ZJFJVRPLNAMIKH-UHFFFAOYSA-N
Pseudo-U
Chemical compound
O=C1NC(=O)C(C)=CN1C1OC(COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)CO)C(O)C1
ZJFJVRPLNAMIKH-UHFFFAOYSA-N
0.000
description
1
206010061920
Psychotic disease
Diseases
0.000
description
1
241000567197
Puccinia graminis f. sp. tritici
Species
0.000
description
1
VMXUWOKSQNHOCA-LCYFTJDESA-N
Ranitidine
Chemical compound
[O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1
VMXUWOKSQNHOCA-LCYFTJDESA-N
0.000
description
1
229960000620
Ranitidine
Drugs
0.000
description
1
108010055016
Rec A Recombinases
Proteins
0.000
description
1
102000001218
Rec A Recombinases
Human genes
0.000
description
1
108010091086
Recombinases
Proteins
0.000
description
1
102000018120
Recombinases
Human genes
0.000
description
1
208000006265
Renal Cell Carcinoma
Diseases
0.000
description
1
229920000970
Repeated sequence (DNA)
Polymers
0.000
description
1
210000001525
Retina
Anatomy
0.000
description
1
101710042981
SHMT1
Proteins
0.000
description
1
102100015194
SLC32A1
Human genes
0.000
description
1
101700063463
SRB8
Proteins
0.000
description
1
102100015380
STRA6
Human genes
0.000
description
1
101700045430
STRA6
Proteins
0.000
description
1
101700083425
SUN2
Proteins
0.000
description
1
210000003079
Salivary Glands
Anatomy
0.000
description
1
101710023234
Segment 5
Proteins
0.000
description
1
230000037165
Serum Concentration
Effects
0.000
description
1
241000700584
Simplexvirus
Species
0.000
description
1
RYMZZMVNJRMUDD-HGQWONQESA-N
Simvastatin
Chemical compound
C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1
RYMZZMVNJRMUDD-HGQWONQESA-N
0.000
description
1
210000002356
Skeleton
Anatomy
0.000
description
1
208000006641
Skin Disease
Diseases
0.000
description
1
108020004459
Small Interfering RNA
Proteins
0.000
description
1
210000004092
Somatosensory Cortex
Anatomy
0.000
description
1
229940075582
Sorbic Acid
Drugs
0.000
description
1
241000193998
Streptococcus pneumoniae
Species
0.000
description
1
229940031000
Streptococcus pneumoniae
Drugs
0.000
description
1
241000320123
Streptococcus pyogenes M1 GAS
Species
0.000
description
1
241001633172
Streptococcus thermophilus LMD-9
Species
0.000
description
1
CZMRCDWAGMRECN-GDQSFJPYSA-N
Sucrose
Natural products
O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1
CZMRCDWAGMRECN-GDQSFJPYSA-N
0.000
description
1
241000282887
Suidae
Species
0.000
description
1
229940044609
Sulfur Dioxide
Drugs
0.000
description
1
108060008041
TADA1
Proteins
0.000
description
1
102100007721
TADA1
Human genes
0.000
description
1
101710024792
TADA2B
Proteins
0.000
description
1
102100017402
TADA2B
Human genes
0.000
description
1
102000025182
TET family
Human genes
0.000
description
1
108091020812
TET family
Proteins
0.000
description
1
101700085225
TET3
Proteins
0.000
description
1
101700015106
TREX2
Proteins
0.000
description
1
229960002180
Tetracycline
Drugs
0.000
description
1
OFVLGDICTFRJMM-WESIUVDSSA-N
Tetracycline
Chemical compound
C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O
OFVLGDICTFRJMM-WESIUVDSSA-N
0.000
description
1
239000004098
Tetracycline
Substances
0.000
description
1
210000001103
Thalamus
Anatomy
0.000
description
1
229920000401
Three prime untranslated region
Polymers
0.000
description
1
108010041111
Thrombopoietin
Proteins
0.000
description
1
102000036902
Thrombopoietin
Human genes
0.000
description
1
210000000515
Tooth
Anatomy
0.000
description
1
229920001949
Transfer RNA
Polymers
0.000
description
1
108020004566
Transfer RNA
Proteins
0.000
description
