RU2018145691A - Заболевания, связанные с токсичным альдегидом, и их лечение - Google Patents
Заболевания, связанные с токсичным альдегидом, и их лечение Download PDFInfo
- Publication number
- RU2018145691A RU2018145691A RU2018145691A RU2018145691A RU2018145691A RU 2018145691 A RU2018145691 A RU 2018145691A RU 2018145691 A RU2018145691 A RU 2018145691A RU 2018145691 A RU2018145691 A RU 2018145691A RU 2018145691 A RU2018145691 A RU 2018145691A
- Authority
- RU
- Russia
- Prior art keywords
- aminomethyl
- acid
- methyl
- phenoxy
- disease
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 31
- 201000010099 disease Diseases 0.000 title claims 17
- 231100000331 toxic Toxicity 0.000 title claims 7
- 230000002588 toxic effect Effects 0.000 title claims 7
- 150000001299 aldehydes Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 16
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 15
- 125000004432 carbon atom Chemical group C* 0.000 claims 15
- 208000035475 disorder Diseases 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 208000017520 skin disease Diseases 0.000 claims 10
- 201000008937 atopic dermatitis Diseases 0.000 claims 8
- 208000030533 eye disease Diseases 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- KRZJRNZICWNMOA-GXSJLCMTSA-N (3s,4r)-4,8-dihydroxy-3-methoxy-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1=CC=C2[C@@H](O)[C@@H](OC)CC(=O)C2=C1O KRZJRNZICWNMOA-GXSJLCMTSA-N 0.000 claims 7
- 208000010668 atopic eczema Diseases 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 239000002537 cosmetic Substances 0.000 claims 6
- -1 3-aminomethyl-5-cyclopentylhexanoic acid -aminomethyl-5-cyclohexylhexanoic acid Chemical compound 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 230000035876 healing Effects 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 206010012434 Dermatitis allergic Diseases 0.000 claims 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims 4
- 206010012442 Dermatitis contact Diseases 0.000 claims 4
- 206010072139 Ocular rosacea Diseases 0.000 claims 4
- 206010048676 Sjogren-Larsson Syndrome Diseases 0.000 claims 4
- 208000027073 Stargardt disease Diseases 0.000 claims 4
- 206010046851 Uveitis Diseases 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 208000010247 contact dermatitis Diseases 0.000 claims 4
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 4
- 206010025135 lupus erythematosus Diseases 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- 208000006934 radiodermatitis Diseases 0.000 claims 4
- 201000004700 rosacea Diseases 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 3
- 208000009299 Benign Mucous Membrane Pemphigoid Diseases 0.000 claims 3
- 208000002177 Cataract Diseases 0.000 claims 3
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 3
- 206010013774 Dry eye Diseases 0.000 claims 3
- 201000001925 Fuchs' endothelial dystrophy Diseases 0.000 claims 3
- 201000002287 Keratoconus Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010039705 Scleritis Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 206010000496 acne Diseases 0.000 claims 3
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 3
- 238000009835 boiling Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 238000002224 dissection Methods 0.000 claims 3
- 230000003176 fibrotic effect Effects 0.000 claims 3
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 206010021198 ichthyosis Diseases 0.000 claims 3
- 206010023365 keratopathy Diseases 0.000 claims 3
- 231100000614 poison Toxicity 0.000 claims 3
- 150000003141 primary amines Chemical class 0.000 claims 3
- 239000000779 smoke Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 230000008961 swelling Effects 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 230000037303 wrinkles Effects 0.000 claims 3
