RU2020123963A - Стабилизированные препараты, содержащие антитела против ngf - Google Patents
Стабилизированные препараты, содержащие антитела против ngf Download PDFInfo
- Publication number
- RU2020123963A RU2020123963A RU2020123963A RU2020123963A RU2020123963A RU 2020123963 A RU2020123963 A RU 2020123963A RU 2020123963 A RU2020123963 A RU 2020123963A RU 2020123963 A RU2020123963 A RU 2020123963A RU 2020123963 A RU2020123963 A RU 2020123963A
- Authority
- RU
- Russia
- Prior art keywords
- antibody
- seq
- lcvr
- hcvr
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Claims (16)
1. Препарат антитела, включающий:
(i) антитело человека, которое специфически связывается с фактором роста нервов человека (hNGF), в концентрации до 150 мг/мл, где антитело человека, которое специфически связывается с hNGF, содержит вариабельную область тяжелой цепи (HCVR) и вариабельную область легкой цепи (LCVR), где HCVR содержит определяющие комплементарность участки тяжелой цепи, содержащие аминокислотные последовательности SEQ ID NO: 6, 8 и 10, и где LCVR содержит определяющие комплементарность участки легкой цепи, содержащие аминокислотные последовательности SEQ ID NO: 14, 16 и 18;
(ii) приблизительно 0,05% полисорбата 20;
(iii) приблизительно 8,0% сахарозы;
(iv) приблизительно 10 мМ ацетата; и
(v) pH 5,0.
2. Препарат антитела по п.1, где антитело содержит пару аминокислотных последовательностей вариабельной области тяжелой цепи и легкой цепи (HCVR/LCVR): (i) SEQ ID NO: 20/22.
3. Препарат антитела по п.1, где антитело присутствует в количестве приблизительно от 0,1 до 100 мг/мл.
4. Препарат антитела по п.1, где антитело присутствует в количестве от приблизительно от 0,2 до 75 мг/мл.
5. Препарат антитела по п.1, где антитело присутствует в количестве приблизительно от 0,6 до 60 мг/мл.
6. Автоинжектор, включающий контейнер, содержащий препарат антитела, содержащий:
(i) антитело человека, которое специфически связывается с фактором роста нервов человека (hNGF), в концентрации до 100 мг/мл, где антитело включает пару аминокислотных последовательностей вариабельной области тяжелой цепи и легкой цепи (HCVR/LCVR): (i) SEQ ID NO: 20/22;
(ii) приблизительно 0,05% полисорбата 20;
(iii) приблизительно 8,0% сахарозы;
(iv) приблизительно 10 мМ ацетата; и
(v) pH 5,0.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36411210P | 2010-07-14 | 2010-07-14 | |
| US61/364,112 | 2010-07-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019126172A Division RU2728575C1 (ru) | 2010-07-14 | 2019-08-20 | Стабилизированные препараты, содержащие антитела против ngf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2020123963A3 RU2020123963A3 (ru) | 2022-01-20 |
| RU2020123963A true RU2020123963A (ru) | 2022-01-20 |
Family
ID=44628867
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017109249A RU2700174C2 (ru) | 2010-07-14 | 2011-07-11 | Стабилизированные препараты, содержащие антитела против ngf |
| RU2013106275/15A RU2013106275A (ru) | 2010-07-14 | 2011-07-11 | Стабилизированные препараты, содержащие антитела против ngf |
