RU2698711C2 - Составы полимеров для носослёзной стимуляции - Google Patents
Составы полимеров для носослёзной стимуляции Download PDFInfo
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- RU2698711C2 RU2698711C2 RU2016137744A RU2016137744A RU2698711C2 RU 2698711 C2 RU2698711 C2 RU 2698711C2 RU 2016137744 A RU2016137744 A RU 2016137744A RU 2016137744 A RU2016137744 A RU 2016137744A RU 2698711 C2 RU2698711 C2 RU 2698711C2
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- hydrogel
- nasal
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- hydration
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461944340P | 2014-02-25 | 2014-02-25 | |
| US61/944,340 | 2014-02-25 | ||
| US201462027139P | 2014-07-21 | 2014-07-21 | |
| US62/027,139 | 2014-07-21 | ||
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Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
| US20140228875A1 (en) | 2013-02-08 | 2014-08-14 | Nidus Medical, Llc | Surgical device with integrated visualization and cauterization |
| EP2967817B1 (en) | 2013-03-12 | 2021-03-10 | Oculeve, Inc. | Implant delivery devices and systems |
| NZ704579A (en) | 2013-04-19 | 2018-10-26 | Oculeve Inc | Nasal stimulation devices and methods |
| US20150031946A1 (en) | 2013-07-24 | 2015-01-29 | Nidus Medical, Llc | Direct vision cryosurgical probe and methods of use |
| WO2015048806A2 (en) | 2013-09-30 | 2015-04-02 | Nidus Medical, Llc | Apparatus and methods for treating rhinitis |
| WO2015130707A2 (en) | 2014-02-25 | 2015-09-03 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
| CA2956176A1 (en) | 2014-07-25 | 2016-01-28 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
| US9763743B2 (en) | 2014-07-25 | 2017-09-19 | Arrinex, Inc. | Apparatus and method for treating rhinitis |
| EP3209370A4 (en) | 2014-10-22 | 2018-05-30 | Oculeve, Inc. | Contact lens for increasing tear production |
| RU2707167C2 (ru) | 2014-10-22 | 2019-11-22 | Окулив, Инк. | Устройства для стимуляции и способы лечения болезни "сухого глаза" |
| WO2016065213A1 (en) | 2014-10-22 | 2016-04-28 | Oculeve, Inc. | Implantable nasal stimulator systems and methods |
| US10743838B2 (en) | 2015-02-25 | 2020-08-18 | Decision Sciences Medical Company, LLC | Acoustic signal transmission couplants and coupling mediums |
| WO2016205107A1 (en) | 2015-06-16 | 2016-12-22 | The Regents Of The University Of Colorado, A Body Corporate | Nasolacrimal implants and related methods for tear stimulation |
| WO2017062690A1 (en) * | 2015-10-06 | 2017-04-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Moisture permeable hydrogel composite materials |
| US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
| EP3413822B1 (en) | 2016-02-11 | 2023-08-30 | Arrinex, Inc. | Device for image guided post-nasal nerve ablation |
| US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
| CA3022683A1 (en) * | 2016-05-02 | 2017-11-09 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
| EP3471638B1 (en) | 2016-06-15 | 2025-01-29 | Arrinex, Inc. | Devices for treating a lateral surface of a nasal cavity |
| US12233017B2 (en) | 2016-10-14 | 2025-02-25 | Olympic Ophthalmics, Inc. | Quiet handheld devices and methods for treatment of disorders |
| US11253312B2 (en) | 2016-10-17 | 2022-02-22 | Arrinex, Inc. | Integrated nasal nerve detector ablation-apparatus, nasal nerve locator, and methods of use |
| KR20190124698A (ko) | 2016-12-02 | 2019-11-05 | 오큘레브, 인크. | 건성안 예측 및 치료 권고를 위한 장치 및 방법 |
| WO2018111949A1 (en) | 2016-12-12 | 2018-06-21 | Neuronoff, Inc. | Electrode curable and moldable to contours of a target in bodily tissue and methods of manufacturing and placement and dispensers therefor |
| WO2018201158A1 (en) | 2017-04-28 | 2018-11-01 | Arrinx, Inc. | Systems and methods for locating blood vessels in the treatment of rhinitis |
| WO2018232338A1 (en) | 2017-06-16 | 2018-12-20 | AesculaTech, Inc. | Thermoresponsive polymers and uses thereof |
| US11147736B2 (en) | 2018-02-26 | 2021-10-19 | Olympic Ophthalmics, Inc. | Therapeutic handheld devices for disorders |
| JP7252204B2 (ja) * | 2018-03-23 | 2023-04-04 | 株式会社 資生堂 | コア－コロナ型ポリマー粒子を用いた化粧料用原料および水中油型乳化化粧料 |
| US12054590B2 (en) | 2018-05-16 | 2024-08-06 | Gl Chemtec Vision Inc. | Hydrogel polymers |
| CN109456444B (zh) * | 2018-10-22 | 2021-03-16 | 西南交通大学 | 一种用于组织修复的黏附导电水凝胶的制备方法 |
| US20200155830A1 (en) * | 2018-11-16 | 2020-05-21 | ALLERGAN / Oculeve | Nasal neurostimulation device with electrically conductive plastic electrode |
| US12017389B2 (en) | 2019-03-06 | 2024-06-25 | Decision Sciences Medical Company, LLC | Methods for manufacturing and distributing semi-rigid acoustic coupling articles and packaging for ultrasound imaging |
| US11154274B2 (en) * | 2019-04-23 | 2021-10-26 | Decision Sciences Medical Company, LLC | Semi-rigid acoustic coupling articles for ultrasound diagnostic and treatment applications |
| CN112023114A (zh) * | 2019-06-03 | 2020-12-04 | 上海禾思凯尔医疗科技有限公司 | 一种用于泪小管栓塞手术的泪小管阻芯材料及其制备方法 |
| US11065461B2 (en) | 2019-07-08 | 2021-07-20 | Bioness Inc. | Implantable power adapter |
| US11807700B2 (en) | 2020-08-17 | 2023-11-07 | Saudi Arabian Oil Company | Electro-responsive hydrogel for reservoir and downhole application |
| US12253467B2 (en) | 2021-12-13 | 2025-03-18 | Saudi Arabian Oil Company | Determining partition coefficients of tracer analytes |
| US12000278B2 (en) | 2021-12-16 | 2024-06-04 | Saudi Arabian Oil Company | Determining oil and water production rates in multiple production zones from a single production well |
| IL318466A (en) * | 2022-07-20 | 2025-03-01 | Texas Heart Inst | Device and method for cardiac ablation using hydrogel |
| US20240268995A1 (en) * | 2022-10-18 | 2024-08-15 | Modular Thermal Technologies, Llc | Thermal transfer apparatus |
| US12276180B2 (en) | 2023-05-17 | 2025-04-15 | Saudi Arabian Oil Company | Hydrogels for carbon sequestration and sealing zones in a wellbore |
| WO2024249599A2 (en) * | 2023-06-02 | 2024-12-05 | Kayser Laure V | Photo-catalyzed formation of conductive hydrogels |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5498681A (en) * | 1993-01-28 | 1996-03-12 | Pilkington Barnes Hind, Inc. | Material for use in the manufacture of polymeric articles |
| US5800685A (en) * | 1996-10-28 | 1998-09-01 | Cardiotronics Systems, Inc. | Electrically conductive adhesive hydrogels |
| US20050137276A1 (en) * | 2003-12-18 | 2005-06-23 | Kimberly-Clark Worldwide, Inc. | Electrically conductive adhesive hydrogels with solubilizer |
| WO2012139063A2 (en) * | 2011-04-07 | 2012-10-11 | Oculeve, Inc. | Stimulation devices and methods |
| US20130270491A1 (en) * | 2012-04-17 | 2013-10-17 | Ik-Ro PARK | Conductive hydrogel and method of preparing the same |
Family Cites Families (425)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2525381A (en) | 1947-09-25 | 1950-10-10 | Tower Paul | Contact-type electrode holder |
| US2512882A (en) | 1949-08-17 | 1950-06-27 | R G Truesdale Co Inc | Serum inoculator |
| US3620219A (en) | 1969-05-07 | 1971-11-16 | Donald E Barker | Facial nerve stimulator |
| US3709228A (en) | 1971-01-07 | 1973-01-09 | D Barker | Apparatus for facial stimulation |
| FR2210298A5 (https=) | 1972-12-08 | 1974-07-05 | Commissariat Energie Atomique | |
| USD257495S (en) | 1979-05-29 | 1980-11-04 | Hot Shot Products Co. | Housing for an electric cattle prod |
| US4684362A (en) | 1981-03-12 | 1987-08-04 | Holt James J | Method for collecting nasal secretions |
| US4520825A (en) | 1982-04-30 | 1985-06-04 | Medtronic, Inc. | Digital circuit for control of gradual turn-on of electrical tissue stimulators |
| US4495676A (en) | 1982-08-02 | 1985-01-29 | Hartmetz Ii Gerald J | Apparatus for electrically stimulating an animal carcass |