1
PBKWZFANFUTEPS-CWUSWOHSSA-N
Transportan
Chemical compound
C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1
PBKWZFANFUTEPS-CWUSWOHSSA-N
0.000
description
1
108010020764
Transposases
Proteins
0.000
description
1
102000008579
Transposases
Human genes
0.000
description
1
QORWJWZARLRLPR-UHFFFAOYSA-H
Tricalcium phosphate
Chemical compound
[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O
QORWJWZARLRLPR-UHFFFAOYSA-H
0.000
description
1
240000008529
Triticum aestivum
Species
0.000
description
1
102000000852
Tumor Necrosis Factor-alpha
Human genes
0.000
description
1
108010001801
Tumor Necrosis Factor-alpha
Proteins
0.000
description
1
229940029983
VITAMINS
Drugs
0.000
description
1
241000700618
Vaccinia virus
Species
0.000
description
1
210000003462
Veins
Anatomy
0.000
description
1
229940021016
Vitamin IV solution additives
Drugs
0.000
description
1
102100009956
XRCC5
Human genes
0.000
description
1
101700029350
XRCC5
Proteins
0.000
description
1
102100009954
XRCC6
Human genes
0.000
description
1
101700032709
XRCC6
Proteins
0.000
description
1
AVTXVDFKYBVTKR-FXSLSZKUSA-N
[(3S,8S,10R,13R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] dihydrogen phosphate
Chemical compound
C1C=C2C[C@@H](OP(O)(O)=O)CC[C@]2(C)C2[C@@H]1C1CCC([C@H](C)CCCC(C)C)[C@@]1(C)CC2
AVTXVDFKYBVTKR-FXSLSZKUSA-N
0.000
description
1
230000003187
abdominal
Effects
0.000
description
1
238000010521
absorption reaction
Methods
0.000
description
1
150000001242
acetic acid derivatives
Chemical class
0.000
description
1
DPXJVFZANSGRMM-UHFFFAOYSA-N
acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium
Chemical compound
[Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O
DPXJVFZANSGRMM-UHFFFAOYSA-N
0.000
description
1
239000002253
acid
Substances
0.000
description
1
230000001154
acute
Effects
0.000
description
1
230000033289
adaptive immune response
Effects
0.000
description
1
238000007792
addition
Methods
0.000
description
1
GFFGJBXGBJISGV-UHFFFAOYSA-N
adenyl group
Chemical group
N1=CN=C2N=CNC2=C1N
GFFGJBXGBJISGV-UHFFFAOYSA-N
0.000
description
1
239000002671
adjuvant
Substances
0.000
description
1
230000000240
adjuvant
Effects
0.000
description
1
239000008272
agar
Substances
0.000
description
1
235000010419
agar
Nutrition
0.000
description
1
230000032683
aging
Effects
0.000
description
1
239000010441
alabaster
Substances
0.000
description
1
235000004279
alanine
Nutrition
0.000
description
1
125000003295
alanine group
Chemical group
N[C@@H](C)C(=O)*
0.000
description
1
125000003172
aldehyde group
Chemical group
0.000
description
1
150000001350
alkyl halides
Chemical class
0.000
description
1
239000002168
alkylating agent
Substances
0.000
description
1
108060003434
alpha
Proteins
0.000
description
1
150000001408
amides
Chemical class
0.000
description
1
125000000539
amino acid group
Chemical group
0.000
description
1
229960003942
amphotericin B
Drugs
0.000
description
1
230000003444
anaesthetic
Effects
0.000
description
1
230000033115
angiogenesis
Effects
0.000
description
1
108010072788
angiogenin
Proteins
0.000
description
1
125000000129
anionic group
Chemical group
0.000
description
1
230000002424
anti-apoptotic
Effects
0.000
description
1
230000003110
anti-inflammatory
Effects
0.000
description
1
230000000845
anti-microbial
Effects
0.000
description
1
230000000111
anti-oxidant
Effects
0.000
description
1
230000001028
anti-proliferant
Effects
0.000
description
1
108090001123
antibodies
Proteins
0.000
description
1
102000004965
antibodies
Human genes
0.000
description
1
