RU2416618C2 - Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты - Google Patents

Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты Download PDF

Info

Publication number
RU2416618C2
RU2416618C2 RU2008138569/10A RU2008138569A RU2416618C2 RU 2416618 C2 RU2416618 C2 RU 2416618C2 RU 2008138569/10 A RU2008138569/10 A RU 2008138569/10A RU 2008138569 A RU2008138569 A RU 2008138569A RU 2416618 C2 RU2416618 C2 RU 2416618C2
Authority
RU
Russia
Prior art keywords
ghrelin
ghs
compounds
growth hormone
peptide
Prior art date
Application number
RU2008138569/10A
Other languages
English (en)
Russian (ru)
Other versions
RU2008138569A (ru
Inventor
ФЕРНАНДЕС Роландо Эдуардо РОДРИГЕС (CU)
ФЕРНАНДЕС Роландо Эдуардо РОДРИГЕС
ЛА НУЕС ВЕУЛЕНС Ания ДЕ (CU)
ЛА НУЕС ВЕУЛЕНС Ания ДЕ
ГАРСИЯ Марио Пабло ЭСТРАДА (CU)
Гарсия Марио Пабло Эстрада
РОДРИГЕС Ребека МАРТИНЕС (CU)
Родригес Ребека Мартинес
САНТЬЯГО Глай ЧИНЕА (CU)
САНТЬЯГО Глай ЧИНЕА
АКОСТА Освальдо РЕЙЕС (CU)
АКОСТА Освальдо РЕЙЕС
МАССО Хулио Рауль ФЕРНАНДЕС (CU)
Массо Хулио Рауль Фернандес
ДЕЛЬ БАРКО ЭРРЕРА Диана ГАРСИЯ (CU)
Дель Барко Эррера Диана Гарсия
АКОСТА Хорхе Амадор БЕРЛАНГА (CU)
АКОСТА Хорхе Амадор БЕРЛАНГА
ЛАСА Алексис МУСАКЧИО (CU)
ЛАСА Алексис МУСАКЧИО
Original Assignee
Сентро Де Инхеньерия Хенетика И Биотекнолохия
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40130780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2416618(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Сентро Де Инхеньерия Хенетика И Биотекнолохия filed Critical Сентро Де Инхеньерия Хенетика И Биотекнолохия
Publication of RU2008138569A publication Critical patent/RU2008138569A/ru
Application granted granted Critical
Publication of RU2416618C2 publication Critical patent/RU2416618C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Peptides Or Proteins (AREA)
RU2008138569/10A 2006-02-28 2007-02-28 Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты RU2416618C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CU2006-0050 2006-02-28

Publications (2)

Publication Number Publication Date
RU2008138569A RU2008138569A (ru) 2010-04-10
RU2416618C2 true RU2416618C2 (ru) 2011-04-20

Family

ID=40130780

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008138569/10A RU2416618C2 (ru) 2006-02-28 2007-02-28 Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты

Country Status (18)

Country Link
US (1) US8367620B2 (cg-RX-API-DMAC7.html)
EP (1) EP1997827B1 (cg-RX-API-DMAC7.html)
JP (1) JP5183496B2 (cg-RX-API-DMAC7.html)
KR (1) KR101409277B1 (cg-RX-API-DMAC7.html)
CN (1) CN101432294B (cg-RX-API-DMAC7.html)
AR (1) AR059646A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007219569B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0708366A2 (cg-RX-API-DMAC7.html)
CA (1) CA2637593C (cg-RX-API-DMAC7.html)
CL (2) CL2007000528A1 (cg-RX-API-DMAC7.html)
CU (1) CU23558A1 (cg-RX-API-DMAC7.html)
ES (1) ES2441441T3 (cg-RX-API-DMAC7.html)
MX (1) MX2008011142A (cg-RX-API-DMAC7.html)
MY (1) MY184130A (cg-RX-API-DMAC7.html)
NO (1) NO20084118L (cg-RX-API-DMAC7.html)
RU (1) RU2416618C2 (cg-RX-API-DMAC7.html)
WO (1) WO2007098716A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200807162B (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2734835C1 (ru) * 2020-02-11 2020-10-23 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) Способ повышения жизнестойкости эмбрионов рыб в аквакультуре
RU2768134C2 (ru) * 2016-11-01 2022-03-23 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение пептида, усиливающего секрецию соматотропного гормона, в качестве адъюванта вакцины
RU2779835C1 (ru) * 2018-08-21 2022-09-13 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение ghrp-6 в качестве кардиозащитного и кардиовосстанавливающего лекарственного средства для позднего лечения