| CH677883A5 (https=) | 1982-11-15 | 1991-07-15 | Symtonic Sa | |
| US4539988A (en) | 1983-07-05 | 1985-09-10 | Packaging Corporation International | Disposable automatic lancet |
| US5025807A (en) | 1983-09-14 | 1991-06-25 | Jacob Zabara | Neurocybernetic prosthesis |
| US4590942A (en) | 1984-02-17 | 1986-05-27 | Biosonics, Inc. | Apparatus and method for inhibiting nasal secretions |
| DE3501095A1 (de) | 1985-01-15 | 1986-07-17 | Gerd Prof. Dr. 8520 Erlangen Kobal | Verfahren zur messung von sensorischen qualitaeten und einrichtung zur durchfuehrung des verfahrens |
| JPS61203935A (ja) | 1985-03-07 | 1986-09-09 | 日石三菱株式会社 | 網膜電図測定用電極 |
| US4628933A (en) | 1985-07-23 | 1986-12-16 | Michelson Robin P | Method and apparatus for visual prosthesis |
| NZ214348A (en) | 1985-11-27 | 1988-07-28 | Walker T H & Sons Ltd | Electrically stunning animals through nose and neck contacts |
| US4868154A (en) | 1986-02-19 | 1989-09-19 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with melanocyte stimulating hormones |
| US4706680A (en) | 1986-06-30 | 1987-11-17 | Nepera Inc. | Conductive adhesive medical electrode assemblies |
| US4777954A (en) | 1986-06-30 | 1988-10-18 | Nepera Inc. | Conductive adhesive medical electrode assemblies |
| US4957480A (en) | 1988-02-02 | 1990-09-18 | Universal Health Products, Inc. | Method of facial toning |
| US4926880A (en) | 1988-11-08 | 1990-05-22 | Microcurrents | Method for relieving sinus and nasal congestion utilizing microcurrents |
| US4988358A (en) | 1988-12-28 | 1991-01-29 | Eppley Barry L | Method for promoting hard tissue growth and repair in mammals |
| US5259373A (en) | 1989-05-19 | 1993-11-09 | Puritan-Bennett Corporation | Inspiratory airway pressure system controlled by the detection and analysis of patient airway sounds |
| RU1799577C (ru) | 1989-08-17 | 1993-03-07 | Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Способ улучшени зрительных функций при заболевани х зрительного нерва и сетчатки и устройство дл его осуществлени |
| US5078733A (en) | 1990-04-12 | 1992-01-07 | Eveleigh Robert B | Pacifier for premature newborns |
| US5090422A (en) | 1990-04-19 | 1992-02-25 | Cardiac Pacemakers, Inc. | Implantable electrode pouch |
| US5099829A (en) | 1990-04-25 | 1992-03-31 | Wu An Chuan | Massage device good for eyes |
| US5342410A (en) | 1990-10-05 | 1994-08-30 | Eric Braverman | Apparatus and method for increasing the amplitude of P300 waves in the human brain |
| US5072724A (en) | 1990-11-23 | 1991-12-17 | Joseph Marcus | Vibrational liquid-wave stimulating therapy mask apparatus for facial health and beauty care |
| US5533470A (en) | 1991-07-05 | 1996-07-09 | Rose; Andrew F. | Electronic nose-clip with solar cell |
| US5640978A (en) | 1991-11-06 | 1997-06-24 | Diolase Corporation | Method for pain relief using low power laser light |
| US5193539A (en) | 1991-12-18 | 1993-03-16 | Alfred E. Mann Foundation For Scientific Research | Implantable microstimulator |
| US6063079A (en) | 1995-06-07 | 2000-05-16 | Arthrocare Corporation | Methods for electrosurgical treatment of turbinates |
| US5352445A (en) | 1992-05-07 | 1994-10-04 | Lavaux Joseph E | Lavaux tear test lacrimal equilibration time (LET) |
| US5514131A (en) | 1992-08-12 | 1996-05-07 | Stuart D. Edwards | Method for the ablation treatment of the uvula |
| US5360438A (en) | 1993-01-26 | 1994-11-01 | Fisher Mary R | Method and device for improving cranial nerve function to improve muscle function and thereby overcome visual/perceptual dysfunction |
| US5345948A (en) | 1993-04-08 | 1994-09-13 | Donnell Jr Francis E O | Method of performing translactrimal laser dacryocystorhinostomy |
| US5545617A (en) | 1993-11-12 | 1996-08-13 | The Schepens Eye Research Institute, Inc. | Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion |
| US5713833A (en) | 1994-01-26 | 1998-02-03 | Milligan; Lee John | Septum nerve stimulator |
| DE69504307T2 (de) | 1994-01-31 | 1999-01-07 | Bausch & Lomb Inc., Rochester, N.Y. | Verfahren zur giessformung torischer kontaktlinsen |
| IL108772A0 (en) | 1994-02-24 | 1994-05-30 | Amcor Ltd | Treatment of rhinitis by biostimulative illumination |
| AUPM982694A0 (en) | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
| US5643336A (en) | 1995-01-09 | 1997-07-01 | Lopez-Claros; Marcelo Enrique | Heating and cooling pad |
| US5735817A (en) | 1995-05-19 | 1998-04-07 | Shantha; T. R. | Apparatus for transsphenoidal stimulation of the pituitary gland and adjoining brain structures |
| US5640764A (en) | 1995-05-22 | 1997-06-24 | Alfred E. Mann Foundation For Scientific Research | Method of forming a tubular feed-through hermetic seal for an implantable medical device |
| US5571101A (en) | 1995-05-25 | 1996-11-05 | Ellman; Alan G. | Electrosurgical electrode for DCR surgical procedure |
| US5707400A (en) | 1995-09-19 | 1998-01-13 | Cyberonics, Inc. | Treating refractory hypertension by nerve stimulation |
| US5607461A (en) | 1995-10-20 | 1997-03-04 | Nexmed, Inc. | Apparatus and method for delivering electrical stimulus to tissue |
| DE19549297C2 (de) | 1995-12-22 | 1998-07-02 | Guenter Stielau | Verfahren und Vorrichtung zur Beeinflussung der menschlichen Psyche |
| US6051017A (en) | 1996-02-20 | 2000-04-18 | Advanced Bionics Corporation | Implantable microstimulator and systems employing the same |
| US5900407A (en) | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US6549800B1 (en) | 1996-04-25 | 2003-04-15 | Johns Hopkins Unversity School Of Medicine | Methods for in vivo magnetic resonance imaging |
| WO1998008073A1 (en) | 1996-08-23 | 1998-02-26 | Osteobiologics, Inc. | Handheld materials tester |
| US5697957A (en) | 1996-08-29 | 1997-12-16 | Pacesetter Ab | Adaptive method and apparatus for extracting an evoked response component from a sensed cardiac signal by suppressing electrode polarization components |
| US6544193B2 (en) | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
| US7460911B2 (en) | 1997-02-26 | 2008-12-02 | Alfred E. Mann Foundation For Scientific Research | System and method suitable for treatment of a patient with a neurological deficit by sequentially stimulating neural pathways using a system of discrete implantable medical devices |
| US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
| US6458157B1 (en) | 1997-08-04 | 2002-10-01 | Suaning Gregg Joergen | Retinal stimulator |
| US6020445A (en) * | 1997-10-09 | 2000-02-01 | Johnson & Johnson Vision Products, Inc. | Silicone hydrogel polymers |
| AU1205799A (en) | 1997-10-29 | 1999-05-17 | J-Med Pharmaceuticals, Inc. | Antihistamine/decongestant regimens for treating rhinitis |
| US6083251A (en) | 1997-11-13 | 2000-07-04 | Shindo; Kohei | Eye treatment method and apparatus |
| FR2771297B1 (fr) | 1997-11-25 | 2000-02-11 | Pierre Andre Jacques Bige | Sonde bicanaliculaire pour le traitement du larmoiement de l'oeil |
| US6050999A (en) | 1997-12-18 | 2000-04-18 | Keravision, Inc. | Corneal implant introducer and method of use |
| US5935155A (en) | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
| US6324429B1 (en) | 1998-05-08 | 2001-11-27 | Massachusetts Eye And Ear Infirmary | Chronically implantable retinal prosthesis |
| US6036891A (en) * | 1998-05-11 | 2000-03-14 | Pharmacia & Upjohn | Polymerizable hydrophilic ultraviolet light absorbing monomers |
| JP2002519138A (ja) | 1998-07-06 | 2002-07-02 | アドヴァンスド バイオニクス コーポレイション | 尿失禁治療処置のための移植可能な刺激器システムおよびその方法 |
| US6035236A (en) | 1998-07-13 | 2000-03-07 | Bionergy Therapeutics, Inc. | Methods and apparatus for electrical microcurrent stimulation therapy |
| US6272382B1 (en) | 1998-07-31 | 2001-08-07 | Advanced Bionics Corporation | Fully implantable cochlear implant system |
