RU2226396C2 - Твердая дозированная лекарственная форма для орального применения, содержащая комбинацию метформина и глибенкламида - Google Patents

Твердая дозированная лекарственная форма для орального применения, содержащая комбинацию метформина и глибенкламида Download PDF

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Publication number
RU2226396C2
RU2226396C2 RU2000109583/15A RU2000109583A RU2226396C2 RU 2226396 C2 RU2226396 C2 RU 2226396C2 RU 2000109583/15 A RU2000109583/15 A RU 2000109583/15A RU 2000109583 A RU2000109583 A RU 2000109583A RU 2226396 C2 RU2226396 C2 RU 2226396C2
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Russia
Prior art keywords
glibenclamide
metformin
particles
tablets
bioavailability
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RU2000109583/15A
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English (en)
Russian (ru)
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RU2000109583A (ru
Inventor
Ив БОНОММ (FR)
Ив БОНОММ
Джеффри НИКОЛСОН (GB)
Джеффри НИКОЛСОН
Джиллиан КЕЙВ (GB)
Джиллиан КЕЙВ
Сара Дж. НИКОЛСОН (GB)
Сара Дж. НИКОЛСОН
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Лифа
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2000109583/15A 1998-07-15 1999-07-12 Твердая дозированная лекарственная форма для орального применения, содержащая комбинацию метформина и глибенкламида RU2226396C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98401781A EP0974356B1 (en) 1998-07-15 1998-07-15 Tablets comprising a combination of metformin and glibenclamide
EP98401781.4 1998-07-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2003126257/15A Division RU2286788C2 (ru) 1998-07-15 1999-07-12 Твердая дозированная лекарственная форма для орального введения, содержащая комбинацию метформина и глибенкламида

Publications (2)

Publication Number Publication Date
RU2000109583A RU2000109583A (ru) 2002-01-27
RU2226396C2 true RU2226396C2 (ru) 2004-04-10

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ID=8235441

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Application Number Title Priority Date Filing Date
RU2000109583/15A RU2226396C2 (ru) 1998-07-15 1999-07-12 Твердая дозированная лекарственная форма для орального применения, содержащая комбинацию метформина и глибенкламида
RU2003126257/15A RU2286788C2 (ru) 1998-07-15 1999-07-12 Твердая дозированная лекарственная форма для орального введения, содержащая комбинацию метформина и глибенкламида

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RU2003126257/15A RU2286788C2 (ru) 1998-07-15 1999-07-12 Твердая дозированная лекарственная форма для орального введения, содержащая комбинацию метформина и глибенкламида

Country Status (27)

Country Link
US (2) US6303146B1 (OSRAM)
EP (4) EP0974356B1 (OSRAM)
JP (2) JP2002520371A (OSRAM)
KR (2) KR20040053177A (OSRAM)
CN (2) CN1146427C (OSRAM)
AP (1) AP1450A (OSRAM)
AR (2) AR013052A1 (OSRAM)
AT (1) ATE250418T1 (OSRAM)
AU (2) AU753604B2 (OSRAM)
BR (1) BR9906600A (OSRAM)
CA (1) CA2303537C (OSRAM)
DE (1) DE69818444T2 (OSRAM)
DK (1) DK0974356T3 (OSRAM)
DZ (1) DZ2846A1 (OSRAM)
ES (1) ES2206868T3 (OSRAM)
ID (1) ID25784A (OSRAM)
MA (1) MA24930A1 (OSRAM)
MY (1) MY129552A (OSRAM)
NZ (1) NZ503248A (OSRAM)
OA (1) OA11400A (OSRAM)
PT (1) PT974356E (OSRAM)
RU (2) RU2226396C2 (OSRAM)
SI (1) SI0974356T1 (OSRAM)
TW (2) TWI245632B (OSRAM)
UY (1) UY25611A1 (OSRAM)
WO (1) WO2000003742A2 (OSRAM)
ZA (1) ZA200001159B (OSRAM)

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US8900638B2 (en) 2007-07-19 2014-12-02 Takeda Pharmaceutical Company Limited Solid preparation comprising alogliptin and metformin hydrochloride