239000002519
antifouling agent
Substances
0.000
description
1
239000003963
antioxidant agent
Substances
0.000
description
1
235000006708
antioxidants
Nutrition
0.000
description
1
239000003816
antisense DNA
Substances
0.000
description
1
229920002847
antisense RNA
Polymers
0.000
description
1
239000000074
antisense oligonucleotide
Substances
0.000
description
1
230000006907
apoptotic process
Effects
0.000
description
1
108010072041
arginyl-glycyl-aspartic acid
Proteins
0.000
description
1
230000001174
ascending
Effects
0.000
description
1
108010006523
asialoglycoprotein receptor family
Proteins
0.000
description
1
102000005427
asialoglycoprotein receptor family
Human genes
0.000
description
1
201000001320
atherosclerosis
Diseases
0.000
description
1
201000007185
autism spectrum disease
Diseases
0.000
description
1
201000009596
autoimmune hypersensitivity disease
Diseases
0.000
description
1
150000001558
benzoic acid derivatives
Chemical class
0.000
description
1
102000015735
beta Catenin
Human genes
0.000
description
1
108060000903
beta Catenin
Proteins
0.000
description
1
239000000227
bioadhesive
Substances
0.000
description
1
230000035514
bioavailability
Effects
0.000
description
1
239000000560
biocompatible material
Substances
0.000
description
1
238000006065
biodegradation reaction
Methods
0.000
description
1
239000003181
biological factor
Substances
0.000
description
1
230000033228
biological regulation
Effects
0.000
description
1
230000037348
biosynthesis
Effects
0.000
description
1
239000010839
body fluid
Substances
0.000
description
1
230000037396
body weight
Effects
0.000
description
1
210000003008
brain-resident macrophage
Anatomy
0.000
description
1
GHWVXCQZPNWFRO-UHFFFAOYSA-N
butane-2,3-diamine
Chemical group
CC(N)C(C)N
GHWVXCQZPNWFRO-UHFFFAOYSA-N
0.000
description
1
238000010804
cDNA synthesis
Methods
0.000
description
1
239000001506
calcium phosphate
Substances
0.000
description
1
229910000389
calcium phosphate
Inorganic materials
0.000
description
1
235000011010
calcium phosphates
Nutrition
0.000
description
1
238000004364
calculation method
Methods
0.000
description
1
239000002775
capsule
Substances
0.000
description
1
239000001768
carboxy methyl cellulose
Substances
0.000
description
1
230000000747
cardiac effect
Effects
0.000
description
1
230000015556
catabolic process
Effects
0.000
description
1
230000000453
cell autonomous
Effects
0.000
description
1
230000034303
cell budding
Effects
0.000
description
1
230000030833
cell death
Effects
0.000
description
1
230000003833
cell viability
Effects
0.000
description
1
230000001413
cellular
Effects
0.000
description
1
238000005119
centrifugation
Methods
0.000
description
1
229960001803
cetirizine
Drugs
0.000
description
1
239000002738
chelating agent
Substances
0.000
description
1
238000007385
chemical modification
Methods
0.000
description
1
102000009410
chemokine receptors
Human genes
0.000
description
1
108050000299
chemokine receptors
Proteins
0.000
description
1
201000006934
chronic myeloid leukemia
Diseases
0.000
description
1
239000007979
citrate buffer
Substances
0.000
description
1
238000000975
co-precipitation
Methods
0.000
description
1
239000011248
coating agent
Substances
0.000
description
1
239000003086
colorant
Substances
0.000
description
1
239000003184
complementary RNA
Substances
0.000
description
1
238000007906
compression
Methods
0.000
description
1
230000001268
conjugating
Effects
0.000
description
1
230000021615
conjugation
Effects
0.000
description
1
239000000470
constituent