| US6240316B1 (en) | 1998-08-14 | 2001-05-29 | Advanced Bionics Corporation | Implantable microstimulation system for treatment of sleep apnea |
| CA2341708A1 (en) | 1998-09-04 | 2000-03-16 | Wolfe Research Pty. Ltd. | Medical implant system |
| US7346389B1 (en) | 1998-09-24 | 2008-03-18 | Newsome David A | Dilation enhancer with pre-medicated contact lenses |
| US5948006A (en) | 1998-10-14 | 1999-09-07 | Advanced Bionics Corporation | Transcutaneous transmission patch |
| US6275737B1 (en) | 1998-10-14 | 2001-08-14 | Advanced Bionics Corporation | Transcutaneous transmission pouch |
| US7076307B2 (en) | 2002-05-09 | 2006-07-11 | Boveja Birinder R | Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders |
| US6366814B1 (en) | 1998-10-26 | 2002-04-02 | Birinder R. Boveja | External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders |
| US6564102B1 (en) | 1998-10-26 | 2003-05-13 | Birinder R. Boveja | Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator |
| US6208902B1 (en) | 1998-10-26 | 2001-03-27 | Birinder Bob Boveja | Apparatus and method for adjunct (add-on) therapy for pain syndromes utilizing an implantable lead and an external stimulator |
| US6205359B1 (en) | 1998-10-26 | 2001-03-20 | Birinder Bob Boveja | Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator |
| US6329485B1 (en) * | 1998-12-11 | 2001-12-11 | Bausch & Lomb Incorporated | High refractive index hydrogel compositions for ophthalmic implants |
| GB2345010B (en) | 1998-12-17 | 2002-12-31 | Electrosols Ltd | A delivery device |
| AU772100B2 (en) | 1999-02-08 | 2004-04-08 | Cochlear Limited | Offset coils for radio frequency transcutaneous links |
| US6438398B1 (en) | 1999-03-05 | 2002-08-20 | The University Of Miami | Process and device for measuring tear fluorescein clearance |
| WO2000056393A1 (en) | 1999-03-24 | 2000-09-28 | Second Sight, Llc | Retinal color prosthesis for color sight restoration |
| US6178352B1 (en) | 1999-05-07 | 2001-01-23 | Woodside Biomedical, Inc. | Method of blood pressure moderation |
| US6200626B1 (en) * | 1999-05-20 | 2001-03-13 | Bausch & Lomb Incorporated | Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization |
| US7177690B2 (en) | 1999-07-27 | 2007-02-13 | Advanced Bionics Corporation | Implantable system having rechargeable battery indicator |
| US6516227B1 (en) | 1999-07-27 | 2003-02-04 | Advanced Bionics Corporation | Rechargeable spinal cord stimulator system |
| US6237604B1 (en) | 1999-09-07 | 2001-05-29 | Scimed Life Systems, Inc. | Systems and methods for preventing automatic identification of re-used single use devices |
| US6368324B1 (en) | 1999-09-24 | 2002-04-09 | Medtronic Xomed, Inc. | Powered surgical handpiece assemblies and handpiece adapter assemblies |
| US6853946B2 (en) | 1999-11-05 | 2005-02-08 | Adam Cohen | Air flow sensing and control for animal confinement system |
| EP1110509A1 (en) | 1999-12-21 | 2001-06-27 | Tomaso Vercellotti | Surgical device for bone surgery |
| US6885888B2 (en) | 2000-01-20 | 2005-04-26 | The Cleveland Clinic Foundation | Electrical stimulation of the sympathetic nerve chain |
| US20040039401A1 (en) | 2000-03-31 | 2004-02-26 | Chow Alan Y. | Implant instrument |
| US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
| US6284765B1 (en) | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
| US7117033B2 (en) | 2000-05-08 | 2006-10-03 | Brainsgate, Ltd. | Stimulation for acute conditions |
| US6853858B2 (en) | 2000-05-08 | 2005-02-08 | Brainsgate, Ltd. | Administration of anti-inflammatory drugs into the central nervous system |
| US7146209B2 (en) | 2000-05-08 | 2006-12-05 | Brainsgate, Ltd. | Stimulation for treating eye pathologies |
| JP4311904B2 (ja) | 2000-05-08 | 2009-08-12 | ブレインスゲート リミテッド | 血液脳関門及び脳血流の性質を改善するための翼口蓋神経節の刺激方法及び装置 |
| US20020035358A1 (en) | 2000-05-09 | 2002-03-21 | Ming Wang | Pulsed electromagnetic field therapy for treatment of corneal disorders and injuries |
| US6327504B1 (en) | 2000-05-10 | 2001-12-04 | Thoratec Corporation | Transcutaneous energy transfer with circuitry arranged to avoid overheating |
| US6592860B1 (en) * | 2000-05-30 | 2003-07-15 | Soluble Systems, Llc | Composition and applicator for topical substance delivery |
| US6526318B1 (en) | 2000-06-16 | 2003-02-25 | Mehdi M. Ansarinia | Stimulation method for the sphenopalatine ganglia, sphenopalatine nerve, or vidian nerve for treatment of medical conditions |
| US6505077B1 (en) | 2000-06-19 | 2003-01-07 | Medtronic, Inc. | Implantable medical device with external recharging coil electrical connection |
| DE60140025D1 (de) | 2000-06-19 | 2009-11-12 | Medtronic Inc | Implantierbares medizinisches Gerät mit einer externen Nachladespule |
| US6871099B1 (en) | 2000-08-18 | 2005-03-22 | Advanced Bionics Corporation | Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain |
| US6535766B1 (en) | 2000-08-26 | 2003-03-18 | Medtronic, Inc. | Implanted medical device telemetry using integrated microelectromechanical filtering |
| US6539253B2 (en) | 2000-08-26 | 2003-03-25 | Medtronic, Inc. | Implantable medical device incorporating integrated circuit notch filters |
| DE60143621D1 (de) | 2000-09-13 | 2011-01-20 | Gerät zur konditionierung von muskeln im schlaf | |
| US6895279B2 (en) | 2000-09-15 | 2005-05-17 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Method and apparatus to treat disorders of gastrointestinal peristalsis |
| US6405079B1 (en) | 2000-09-22 | 2002-06-11 | Mehdi M. Ansarinia | Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions |
| US6652095B2 (en) | 2000-11-17 | 2003-11-25 | Hsiao-Ching Tung | Orthokeratology and bi-focal contact lens |
| US20050251061A1 (en) | 2000-11-20 | 2005-11-10 | Schuler Eleanor L | Method and system to record, store and transmit waveform signals to regulate body organ function |
| JP2002159340A (ja) | 2000-11-28 | 2002-06-04 | Ya Man Ltd | 美顔装置 |
| WO2002060522A2 (en) | 2001-01-30 | 2002-08-08 | Saliwizer Itd. | System and method for electrical stimulation of salivation |
| EP1234553A1 (de) | 2001-02-14 | 2002-08-28 | Boris-Wolfgang Hochleitner | Bioartifizielles Gerät |
| JP4781576B2 (ja) | 2001-02-28 | 2011-09-28 | 株式会社ニデック | 眼内埋め込み型視覚刺激装置 |
| NO313683B1 (no) | 2001-03-21 | 2002-11-18 | Turid Bergersen | Anordning for akupressurisk behandling |
| US6701189B2 (en) | 2001-03-30 | 2004-03-02 | Neurocontrol Corporation | Systems and methods for performing prosthetic or therapeutic neuromuscular stimulation using a universal external controller accommodating different control inputs and/or different control outputs |
| EP1372780A4 (en) | 2001-03-30 | 2006-06-14 | Univ Case Western Reserve | SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING PARTS LOCATED IN THE INTERNAL HATEYER NERVE ON OR NEAR THE NERF, OR FOR SELECTIVE STIMULATION OF NERVE RAMIFICATIONS IN QUESTION TO INDUCE SPECIFIC PHYSIOLOGICAL RESPONSES |
| US7369897B2 (en) | 2001-04-19 | 2008-05-06 | Neuro And Cardiac Technologies, Llc | Method and system of remotely controlling electrical pulses provided to nerve tissue(s) by an implanted stimulator system for neuromodulation therapies |
| US6662052B1 (en) | 2001-04-19 | 2003-12-09 | Nac Technologies Inc. | Method and system for neuromodulation therapy using external stimulator with wireless communication capabilites |
| WO2002086105A1 (en) | 2001-04-20 | 2002-10-31 | Chiron Corporation | Delivery of polynucleotide agents to the central nervous sysstem |
| US6907295B2 (en) | 2001-08-31 | 2005-06-14 | Biocontrol Medical Ltd. | Electrode assembly for nerve control |
| US20050113510A1 (en) * | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| AT411150B (de) | 2001-05-25 | 2003-10-27 | Nova Technical Res Gmbh | Einrichtung zum einbringen von stoffen |
