GB9425211D0 - Substituted 1H-imidazoles - Google Patents
Substituted 1H-imidazolesInfo
- Publication number
- GB9425211D0 GB9425211D0 GBGB9425211.1A GB9425211A GB9425211D0 GB 9425211 D0 GB9425211 D0 GB 9425211D0 GB 9425211 A GB9425211 A GB 9425211A GB 9425211 D0 GB9425211 D0 GB 9425211D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- imidazoles
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
MX9505063A MX9505063A (es) | 1994-12-14 | 1995-12-05 | Tetralina- e indano-1h-imidazoles. |
RO95-02138A RO113346B1 (ro) | 1994-12-14 | 1995-12-08 | Derivati de 1h-imidazol si procedee pentru prepararea acestora |
US08/569,947 US5658938A (en) | 1994-12-14 | 1995-12-08 | Substituted 1H-imidazoles |
TW084113098A TW303362B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-12-14 | 1995-12-08 | |
SG1995002072A SG33624A1 (en) | 1994-12-14 | 1995-12-08 | Substituted 1H-imidazoles |
PL95311736A PL311736A1 (en) | 1994-12-14 | 1995-12-08 | Derivatives of 1h-imidazoles |
IS4311A IS4311A (is) | 1994-12-14 | 1995-12-08 | Setin 1H-imíðazól, aðferð til framleiðslu þeirra og notkun þeirra |
BG100208A BG63043B1 (bg) | 1994-12-14 | 1995-12-08 | Заместени 1н-имидазоли, метод за тяхното получаване и приложението им като лекарствени средства |
NZ280646A NZ280646A (en) | 1994-12-14 | 1995-12-11 | 4-naphthalenyl (and indenyl)-1h-imidazole derivatives; pharmaceutical compositions |
FI955927A FI955927A7 (fi) | 1994-12-14 | 1995-12-11 | Substituoidut 1H-imidatsolit |
IL11632595A IL116325A (en) | 1994-12-14 | 1995-12-11 | Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazoles and substituted 4-(2,3-dihydro-1h-inden-1-yl)-1h-imidazoles the optically active isomers thereof and racemic mixtures thereof their preparation and pharmaceutical compositions containing them |
SK1550-95A SK155095A3 (en) | 1994-12-14 | 1995-12-11 | Substituted 1h-imidazoles |
ZA9510554A ZA9510554B (en) | 1994-12-14 | 1995-12-12 | Substituted 1H-imidazoles |
HU9503549A HUT73980A (en) | 1994-12-14 | 1995-12-12 | Substituted 1h-imidazoles and pharmaceutical compositions containing them |
AU40368/95A AU693614B2 (en) | 1994-12-14 | 1995-12-12 | Substituted 1H-imidazoles |
CN95120834A CN1054376C (zh) | 1994-12-14 | 1995-12-12 | 取代的1h-咪唑 |
EE9500064A EE9500064A (et) | 1994-12-14 | 1995-12-12 | Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid |
ARP950100512A AR002257A1 (es) | 1994-12-14 | 1995-12-12 | Compuesto 1h-imidazol util como agente anti-isquemico cardiaco o agente anti-hipertensivo. procedimiento para su preparacion y composicion farmaceuticaque lo contiene. |
NO955034A NO305316B1 (no) | 1994-12-14 | 1995-12-12 | Nye substituerte 1H-imidazoler og farmas°ytiske preparater inneholdende disse |
CZ953271A CZ327195A3 (en) | 1994-12-14 | 1995-12-12 | Substituted 1h-imidazoles |
CA002165133A CA2165133A1 (en) | 1994-12-14 | 1995-12-13 | Substituted 1h-imidazoles |
BR9505815A BR9505815A (pt) | 1994-12-14 | 1995-12-13 | Composto processos para a preparação do mesmo e para obter um efeito anti-isquêmico e anti-hipertensivo e para produzir atividade agonista 2 pré-sináptica e antagonista 1 pós-sináptica em um paciente e composição farmacêutica |