Substances
0.000
description
1
230000009089
cytolysis
Effects
0.000
description
1
230000003013
cytotoxicity
Effects
0.000
description
1
231100000135
cytotoxicity
Toxicity
0.000
description
1
230000002498
deadly
Effects
0.000
description
1
230000004059
degradation
Effects
0.000
description
1
238000006731
degradation reaction
Methods
0.000
description
1
238000000432
density-gradient centrifugation
Methods
0.000
description
1
238000011026
diafiltration
Methods
0.000
description
1
150000004985
diamines
Chemical class
0.000
description
1
RNPXCFINMKSQPQ-UHFFFAOYSA-N
dicetyl hydrogen phosphate
Chemical compound
CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC
RNPXCFINMKSQPQ-UHFFFAOYSA-N
0.000
description
1
229940093541
dicetylphosphate
Drugs
0.000
description
1
239000003085
diluting agent
Substances
0.000
description
1
238000010790
dilution
Methods
0.000
description
1
229960000520
diphenhydramine
Drugs
0.000
description
1
239000002270
dispersing agent
Substances
0.000
description
1
239000002552
dosage form
Substances
0.000
description
1
231100000371
dose-limiting toxicity
Toxicity
0.000
description
1
231100000673
dose–response relationship
Toxicity
0.000
description
1
239000003937
drug carrier
Substances
0.000
description
1
230000004064
dysfunction
Effects
0.000
description
1
230000002500
effect on skin
Effects
0.000
description
1
238000001493
electron microscopy
Methods
0.000
description
1
239000012039
electrophile
Substances
0.000
description
1
239000003995
emulsifying agent
Substances
0.000
description
1
239000008393
encapsulating agent
Substances
0.000
description
1
238000007459
endoscopic retrograde cholangiopancreatography
Methods
0.000
description
1
238000001839
endoscopy
Methods
0.000
description
1
230000001973
epigenetic
Effects
0.000
description
1
210000002919
epithelial cells
Anatomy
0.000
description
1
229940105423
erythropoietin
Drugs
0.000
description
1
229940073505
ethyl vanillin
Drugs
0.000
description
1
238000011156
evaluation
Methods
0.000
description
1
230000002964
excitative
Effects
0.000
description
1
239000004744
fabric
Substances
0.000
description
1
239000003925
fat
Substances
0.000
description
1
235000019197
fats
Nutrition
0.000
description
1
210000002950
fibroblast
Anatomy
0.000
description
1
230000037320
fibronectin
Effects
0.000
description
1
230000004761
fibrosis
Effects
0.000
description
1
239000007888
film coating
Substances
0.000
description
1
239000000796
flavoring agent
Substances
0.000
description
1
235000019634
flavors
Nutrition
0.000
description
1
235000013305
food
Nutrition
0.000
description
1
108010022687
fumarylacetoacetase
Proteins
0.000
description
1
230000005714
functional activity
Effects
0.000
description
1
238000002825
functional assay
Methods
0.000
description
1
229940083124
ganglion-blocking antiadrenergic Secondary and tertiary amines
Drugs
0.000
description
1
239000007789
gas
Substances
0.000
description
1
239000008273
gelatin
Substances
0.000
description
1
229920000159
gelatin
Polymers
0.000
description
1
235000019322
gelatine
Nutrition
0.000
description
1
235000011852
gelatine desserts
Nutrition
0.000
description
1
239000003349
gelling agent
Substances
0.000
description
1
238000010363
gene targeting
Methods
0.000
description
1
201000002406
genetic disease
Diseases
0.000
description
1
238000010353
genetic engineering
Methods
0.000
description
1
238000010448
genetic screening
Methods
0.000
description
1
238000010355
genome engineering
Methods
0.000
description
1
230000001434
glomerular
Effects
0.000
