RU2156239C2 - Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе - Google Patents
Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе Download PDFInfo
- Publication number
- RU2156239C2 RU2156239C2 RU95120582/04A RU95120582A RU2156239C2 RU 2156239 C2 RU2156239 C2 RU 2156239C2 RU 95120582/04 A RU95120582/04 A RU 95120582/04A RU 95120582 A RU95120582 A RU 95120582A RU 2156239 C2 RU2156239 C2 RU 2156239C2
- Authority
- RU
- Russia
- Prior art keywords
- tetrahydro
- imidazole
- naphthalenyl
- pharmaceutically acceptable
- acceptable acids
- Prior art date
Links
- 0 CC1=C(*)C(CC=C2C3=C(CS)CNCN3)=C2I(*)=C1C Chemical compound CC1=C(*)C(CC=C2C3=C(CS)CNCN3)=C2I(*)=C1C 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
GB9425211.1 | 1994-12-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU95120582A RU95120582A (ru) | 1997-11-10 |
RU2156239C2 true RU2156239C2 (ru) | 2000-09-20 |
Family
ID=10765918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95120582/04A RU2156239C2 (ru) | 1994-12-14 | 1995-12-13 | Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе |
Country Status (26)
Families Citing this family (51)
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GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
GB9520150D0 (en) | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
ZA981080B (en) * | 1997-02-11 | 1998-08-12 | Warner Lambert Co | Bicyclic inhibitors of protein farnesyl transferase |
US20030073850A1 (en) * | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
US6503935B1 (en) * | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
EP1280779B1 (en) | 2000-05-08 | 2005-08-24 | Orion Corporation | New polycyclic indanylimidazoles with alpha2 adrenergic activity |
TW200930291A (en) * | 2002-04-29 | 2009-07-16 | Bayer Cropscience Ag | Pesticidal heterocycles |
US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
FI20022159A0 (fi) * | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
CN101374517A (zh) * | 2006-01-27 | 2009-02-25 | 弗·哈夫曼-拉罗切有限公司 | 2-咪唑类化合物用于治疗cns病症的用途 |
EP2076497B1 (en) * | 2006-10-19 | 2012-02-22 | F. Hoffmann-La Roche AG | Aminomethyl-4-imidazoles |
RU2009112495A (ru) * | 2006-10-19 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Аминометил-2-имидазолы со сродством к рецепторам, ассоциированным со следовыми аминами |
ATE533755T1 (de) * | 2006-11-02 | 2011-12-15 | Hoffmann La Roche | Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren |
AU2007321376A1 (en) * | 2006-11-16 | 2008-05-22 | F. Hoffmann-La Roche Ag | Substituted 4-imidazoles |
BRPI0720047A2 (pt) * | 2006-12-13 | 2013-12-24 | Hoffmann La Roche | 2-imidazóis como ligantes para receptores associados a aminas de traço (taar) |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
CN101600700B (zh) * | 2007-02-02 | 2013-08-21 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体用于cns病症的新的2-氨基噁唑啉 |
US8017642B2 (en) * | 2007-02-13 | 2011-09-13 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
AU2008216797A1 (en) * | 2007-02-13 | 2008-08-21 | Pharmacopeia, Llc | Functionally selective alpha2C adrenoreceptor agonists |
JP2010518161A (ja) * | 2007-02-13 | 2010-05-27 | シェーリング コーポレイション | 機能選択性α2Cアドレナリン受容体アゴニストとしてのクロマン誘導体および類似体 |
EP2121641B1 (en) * | 2007-02-15 | 2014-09-24 | F. Hoffmann-La Roche AG | 2-aminooxazolines as taar1 ligands |
JP2010531837A (ja) | 2007-07-02 | 2010-09-30 | エフ.ホフマン−ラ ロシュ アーゲー | 微量アミン関連レセプター(taar)に対して良好な親和性を有する2−イミダゾリン |
CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
AU2008281918A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands |
AU2008281877A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of CNS disorders |
CA2695331A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
WO2009105504A2 (en) | 2008-02-21 | 2009-08-27 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
KR101307007B1 (ko) * | 2008-07-24 | 2013-09-11 | 에프. 호프만-라 로슈 아게 | 4,5-다이하이드로-옥사졸-2-일 유도체 |
WO2010017120A1 (en) * | 2008-08-04 | 2010-02-11 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
US8324213B2 (en) | 2008-10-07 | 2012-12-04 | Merck Sharp & Dohme Corp. | Biaryl-spiroaminooxazoline analogues as alpha 2C adrenergic receptor modulators |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8673950B2 (en) | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
US8802673B2 (en) | 2011-03-24 | 2014-08-12 | Hoffmann-La Roche Inc | Heterocyclic amine derivatives |
US9073911B2 (en) | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
US9029370B2 (en) | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
KR101631003B1 (ko) | 2012-01-12 | 2016-06-15 | 에프. 호프만-라 로슈 아게 | 미량 아민 결합 수용체(taar)로서 헤테로환형 유도체 |