EP95870132A EP0717037A1 (fr) | 1994-12-14 | 1995-12-13 | 1H-imidazoles substitués ayant une activité alpha 2-agoniste et alpha 1-antagoniste |
RU95120582/04A RU2156239C2 (ru) | 1994-12-14 | 1995-12-13 | Замещенные 4-(1,2,3,4-тетрагидро-1-нафталинил)-1н-имидазолы и 4-(2,3-дигидро-1н-инден-1-ил)-1н-имидазолы, способы их получения и фармацевтическая композиция на их основе |
JP7324502A JPH08208622A (ja) | 1994-12-14 | 1995-12-13 | 置換された1h−イミダゾール |
KR1019950049572A KR960022474A (ko) | 1994-12-14 | 1995-12-14 | 치환된 1h-이미다졸 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9425211.1A GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
GB9425211D0 true GB9425211D0 (en) | 1995-02-15 |
Family
ID=10765918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB9425211.1A Pending GB9425211D0 (en) | 1994-12-14 | 1994-12-14 | Substituted 1H-imidazoles |
Country Status (26)
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
GB9520150D0 (en) | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
ZA981080B (en) * | 1997-02-11 | 1998-08-12 | Warner Lambert Co | Bicyclic inhibitors of protein farnesyl transferase |
US20030073850A1 (en) * | 1998-08-07 | 2003-04-17 | Altenbach Robert J. | 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use |
US6503935B1 (en) * | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
US6388090B2 (en) | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
EP1280779B1 (en) | 2000-05-08 | 2005-08-24 | Orion Corporation | New polycyclic indanylimidazoles with alpha2 adrenergic activity |
TW200930291A (en) * | 2002-04-29 | 2009-07-16 | Bayer Cropscience Ag | Pesticidal heterocycles |
US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
FI20022159A0 (fi) * | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
CN101374517A (zh) * | 2006-01-27 | 2009-02-25 | 弗·哈夫曼-拉罗切有限公司 | 2-咪唑类化合物用于治疗cns病症的用途 |
EP2076497B1 (en) * | 2006-10-19 | 2012-02-22 | F. Hoffmann-La Roche AG | Aminomethyl-4-imidazoles |
RU2009112495A (ru) * | 2006-10-19 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Аминометил-2-имидазолы со сродством к рецепторам, ассоциированным со следовыми аминами |
ATE533755T1 (de) * | 2006-11-02 | 2011-12-15 | Hoffmann La Roche | Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren |
AU2007321376A1 (en) * | 2006-11-16 | 2008-05-22 | F. Hoffmann-La Roche Ag | Substituted 4-imidazoles |
BRPI0720047A2 (pt) * | 2006-12-13 | 2013-12-24 | Hoffmann La Roche | 2-imidazóis como ligantes para receptores associados a aminas de traço (taar) |
US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
CN101600700B (zh) * | 2007-02-02 | 2013-08-21 | 弗·哈夫曼-拉罗切有限公司 | 作为taar1配体用于cns病症的新的2-氨基噁唑啉 |
US8017642B2 (en) * | 2007-02-13 | 2011-09-13 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
AU2008216797A1 (en) * | 2007-02-13 | 2008-08-21 | Pharmacopeia, Llc | Functionally selective alpha2C adrenoreceptor agonists |
JP2010518161A (ja) * | 2007-02-13 | 2010-05-27 | シェーリング コーポレイション | 機能選択性α2Cアドレナリン受容体アゴニストとしてのクロマン誘導体および類似体 |