| US6537265B2 (en) | 2001-06-08 | 2003-03-25 | Health Research, Inc. | Method for nasal application of a medicinal substance |
| US6792314B2 (en) | 2001-06-18 | 2004-09-14 | Alfred E. Mann Foundation For Scientific Research | Miniature implantable array and stimulation system suitable for eyelid stimulation |
| US7054692B1 (en) | 2001-06-22 | 2006-05-30 | Advanced Bionics Corporation | Fixation device for implantable microdevices |
| US7031776B2 (en) | 2001-06-29 | 2006-04-18 | Optobionics | Methods for improving damaged retinal cell function |
| US20050004625A1 (en) | 2001-06-29 | 2005-01-06 | Chow Alan Y. | Treatment of degenerative retinal disease via electrical stimulation of surface structures |
| US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
| US7974693B2 (en) | 2001-08-31 | 2011-07-05 | Bio Control Medical (B.C.M.) Ltd. | Techniques for applying, configuring, and coordinating nerve fiber stimulation |
| US7778711B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
| US7885709B2 (en) | 2001-08-31 | 2011-02-08 | Bio Control Medical (B.C.M.) Ltd. | Nerve stimulation for treating disorders |
| US7778703B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Selective nerve fiber stimulation for treating heart conditions |
| US6792312B2 (en) | 2001-09-06 | 2004-09-14 | Medtronic, Inc. | Connector module having internal weld plates |
| US20030062050A1 (en) | 2001-10-01 | 2003-04-03 | Bruno Schmidt | Anti-snoring devices and methods |
| US6829508B2 (en) | 2001-10-19 | 2004-12-07 | Alfred E. Mann Foundation For Scientific Research | Electrically sensing and stimulating system for placement of a nerve stimulator or sensor |
| US6562036B1 (en) | 2001-12-10 | 2003-05-13 | Ellman Alan G | Electrosurgical electrode for rhinoplasty |
| JP2003210513A (ja) | 2002-01-23 | 2003-07-29 | Nidek Co Ltd | 眼科用治療装置 |
| JP3838933B2 (ja) * | 2002-03-19 | 2006-10-25 | 積水化成品工業株式会社 | 高分子ハイドロゲル電極 |
| EP1487536A4 (en) | 2002-03-27 | 2009-12-02 | Cvrx Inc | DEVICES AND METHODS FOR CARDIOVASCULAR REFLEX CONTROL OF COUPLED ELECTRODES |
| US6641799B2 (en) | 2002-04-03 | 2003-11-04 | Nos Spray, Inc. | Nasal spray for decongesting nasal passages |
| US6974533B2 (en) | 2002-04-11 | 2005-12-13 | Second Sight Medical Products, Inc. | Platinum electrode and method for manufacturing the same |
| US7645262B2 (en) | 2002-04-11 | 2010-01-12 | Second Sight Medical Products, Inc. | Biocompatible bonding method and electronics package suitable for implantation |
| US7142909B2 (en) | 2002-04-11 | 2006-11-28 | Second Sight Medical Products, Inc. | Biocompatible bonding method and electronics package suitable for implantation |
| US6604528B1 (en) | 2002-04-22 | 2003-08-12 | Lloyd P. Duncan | Acid reflux and snoring device |
| WO2004043218A2 (en) | 2002-11-14 | 2004-05-27 | Brainsgate Ltd. | Surgical tools and techniques for stimulation |
| US20060004423A1 (en) | 2002-05-09 | 2006-01-05 | Boveja Birinder R | Methods and systems to provide therapy or alleviate symptoms of chronic headache, transformed migraine, and occipital neuralgia by providing rectangular and/or complex electrical pulses to occipital nerves |
| US8204591B2 (en) | 2002-05-23 | 2012-06-19 | Bio Control Medical (B.C.M.) Ltd. | Techniques for prevention of atrial fibrillation |
| US8036745B2 (en) | 2004-06-10 | 2011-10-11 | Bio Control Medical (B.C.M.) Ltd. | Parasympathetic pacing therapy during and following a medical procedure, clinical trauma or pathology |
| WO2003101535A1 (en) | 2002-06-03 | 2003-12-11 | Med-El Elektromedizinische Geraete Gmbh | Implantable device with flexible interconnect to coil |
| US7069084B2 (en) | 2002-06-14 | 2006-06-27 | Seefit Incorporated | Method and apparatus for preventing and treating eyelid problems |
| US7860570B2 (en) | 2002-06-20 | 2010-12-28 | Boston Scientific Neuromodulation Corporation | Implantable microstimulators and methods for unidirectional propagation of action potentials |
| US20040147973A1 (en) | 2002-06-27 | 2004-07-29 | Hauser Robert G. | Intra cardiac pacer and method |
| US6904868B2 (en) | 2002-07-12 | 2005-06-14 | Robert S. Block | Interactive mobile food dispenser |
| CN1301692C (zh) | 2002-09-18 | 2007-02-28 | 阿勒根公司 | 眼植入物导入的器械 |
| US7169163B2 (en) | 2002-09-30 | 2007-01-30 | Bruce Becker | Transnasal method and catheter for lacrimal system |
| EP1551499A1 (en) | 2002-10-04 | 2005-07-13 | Microchips, Inc. | Medical device for neural stimulation and controlled drug delivery |
| US7349741B2 (en) | 2002-10-11 | 2008-03-25 | Advanced Bionics, Llc | Cochlear implant sound processor with permanently integrated replenishable power source |
| US7024241B1 (en) | 2002-12-05 | 2006-04-04 | Pacesetter, Inc. | Pacing pulse waveforms that support simultaneous intracardiac signal sensing and analysis |
| TR200202651A2 (tr) | 2002-12-12 | 2004-07-21 | Met�N�Tulgar | VücutÁdışındanÁdirekÁtedaviÁsinyaliÁtransferliÁÁbeyinÁpili |
| US7264859B2 (en) * | 2002-12-19 | 2007-09-04 | Kimberly-Clark Worldwide, Inc. | Lubricious coating for medical devices |
| US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
| US7228184B2 (en) | 2003-02-22 | 2007-06-05 | Chester Heath | Viral-inhibiting method |
| US7321795B2 (en) | 2003-03-24 | 2008-01-22 | Les Bogdanowicz | Compositions for electric stimulation of the eye |
| WO2004091453A1 (en) | 2003-04-15 | 2004-10-28 | Eyeborn (Proprietary) Limited | An orbital implant applicator |
| US20060074450A1 (en) | 2003-05-11 | 2006-04-06 | Boveja Birinder R | System for providing electrical pulses to nerve and/or muscle using an implanted stimulator |
| US7317947B2 (en) | 2003-05-16 | 2008-01-08 | Medtronic, Inc. | Headset recharger for cranially implantable medical devices |
| WO2005007234A2 (en) | 2003-07-10 | 2005-01-27 | Science Medicus, Inc. | Regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
| US7725176B2 (en) | 2003-07-10 | 2010-05-25 | Schuler Eleanor L | Method and system for regulation of endocrine and exocrine glands by means of neuro-electrical coded signals |
| JP2005052461A (ja) | 2003-08-06 | 2005-03-03 | Pop Denshi Kk | 生体への電流印加装置 |
| CN1253147C (zh) * | 2003-08-13 | 2006-04-26 | 复旦大学 | 一种超多孔水凝胶复合物,其制备方法及其在药剂学中的应用 |
| ES2243116B1 (es) | 2003-09-22 | 2007-02-01 | Josep Duran Von Arx | Estimulador nasal. |
| US7225032B2 (en) | 2003-10-02 | 2007-05-29 | Medtronic Inc. | External power source, charger and system for an implantable medical device having thermal characteristics and method therefore |
| DE10353000A1 (de) | 2003-11-13 | 2005-06-16 | Physiomed Elektromedizin Ag | Vorrichtung zur Elektrotherapie |
| AU2003296968A1 (en) | 2003-12-12 | 2005-07-14 | Richard W. Yee | Method and apparatus for preventing and treating eyelid problems |
| CA2553901C (en) | 2004-01-22 | 2015-01-20 | Rehabtronics Inc. | Method of routing electrical current to bodily tissues via implanted passive conductors |
| US8055347B2 (en) | 2005-08-19 | 2011-11-08 | Brainsgate Ltd. | Stimulation for treating brain events and other conditions |
| US20050203600A1 (en) | 2004-03-12 | 2005-09-15 | Scimed Life Systems, Inc. | Collapsible/expandable tubular electrode leads |
| US7993381B2 (en) | 2004-04-01 | 2011-08-09 | Mac Beam, Inc. | Method and apparatus for treating the body |
| US7571007B2 (en) | 2004-04-12 | 2009-08-04 | Advanced Neuromodulation Systems, Inc. | Systems and methods for use in pulse generation |
| US7654997B2 (en) * | 2004-04-21 | 2010-02-02 | Acclarent, Inc. | Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat |
| US7359751B1 (en) | 2004-05-05 | 2008-04-15 | Advanced Neuromodulation Systems, Inc. | Clinician programmer for use with trial stimulator |