| RU2019126172A RU2728575C1 (ru) | 2010-07-14 | 2019-08-20 | Стабилизированные препараты, содержащие антитела против ngf |
| RU2020123963A RU2020123963A (ru) | 2010-07-14 | 2020-07-20 | Стабилизированные препараты, содержащие антитела против ngf |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017109249A RU2700174C2 (ru) | 2010-07-14 | 2011-07-11 | Стабилизированные препараты, содержащие антитела против ngf |
| RU2013106275/15A RU2013106275A (ru) | 2010-07-14 | 2011-07-11 | Стабилизированные препараты, содержащие антитела против ngf |
| RU2019126172A RU2728575C1 (ru) | 2010-07-14 | 2019-08-20 | Стабилизированные препараты, содержащие антитела против ngf |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20120014968A1 (ru) |
| EP (3) | EP3881867A1 (ru) |
| KR (1) | KR101869682B1 (ru) |
| CN (1) | CN103108656B (ru) |
| AR (1) | AR082171A1 (ru) |
| AU (3) | AU2011279450B2 (ru) |
| BR (1) | BR112013002764B1 (ru) |
| CA (1) | CA2805388C (ru) |
| ES (2) | ES2694771T3 (ru) |
| JO (2) | JOP20190250A1 (ru) |
| MX (1) | MX340524B (ru) |
| MY (1) | MY164610A (ru) |
| NZ (1) | NZ606078A (ru) |
| RU (4) | RU2700174C2 (ru) |
| SG (1) | SG187128A1 (ru) |
| TW (1) | TWI481414B (ru) |
| UA (1) | UA111825C2 (ru) |
| UY (1) | UY33515A (ru) |
| WO (1) | WO2012009254A1 (ru) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| AU2011336470B8 (en) | 2010-12-01 | 2017-09-14 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| EP2790681B9 (en) | 2011-11-18 | 2023-07-26 | Regeneron Pharmaceuticals, Inc. | Method of manufacturing an extended release pharmaceutical formulation comprising polymer coated protein microparticles using spray-drying |
| EP2859018B1 (en) | 2012-06-06 | 2021-09-22 | Zoetis Services LLC | Caninized anti-ngf antibodies and methods thereof |
| US8906900B2 (en) | 2012-12-21 | 2014-12-09 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| WO2014100716A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9221794B2 (en) | 2012-12-21 | 2015-12-29 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| US8940726B2 (en) | 2012-12-21 | 2015-01-27 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP6678455B2 (ja) | 2012-12-21 | 2020-04-08 | エピザイム，インコーポレイティド | Ｐｒｍｔ５阻害剤およびその使用 |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| US11058768B2 (en) * | 2014-04-16 | 2021-07-13 | Biocon Ltd. | Stable protein formulations comprising a molar excess of sorbitol |
| WO2016022605A1 (en) | 2014-08-04 | 2016-02-11 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| RU2708974C2 (ru) * | 2014-10-30 | 2019-12-12 | Ф. Хоффманн-Ля Рош Аг | Шприц и способ подготовки шприца |
| EP3213786A4 (en) * | 2014-10-30 | 2018-07-11 | Chugai Seiyaku Kabushiki Kaisha | Pre-filled syringe preparation with needle, which is equipped with syringe cap |
| JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
| TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| RU2599031C1 (ru) * | 2015-08-11 | 2016-10-10 | Общество с ограниченной ответственностью "АйВиФарма" | Водная композиция рекомбинантного фолликулостимулирующего гормона человека (варианты) |
| CN114404371A (zh) * | 2015-12-16 | 2022-04-29 | 瑞泽恩制药公司 | 制造蛋白质微粒的组合物和方法 |