EP2121641B1 (en) * | 2007-02-15 | 2014-09-24 | F. Hoffmann-La Roche AG | 2-aminooxazolines as taar1 ligands |
JP2010531837A (ja) | 2007-07-02 | 2010-09-30 | エフ.ホフマン−ラ ロシュ アーゲー | 微量アミン関連レセプター(taar)に対して良好な親和性を有する2−イミダゾリン |
CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
AU2008281918A1 (en) * | 2007-07-27 | 2009-02-05 | F. Hoffmann-La Roche Ag | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands |
AU2008281877A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of CNS disorders |
CA2695331A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
WO2009105504A2 (en) | 2008-02-21 | 2009-08-27 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
KR101307007B1 (ko) * | 2008-07-24 | 2013-09-11 | 에프. 호프만-라 로슈 아게 | 4,5-다이하이드로-옥사졸-2-일 유도체 |
WO2010017120A1 (en) * | 2008-08-04 | 2010-02-11 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
US8324213B2 (en) | 2008-10-07 | 2012-12-04 | Merck Sharp & Dohme Corp. | Biaryl-spiroaminooxazoline analogues as alpha 2C adrenergic receptor modulators |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US8673950B2 (en) | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
US8802673B2 (en) | 2011-03-24 | 2014-08-12 | Hoffmann-La Roche Inc | Heterocyclic amine derivatives |
US9073911B2 (en) | 2011-06-09 | 2015-07-07 | Hoffmann-La Roche Inc. | Pyrazole derivatives |
US9029370B2 (en) | 2011-06-10 | 2015-05-12 | Hoffmann-La Roche Inc. | Substituted benzamide derivatives |
KR101631003B1 (ko) | 2012-01-12 | 2016-06-15 | 에프. 호프만-라 로슈 아게 | 미량 아민 결합 수용체(taar)로서 헤테로환형 유도체 |
MX363362B (es) | 2012-09-14 | 2019-03-21 | Hoffmann La Roche | Derivados de pirazol carboxamida como moduladores de los receptores asociados con las aminas traza (taar) para uso en el tratamiento de varios trastornos, tales como depresión, diabetes y enfermedades de parkinson. |
KR101676208B1 (ko) | 2012-09-17 | 2016-11-14 | 에프. 호프만-라 로슈 아게 | 트라이아졸 카복스아미드 유도체 |
WO2015165085A1 (en) | 2014-04-30 | 2015-11-05 | F.Hoffmann-La Roche Ag | Morpholin-pyridine derivatives |
MX2016016488A (es) | 2014-08-27 | 2017-03-30 | Hoffmann La Roche | Derivados de azetidina sustituidos como ligandos de receptores asociados a aminas en trazas (taar). |
WO2016030306A1 (en) | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders |
PE20181446A1 (es) | 2016-03-17 | 2018-09-12 | Hoffmann La Roche | Derivados de 5-etil-4-metil-pirazol-3-carboxamida con actividad como de taar |
AU2017232377C1 (en) * | 2016-03-17 | 2022-05-19 | Fmc Ip Technology Gmbh | Process for converting S-enantiomer to its racemic form |
CN116496261B (zh) * | 2023-03-09 | 2025-06-27 | 中国人民解放军军事科学院军事医学研究院 | 4-(1h)-咪唑类衍生物及其医药用途 |
CN118684628B (zh) * | 2024-05-20 | 2025-06-17 | 中国人民解放军军事科学院军事医学研究院 | 取代二氢茚基咪唑类化合物及其制备方法和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6048972A (ja) * | 1983-08-25 | 1985-03-16 | Dai Ichi Seiyaku Co Ltd | テトラヒドロナフタレン誘導体 |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
US5151526A (en) * | 1990-10-11 | 1992-09-29 | The United States Of America As Represented By The Secretary Of The Army | 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic |