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4831551B2 (ja) * 2008-11-06 2011-12-07 国立大学法人名古屋大学 非虚血性心筋障害に対する医薬

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849597B2 (en) * 1999-12-28 2005-02-01 Kaken Pharmaceutical Co., Ltd. Neuroprotective drug
US6939880B2 (en) * 1995-12-22 2005-09-06 Novo Nordisk A/S Compounds with growth hormone releasing properties

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239345A (en) 1965-02-15 1966-03-08 Estrogenic compounds and animal growth promoters
US4411890A (en) 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4036979A (en) 1974-01-25 1977-07-19 American Cyanamid Company Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate
JPH03502326A (ja) 1988-01-28 1991-05-30 ポリゲン　ホールディング　コーポレイション 成長ホルモン放出活性を有するポリペプチド化合物類
ATE122357T1 (de) 1988-01-28 1995-05-15 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
WO1992007578A1 (en) 1990-10-25 1992-05-14 Genentech, Inc. Use of protective agents against reactive oxygen species
US5663146A (en) 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
JPH08503213A (ja) 1992-11-06 1996-04-09 メルク エンド カンパニー インコーポレーテッド 成長ホルモンの放出を促進する置換ジペプチド同族体
US5726319A (en) 1992-11-06 1998-03-10 Merck & Co., Inc. Biphenyl substituted dipeptide analogs promote release of growth hormone
US5536716A (en) 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
CZ151495A3 (en) 1992-12-11 1995-12-13 Merck & Co Inc Spiropiperidine derivatives, process of their preparation and a pharmaceutical composition containing thereof
EP0813414A4 (en) 1993-10-19 1999-07-21 Merck & Co Inc Combination of bisphosphonates and growth hormone secretagogues
US5494919A (en) 1993-11-09 1996-02-27 Merck & Co., Inc. 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US5492916A (en) 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
PL322706A1 (en) 1993-11-09 1998-02-16 Merck & Co Inc Piperidines, pyrolidines and hexahydro-1h-azepins enhancing growth hormone liberation
WO1995014666A1 (en) 1993-11-24 1995-06-01 Merck & Co., Inc. Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)
US5721251A (en) 1993-12-10 1998-02-24 Merck & Co., Inc. Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
US5721250A (en) 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
HU221092B1 (en) 1993-12-23 2002-08-28 Novo Nordisk As Compounds with growth hormone releasing properties
PT736039E (pt) 1993-12-23 2001-04-30 Novo Nordisk As Compostos com propriedades para liberar a hormona de crescimento
US5777112A (en) 1994-06-13 1998-07-07 Merck & Co., Inc Piperazine compounds promote release of growth hormone
WO1996002530A1 (en) 1994-07-20 1996-02-01 Merck & Co., Inc. Piperidines and hexahydro-1h-azepines spiro substituted at the 4-position promote release of growth hormone
US5798337A (en) 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
AU4495996A (en) 1995-01-25 1996-08-14 Nippon Chemiphar Co. Ltd. Dihydrophenazine derivatives
DE69633003T2 (de) 1995-01-27 2005-08-18 Novo Nordisk A/S Verbindungen mit wachstumshormon-freisetzenden eigenschaften
AU4534596A (en) 1995-02-09 1996-08-27 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1996024587A1 (en) 1995-02-09 1996-08-15 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5559128A (en) 1995-04-18 1996-09-24 Merck & Co., Inc. 3-substituted piperidines promote release of growth hormone