MX363362B (es) | 2012-09-14 | 2019-03-21 | Hoffmann La Roche | Derivados de pirazol carboxamida como moduladores de los receptores asociados con las aminas traza (taar) para uso en el tratamiento de varios trastornos, tales como depresión, diabetes y enfermedades de parkinson. |
KR101676208B1 (ko) | 2012-09-17 | 2016-11-14 | 에프. 호프만-라 로슈 아게 | 트라이아졸 카복스아미드 유도체 |
WO2015165085A1 (en) | 2014-04-30 | 2015-11-05 | F.Hoffmann-La Roche Ag | Morpholin-pyridine derivatives |
MX2016016488A (es) | 2014-08-27 | 2017-03-30 | Hoffmann La Roche | Derivados de azetidina sustituidos como ligandos de receptores asociados a aminas en trazas (taar). |
WO2016030306A1 (en) | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders |
PE20181446A1 (es) | 2016-03-17 | 2018-09-12 | Hoffmann La Roche | Derivados de 5-etil-4-metil-pirazol-3-carboxamida con actividad como de taar |
AU2017232377C1 (en) * | 2016-03-17 | 2022-05-19 | Fmc Ip Technology Gmbh | Process for converting S-enantiomer to its racemic form |
CN116496261B (zh) * | 2023-03-09 | 2025-06-27 | 中国人民解放军军事科学院军事医学研究院 | 4-(1h)-咪唑类衍生物及其医药用途 |
CN118684628B (zh) * | 2024-05-20 | 2025-06-17 | 中国人民解放军军事科学院军事医学研究院 | 取代二氢茚基咪唑类化合物及其制备方法和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6048972A (ja) * | 1983-08-25 | 1985-03-16 | Dai Ichi Seiyaku Co Ltd | テトラヒドロナフタレン誘導体 |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
US5151526A (en) * | 1990-10-11 | 1992-09-29 | The United States Of America As Represented By The Secretary Of The Army | 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic |
JPH04210680A (ja) * | 1990-12-01 | 1992-07-31 | Nissan Chem Ind Ltd | イミダゾール誘導体および植物生長調節剤 |
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
-
1994
- 1994-12-14 GB GBGB9425211.1A patent/GB9425211D0/en active Pending
-
1995
- 1995-12-05 MX MX9505063A patent/MX9505063A/es not_active IP Right Cessation
- 1995-12-08 BG BG100208A patent/BG63043B1/bg unknown
- 1995-12-08 TW TW084113098A patent/TW303362B/zh active
- 1995-12-08 US US08/569,947 patent/US5658938A/en not_active Expired - Fee Related
- 1995-12-08 IS IS4311A patent/IS4311A/is unknown
- 1995-12-08 RO RO95-02138A patent/RO113346B1/ro unknown
- 1995-12-08 PL PL95311736A patent/PL311736A1/xx unknown
- 1995-12-11 FI FI955927A patent/FI955927A7/fi unknown
- 1995-12-11 NZ NZ280646A patent/NZ280646A/en unknown
- 1995-12-11 IL IL11632595A patent/IL116325A/xx not_active IP Right Cessation
- 1995-12-11 SK SK1550-95A patent/SK155095A3/sk unknown
- 1995-12-12 NO NO955034A patent/NO305316B1/no not_active IP Right Cessation
- 1995-12-12 CN CN95120834A patent/CN1054376C/zh not_active Expired - Fee Related
- 1995-12-12 AU AU40368/95A patent/AU693614B2/en not_active Ceased
- 1995-12-12 HU HU9503549A patent/HUT73980A/hu unknown
- 1995-12-12 CZ CZ953271A patent/CZ327195A3/cs unknown
- 1995-12-12 ZA ZA9510554A patent/ZA9510554B/xx unknown
- 1995-12-12 EE EE9500064A patent/EE9500064A/xx unknown
- 1995-12-12 AR ARP950100512A patent/AR002257A1/es unknown
- 1995-12-13 RU RU95120582/04A patent/RU2156239C2/ru active
- 1995-12-13 JP JP7324502A patent/JPH08208622A/ja active Pending
- 1995-12-13 BR BR9505815A patent/BR9505815A/pt not_active Application Discontinuation
- 1995-12-13 EP EP95870132A patent/EP0717037A1/fr not_active Withdrawn
- 1995-12-13 CA CA002165133A patent/CA2165133A1/en not_active Abandoned
- 1995-12-14 KR KR1019950049572A patent/KR960022474A/ko not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
FI955927L (fi) | 1996-06-15 |
AU693614B2 (en) | 1998-07-02 |
BR9505815A (pt) | 1998-01-06 |
PL311736A1 (en) | 1996-06-24 |
FI955927A7 (fi) | 1996-06-15 |
EP0717037A1 (fr) | 1996-06-19 |
CN1054376C (zh) | 2000-07-12 |
IL116325A (en) | 1999-10-28 |
IS4311A (is) | 1996-06-15 |
FI955927A0 (fi) | 1995-12-11 |
CZ327195A3 (en) | 1996-07-17 |
BG100208A (bg) | 1996-07-31 |
NO305316B1 (no) | 1999-05-10 |
NZ280646A (en) | 1996-08-27 |
US5658938A (en) | 1997-08-19 |
TW303362B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-04-21 |
JPH08208622A (ja) | 1996-08-13 |
BG63043B1 (bg) | 2001-02-28 |
AU4036895A (en) | 1996-06-20 |
GB9425211D0 (en) | 1995-02-15 |
SK155095A3 (en) | 1997-02-05 |
CN1133837A (zh) | 1996-10-23 |
EE9500064A (et) | 1996-06-17 |
IL116325A0 (en) | 1996-03-31 |
MX9505063A (es) | 1997-01-31 |
HU9503549D0 (en) | 1996-02-28 |
NO955034L (no) | 1996-06-17 |
ZA9510554B (en) | 1996-06-13 |
RO113346B1 (ro) | 1998-06-30 |
HUT73980A (en) | 1996-10-28 |
AR002257A1 (es) | 1998-03-11 |
CA2165133A1 (en) | 1996-06-15 |
NO955034D0 (no) | 1995-12-12 |
KR960022474A (ko) | 1996-07-18 |
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