JPH04210680A (ja) * | 1990-12-01 | 1992-07-31 | Nissan Chem Ind Ltd | イミダゾール誘導体および植物生長調節剤 |
GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
-
1994
- 1994-12-14 GB GBGB9425211.1A patent/GB9425211D0/en active Pending
-
1995
- 1995-12-05 MX MX9505063A patent/MX9505063A/es not_active IP Right Cessation
- 1995-12-08 BG BG100208A patent/BG63043B1/bg unknown
- 1995-12-08 TW TW084113098A patent/TW303362B/zh active
- 1995-12-08 US US08/569,947 patent/US5658938A/en not_active Expired - Fee Related
- 1995-12-08 IS IS4311A patent/IS4311A/is unknown
- 1995-12-08 RO RO95-02138A patent/RO113346B1/ro unknown
- 1995-12-08 PL PL95311736A patent/PL311736A1/xx unknown
- 1995-12-11 FI FI955927A patent/FI955927A7/fi unknown
- 1995-12-11 NZ NZ280646A patent/NZ280646A/en unknown
- 1995-12-11 IL IL11632595A patent/IL116325A/xx not_active IP Right Cessation
- 1995-12-11 SK SK1550-95A patent/SK155095A3/sk unknown
- 1995-12-12 NO NO955034A patent/NO305316B1/no not_active IP Right Cessation
- 1995-12-12 CN CN95120834A patent/CN1054376C/zh not_active Expired - Fee Related
- 1995-12-12 AU AU40368/95A patent/AU693614B2/en not_active Ceased
- 1995-12-12 HU HU9503549A patent/HUT73980A/hu unknown
- 1995-12-12 CZ CZ953271A patent/CZ327195A3/cs unknown
- 1995-12-12 ZA ZA9510554A patent/ZA9510554B/xx unknown
- 1995-12-12 EE EE9500064A patent/EE9500064A/xx unknown
- 1995-12-12 AR ARP950100512A patent/AR002257A1/es unknown
- 1995-12-13 RU RU95120582/04A patent/RU2156239C2/ru active
- 1995-12-13 JP JP7324502A patent/JPH08208622A/ja active Pending
- 1995-12-13 BR BR9505815A patent/BR9505815A/pt not_active Application Discontinuation
- 1995-12-13 EP EP95870132A patent/EP0717037A1/fr not_active Withdrawn
- 1995-12-13 CA CA002165133A patent/CA2165133A1/en not_active Abandoned
- 1995-12-14 KR KR1019950049572A patent/KR960022474A/ko not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
FI955927L (fi) | 1996-06-15 |
AU693614B2 (en) | 1998-07-02 |
BR9505815A (pt) | 1998-01-06 |
PL311736A1 (en) | 1996-06-24 |
FI955927A7 (fi) | 1996-06-15 |
EP0717037A1 (fr) | 1996-06-19 |
CN1054376C (zh) | 2000-07-12 |
IL116325A (en) | 1999-10-28 |
IS4311A (is) | 1996-06-15 |
FI955927A0 (fi) | 1995-12-11 |
CZ327195A3 (en) | 1996-07-17 |
BG100208A (bg) | 1996-07-31 |
NO305316B1 (no) | 1999-05-10 |
NZ280646A (en) | 1996-08-27 |
US5658938A (en) | 1997-08-19 |
TW303362B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-04-21 |
JPH08208622A (ja) | 1996-08-13 |
BG63043B1 (bg) | 2001-02-28 |
RU2156239C2 (ru) | 2000-09-20 |
AU4036895A (en) | 1996-06-20 |
SK155095A3 (en) | 1997-02-05 |
CN1133837A (zh) | 1996-10-23 |
EE9500064A (et) | 1996-06-17 |
IL116325A0 (en) | 1996-03-31 |
MX9505063A (es) | 1997-01-31 |
HU9503549D0 (en) | 1996-02-28 |
NO955034L (no) | 1996-06-17 |
ZA9510554B (en) | 1996-06-13 |
RO113346B1 (ro) | 1998-06-30 |
HUT73980A (en) | 1996-10-28 |
AR002257A1 (es) | 1998-03-11 |
CA2165133A1 (en) | 1996-06-15 |
NO955034D0 (no) | 1995-12-12 |
KR960022474A (ko) | 1996-07-18 |
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