description
1
210000003904
glomerular cell
Anatomy
0.000
description
1
239000008103
glucose
Substances
0.000
description
1
239000008187
granular material
Substances
0.000
description
1
210000004884
grey matter
Anatomy
0.000
description
1
239000003102
growth factor
Substances
0.000
description
1
230000003394
haemopoietic
Effects
0.000
description
1
108090001102
hammerhead ribozyme
Proteins
0.000
description
1
231100000888
hearing loss
Toxicity
0.000
description
1
229920000669
heparin
Polymers
0.000
description
1
231100000304
hepatotoxicity
Toxicity
0.000
description
1
210000004295
hippocampal neuron
Anatomy
0.000
description
1
239000003906
humectant
Substances
0.000
description
1
CPELXLSAUQHCOX-UHFFFAOYSA-N
hydrogen bromide
Chemical compound
Br
CPELXLSAUQHCOX-UHFFFAOYSA-N
0.000
description
1
238000005984
hydrogenation reaction
Methods
0.000
description
1
125000001165
hydrophobic group
Chemical group
0.000
description
1
238000003384
imaging method
Methods
0.000
description
1
230000002519
immonomodulatory
Effects
0.000
description
1
230000001900
immune effect
Effects
0.000
description
1
238000002318
immunoblotting
Methods
0.000
description
1
238000010185
immunofluorescence analysis
Methods
0.000
description
1
239000012535
impurity
Substances
0.000
description
1
230000002779
inactivation
Effects
0.000
description
1
238000010348
incorporation
Methods
0.000
description
1
230000002458
infectious
Effects
0.000
description
1
230000002757
inflammatory
Effects
0.000
description
1
200000000018
inflammatory disease
Diseases
0.000
description
1
230000015788
innate immune response
Effects
0.000
description
1
102000006495
integrins
Human genes
0.000
description
1
108010044426
integrins
Proteins
0.000
description
1
238000001361
intraarterial administration
Methods
0.000
description
1
238000007918
intramuscular administration
Methods
0.000
description
1
238000007912
intraperitoneal administration
Methods
0.000
description
1
238000007913
intrathecal administration
Methods
0.000
description
1
238000007914
intraventricular administration
Methods
0.000
description
1
230000003447
ipsilateral
Effects
0.000
description
1
210000002384
kidney collecting duct cell
Anatomy
0.000
description
1
210000000629
knee joint
Anatomy
0.000
description
1
239000008101
lactose
Substances
0.000
description
1
GUBGYTABKSRVRQ-XLOQQCSPSA-N
lactose
Chemical compound
O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O
GUBGYTABKSRVRQ-XLOQQCSPSA-N
0.000
description
1
238000002357
laparoscopic surgery
Methods
0.000
description
1
230000002045
lasting
Effects
0.000
description
1
239000004816
latex
Substances
0.000
description
1
ZKLPARSLTMPFCP-UHFFFAOYSA-N
levocetirizine
Chemical compound
C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1
ZKLPARSLTMPFCP-UHFFFAOYSA-N
0.000
description
1
150000002634
lipophilic molecules
Chemical class
0.000
description
1
238000007449
liver function test
Methods
0.000
description
1
244000144972
livestock
Species
0.000
description
1
230000002934
lysing
Effects
0.000
description
1
230000014759
maintenance of location
Effects
0.000
description
1
230000003211
malignant
Effects
0.000
description
1
150000002690
malonic acid derivatives
Chemical class
0.000
description
1
108010031099
mannose receptor
Proteins
0.000
description
1
239000003550
marker
Substances
0.000
description
1
238000005259
measurement
Methods
0.000
description
1
201000001441
melanoma
Diseases
0.000
description
1
210000004779
membrane envelope
Anatomy
0.000
description
1
230000005056
memory consolidation
Effects