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FR2816841B1 (fr) * 2000-11-22 2004-02-06 Lipha Nouvelles compositions pharmaceutiques a action antidiabetique et leur procede de preparation
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US7767249B2 (en) * 2001-06-07 2010-08-03 Hewlett-Packard Development Company, L.P. Preparation of nanoparticles
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AU2003246791A1 (en) 2002-04-09 2003-10-20 Flamel Technologies Oral suspension of amoxicillin capsules
PT1492511E (pt) 2002-04-09 2009-04-09 Flamel Tech Sa Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s)
US8911781B2 (en) 2002-06-17 2014-12-16 Inventia Healthcare Private Limited Process of manufacture of novel drug delivery system: multilayer tablet composition of thiazolidinedione and biguanides
US7445796B2 (en) * 2002-08-19 2008-11-04 L. Perrigo Company Pharmaceutically active particles of a monomodal particle size distribution and method
CN1729005A (zh) * 2002-11-15 2006-02-01 兰贝克赛实验室有限公司 含双胍－磺酰脲类组合的药物剂型
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KR100760430B1 (ko) * 2004-12-31 2007-10-04 한미약품 주식회사 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법
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KR20100040937A (ko) 2007-07-26 2010-04-21 암젠 인크 변형된 레시틴-콜레스테롤 아실트랜스퍼라제 효소
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
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RU2451506C1 (ru) 2011-06-02 2012-05-27 Сергей Юрьевич Лешков Комбинация для лечения сахарного диабета и его осложнений
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CA2859174C (en) * 2011-12-12 2019-03-05 Orbis Biosciences, Inc. Sustained release particle formulations
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CN105030793A (zh) * 2015-08-25 2015-11-11 瑞阳制药有限公司 二甲双胍格列本脲胶囊及其制备方法
WO2019070109A1 (es) * 2017-10-03 2019-04-11 Infinite Clinical Research International, S.A. De C.V. Triconjugado para el tratamiento de diabetes mellitus
CN115461344B (zh) 2020-04-01 2024-01-12 杭州中美华东制药有限公司 一种glp-1受体激动剂的晶型a及其制备方法
JP2023528726A (ja) 2020-04-01 2023-07-06 ハンジョウ ジョンメイ フアドン ファーマシューティカル シーオー．，エルティーディー． Ｇｌｐ１ｒアゴニスト遊離塩基の薬学的に許容される酸塩類およびその調製法
KR102484756B1 (ko) * 2020-11-13 2023-01-06 한국생산기술연구원 용해성 증대 및 취급용이성을 갖는 파우더 배지의 과립화 방법
CN113143940A (zh) * 2020-12-30 2021-07-23 成都恒瑞制药有限公司 一种抗糖尿病药物组合物的制备方法

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8900638B2 (en) 2007-07-19 2014-12-02 Takeda Pharmaceutical Company Limited Solid preparation comprising alogliptin and metformin hydrochloride

Also Published As

Publication number Publication date
WO2000003742A2 (en) 2000-01-27
JP2003292443A (ja) 2003-10-15
KR100478347B1 (ko) 2005-03-23
CN1146427C (zh) 2004-04-21
EP1011684A2 (en) 2000-06-28
ATE250418T1 (de) 2003-10-15
KR20040053177A (ko) 2004-06-23
EP2269613A2 (en) 2011-01-05
US6303146B1 (en) 2001-10-16
AU2003261560A1 (en) 2005-05-26
EP1435240A2 (en) 2004-07-07
DK0974356T3 (da) 2003-10-27
CA2303537A1 (en) 2000-01-27
TW200303208A (en) 2003-09-01
DZ2846A1 (fr) 2003-12-01
ID25784A (id) 2000-11-02
RU2286788C2 (ru) 2006-11-10
TW555560B (en) 2003-10-01
EP2269613A3 (en) 2012-10-17
DE69818444D1 (de) 2003-10-30
DE69818444T2 (de) 2004-05-06
PT974356E (pt) 2004-02-27
SI0974356T1 (en) 2003-12-31
NZ503248A (en) 2002-09-27
CA2303537C (en) 2005-12-06
CN1486698A (zh) 2004-04-07
ZA200001159B (en) 2001-05-31
OA11400A (en) 2004-04-08
MY129552A (en) 2007-04-30
EP0974356A1 (en) 2000-01-26
AU753604B2 (en) 2002-10-24
MA24930A1 (fr) 2000-04-01
ES2206868T3 (es) 2004-05-16
AR065970A2 (es) 2009-07-15
AU5417999A (en) 2000-02-07
USRE38629E1 (en) 2004-10-19
CN1275082A (zh) 2000-11-29
BR9906600A (pt) 2000-07-18
RU2003126257A (ru) 2005-02-27
AP1450A (en) 2005-07-25
EP1435240A3 (en) 2009-08-12
UY25611A1 (es) 2000-08-21
KR20010030603A (ko) 2001-04-16
AP2000001757A0 (en) 2000-03-31
AR013052A1 (es) 2000-11-22
WO2000003742A3 (en) 2000-04-20
JP2002520371A (ja) 2002-07-09
TWI245632B (en) 2005-12-21
EP0974356B1 (en) 2003-09-24

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