| EP3504328A1 (en) | 2016-08-24 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| KR20210084695A (ko) | 2017-07-06 | 2021-07-07 | 리제너론 파마슈티칼스 인코포레이티드 | 당단백질을 만들기 위한 세포 배양 과정 |
| EP3727629A1 (en) | 2017-12-22 | 2020-10-28 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
| CN111655722A (zh) | 2018-01-31 | 2020-09-11 | 瑞泽恩制药公司 | 用于表征药物产品杂质的系统和方法 |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| SG11202007805SA (en) | 2018-02-16 | 2020-09-29 | Incyte Corp | Jak1 pathway inhibitors for the treatment of cytokine-related disorders |
| BR112020013426A2 (pt) | 2018-02-28 | 2020-12-01 | Regeneron Pharmaceuticals, Inc. | métodos para identificação de um vírus em uma amostra e para detecção de ácidos nucleicos virais em uma amostra de cultura de células |
| CN111868085A (zh) | 2018-03-19 | 2020-10-30 | 瑞泽恩制药公司 | 微芯片毛细管电泳测定法及试剂 |
| KR20200139720A (ko) | 2018-04-02 | 2020-12-14 | 암젠 인크 | 에레누맙 조성물 및 이의 용도 |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| KR20200010103A (ko) | 2018-07-19 | 2020-01-30 | (주)셀트리온 | 안정한 액체 약제학적 제제 |
| MX2021001549A (es) | 2018-08-10 | 2021-04-13 | Regeneron Pharma | Una composicion farmaceutica para el tratamiento seguro y efectivo del dolor de rodilla y/o cadera. |
| CN112218877A (zh) | 2018-08-27 | 2021-01-12 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| CN112601963A (zh) | 2018-08-30 | 2021-04-02 | 瑞泽恩制药公司 | 用于表征蛋白质复合物的方法 |
| CA3116732A1 (en) | 2019-01-16 | 2020-07-23 | Regeneron Pharmaceuticals, Inc. | Methods for identifying free thiols in proteins |
| MA55033A (fr) | 2019-02-18 | 2021-12-29 | Lilly Co Eli | Formulation d'anticorps thérapeutique |
| EP3969908A1 (en) | 2019-05-13 | 2022-03-23 | Regeneron Pharmaceuticals, Inc. | Improved competitive ligand binding assays |
| KR20220104797A (ko) | 2019-11-25 | 2022-07-26 | 리제너론 파마슈티칼스 인코포레이티드 | 비수성 에멀전을 이용한 지속 방출 제형 |
| KR102544013B1 (ko) | 2020-01-21 | 2023-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 당질화된 단백질의 전기영동을 위한 탈당질화 방법 |
| EP4204578A1 (en) | 2020-08-31 | 2023-07-05 | Regeneron Pharmaceuticals, Inc. | Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants |
| KR20230113280A (ko) | 2020-11-25 | 2023-07-28 | 리제너론 파마슈티칼스 인코포레이티드 | 비수성 멤브레인 유화법을 사용한 지속 방출 제형 |
| KR20230118118A (ko) | 2020-12-08 | 2023-08-10 | 인사이트 코포레이션 | 백반증의 치료를 위한 jak1 경로 저해제 |
| KR20230121854A (ko) | 2020-12-17 | 2023-08-21 | 리제너론 파아마슈티컬스, 인크. | 단백질-캡슐화 마이크로겔의 제작 |
| TW202233827A (zh) | 2021-01-20 | 2022-09-01 | 美商再生元醫藥公司 | 改良細胞培養中蛋白質效價的方法 |
| AU2022230987A1 (en) | 2021-03-03 | 2023-08-31 | Regeneron Pharmaceuticals, Inc. | Systems and methods for quantifying and modifying protein viscosity |
| EP4348234A1 (en) | 2021-06-01 | 2024-04-10 | Regeneron Pharmaceuticals, Inc. | Micropchip capillary electrophoresis assays and reagents |
| WO2023039457A1 (en) | 2021-09-08 | 2023-03-16 | Regeneron Pharmaceuticals, Inc. | A high-throughput and mass-spectrometry-based method for quantitating antibodies and other fc-containing proteins |
| CA3232463A1 (en) | 2021-09-20 | 2023-03-23 | Philip Mellors | Methods of controlling antibody heterogeneity |
