RU2241458C2 - Комбинации агонист/антагонист опиоида - Google Patents

Комбинации агонист/антагонист опиоида Download PDF

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Publication number
RU2241458C2
RU2241458C2 RU2000119778/15A RU2000119778A RU2241458C2 RU 2241458 C2 RU2241458 C2 RU 2241458C2 RU 2000119778/15 A RU2000119778/15 A RU 2000119778/15A RU 2000119778 A RU2000119778 A RU 2000119778A RU 2241458 C2 RU2241458 C2 RU 2241458C2
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RU
Russia
Prior art keywords
naltrexone
opioid
dosage form
ratio
antagonist
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Application number
RU2000119778/15A
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English (en)
Russian (ru)
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RU2000119778A (ru
Inventor
Роберт Ф. КАИКО (US)
Роберт Ф. КАИКО
Роберт Д. КОЛУЧЧИ (US)
Роберт Д. КОЛУЧЧИ
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Эро-Селтик, С.А.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22082853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2241458(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эро-Селтик, С.А. filed Critical Эро-Селтик, С.А.
Publication of RU2000119778A publication Critical patent/RU2000119778A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Peptides Or Proteins (AREA)
RU2000119778/15A 1997-12-22 1998-12-22 Комбинации агонист/антагонист опиоида RU2241458C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6848097P 1997-12-22 1997-12-22
US60/068,480 1997-12-22

Publications (2)

Publication Number Publication Date
RU2000119778A RU2000119778A (ru) 2002-11-27
RU2241458C2 true RU2241458C2 (ru) 2004-12-10

Family

ID=22082853

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2000119778/15A RU2241458C2 (ru) 1997-12-22 1998-12-22 Комбинации агонист/антагонист опиоида

Country Status (28)

Country Link
US (11) US6277384B1 (cg-RX-API-DMAC7.html)
EP (3) EP1041987B1 (cg-RX-API-DMAC7.html)
JP (5) JP2001526228A (cg-RX-API-DMAC7.html)
KR (1) KR100417489B1 (cg-RX-API-DMAC7.html)
CN (1) CN1234362C (cg-RX-API-DMAC7.html)
AT (1) ATE323491T1 (cg-RX-API-DMAC7.html)
AU (2) AU773642C (cg-RX-API-DMAC7.html)
BR (1) BR9813827A (cg-RX-API-DMAC7.html)
CA (1) CA2314893C (cg-RX-API-DMAC7.html)
CY (4) CY1106099T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ299283B6 (cg-RX-API-DMAC7.html)
DE (1) DE69834268T2 (cg-RX-API-DMAC7.html)
DK (3) DK1041987T3 (cg-RX-API-DMAC7.html)
ES (3) ES2412409T3 (cg-RX-API-DMAC7.html)
HU (2) HU1500214D0 (cg-RX-API-DMAC7.html)
IL (2) IL136804A (cg-RX-API-DMAC7.html)
LU (1) LU92292I2 (cg-RX-API-DMAC7.html)
ME (1) ME00527B (cg-RX-API-DMAC7.html)
NO (1) NO321625B1 (cg-RX-API-DMAC7.html)
NZ (2) NZ505193A (cg-RX-API-DMAC7.html)
PL (1) PL193273B1 (cg-RX-API-DMAC7.html)
PT (3) PT1685839E (cg-RX-API-DMAC7.html)
RS (1) RS50070B (cg-RX-API-DMAC7.html)
RU (1) RU2241458C2 (cg-RX-API-DMAC7.html)
SI (3) SI1685839T1 (cg-RX-API-DMAC7.html)
TR (1) TR200001942T2 (cg-RX-API-DMAC7.html)
UA (1) UA55507C2 (cg-RX-API-DMAC7.html)
WO (1) WO1999032119A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
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WO2009032246A3 (en) * 2007-09-03 2009-04-23 Nanotherapeutics Inc Particulate compositions for delivery of poorly soluble drugs
RU2519060C2 (ru) * 2008-04-25 2014-06-10 Лабораторьос Дель Др. Эстеве, С.А. 1-арил-3-аминоалкоксипиразолы как сигма-лиганды, усиливающие обезболивающее действие опиоидов и ослабляющие зависимость от них

Families Citing this family (240)

* Cited by examiner, † Cited by third party
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RS49982B (sr) 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
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