AU5486396A (en) 1995-04-19 1996-11-07 Merck & Co., Inc. Process for the preparation of spiroindolines
WO1996035713A1 (en) 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
ATE288444T1 (de) 1995-05-29 2005-02-15 Pfizer Dipeptide, die die ausschüttung von wachstumshormonen stimulieren
BR9608909A (pt) 1995-06-22 1999-03-02 Novo Nordisk As Composto composição farmacêutica processos para estimular a liberação do hormônio do crescimento da patuitária e aumentar a velocidade e extensão do crescimento dos animais para aumentar a produção de leite ou lã de animais ou para para doenças e uso do composto
CA2203424A1 (en) 1995-08-21 1997-02-27 Eli Lilly And Company 2-acylaminopropanamines as growth hormone secretagogues
EP0761220A1 (en) 1995-08-21 1997-03-12 Eli Lilly And Company 2-Acylaminopropanamides as growth hormone secretagogues
EP0766966A3 (en) 1995-09-08 2001-02-28 Eli Lilly And Company Method of treating insulin resistance
WO1997011697A1 (en) 1995-09-26 1997-04-03 Merck & Co., Inc. 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone
JPH11513989A (ja) 1995-10-27 1999-11-30 メルク エンド カンパニー インコーポレーテッド 成長ホルモン分泌促進薬の湿式造粒製剤
US5723616A (en) 1995-10-27 1998-03-03 Merck & Co., Inc. Process for the preparation of a growth hormone secretagogue
US5767124A (en) 1995-10-27 1998-06-16 Merck & Co., Inc. Polymorphic forms of a growth hormone secretagogue
KR19990067097A (ko) 1995-10-27 1999-08-16 폴락 돈나 엘. 성장 호르몬 분비 촉진제의 제조 방법
ES2268713T3 (es) 1995-12-13 2007-03-16 MERCK & CO., INC. Ensayos de receptores de secretagogos de la hormona de crecimiento.
ATE279440T1 (de) 1995-12-13 2004-10-15 Merck & Co Inc Wachstumshormonsekretionsförderer rezeptorfamilie
IT1277113B1 (it) 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
WO1997022367A1 (en) 1995-12-20 1997-06-26 Merck & Co., Inc. Radiolabeled growth hormone secretagogue
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
AU2334097A (en) 1996-03-21 1997-10-10 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
WO1997036873A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
SE9601397D0 (sv) 1996-04-12 1996-04-12 Pharmacia Ab Use of growth hormone
WO1997040071A1 (en) 1996-04-19 1997-10-30 Novo Nordisk A/S Compounds with growth hormone releasing properties
EP0907643B1 (en) 1996-04-24 2003-01-15 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5919777A (en) 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
CA2253390A1 (en) 1996-05-07 1997-11-13 Merck & Co., Inc. Enhancement of sleep with a growth hormone secretagogue
AU2931997A (en) 1996-05-07 1997-11-26 Merck & Co., Inc. Treatment of mood disorders with a growth hormone secretagogue
WO1997043278A1 (en) 1996-05-14 1997-11-20 Novo Nordisk A/S Somatostatin agonists and antagonists
US6071926A (en) 1996-05-22 2000-06-06 Arch Development Corporation Sleep quality improvement using a growth hormone secretagogue
PL330239A1 (en) 1996-05-31 1999-05-10 Novo Nordisk As Growt hormone constituent and bone reserption preventing factor in cyclic (coherent) treatment
AU3434697A (en) 1996-07-22 1998-02-10 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU4342097A (en) 1996-09-13 1998-04-02 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
AU4993497A (en) 1996-10-25 1998-05-22 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