| WO2023059800A2 (en) | 2021-10-07 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Systems and methods of ph modeling and control |
| AU2022359898A1 (en) | 2021-10-07 | 2024-03-21 | Regeneron Pharmaceuticals, Inc. | Ph meter calibration and correction |
| WO2023066988A1 (en) * | 2021-10-19 | 2023-04-27 | Sandoz Ag | Glass container with low aluminum content and gas overlay to prevent oxidation of sensitive therapeutic agents |
| TW202330104A (zh) | 2021-10-26 | 2023-08-01 | 美商再生元醫藥公司 | 用於產生實驗室用水及分配不同溫度之實驗室用水的系統及方法 |
| WO2023092052A1 (en) | 2021-11-19 | 2023-05-25 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for reducing centralized pain |
| US20240002491A1 (en) | 2022-04-27 | 2024-01-04 | Regeneron Pharmaceuticals, Inc. | Methods for selecting patients for treatment with an ngf antagonist |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0747045B2 (ja) | 1986-10-15 | 1995-05-24 | 株式会社大協精工 | 積層した注射器用滑栓 |
| JP3100727B2 (ja) | 1992-01-23 | 2000-10-23 | 株式会社大協精工 | 変性ポリシロキサン組成物及び該組成物を被覆した衛生ゴム製品 |
| JP3172057B2 (ja) | 1995-04-05 | 2001-06-04 | 株式会社大協精工 | ラミネートゴム栓 |
| EP0999853B1 (en) * | 1997-06-13 | 2003-01-02 | Genentech, Inc. | Stabilized antibody formulation |
| JP3512349B2 (ja) | 1999-01-29 | 2004-03-29 | 株式会社大協精工 | 柱状ゴム要素の成形型 |
| US6659982B2 (en) | 2000-05-08 | 2003-12-09 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
| US6629949B1 (en) | 2000-05-08 | 2003-10-07 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
| JP2002209975A (ja) | 2001-01-19 | 2002-07-30 | Daikyo Seiko Ltd | 医薬バイアル用ラミネートゴム栓 |
| MXPA04000747A (es) * | 2001-07-25 | 2004-07-08 | Protein Desing Labs Inc | Formulacion farmaceutica liofilizada estable de anticuerpos igg. |
| AU2003293543A1 (en) * | 2002-12-13 | 2004-07-09 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| ES2776657T3 (es) * | 2005-06-14 | 2020-07-31 | Amgen Inc | Formulaciones de proteínas autotamponantes |
| ME00977B (me) | 2007-08-10 | 2012-06-20 | Regeneron Pharma | Humana antitijela visokog afiniteta prema humanom nervnom faktoru rasta |
| US20110256135A1 (en) * | 2010-03-17 | 2011-10-20 | Wolfgang Fraunhofer | Anti-nerve growth factor (ngf) antibody compositions |
-
2010
- 2010-07-14 JO JOP/2019/0250A patent/JOP20190250A1/ar unknown
-
2011
- 2011-07-11 ES ES11735738.4T patent/ES2694771T3/es active Active
- 2011-07-11 RU RU2017109249A patent/RU2700174C2/ru active
- 2011-07-11 NZ NZ606078A patent/NZ606078A/en unknown
- 2011-07-11 WO PCT/US2011/043511 patent/WO2012009254A1/en active Application Filing
- 2011-07-11 AU AU2011279450A patent/AU2011279450B2/en active Active
- 2011-07-11 SG SG2013004056A patent/SG187128A1/en unknown
- 2011-07-11 EP EP21163617.0A patent/EP3881867A1/en active Pending
- 2011-07-11 EP EP18188992.4A patent/EP3427752B1/en active Active
- 2011-07-11 MY MYPI2013000189A patent/MY164610A/en unknown
- 2011-07-11 MX MX2013000587A patent/MX340524B/es active IP Right Grant
- 2011-07-11 RU RU2013106275/15A patent/RU2013106275A/ru unknown
- 2011-07-11 EP EP11735738.4A patent/EP2593137B1/en active Active