0.000
description
1
230000004060
metabolic process
Effects
0.000
description
1
230000035786
metabolism
Effects
0.000
description
1
229910052751
metal
Inorganic materials
0.000
description
1
239000002184
metal
Substances
0.000
description
1
150000002739
metals
Chemical class
0.000
description
1
238000002493
microarray
Methods
0.000
description
1
230000000813
microbial
Effects
0.000
description
1
239000008108
microcrystalline cellulose
Substances
0.000
description
1
235000019813
microcrystalline cellulose
Nutrition
0.000
description
1
229940016286
microcrystalline cellulose
Drugs
0.000
description
1
238000000520
microinjection
Methods
0.000
description
1
230000000394
mitotic
Effects
0.000
description
1
239000003607
modifier
Substances
0.000
description
1
108010045030
monoclonal antibodies
Proteins
0.000
description
1
102000005614
monoclonal antibodies
Human genes
0.000
description
1
239000000178
monomer
Substances
0.000
description
1
230000004660
morphological change
Effects
0.000
description
1
230000003505
mutagenic
Effects
0.000
description
1
231100000243
mutagenic effect
Toxicity
0.000
description
1
YNTOKMNHRPSGFU-UHFFFAOYSA-N
n-Propyl carbamate
Chemical compound
CCCOC(N)=O
YNTOKMNHRPSGFU-UHFFFAOYSA-N
0.000
description
1
239000002101
nanobubble
Substances
0.000
description
1
239000002086
nanomaterial
Substances
0.000
description
1
229940042880
natural phospholipids
Drugs
0.000
description
1
210000000653
nervous system
Anatomy
0.000
description
1
230000000926
neurological
Effects
0.000
description
1
230000002981
neuropathic
Effects
0.000
description
1
201000006487
neurotic disease
Diseases
0.000
description
1
230000003472
neutralizing
Effects
0.000
description
1
239000002547
new drug
Substances
0.000
description
1
238000007481
next generation sequencing
Methods
0.000
description
1
125000002560
nitrile group
Chemical group
0.000
description
1
125000004433
nitrogen atoms
Chemical group
N*
0.000
description
1
230000003000
nontoxic
Effects
0.000
description
1
231100000252
nontoxic
Toxicity
0.000
description
1
239000002777
nucleoside
Substances
0.000
description
1
150000003833
nucleoside derivatives
Chemical class
0.000
description
1
235000015097
nutrients
Nutrition
0.000
description
1
230000003287
optical
Effects
0.000
description
1
210000000963
osteoblast
Anatomy
0.000
description
1
230000000790
osteoblast
Effects
0.000
description
1
230000002018
overexpression
Effects
0.000
description
1
RZVAJINKPMORJF-UHFFFAOYSA-N
p-acetaminophenol
Chemical compound
CC(=O)NC1=CC=C(O)C=C1
RZVAJINKPMORJF-UHFFFAOYSA-N
0.000
description
1
239000006179
pH buffering agent
Substances
0.000
description
1
229960005489
paracetamol
Drugs
0.000
description
1
229940090668
parachlorophenol
Drugs
0.000
description
1
230000001936
parietal
Effects
0.000
description
1
230000001575
pathological
Effects
0.000
description
1
235000021400
peanut butter
Nutrition
0.000
description
1
239000001814
pectin
Substances
0.000
description
1
235000010987
pectin
Nutrition
0.000
description
1
229920001277
pectin
Polymers
0.000
description
1
239000008188
pellet
Substances
0.000
description
1
108010043655
penetratin
Proteins
0.000
description
1
230000000149
penetrating
Effects
0.000
description
1
230000035515
penetration
Effects
0.000
description
1
239000000816
peptidomimetic
Substances
0.000
description
1
230000002093
peripheral
Effects
0.000
description
1
239000011886
peripheral blood
Substances
0.000
description
1
239000008194
pharmaceutical composition
Substances
0.000
description
1
230000003285