| US7402175B2 (en) | 2004-05-17 | 2008-07-22 | Massachusetts Eye & Ear Infirmary | Vision prosthesis orientation |
| US7330762B2 (en) | 2004-06-07 | 2008-02-12 | Neuro And Cardiac Technologies, Llc | Method and system for providing pulsed electrical stimulation to provide therapy for erectile/sexual dysfunction, prostatitis, prostatitis pain, and chronic pelvic pain |
| US20050268472A1 (en) | 2004-06-07 | 2005-12-08 | Bourilkov Jordan T | Shaving systems |
| US20060018872A1 (en) * | 2004-06-16 | 2006-01-26 | Tew Gregory N | Poly(lactic acid) copolymer hydrogels and related methods of drug delivery |
| US20090299418A1 (en) | 2004-08-23 | 2009-12-03 | Brainsgate Ltd. | Concurrent bilateral spg modulation |
| US20090099623A1 (en) | 2004-09-13 | 2009-04-16 | Neuronix Ltd. | Systems and methods for treatment of medical conditions related to the central nervous system and for enhancing cognitive functions |
| US7641688B2 (en) | 2004-09-16 | 2010-01-05 | Evera Medical, Inc. | Tissue augmentation device |
| GB2418143B (en) | 2004-09-21 | 2010-03-17 | Can Do Corp Ltd | Apparatus for behaviour modification |
| US7247692B2 (en) * | 2004-09-30 | 2007-07-24 | Johnson & Johnson Vision Care, Inc. | Biomedical devices containing amphiphilic block copolymers |
| US7647109B2 (en) | 2004-10-20 | 2010-01-12 | Boston Scientific Scimed, Inc. | Leadless cardiac stimulation systems |
| CA2583404A1 (en) | 2004-10-20 | 2006-04-27 | Boston Scientific Limited | Leadless cardiac stimulation systems |
| US7497836B2 (en) | 2004-10-22 | 2009-03-03 | General Patent Llc | Germicidal method for treating or preventing sinusitis |
| CN101087822B (zh) * | 2004-10-28 | 2012-05-30 | 拜尔健康护理有限责任公司 | 水凝胶组合物 |
| US20060095077A1 (en) | 2004-10-29 | 2006-05-04 | Tronnes Carole A | Expandable fixation structures |
| US8489189B2 (en) | 2004-10-29 | 2013-07-16 | Medtronic, Inc. | Expandable fixation mechanism |
| ATE408432T1 (de) | 2004-11-02 | 2008-10-15 | Sydney Biotech Pty Ltd | Extraokulare vorrichtung |
| US20090264966A1 (en) | 2004-11-02 | 2009-10-22 | Pixeloptics, Inc. | Device for Inductive Charging of Implanted Electronic Devices |
| US7547447B2 (en) | 2004-11-15 | 2009-06-16 | Doheny Eye Institute | Bioartificial lacrimal gland |
| US20060107958A1 (en) | 2004-11-22 | 2006-05-25 | Sleeper Geoffrey P | Adjustable sealing nasal cannula |
| EP1671670A1 (fr) | 2004-12-14 | 2006-06-21 | STX Sprl | Appareil pour l'electro-inhibition des muscles de la face |
| US20070250119A1 (en) | 2005-01-11 | 2007-10-25 | Wicab, Inc. | Systems and methods for altering brain and body functions and for treating conditions and diseases of the same |
| US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
| US20120053648A1 (en) | 2005-02-08 | 2012-03-01 | Rolf Neher | Systems and methods for smoking cessation. |
| US20070248930A1 (en) | 2005-02-17 | 2007-10-25 | Biolux Research Ltd. | Light therapy apparatus and methods |
| US8224444B2 (en) | 2005-02-18 | 2012-07-17 | Bio Control Medical (B.C.M.) Ltd. | Intermittent electrical stimulation |
| JP4597702B2 (ja) | 2005-02-24 | 2010-12-15 | ピジョン株式会社 | 口唇閉鎖具 |
| US20070060954A1 (en) | 2005-02-25 | 2007-03-15 | Tracy Cameron | Method of using spinal cord stimulation to treat neurological disorders or conditions |
| US7555345B2 (en) | 2005-03-11 | 2009-06-30 | Medtronic, Inc. | Implantable neurostimulator device |
| US7565204B2 (en) | 2005-03-24 | 2009-07-21 | Alfred E. Mann Foundation For Scientific Research | Implantable device for controlling received power by a power receiving unit therein |
| WO2006113397A2 (en) | 2005-04-13 | 2006-10-26 | Nagi Hatoum | System and method for providing a waveform for stimulating biological tissue |
| US20060235430A1 (en) | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
| JP2008536866A (ja) | 2005-04-15 | 2008-09-11 | ボード、オブ、トラスティーズ、オブ、ミシガン、ステイト、ユニバーシティ | アミン作動性医薬組成物および方法 |
| JP2006311917A (ja) | 2005-05-09 | 2006-11-16 | Shozo Terauchi | 低周波電気刺激装置 |
| US7551958B2 (en) | 2005-05-24 | 2009-06-23 | Cardiac Pacemakers, Inc. | Safety control system for implantable neural stimulator |
| US7947076B2 (en) | 2005-06-03 | 2011-05-24 | Medtronic Xomed, Inc. | Nasal valve treatment method and apparatus |
| US20060276738A1 (en) | 2005-06-06 | 2006-12-07 | Becker Bruce B | Lacrimal drainage bypass device and method |
| US7792591B2 (en) | 2005-06-09 | 2010-09-07 | Medtronic, Inc. | Introducer for therapy delivery elements |
| US8204607B2 (en) | 2005-06-09 | 2012-06-19 | Medtronic, Inc. | Implantable medical lead |
| US8606362B2 (en) | 2005-07-08 | 2013-12-10 | Boston Scientific Neuromodulation Corporation | Current output architecture for an implantable stimulator device |
| DE102005032989A1 (de) | 2005-07-14 | 2007-01-25 | Imi Intelligent Medical Implants Ag | Extraokulares Epiretinal-Implantat |
| US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US8083787B2 (en) | 2005-07-18 | 2011-12-27 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction |
| US9962558B2 (en) | 2005-08-05 | 2018-05-08 | Gholam A. Peyman | Methods to regulate polarization and enhance function of cells |
| US20070031341A1 (en) | 2005-08-08 | 2007-02-08 | Dimauro Thomas M | Methods of delivering therapeutics to the brain |
| JP2007044323A (ja) | 2005-08-11 | 2007-02-22 | Nidek Co Ltd | 視覚再生補助装置 |
| US8005526B2 (en) | 2005-08-31 | 2011-08-23 | The Regents Of The University Of Michigan | Biologically integrated electrode devices |
| US7805202B2 (en) | 2005-09-30 | 2010-09-28 | Boston Scientific Neuromodulation Corporation | Implantable electrodes and insertion methods and tools |
| US8676324B2 (en) | 2005-11-10 | 2014-03-18 | ElectroCore, LLC | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
| US7729758B2 (en) | 2005-11-30 | 2010-06-01 | Boston Scientific Neuromodulation Corporation | Magnetically coupled microstimulators |
| US7444181B2 (en) | 2005-12-14 | 2008-10-28 | Boston Scientific Neuromodulation Corporation | Techniques for sensing and adjusting a compliance voltage in an implantable stimulator device |
| JP2009523503A (ja) | 2006-01-16 | 2009-06-25 | コンティネンス コントロール システムズ インターナショナル プロプライエタリー リミテッド | 身体機能を制御するための刺激装置 |
| EP1979023B1 (en) | 2006-01-17 | 2015-07-22 | Transcend Medical, Inc. | Glaucoma treatment device |
| US8118752B2 (en) | 2006-02-16 | 2012-02-21 | The Board Of Trustees Of The University Of Illinois | Apparatus and methods for mapping retinal function |
| WO2007098200A2 (en) | 2006-02-16 | 2007-08-30 | Imthera Medical, Inc. | An rfid-based apparatus, system, and method for therapeutic treatment of obstructive sleep apnea |
| IES20060134A2 (en) | 2006-02-23 | 2007-09-05 | Sensor Technologies And Device | Biomedical surface electrode |
| US20070219600A1 (en) | 2006-03-17 | 2007-09-20 | Michael Gertner | Devices and methods for targeted nasal phototherapy |
| US20070237797A1 (en) | 2006-03-28 | 2007-10-11 | Gholam A. Peyman | Neural Conduit Agent Dissemination |
| US20070250135A1 (en) | 2006-04-21 | 2007-10-25 | Bartz-Schmidt Karl U | Compound subretinal prostheses with extra-ocular parts and surgical technique therefore |
| US20070255333A1 (en) | 2006-04-28 | 2007-11-01 | Medtronic, Inc. | Neuromodulation therapy for perineal or dorsal branch of pudendal nerve |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| EP2024002A2 (en) | 2006-05-26 | 2009-02-18 | Bruce B. Becker | Nasolacrimal system surgical tool and method |
| US20070299462A1 (en) | 2006-06-23 | 2007-12-27 | Becker Bruce B | Nasolacrimal system irrigation and dilatation tool |
| US20070276314A1 (en) | 2006-05-26 | 2007-11-29 | Becker Bruce B | Nasolacrimal duct probing, intubating and irrigating device |
