RU2156239C2 - Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе - Google Patents

Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе Download PDF

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RU2156239C2
RU2156239C2 RU95120582/04A RU95120582A RU2156239C2 RU 2156239 C2 RU2156239 C2 RU 2156239C2 RU 95120582/04 A RU95120582/04 A RU 95120582/04A RU 95120582 A RU95120582 A RU 95120582A RU 2156239 C2 RU2156239 C2 RU 2156239C2
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Russia
Prior art keywords
tetrahydro
imidazole
naphthalenyl
pharmaceutically acceptable
acceptable acids
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RU95120582/04A
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English (en)
Russian (ru)
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RU95120582A (ru
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ЖЕЕР Жан-Пьер
МОТ Женевьев
ДИФФЕРДИНГ Эдмон
ЭНИШАР Жан-Пьер
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Юцб С.А.
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Publication of RU95120582A publication Critical patent/RU95120582A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU95120582/04A 1994-12-14 1995-12-13 Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе RU2156239C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9425211.1 1994-12-14
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (2)

Publication Number Publication Date
RU95120582A RU95120582A (ru) 1997-11-10
RU2156239C2 true RU2156239C2 (ru) 2000-09-20

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RU95120582/04A RU2156239C2 (ru) 1994-12-14 1995-12-13 Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе

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US (1) US5658938A (member.php)
EP (1) EP0717037A1 (member.php)
JP (1) JPH08208622A (member.php)
KR (1) KR960022474A (member.php)
CN (1) CN1054376C (member.php)
AR (1) AR002257A1 (member.php)
AU (1) AU693614B2 (member.php)
BG (1) BG63043B1 (member.php)
BR (1) BR9505815A (member.php)
CA (1) CA2165133A1 (member.php)
CZ (1) CZ327195A3 (member.php)
EE (1) EE9500064A (member.php)
FI (1) FI955927L (member.php)
GB (1) GB9425211D0 (member.php)
HU (1) HUT73980A (member.php)
IL (1) IL116325A (member.php)
IS (1) IS4311A (member.php)
MX (1) MX9505063A (member.php)
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NZ (1) NZ280646A (member.php)
PL (1) PL311736A1 (member.php)
RO (1) RO113346B1 (member.php)
RU (1) RU2156239C2 (member.php)
SK (1) SK155095A3 (member.php)
TW (1) TW303362B (member.php)
ZA (1) ZA9510554B (member.php)

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JP5130305B2 (ja) * 2007-02-15 2013-01-30 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしての２−アミノオキサゾリン
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JP2010531836A (ja) * 2007-07-03 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー ４−イミダゾリン及びそれらの抗うつ剤としての使用
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WO2009016088A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of cns disorders
CA2695331A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
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US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
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MA37944B2 (fr) 2012-09-14 2017-10-31 Hoffmann La Roche Dérivés de pyrazole-carboxamide en tant que modulateurs de taar pour utilisation dans le traitement de plusieurs troubles, tels que la dépression, le diabète et la maladie de parkinson
CN104603129A (zh) * 2012-09-17 2015-05-06 霍夫曼-拉罗奇有限公司 三唑甲酰胺衍生物
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CN107001259B (zh) 2014-08-27 2019-12-06 豪夫迈·罗氏有限公司 作为taar配体的取代的氮杂环丁烷衍生物
JP6814814B2 (ja) 2016-03-17 2021-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｔａａｒのアゴニストとしての活性を有する５−エチル−４−メチル−ピラゾール−３−カルボキサミド誘導体
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AR002257A1 (es) 1998-03-11
EP0717037A1 (fr) 1996-06-19
NZ280646A (en) 1996-08-27
FI955927A7 (fi) 1996-06-15
SK155095A3 (en) 1997-02-05
BG100208A (bg) 1996-07-31
MX9505063A (es) 1997-01-31
NO305316B1 (no) 1999-05-10
EE9500064A (et) 1996-06-17
TW303362B (member.php) 1997-04-21
FI955927L (fi) 1996-06-15
US5658938A (en) 1997-08-19
CZ327195A3 (en) 1996-07-17
IL116325A0 (en) 1996-03-31
BR9505815A (pt) 1998-01-06
HUT73980A (en) 1996-10-28
BG63043B1 (bg) 2001-02-28
IL116325A (en) 1999-10-28
PL311736A1 (en) 1996-06-24
CN1133837A (zh) 1996-10-23
AU4036895A (en) 1996-06-20
CN1054376C (zh) 2000-07-12
IS4311A (is) 1996-06-15
JPH08208622A (ja) 1996-08-13
FI955927A0 (fi) 1995-12-11
KR960022474A (ko) 1996-07-18
CA2165133A1 (en) 1996-06-15
RO113346B1 (ro) 1998-06-30
NO955034L (no) 1996-06-17
NO955034D0 (no) 1995-12-12
HU9503549D0 (en) 1996-02-28
ZA9510554B (en) 1996-06-13
AU693614B2 (en) 1998-07-02
GB9425211D0 (en) 1995-02-15

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