RU2055892C1 - Способ получения проинсулина - Google Patents

Способ получения проинсулина Download PDF

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Publication number
RU2055892C1
RU2055892C1 SU914895292A SU4895292A RU2055892C1 RU 2055892 C1 RU2055892 C1 RU 2055892C1 SU 914895292 A SU914895292 A SU 914895292A SU 4895292 A SU4895292 A SU 4895292A RU 2055892 C1 RU2055892 C1 RU 2055892C1
Authority
RU
Russia
Prior art keywords
tendamistat
amino acids
proinsulin
fragment
plasmid
Prior art date
Application number
SU914895292A
Other languages
English (en)
Russian (ru)
Inventor
Коллер Клаус-Петер
Рис Гюнтер
Original Assignee
Хехст АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст АГ filed Critical Хехст АГ
Application granted granted Critical
Publication of RU2055892C1 publication Critical patent/RU2055892C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
SU914895292A 1990-04-21 1991-04-19 Способ получения проинсулина RU2055892C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4012818.0 1990-04-21
DE4012818A DE4012818A1 (de) 1990-04-21 1990-04-21 Verfahren zur herstellung von fremdproteinen in streptomyceten

Publications (1)

Publication Number Publication Date
RU2055892C1 true RU2055892C1 (ru) 1996-03-10

Family

ID=6404857

Family Applications (1)

Application Number Title Priority Date Filing Date
SU914895292A RU2055892C1 (ru) 1990-04-21 1991-04-19 Способ получения проинсулина

Country Status (29)

Country Link
EP (1) EP0453969B1 (show.php)
JP (1) JP3319605B2 (show.php)
KR (1) KR0168669B1 (show.php)
CN (1) CN1049248C (show.php)
AT (1) ATE142263T1 (show.php)
AU (1) AU630287B2 (show.php)
BR (1) BR9101587A (show.php)
CA (1) CA2040810C (show.php)
CZ (1) CZ285440B6 (show.php)
DE (2) DE4012818A1 (show.php)
DK (1) DK0453969T3 (show.php)
ES (1) ES2093043T3 (show.php)
FI (1) FI911882A7 (show.php)
GR (1) GR3021040T3 (show.php)
HR (1) HRP940770A2 (show.php)
HU (1) HU210358B (show.php)
IE (1) IE911322A1 (show.php)
IL (1) IL97903A0 (show.php)
LT (1) LT3686B (show.php)
LV (1) LV10494B (show.php)
NO (1) NO911557L (show.php)
NZ (1) NZ237882A (show.php)
PL (2) PL169596B1 (show.php)
PT (1) PT97427B (show.php)
RU (1) RU2055892C1 (show.php)
SK (1) SK110191A3 (show.php)
TW (1) TW213487B (show.php)
YU (1) YU48435B (show.php)
ZA (1) ZA912937B (show.php)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2122581C1 (ru) * 1997-11-27 1998-11-27 Закрытое акционерное общество "Фосфосорб" Штамм escherichia coli xli-blue/pinsr - продуцент препроинсулина
RU2162102C1 (ru) * 1999-09-08 2001-01-20 Головков Алексей Леонардович Рекомбинантная плазмида, кодирующая гибридный белок с проинсулином человека (варианты)
RU2395296C1 (ru) * 2009-02-19 2010-07-27 Общество С Ограниченной Ответственностью "Концерн О3" Способ получения препарата проинсулина для перорального применения