| US8231218B2 (en) * | 2006-06-15 | 2012-07-31 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
| US8311634B2 (en) | 2006-06-16 | 2012-11-13 | Second Sight Medical Products Inc. | Apparatus and method for electrical stimulation of human retina |
| US20070299420A1 (en) | 2006-06-23 | 2007-12-27 | Minu, L.L.C. | Delivery of an agent using iontophoresis |
| US8080047B2 (en) | 2006-08-01 | 2011-12-20 | Mesure Technology Co., Ltd. | Light therapy device |
| US8295529B2 (en) | 2006-08-28 | 2012-10-23 | Bcinet, Inc. | Gaming headset with integrated microphone and adapted for olfactory stimulation |
| JP2008055000A (ja) | 2006-08-31 | 2008-03-13 | Nidek Co Ltd | 視覚再生補助装置 |
| EP2064337B1 (en) | 2006-09-20 | 2012-07-18 | Genzyme Corporation | A facs-and reporter protein-based system for high throughput development of therapeutic proteins |
| EP2068710A4 (en) | 2006-09-27 | 2009-10-21 | Huntington Medical Res Inst | APPARATUS AND METHOD FOR TREATING AN OBSTRUCTIVE SLEEP APNEA |
| US20080082057A1 (en) | 2006-09-29 | 2008-04-03 | Korb Donald R | Method and apparatus for diagnosing meibomian gland dysfunction |
| US20080082131A1 (en) | 2006-10-03 | 2008-04-03 | Myriam Ivette Llanos | Facial Nerve Stimulator (FNS) |
| DE102006048819A1 (de) | 2006-10-10 | 2008-04-17 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Vorrichtung mit einem Grundkörper |
| DE202007019439U1 (de) | 2006-10-13 | 2012-09-12 | Apnex Medical, Inc. | Geräte, Systeme und Methoden zur Behandlung von obstruktiver Schalfapnoe |
| ES2559058T3 (es) | 2006-10-18 | 2016-02-10 | Boston Scientific Neuromodulation Corp. | Dispositivo estimulador implantable de múltiples electrodos con un condensador único de desacoplamiento de trayectoria de corriente |
| US10856904B2 (en) | 2006-11-30 | 2020-12-08 | Medtronic, Inc. | Flexible introducer |
| DK2124856T3 (en) | 2007-01-09 | 2019-02-11 | Fovea Pharmaceuticals | DEVICE FOR INTRAOCULAR INJECTION |
| DE102007002783A1 (de) * | 2007-01-18 | 2008-08-07 | Bayer Materialscience Ag | Hydrogele aus hydrophilen Polyurethan(meth)acrylaten |
| AR064985A1 (es) | 2007-01-22 | 2009-05-06 | E Vision Llc | Lente electroactivo flexible |
| US20080183242A1 (en) | 2007-01-29 | 2008-07-31 | Nidek Co., Ltd. | Electrical stimulation method for vision improvement |
| JP4970069B2 (ja) | 2007-01-30 | 2012-07-04 | 株式会社ニデック | 視覚再生補助装置 |
| US8755896B2 (en) | 2007-02-05 | 2014-06-17 | University Of Southern California | Treatment of consumption disorders with biostimulation |
| WO2008101225A2 (en) | 2007-02-16 | 2008-08-21 | Second Sight Medical Products, Inc. | Flexible circuit electrode array with wire or film support |
| RU2338492C1 (ru) | 2007-02-21 | 2008-11-20 | Андрей Анатольевич Бессонов | Способ лечения недостаточности слезопродукции при синдроме сухости глаза |
| US7949403B2 (en) | 2007-02-27 | 2011-05-24 | Accelerated Care Plus Corp. | Electrical stimulation device and method for the treatment of neurological disorders |
| GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
| US20080269648A1 (en) | 2007-04-30 | 2008-10-30 | Ultra License Holdings, Inc. | Method for increasing saliva and tear production with ultrasound |
| US8251983B2 (en) | 2007-05-14 | 2012-08-28 | The Regents Of The University Of Colorado, A Body Corporate | Laser tissue fusion of septal membranes |
| SE531172C2 (sv) | 2007-05-16 | 2009-01-13 | Rhinomed Ab | Vibrationsanordning avsedd att användas i kroppskaviteter, företrädesvis i näshålan |
| US8032222B2 (en) * | 2007-06-19 | 2011-10-04 | Loushin Michael K H | Device for electrically and mechanically stimulating a compartment in a body |
| US7758190B2 (en) | 2007-06-20 | 2010-07-20 | Tearscience, Inc. | Tear film measurement |
| US7676276B2 (en) | 2007-07-02 | 2010-03-09 | Manuel L Karell | Stimulator combined with an intranasal respiratory method and device for improved breathing |
| US8145322B1 (en) | 2007-07-19 | 2012-03-27 | Second Sight Medical Products, Inc. | Flexible circuit electrode array device and a method for backside processing of a flexible circuit electrode device |
| EP3088045B1 (en) | 2007-07-20 | 2019-06-19 | Boston Scientific Neuromodulation Corporation | Use of stimulation pulse shape to control neural recruitment order and clinical effect |
| US9592377B2 (en) | 2007-07-27 | 2017-03-14 | Second Sight Medical Products, Inc. | Implantable device for the brain |
| US8805510B2 (en) | 2007-08-02 | 2014-08-12 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade |
| US8088120B2 (en) | 2007-09-05 | 2012-01-03 | Maya Worsoff | Method and apparatus for alleviating nasal congestion |
| US9011361B2 (en) | 2007-09-07 | 2015-04-21 | Mati Therapeutics Inc. | Lacrimal implant detection |
| US8315689B2 (en) | 2007-09-24 | 2012-11-20 | MRI Interventions, Inc. | MRI surgical systems for real-time visualizations using MRI image data and predefined data of surgical tools |
| US8019419B1 (en) | 2007-09-25 | 2011-09-13 | Dorin Panescu | Methods and apparatus for leadless, battery-less, wireless stimulation of tissue |
| US8357767B2 (en) * | 2007-10-03 | 2013-01-22 | Polynovo Biomaterials Limited | High modulus polyurethane and polyurethane/urea compositions |
| EP2197536A1 (en) | 2007-10-09 | 2010-06-23 | Imthera Medical, Inc. | System and method for neural stimulation |
| US7873421B2 (en) | 2007-10-23 | 2011-01-18 | Manuel L Karell | Nasal dilator adapted to provide electrical stimulation |
| US20090157145A1 (en) | 2007-11-26 | 2009-06-18 | Lawrence Cauller | Transfer Coil Architecture |
| DE112008003184T5 (de) | 2007-11-26 | 2011-01-05 | MicroTransponder, Inc., DALLAS | Impulsstimulationssysteme und -verfahren für implantierbare Transponder |
| US8457757B2 (en) | 2007-11-26 | 2013-06-04 | Micro Transponder, Inc. | Implantable transponder systems and methods |
| GB2456002A (en) * | 2007-12-31 | 2009-07-01 | William M Hung | A method for the manufacture of silicone hydrogel contact lenses in which filler material is introduced, the lens formed and the filler extracted. |
| US8165694B2 (en) | 2008-01-29 | 2012-04-24 | Boston Scientific Neuromodulation Corporation | Thermal management of implantable medical devices |
| USD614303S1 (en) | 2008-02-06 | 2010-04-20 | Tearscience, Inc. | Eye treatment apparatus |
| USD613408S1 (en) | 2008-02-06 | 2010-04-06 | Tearscience, Inc. | Eye treatment head gear |
| USD617443S1 (en) | 2008-02-06 | 2010-06-08 | Tearscience, Inc. | Eye treatment goggles |
| EP2259843B1 (en) | 2008-03-20 | 2012-08-29 | IMI Intelligent Medical Implants AG | Power supply for a retina implant |
| US7832355B2 (en) | 2008-04-01 | 2010-11-16 | Frances Kay Mills | Animal feeder |
| US8543211B2 (en) | 2008-04-10 | 2013-09-24 | ElectroCore, LLC | Methods and apparatus for deep brain stimulation |
| US7846124B2 (en) | 2008-05-07 | 2010-12-07 | Becker Bruce B | Punctal anchor for lacrimal stent, introducer tool and method |
| EP2318091B1 (en) | 2008-05-09 | 2016-09-14 | Medtronic, Inc. | Peripheral nerve field stimulation control |
| US8855777B2 (en) | 2008-05-09 | 2014-10-07 | Medtronic, Inc. | Programming techniques for peripheral nerve field stimulation |
| WO2009142743A1 (en) * | 2008-05-20 | 2009-11-26 | Cantimer, Inc. | Methods, systems and devices for analyzing a surfactant-treated biological fluid sample |
| DE102008002228A1 (de) | 2008-06-05 | 2009-12-10 | Biotronik Crm Patent Ag | Langgestrecktes Implantat mit externer Energieeinkopplung |
| ITRM20080309A1 (it) | 2008-06-12 | 2009-12-13 | Massimo Filippello | Metodo di trattamento oculare per la prevenzione della presbiopia e del glaucoma e mezzi per effettuare tale trattamento |
| US8626306B2 (en) | 2008-06-12 | 2014-01-07 | Second Sight Medical Products, Inc. | Visual prosthesis for control of spatiotemporal interactions |