pharmacodynamic
Effects
0.000
description
1
230000000275
pharmacokinetic
Effects
0.000
description
1
OAICVXFJPJFONN-UHFFFAOYSA-N
phosphorus
Chemical compound
[P]
OAICVXFJPJFONN-UHFFFAOYSA-N
0.000
description
1
239000011574
phosphorus
Substances
0.000
description
1
238000000053
physical method
Methods
0.000
description
1
238000003976
plant breeding
Methods
0.000
description
1
210000001778
pluripotent stem cell
Anatomy
0.000
description
1
229920000962
poly(amidoamine)
Polymers
0.000
description
1
229920001606
poly(lactic acid-co-glycolic acid)
Polymers
0.000
description
1
239000004417
polycarbonate
Substances
0.000
description
1
229920000515
polycarbonate
Polymers
0.000
description
1
229920000867
polyelectrolyte
Polymers
0.000
description
1
230000003234
polygenic
Effects
0.000
description
1
229920005597
polymer membrane
Polymers
0.000
description
1
238000006116
polymerization reaction
Methods
0.000
description
1
239000000244
polyoxyethylene sorbitan monooleate
Substances
0.000
description
1
235000010482
polyoxyethylene sorbitan monooleate
Nutrition
0.000
description
1
229920001184
polypeptide
Polymers
0.000
description
1
229920000053
polysorbate 80
Polymers
0.000
description
1
229920002981
polyvinylidene fluoride
Polymers
0.000
description
1
239000004302
potassium sorbate
Substances
0.000
description
1
235000010241
potassium sorbate
Nutrition
0.000
description
1
244000144977
poultry
Species
0.000
description
1
230000035935
pregnancy
Effects
0.000
description
1
230000002028
premature
Effects
0.000
description
1
230000002335
preservative
Effects
0.000
description
1
239000003755
preservative agent
Substances
0.000
description
1
230000003405
preventing
Effects
0.000
description
1
230000002265
prevention
Effects
0.000
description
1
230000003449
preventive
Effects
0.000
description
1
150000003141
primary amines
Chemical class
0.000
description
1
230000002062
proliferating
Effects
0.000
description
1
230000035755
proliferation
Effects
0.000
description
1
230000001737
promoting
Effects
0.000
description
1
XBDQKXXYIPTUBI-UHFFFAOYSA-M
propionate
Chemical class
CCC([O-])=O
XBDQKXXYIPTUBI-UHFFFAOYSA-M
0.000
description
1
ZTHYODDOHIVTJV-UHFFFAOYSA-N
propyl 3,4,5-trihydroxybenzoate
Chemical compound
CCCOC(=O)C1=CC(O)=C(O)C(O)=C1
ZTHYODDOHIVTJV-UHFFFAOYSA-N
0.000
description
1
239000000473
propyl gallate
Substances
0.000
description
1
235000010388
propyl gallate
Nutrition
0.000
description
1
230000001681
protective
Effects
0.000
description
1
230000036678
protein binding
Effects
0.000
description
1
239000002096
quantum dot
Substances
0.000
description
1
230000002285
radioactive
Effects
0.000
description
1
108010005597
ran GTP-Binding Protein
Proteins
0.000
description
1
238000003753
real-time PCR
Methods
0.000
description
1
108010054624
red fluorescent protein
Proteins
0.000
description
1
239000004627
regenerated cellulose
Substances
0.000
description
1
238000007634
remodeling
Methods
0.000
description
1
238000007894
restriction fragment length polymorphism technique
Methods
0.000
description
1
108010056030
retronectin
Proteins
0.000
description
1
229920002033
ribozyme
Polymers
0.000
description
1
150000003839
salts
Chemical class
0.000
description
1
238000005070
sampling
Methods
0.000
description
1
238000007480
sanger sequencing
Methods
0.000
description
1
230000035945
sensitivity
Effects
0.000
description
1
238000000926
separation method
Methods
0.000
description
1
235000011803
sesame oil
Nutrition
0.000
description
1
239000008159
sesame oil
Substances
0.000
description
1