- 2011-07-11 US US13/179,910 patent/US20120014968A1/en not_active Abandoned
- 2011-07-11 JO JOP/2011/0228A patent/JO3449B1/ar active
- 2011-07-11 CN CN201180040615.1A patent/CN103108656B/zh active Active
- 2011-07-11 ES ES18188992T patent/ES2882135T3/es active Active
- 2011-07-11 BR BR112013002764-9A patent/BR112013002764B1/pt active IP Right Grant
- 2011-07-11 KR KR1020137003626A patent/KR101869682B1/ko active IP Right Grant
- 2011-07-11 CA CA2805388A patent/CA2805388C/en active Active
- 2011-07-13 AR ARP110102522A patent/AR082171A1/es not_active Application Discontinuation
- 2011-07-13 TW TW100124806A patent/TWI481414B/zh active
- 2011-07-14 UY UY0001033515A patent/UY33515A/es not_active Application Discontinuation
- 2011-11-07 UA UAA201301788A patent/UA111825C2/uk unknown
-
2015
- 2015-05-27 AU AU2015202886A patent/AU2015202886B2/en active Active
- 2015-10-05 US US14/875,457 patent/US20160017029A1/en not_active Abandoned
-
2016
- 2016-06-29 AU AU2016204515A patent/AU2016204515B2/en active Active
-
2018
- 2018-09-19 US US16/135,953 patent/US20190010222A1/en not_active Abandoned
-
2019
- 2019-08-20 RU RU2019126172A patent/RU2728575C1/ru active
-
2020
- 2020-07-20 RU RU2020123963A patent/RU2020123963A/ru unknown
- 2020-12-07 US US17/113,642 patent/US20210107974A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2020123963A (ru) | Стабилизированные препараты, содержащие антитела против ngf | |
| NZ627859A (en) | Stabilized formulations containing anti-ang2 antibodies | |
| JP6537492B2 (ja) | 呼吸器合胞体ウイルスｆタンパク質に対するヒト抗体及びその使用方法 | |
| CN103314011B (zh) | 胰高血糖素受体的人抗体 | |
| ES2888224T3 (es) | Anticuerpos humanos contra PD-1 | |
| ES2628093T3 (es) | Moléculas de unión al receptor OX40 humano | |
| RU2014140137A (ru) | Лекарственный препарат антитела к бета-амилоиду | |
| UA107211C2 (uk) | Стабілізовані склади, які містять антитіла до рецептора інтерлейкіну 6 (il-6r) | |
| IL283424B2 (en) | Stabilized formulations that include antibodies against the interleukin receptor (il-4r) | |
| RU2539774C3 (ru) | Человеческие антитела с высокой аффинностью к рецепторам il-4 человека | |
| SG194707A1 (en) | Amino acid sequence presenting fusion polypeptide and its use | |
| JP2014510152A5 (ru) | ||
| JP7352973B2 (ja) | 二重特異性抗体及びその使用 | |
| NZ630020A (en) | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof | |
| HRP20210393T1 (hr) | Anti-tfr antitijela i njihova uporaba u liječenju proliferativnih i upalnih poremećaja | |
| CN107922478A (zh) | 抗angptl8抗体及其用途 | |
| MY182680A (en) | Antibody formulation and therapeutic regimens | |
| PE20130226A1 (es) | Anticuerpos hacia gdf8 humano | |
| RU2011142184A (ru) | Фармацевтический состав, содержащий молекулы антител с улучшенными свойствами | |
| RU2012131099A (ru) | Препарат антитела | |
| RU2016123839A (ru) | Новые модуляторы и способы их применения | |
| NZ597676A (en) | Crystalline anti-hTNFalpha antibodies | |
| RU2009149294A (ru) | Антиген-связывающие белки, нацеленные на orf0657n s.aureus | |
| TW201313738A (zh) | 人類類血管生成素蛋白３之人類抗體 | |
| RU2018102606A (ru) | Молекулы, связывающиеся с psl pseudomonas, и пути их применения |