| NL2001698C2 (en) | 2008-06-18 | 2009-12-22 | Nasophlex B V | Cardioverter / defibrillator. |
| NL2001697C2 (en) | 2008-06-18 | 2009-12-22 | Nasophlex B V | Nose stimulator for producing a stimulation signal to a nose. |
| WO2010003011A1 (en) | 2008-07-01 | 2010-01-07 | Bruce Becker | Retrobulbar needle and methods of use |
| CA2730101A1 (en) | 2008-07-08 | 2010-01-14 | Qlt Plug Delivery, Inc. | Lacrimal implant body including comforting agent |
| WO2010027743A1 (en) | 2008-08-25 | 2010-03-11 | Alpha Synergy Development, Inc. | Pharmaceutical compositions and methods for the treatment of dry eye |
| JP2010051562A (ja) | 2008-08-28 | 2010-03-11 | Tohoku Univ | 生体の深部刺激方法及び生体深部の刺激装置 |
| JP2012502763A (ja) | 2008-09-19 | 2012-02-02 | アヴェドロ・インコーポレーテッド | 眼療法システム |
| JP2012504472A (ja) | 2008-10-01 | 2012-02-23 | アヴェドロ・インコーポレーテッド | 眼治療システム |
| AU2009308359B2 (en) | 2008-10-22 | 2014-11-13 | Advanced Neuromodulation Systems, Inc. | Method for processing electrodes for stimulation lead |
| US8448273B2 (en) | 2008-10-29 | 2013-05-28 | Smartsilk Corporation Inc. | Pillow and cover for a pillow |
| US20100114273A1 (en) * | 2008-10-30 | 2010-05-06 | Philip Edward Muccio | Electrode for functional electrical stimulation |
| WO2010065960A2 (en) * | 2008-12-05 | 2010-06-10 | Semprus Biosciences Corp. | Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions |
| WO2010077980A1 (en) | 2008-12-16 | 2010-07-08 | Aardvark Medical, Inc. | Methods and systems for delivery of fluids, aerosols and acoustic energy to tissue surfaces, cavities and obstructed passages such as intranasal ostia |
| USD614774S1 (en) | 2008-12-18 | 2010-04-27 | Tearscience, Inc. | Ocular imaging apparatus |
| WO2010069317A1 (en) | 2008-12-19 | 2010-06-24 | Neurodan A/S | Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation |
| US20100161004A1 (en) | 2008-12-22 | 2010-06-24 | Integrated Sensing Systems, Inc. | Wireless dynamic power control of an implantable sensing device and methods therefor |
| US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
| US8235932B2 (en) | 2009-01-09 | 2012-08-07 | Becker Bruce B | Side-by-side lacrimal intubation threader and method |
| US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
| US9233254B2 (en) | 2009-02-17 | 2016-01-12 | Boston Scientific Neuromodulation Corporation | Selectable boost converter and charge pump for compliance voltage generation in an implantable stimulator device |
| WO2010099818A1 (en) | 2009-03-03 | 2010-09-10 | Ao Technology Ag | Thermoreversible polysaccharide hydrogel |
| CN101503491B (zh) * | 2009-03-10 | 2011-11-30 | 海昌隐形眼镜有限公司 | 一种高透氧氟硅氧烷水凝胶接触镜材料及其制备方法 |
| US20100280509A1 (en) | 2009-04-02 | 2010-11-04 | Avedro, Inc. | Eye Therapy System |
| WO2010123704A2 (en) | 2009-04-24 | 2010-10-28 | Medtronic, Inc. | Incontinence therapy |
| WO2010141831A1 (en) | 2009-06-05 | 2010-12-09 | Aciex Therapeutics, Inc. | Ophthalmic formulations, methods of manufacture, and methods of using same |
| US20100318159A1 (en) | 2009-06-12 | 2010-12-16 | Boston Scientific Neuromodulation Corporation | Miniature remote controller for implantable medical device |
| CA2768849A1 (en) | 2009-07-21 | 2011-01-27 | Leonard V. Covello | Devices and methods for minimally invasive access to sinuses and treatment of sinusitis |
| JP5578540B2 (ja) | 2009-07-31 | 2014-08-27 | 株式会社ニデック | 視覚再生補助装置及び視覚再生補助装置の製造方法 |
| US8283890B2 (en) | 2009-09-25 | 2012-10-09 | Bard Peripheral Vascular, Inc. | Charging station for battery powered biopsy apparatus |
| AU2009222439B2 (en) | 2009-09-28 | 2011-07-21 | Cochlear Limited | Method and circuitry for measurement and control of stimulation current |
| WO2011044179A1 (en) | 2009-10-05 | 2011-04-14 | The Regents Of The University Of California | Extracranial implantable devices, systems and methods for the treatment of neuropsychiatric disorders |
| USD638128S1 (en) | 2009-10-06 | 2011-05-17 | Tearscience, Inc. | Ocular device design |
| US8571677B2 (en) | 2009-10-21 | 2013-10-29 | Medtronic, Inc. | Programming techniques for stimulation with utilization of case electrode |
| IL202462A0 (en) | 2009-12-02 | 2010-06-30 | Feldman Joseph | Device for treatment of rhinitis by biostimulative illumination |
| US8622993B2 (en) | 2009-12-18 | 2014-01-07 | Healthpartners Research Foundation | Device and method for delivering therapeutic substances to the maxillary sinus of a patient |
| US8620442B2 (en) | 2010-01-27 | 2013-12-31 | Second Sight Medical Products, Inc. | Multi-electrode integration in a visual prosthesis |
| US20110202121A1 (en) | 2010-02-16 | 2011-08-18 | Shin-Heng Wen | Electrical nerve stimulator |
| US20120315329A1 (en) * | 2010-02-18 | 2012-12-13 | Dow Corning Corporation | Siloxane surface-modified hydrogel and hydrogel microparticle compositions |
| US8447404B2 (en) | 2010-03-05 | 2013-05-21 | Endostim, Inc. | Device and implantation system for electrical stimulation of biological systems |
| TWM389271U (en) | 2010-03-23 | 2010-09-21 | Guo-Ren Ye | Healthcare eyeglasses |
| US8364272B2 (en) | 2010-04-30 | 2013-01-29 | Medtronic, Inc. | Brain stimulation programming |
| EP2563464B1 (en) | 2010-04-30 | 2018-06-06 | Second Sight Medical Products, Inc. | Improved biocompatible bonding method |
| US9522980B2 (en) * | 2010-05-06 | 2016-12-20 | Johnson & Johnson Vision Care, Inc. | Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same |
| US8968783B2 (en) * | 2010-05-27 | 2015-03-03 | Covidien Lp | Hydrogel implants with varying degrees of crosslinking |
| AP2012006639A0 (en) | 2010-06-04 | 2012-12-31 | Us Gov Ct Disease Contr & Prev | Nasal aerosol delivery system |
| US8942819B2 (en) | 2010-06-16 | 2015-01-27 | Cardiac Pacemakers, Inc. | Automatic neural stimulation titration sweep |
| EP2591023A2 (en) * | 2010-07-05 | 2013-05-15 | Reluceo Inc. | Degradable superabsorbent polymers |
| JP5776165B2 (ja) | 2010-11-05 | 2015-09-09 | 株式会社ニデック | 生体組織用刺激回路 |
| JP2012115545A (ja) | 2010-12-02 | 2012-06-21 | Nidek Co Ltd | 生体組織用刺激回路 |
| US9937355B2 (en) | 2010-11-08 | 2018-04-10 | Zoll Medical Corporation | Remote medical device alarm |
| US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
| WO2012068247A1 (en) * | 2010-11-16 | 2012-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for treatment of dry eye |
| WO2012075192A2 (en) | 2010-11-30 | 2012-06-07 | The Regents Of The University Of California | Pulse generator for cranial nerve stimulation |
| US20120133887A1 (en) | 2010-11-30 | 2012-05-31 | Optovue, Inc. | Tear film and tear meniscus dynamics with time-lapse optical coherence tomography |
| US20110081333A1 (en) | 2010-12-10 | 2011-04-07 | Shantha Totada R | Apparatus and system for treatment and prevention of bags under eyes |
| US8706233B2 (en) | 2011-01-28 | 2014-04-22 | Medtronic, Inc. | Stimulation therapy including substantially simultaneous bilateral stimulation |
| US20120232615A1 (en) | 2011-03-07 | 2012-09-13 | Giancarlo Barolat | Modular Limb Peripheral Nerve Stimulation System and Method of Use |
| US8644921B2 (en) | 2011-03-28 | 2014-02-04 | Neurostream Technologies G. P. | Neuromodulation system and method for treating apnea |
| JP5419174B2 (ja) | 2011-03-28 | 2014-02-19 | 国立大学法人 新潟大学 | 嚥下誘発装置 |
| DK3357533T3 (da) | 2011-05-13 | 2021-11-15 | Saluda Medical Pty Ltd | Apparat til kontrol af en neural stimulus |
| US8944052B2 (en) | 2011-05-26 | 2015-02-03 | Ivan Osorio | Apparatus and methods for delivery of therapeutic agents to mucous or serous membrane |
| US20120316557A1 (en) | 2011-06-08 | 2012-12-13 | Tyco Healthcare Group Lp | Septoplasty Instrument |