SE9703929D0 (sv) 1996-11-22 1997-10-28 Pharmacia & Upjohn Ab Therapeutical use and method
AU6747498A (en) 1997-04-11 1998-11-11 Sumitomo Pharmaceuticals Company, Limited Benzene derivatives
JP2000514838A (ja) 1997-05-14 2000-11-07 藤沢薬品工業株式会社 成長ホルモンの放出を促進するピペリジノ誘導体
US5861149A (en) 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
EP1005484A1 (en) 1997-06-20 2000-06-07 Novo Nordisk A/S Compounds with growth hormone releasing properties
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
WO1998058947A1 (en) 1997-06-25 1998-12-30 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)
ZA987383B (en) 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
DE69836386T2 (de) 1997-08-22 2007-10-11 Kaken Pharmaceutical Co., Ltd. Amide zur Förderung der Ausschüttung von Wachstumshormonen
IL137007A0 (en) 1998-01-16 2001-06-14 Novo Nordisk As Compounds with growth hormone releasing properties
WO1999039730A1 (en) 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Oral preparations containing peptides promoting the secretion of growth hormone
HUP0100998A3 (en) 1998-03-03 2001-12-28 Novo Nordisk As (2e)-5-amino-5-methylhex-2-enoic acid n-methyl-n-((1r)-1-(n-methyl-n-((1r)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphtyl)ethyl)amide salts, methods for their preparation, pharmaceutical compositions comprising thereof and their use
PL194560B1 (pl) 1998-05-11 2007-06-29 Novo Nordisk As Związki o właściwościach uwalniania hormonu wzrostu, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie
JP4574849B2 (ja) 1998-06-09 2010-11-04 サファイア セラピューティクス，インコーポレイティド 成長ホルモン放出特性を有する化合物を調製するための方法
HN1999000097A (es) 1998-06-16 1999-11-03 Pfizer Prod Inc Terapia de combinacion para la fragilidad muscoloesqueletica
KR20010052817A (ko) 1998-06-16 2001-06-25 실버스타인 아써 에이. 근골격 무름을 치료하기 위한 선택적인 에스트로겐 수용체조절제 및 성장 호르몬 분비촉진제의 치료적 혼합물
CA2334315C (en) 1998-06-30 2011-07-26 Novo Nordisk A/S Compounds with growth hormone releasing properties
KR100680085B1 (ko) 1998-08-20 2007-02-28 다이닛본 스미토모 세이야꾸 가부시끼가이샤 성장호르몬 방출촉진제로서 옥신돌 유도체
US6358951B1 (en) 1998-08-21 2002-03-19 Pfizer Inc. Growth hormone secretagogues
CA2411667A1 (en) 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
ES2333097T3 (es) 2000-05-31 2010-02-17 Raqualia Pharma Inc Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal.
CN1232507C (zh) 2000-06-13 2005-12-21 曾塔里斯股份公司 生长激素促分泌剂
EP1297839A4 (en) 2000-06-23 2005-12-07 Kaken Pharma Co Ltd PREVENTIVA OR THERAPEUTIC AGAINST HEART FAILURE
ITMI20011445A1 (it) 2001-07-06 2003-01-06 Europ Geie Analoghi della cortistantina capaci di legarsi selettivamente ai recettori dei secretagoghi dell'ormone della crescita
CU23043A1 (es) 2001-12-20 2005-05-20 Ct Ingenieria Genetica Biotech Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005039625A1 (en) 2003-10-28 2005-05-06 Rheoscience A/S Growth hormone secretagogue receptor agonists
EP1682136A4 (en) 2003-11-04 2009-06-03 Elixir Pharmaceuticals Inc THERAPEUTIC COMPOUNDS AND CORRESPONDING USES THEREOF
WO2005048916A2 (en) 2003-11-20 2005-06-02 Biovitrum Ab Tetrahydrospiro-beta-carboline-1,3 '-pyrrolidine derivatives and their use in ghsr-related disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939880B2 (en) * 1995-12-22 2005-09-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6849597B2 (en) * 1999-12-28 2005-02-01 Kaken Pharmaceutical Co., Ltd. Neuroprotective drug