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ239652A (en) * 1990-09-05 1992-09-25 Hoechst Ag Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
ES2097426T3 (es) 1992-12-02 1997-04-01 Hoechst Ag Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
EP0622376B1 (de) * 1993-04-27 2001-08-08 Hoechst Aktiengesellschaft Amorphe monosphärische Formen von Insulinderivaten
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
CN1061375C (zh) * 1996-07-19 2001-01-31 中国科学院上海生物工程研究中心 利用异源启动子在链霉菌中表达透明颤菌血红蛋白
PT821006E (pt) 1996-07-26 2004-09-30 Aventis Pharma Gmbh Derivados de insulina com ligacao a zinco aumentada
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
CN1298742C (zh) * 2003-06-03 2007-02-07 上海新药研究开发中心 一种适合于高效表达的融合蛋白及其生产方法
CN104818291A (zh) * 2015-05-08 2015-08-05 江南大学 一种链霉菌重组表达载体的构建及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
DE3418274A1 (de) 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt Signalpeptid fuer die exkretion von peptiden in streptomyceten
DE3707150A1 (de) * 1987-03-06 1988-09-15 Hoechst Ag Tendamistat-derivate
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3715033A1 (de) 1987-05-06 1988-11-17 Hoechst Ag Verfahren zur isolierung von fusionsproteinen
DE3716722A1 (de) 1987-05-19 1988-12-01 Hoechst Ag Gentechnologisches verfahren zur herstellung von angiogeninen
DE3843713A1 (de) * 1988-04-25 1989-11-02 Henkel Kgaa Verwendung von calcinierten hydrotalciten als katalysatoren fuer die ethoxylierung bzw. propoxylierung
ES2081826T3 (es) * 1988-11-03 1996-03-16 Hoechst Ag Procedimiento para la preparacion de un producto previo de insulina en estreptomicetos.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ЕР, 0177827, C 12N 15/00, 1986. ЕР, 0289936, C 12N 15/00, 1988. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2122581C1 (ru) * 1997-11-27 1998-11-27 Закрытое акционерное общество "Фосфосорб" Штамм escherichia coli xli-blue/pinsr - продуцент препроинсулина
RU2162102C1 (ru) * 1999-09-08 2001-01-20 Головков Алексей Леонардович Рекомбинантная плазмида, кодирующая гибридный белок с проинсулином человека (варианты)
RU2395296C1 (ru) * 2009-02-19 2010-07-27 Общество С Ограниченной Ответственностью "Концерн О3" Способ получения препарата проинсулина для перорального применения
WO2010095978A3 (ru) * 2009-02-19 2010-12-02 Общество С Ограниченной Ответственностью "Концерн О3" Способ получения препарата проинсулина для перорального применения

Also Published As

Publication number Publication date
JP3319605B2 (ja) 2002-09-03
YU48435B (sh) 1998-07-10
EP0453969B1 (de) 1996-09-04
ATE142263T1 (de) 1996-09-15
HU210358B (en) 1995-04-28
ZA912937B (en) 1991-12-24
PT97427B (pt) 1998-08-31
BR9101587A (pt) 1991-12-10
FI911882L (fi) 1991-10-22
IL97903A0 (en) 1992-06-21
PL169596B1 (pl) 1996-08-30
HUT57268A (en) 1991-11-28
AU7515491A (en) 1991-10-24
DK0453969T3 (show.php) 1997-02-10
KR0168669B1 (ko) 1999-01-15
PL289953A1 (en) 1991-11-04
LV10494A (lv) 1995-02-20
FI911882A0 (fi) 1991-04-18
CZ285440B6 (cs) 1999-08-11
CN1049248C (zh) 2000-02-09
NO911557D0 (no) 1991-04-19
NZ237882A (en) 1993-12-23
CZ110191A3 (en) 1993-08-11
YU69691A (sh) 1995-12-04
DE59108128D1 (de) 1996-10-10
PT97427A (pt) 1992-01-31
EP0453969A1 (de) 1991-10-30
LV10494B (en) 1996-02-20
LT3686B (en) 1996-01-25
HU911302D0 (en) 1991-10-28
SK110191A3 (en) 1995-07-11
CA2040810C (en) 2001-07-24
FI911882A7 (fi) 1991-10-22
TW213487B (show.php) 1993-09-21
HRP940770A2 (en) 1997-06-30
CA2040810A1 (en) 1991-10-22
AU630287B2 (en) 1992-10-22
PL169178B1 (pl) 1996-06-28
NO911557L (no) 1991-10-22
IE911322A1 (en) 1991-10-23
LTIP1523A (en) 1995-06-26
DE4012818A1 (de) 1991-10-24
JPH04228086A (ja) 1992-08-18
GR3021040T3 (en) 1996-12-31
CN1055952A (zh) 1991-11-06
ES2093043T3 (es) 1996-12-16
KR910018551A (ko) 1991-11-30

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