230000019491
signal transduction
Effects
0.000
description
1
230000011664
signaling
Effects
0.000
description
1
229960002930
sirolimus
Drugs
0.000
description
1
210000000813
small intestine
Anatomy
0.000
description
1
239000011734
sodium
Substances
0.000
description
1
235000019812
sodium carboxymethyl cellulose
Nutrition
0.000
description
1
229920001027
sodium carboxymethylcellulose
Polymers
0.000
description
1
230000003381
solubilizing
Effects
0.000
description
1
239000002904
solvent
Substances
0.000
description
1
230000000392
somatic
Effects
0.000
description
1
210000001082
somatic cell
Anatomy
0.000
description
1
WSWCOQWTEOXDQX-UHFFFAOYSA-N
sorbic acid
Chemical compound
CC=CC=CC(O)=O
WSWCOQWTEOXDQX-UHFFFAOYSA-N
0.000
description
1
239000004334
sorbic acid
Substances
0.000
description
1
235000010199
sorbic acid
Nutrition
0.000
description
1
239000003381
stabilizer
Substances
0.000
description
1
239000007858
starting material
Substances
0.000
description
1
210000004500
stellate cell
Anatomy
0.000
description
1
238000002672
stereotactic surgery
Methods
0.000
description
1
230000004936
stimulating
Effects
0.000
description
1
239000011550
stock solution
Substances
0.000
description
1
239000005720
sucrose
Substances
0.000
description
1
235000010269
sulphur dioxide
Nutrition
0.000
description
1
238000001356
surgical procedure
Methods
0.000
description
1
230000002889
sympathetic
Effects
0.000
description
1
201000010874
syndrome
Diseases
0.000
description
1
229930003347
taxol
Natural products
0.000
description
1
235000019364
tetracycline
Nutrition
0.000
description
1
150000003568
thioethers
Chemical class
0.000
description
1
230000036962
time dependent
Effects
0.000
description
1
238000011099
tissue engineering
Methods
0.000
description
1
230000017423
tissue regeneration
Effects
0.000
description
1
239000003053
toxin
Substances
0.000
description
1
108091006091
transcriptional repressors
Proteins
0.000
description
1
239000012581
transferrin
Substances
0.000
description
1
238000000844
transformation
Methods
0.000
description
1
230000001052
transient
Effects
0.000
description
1
108010062760
transportan
Proteins
0.000
description
1
230000004614
tumor growth
Effects
0.000
description
1
241001529453
unidentified herpesvirus
Species
0.000
description
1
241001430294
unidentified retrovirus
Species
0.000
description
1
235000015112
vegetable and seed oil
Nutrition
0.000
description
1
239000008158
vegetable oil
Substances
0.000
description
1
GPXBXXGIAQBQNI-UHFFFAOYSA-N
vemurafenib
Chemical compound
CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F
GPXBXXGIAQBQNI-UHFFFAOYSA-N
0.000
description
1
229960003862
vemurafenib
Drugs
0.000
description
1
230000001720
vestibular
Effects
0.000
description
1
230000000007
visual effect
Effects
0.000
description
1
235000013343
vitamin
Nutrition
0.000
description
1
239000011782
vitamin
Substances
0.000
description
1
229930003231
vitamins
Natural products
0.000
description
1
230000003442
weekly
Effects
0.000
description
1
230000004580
weight loss
Effects
0.000
description
1
239000000080
wetting agent
Substances
0.000
description
1
235000021307
wheat
Nutrition
0.000
description
1
210000004885
white matter
Anatomy
0.000
description
1
200000000019
wound
Diseases
0.000
description
1
235000013618
yogurt
Nutrition
0.000
description
1
HCHKCACWOHOZIP-UHFFFAOYSA-N
zinc
Chemical compound
[Zn]
HCHKCACWOHOZIP-UHFFFAOYSA-N
0.000
description
1
229910052725
zinc
Inorganic materials
0.000
description
1
239000011701
zinc
Substances
0.000
description
1