| WO2012174161A1 (en) | 2011-06-14 | 2012-12-20 | Aerin Medical, Inc. | Devices for treating nasal airways |
| US8986301B2 (en) | 2012-06-13 | 2015-03-24 | Aerin Medical Inc. | Methods and devices to treat nasal airways |
| US20120330376A1 (en) | 2011-06-27 | 2012-12-27 | Equine OrthoCare, LLC | Systems and methods for making and using electrical stimulation systems for providing therapy to large animals |
| MX348560B (es) | 2011-08-26 | 2017-06-20 | Scerbo Louis | Aparato para el rejuvenecimiento facial. |
| US8965511B2 (en) | 2011-08-30 | 2015-02-24 | Valencia Technologies Corporation | Implantable electroacupuncture system and method for reducing hypertension |
| US8996125B2 (en) | 2011-09-23 | 2015-03-31 | Valencia Technologies Corporation | Implantable electroacupuncture system and method for treating cardiovascular disease |
| US9173811B2 (en) | 2011-09-29 | 2015-11-03 | Valencia Technologies Corporation | Implantable electroacupuncture system and method for treating depression and similar mental conditions |
| CN106955417B (zh) | 2011-10-11 | 2021-08-20 | 杜克大学 | 医疗刺激系统 |
| US9486381B2 (en) | 2011-12-16 | 2016-11-08 | Chordate Medical Ab | ALS treatment |
| USD681839S1 (en) | 2011-12-16 | 2013-05-07 | Micromode Medical Limited | Electrostimulation device |
| US9724230B2 (en) | 2012-01-04 | 2017-08-08 | Sight Sciences, Inc. | Dry eye treatment apparatus and methods |
| US9549966B2 (en) | 2012-02-21 | 2017-01-24 | Massachusetts Eye & Ear Infirmary | Inflammatory eye disorders |
| US9314399B2 (en) | 2012-03-06 | 2016-04-19 | Valencia Technologies Corporation | Implantable electroacupuncture system and method for treating dyslipidemia and obesity |
| US20130253387A1 (en) | 2012-03-08 | 2013-09-26 | Sonitec, LLC | Vibratory energy systems and methods for occluded body cavities |
| US20130261706A1 (en) | 2012-03-30 | 2013-10-03 | Neuropace, Inc. | Systems and methods for applying rapid sequential electrode stimulation |
| US9623247B2 (en) | 2012-04-17 | 2017-04-18 | The Ohio State University | Neuromodulatory method for treating chronic or refractory rhinitis |
| EP2844335A1 (en) | 2012-04-17 | 2015-03-11 | The Ohio State University | Neuromodulatory method for treating chronic rhinosinusitis |
| JP5927014B2 (ja) * | 2012-04-18 | 2016-05-25 | Hoya株式会社 | 湿潤性表面を有するシリコーンハイドロゲルソフトコンタクトレンズ |
| JP6070828B2 (ja) | 2012-04-27 | 2017-02-01 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 埋込可能刺激デバイスでパルスを生成するためのタイミングチャネル回路 |
| WO2013165697A1 (en) | 2012-04-30 | 2013-11-07 | Vigilant Medical Solutions, Inc. | Indirect and non-invasive trigeminal neuromodulation for the treatment of disease |
| WO2013166353A1 (en) | 2012-05-04 | 2013-11-07 | Alcon Research, Ltd. | Method for diagnosing dry eye and meibomian gland disease using meibomian secretions |
| US9700721B2 (en) | 2012-05-14 | 2017-07-11 | Autonomic Technologies, Inc. | Stimulation method for treatment of ocular conditions |
| US20120323214A1 (en) | 2012-05-16 | 2012-12-20 | Totada R Shantha | Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis |
| US10232184B2 (en) | 2012-05-18 | 2019-03-19 | The Guy P. Curtis And Frances L. Curtis Trust | Extracorporeal unit for inspecting the insulation of an electrical wire of an implanted medical device |
| US20120234332A1 (en) | 2012-06-01 | 2012-09-20 | Shantha Totada R | Snoring and obstructive sleep apnea prevention and treatment device |
| US9968297B2 (en) | 2012-06-14 | 2018-05-15 | Medibotics Llc | EEG glasses (electroencephalographic eyewear) |
| WO2014153218A1 (en) | 2013-03-14 | 2014-09-25 | Tyler Perryman Laura | Devices and methods for treating craniofacial pain |
| US9226818B2 (en) | 2012-11-30 | 2016-01-05 | Novartis Ag | Sensors for triggering electro-active ophthalmic lenses |
| US9826963B2 (en) | 2012-12-07 | 2017-11-28 | Medtronic, Inc. | Minimally invasive implantable neurostimulation system |
| US9174049B2 (en) | 2013-01-27 | 2015-11-03 | ElectroCore, LLC | Systems and methods for electrical stimulation of sphenopalatine ganglion and other branches of cranial nerves |
| US10238534B2 (en) | 2013-03-07 | 2019-03-26 | Novartis Ag | Systems and processes for eye moisturizing during ocular surgery |
| US9265956B2 (en) | 2013-03-08 | 2016-02-23 | Oculeve, Inc. | Devices and methods for treating dry eye in animals |
| EP2967817B1 (en) | 2013-03-12 | 2021-03-10 | Oculeve, Inc. | Implant delivery devices and systems |
| NZ704579A (en) | 2013-04-19 | 2018-10-26 | Oculeve Inc | Nasal stimulation devices and methods |
| US20140371565A1 (en) | 2013-06-14 | 2014-12-18 | University Of Houston System | Accommodation stimulation and recording device |
| CN103467652B (zh) * | 2013-09-03 | 2015-08-26 | 东南大学 | 一种水凝胶接触镜及其制备方法 |
| WO2015130707A2 (en) | 2014-02-25 | 2015-09-03 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
| AU358535S (en) | 2014-04-18 | 2014-11-03 | Oculeve | Nasal stimulator device |
| US10317702B2 (en) | 2014-06-13 | 2019-06-11 | Verily Life Sciences Llc | Failsafe operation of eye-mountable device |
| CA2956176A1 (en) | 2014-07-25 | 2016-01-28 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
| CA3297330A1 (en) | 2014-08-10 | 2026-03-02 | Autonomix Medical, Inc. | Ans assessment systems, kits, and methods |
| US10201451B2 (en) | 2014-08-29 | 2019-02-12 | Camras Vision Inc. | Device and method for reducing intraocular pressure |
| US9699436B2 (en) | 2014-09-16 | 2017-07-04 | Microsoft Technology Licensing, Llc | Display with eye-discomfort reduction |
| EP3209370A4 (en) | 2014-10-22 | 2018-05-30 | Oculeve, Inc. | Contact lens for increasing tear production |
| WO2016065213A1 (en) | 2014-10-22 | 2016-04-28 | Oculeve, Inc. | Implantable nasal stimulator systems and methods |
| RU2707167C2 (ru) | 2014-10-22 | 2019-11-22 | Окулив, Инк. | Устройства для стимуляции и способы лечения болезни "сухого глаза" |
| NZ773822A (en) | 2015-03-16 | 2022-07-29 | Magic Leap Inc | Methods and systems for diagnosing and treating health ailments |
| WO2016205107A1 (en) | 2015-06-16 | 2016-12-22 | The Regents Of The University Of Colorado, A Body Corporate | Nasolacrimal implants and related methods for tear stimulation |
| US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
| US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
| CA3022683A1 (en) | 2016-05-02 | 2017-11-09 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
| EP3547896A4 (en) | 2016-12-01 | 2020-08-19 | Oculeve, Inc. | EXTRANASAL STIMULATION DEVICES AND METHODS |
| KR20190124698A (ko) | 2016-12-02 | 2019-11-05 | 오큘레브, 인크. | 건성안 예측 및 치료 권고를 위한 장치 및 방법 |
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- 2018-02-23 US US15/904,036 patent/US10799696B2/en active Active
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- 2019-10-15 JP JP2019188335A patent/JP2020022785A/ja not_active Ceased
-
2020
- 2020-09-11 US US17/018,888 patent/US20210069496A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5498681A (en) * | 1993-01-28 | 1996-03-12 | Pilkington Barnes Hind, Inc. | Material for use in the manufacture of polymeric articles |
| US5800685A (en) * | 1996-10-28 | 1998-09-01 | Cardiotronics Systems, Inc. | Electrically conductive adhesive hydrogels |
| US20050137276A1 (en) * | 2003-12-18 | 2005-06-23 | Kimberly-Clark Worldwide, Inc. | Electrically conductive adhesive hydrogels with solubilizer |
| WO2012139063A2 (en) * | 2011-04-07 | 2012-10-11 | Oculeve, Inc. | Stimulation devices and methods |
| US20130270491A1 (en) * | 2012-04-17 | 2013-10-17 | Ik-Ro PARK | Conductive hydrogel and method of preparing the same |
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| EP3110405B1 (en) | 2020-05-06 |
| CN106470673A (zh) | 2017-03-01 |
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