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CORT J.H. et al. Regional and systemic haemodynamic effects of some vasopressin, Europ. J. Clin. Invest., 1975, 5, 165-175. LAMMEK В. et al. Synthesis of three NH2-terminally extended arginine vasopressin with prolonged biological activities, Experentia, 1987, 43, 1211-1212. ШУНДЕРОВИЧ М.Д. и др. Исследование пространственной структуры des-Gly9-[Arg8]вазопрессина методами двумерной спектроскопии ЯМР и теоретического конформационного анализа, Биоорганическая химия, 1985, 11 (9), 1180-1191. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2768134C2 (ru) * 2016-11-01 2022-03-23 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение пептида, усиливающего секрецию соматотропного гормона, в качестве адъюванта вакцины
RU2779835C1 (ru) * 2018-08-21 2022-09-13 Сентро Де Инхеньерия Хенетика И Биотекнолохия Применение ghrp-6 в качестве кардиозащитного и кардиовосстанавливающего лекарственного средства для позднего лечения
RU2734835C1 (ru) * 2020-02-11 2020-10-23 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) Способ повышения жизнестойкости эмбрионов рыб в аквакультуре

Also Published As

Publication number Publication date
ZA200807162B (en) 2009-06-24
CU23558A1 (es) 2010-07-20
CA2637593A1 (en) 2007-09-07
JP2009528303A (ja) 2009-08-06
BRPI0708366A2 (pt) 2011-05-24
KR20080110763A (ko) 2008-12-19
WO2007098716A8 (es) 2008-12-18
CA2637593C (en) 2015-04-14
US8367620B2 (en) 2013-02-05
MX2008011142A (es) 2008-09-08
AU2007219569B2 (en) 2012-03-15
CN101432294A (zh) 2009-05-13
WO2007098716A1 (es) 2007-09-07
CL2016001648A1 (es) 2017-02-24
NO20084118L (no) 2008-09-29
ES2441441T3 (es) 2014-02-04
EP1997827B1 (en) 2013-10-09
CL2007000528A1 (es) 2008-01-18
AR059646A1 (es) 2008-04-16
KR101409277B1 (ko) 2014-06-24
AU2007219569A1 (en) 2007-09-07
US20100055118A1 (en) 2010-03-04
EP1997827A1 (en) 2008-12-03
CN101432294B (zh) 2013-09-11
MY184130A (en) 2021-03-19
JP5183496B2 (ja) 2013-04-17
RU2008138569A (ru) 2010-04-10

Similar Documents

Publication Publication Date Title
Bednarek et al. Structure− function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
Muccioli et al. Heterogeneity of ghrelin/growth hormone secretagogue receptors: toward the understanding of the molecular identity of novel ghrelin/GHS receptors
Smith Development of growth hormone secretagogues
KR20160142322A (ko) 펩티드 이중 glp-1/글루카곤 수용체 효능제로서의 엑센딘-4 유도체
EP2272524A2 (en) Y2 selective receptor agonists for therapeutic interventions
Vodnik et al. Ghrelin receptor ligands reaching clinical trials: from peptides to peptidomimetics; from agonists to antagonists
CN100425282C (zh) 用于治疗性干预的y2/y4选择性受体激动剂
ES2818556T3 (es) Péptido con eficacia antiobesidad y antidiabética y uso del mismo
Eliakim et al. Exercise, training, and the GH-IGF-I axis
Gonzalez et al. Pituitary adenylate cyclase-activating polypeptide
RU2416618C2 (ru) Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты
Masuda et al. PEGylated neuromedin U-8 shows long-lasting anorectic activity and anti-obesity effect in mice by peripheral administration
Tachibana et al. Central ghrelin acts as an anti-dipsogenic peptide in chicks
Goetze et al. Procholecystokinin expression and processing in cardiac myocytes
Fang et al. Cardiovascular effects of intravenous administered 26RFa, a novel RFamide peptide ligand for GPR103, in anaesthetised rats
KR101920047B1 (ko) 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도
US20240279278A1 (en) Nmu receptor 2 agonists
Muccioli et al. Known and unknown growth hormone secretagogue receptors and their ligands
Kojima et al. Discovery of Ghrelin, an Endogenous Ligand for the Growth-Hormone Secret Agogue Receptor
Soll et al. On the role of neuropeptides in the hypothalamic regulation of food intake
KOJIMA et al. Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor
Frago et al. Concepts and Trends in Obesity and Neuropeptide Research

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20180301