- FEWJHICLKRAPHS-OCCSQVGLSA-N (3s,5r)-3-(aminomethyl)-5-methyl-7-phenylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1=CC=CC=C1 FEWJHICLKRAPHS-OCCSQVGLSA-N 0.000 claims 2
- JBBFMHZVKGOWPT-YPMHNXCESA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-phenylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1=CC=CC=C1 JBBFMHZVKGOWPT-YPMHNXCESA-N 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 210000004087 cornea Anatomy 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 238000000354 decomposition reaction Methods 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 210000004561 lacrimal apparatus Anatomy 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 208000015200 ocular cicatricial pemphigoid Diseases 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- AYXYPKUFHZROOJ-SSDOTTSWSA-N pregabalin Chemical compound CC(C)C[C@@H](CN)CC(O)=O AYXYPKUFHZROOJ-SSDOTTSWSA-N 0.000 claims 2
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000003440 toxic substance Substances 0.000 claims 2
- IASDTUBNBCYCJG-SFYZADRCSA-N (3r,4r)-3-(azaniumylmethyl)-4,5-dimethylhexanoate Chemical compound CC(C)[C@@H](C)[C@H](CN)CC(O)=O IASDTUBNBCYCJG-SFYZADRCSA-N 0.000 claims 1
- IASDTUBNBCYCJG-YUMQZZPRSA-N (3r,4s)-3-(azaniumylmethyl)-4,5-dimethylhexanoate Chemical compound CC(C)[C@H](C)[C@H](CN)CC(O)=O IASDTUBNBCYCJG-YUMQZZPRSA-N 0.000 claims 1
- IASDTUBNBCYCJG-JGVFFNPUSA-N (3s,4s)-3-(aminomethyl)-4,5-dimethylhexanoic acid Chemical compound CC(C)[C@H](C)[C@@H](CN)CC(O)=O IASDTUBNBCYCJG-JGVFFNPUSA-N 0.000 claims 1
- BGQCKHBIIZKBJU-ZJUUUORDSA-N (3s,5r)-3-(aminomethyl)-5,7-dimethyloctanoic acid Chemical compound CC(C)C[C@@H](C)C[C@H](CN)CC(O)=O BGQCKHBIIZKBJU-ZJUUUORDSA-N 0.000 claims 1
- CRENPLBKNGOMEN-MNOVXSKESA-N (3s,5r)-3-(aminomethyl)-5,8-dimethylnonanoic acid Chemical compound CC(C)CC[C@@H](C)C[C@H](CN)CC(O)=O CRENPLBKNGOMEN-MNOVXSKESA-N 0.000 claims 1
- ADANSFWHWWMFDU-NEPJUHHUSA-N (3s,5r)-3-(aminomethyl)-5,9-dimethyldecanoic acid Chemical compound CC(C)CCC[C@@H](C)C[C@H](CN)CC(O)=O ADANSFWHWWMFDU-NEPJUHHUSA-N 0.000 claims 1
- IMLWGNYZSUWXIA-OLZOCXBDSA-N (3s,5r)-3-(aminomethyl)-5-methyldodecanoic acid Chemical compound CCCCCCC[C@@H](C)C[C@H](CN)CC(O)=O IMLWGNYZSUWXIA-OLZOCXBDSA-N 0.000 claims 1
- SIRQBZJUYVPMIC-SFYZADRCSA-N (3s,5r)-3-(aminomethyl)-5-methylheptanoic acid Chemical compound CC[C@@H](C)C[C@H](CN)CC(O)=O SIRQBZJUYVPMIC-SFYZADRCSA-N 0.000 claims 1
- KUSIIZRBOLFILF-ZJUUUORDSA-N (3s,5r)-3-(aminomethyl)-5-methylnonanoic acid Chemical compound CCCC[C@@H](C)C[C@H](CN)CC(O)=O KUSIIZRBOLFILF-ZJUUUORDSA-N 0.000 claims 1
- YAMOPJPIJYQIGY-BDAKNGLRSA-N (3s,5r)-3-(aminomethyl)-5-methyloct-7-enoic acid Chemical compound C=CC[C@@H](C)C[C@H](CN)CC(O)=O YAMOPJPIJYQIGY-BDAKNGLRSA-N 0.000 claims 1
- KKXFMWXZXDUYBF-BDAKNGLRSA-N (3s,5r)-3-(aminomethyl)-5-methyloctanoic acid Chemical compound CCC[C@@H](C)C[C@H](CN)CC(O)=O KKXFMWXZXDUYBF-BDAKNGLRSA-N 0.000 claims 1
- HLRPRVFNTZZSHY-NEPJUHHUSA-N (3s,5r)-3-(aminomethyl)-5-methylundecanoic acid Chemical compound CCCCCC[C@@H](C)C[C@H](CN)CC(O)=O HLRPRVFNTZZSHY-NEPJUHHUSA-N 0.000 claims 1
- SHMPJXGCBKABBT-KOLCDFICSA-N (3s,5r)-3-(aminomethyl)-6-cyclobutyl-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1CCC1 SHMPJXGCBKABBT-KOLCDFICSA-N 0.000 claims 1
- LUHAQNAPMJQCNM-YPMHNXCESA-N (3s,5r)-3-(aminomethyl)-6-cyclohexyl-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1CCCCC1 LUHAQNAPMJQCNM-YPMHNXCESA-N 0.000 claims 1
- SSFYNNBUYYSXPA-PWSUYJOCSA-N (3s,5r)-3-(aminomethyl)-6-cyclopentyl-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1CCCC1 SSFYNNBUYYSXPA-PWSUYJOCSA-N 0.000 claims 1
- NOTGKXLKLLOOEU-SCZZXKLOSA-N (3s,5r)-3-(aminomethyl)-6-cyclopropyl-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1CC1 NOTGKXLKLLOOEU-SCZZXKLOSA-N 0.000 claims 1
- SMNXTMSRSMKVKF-NEPJUHHUSA-N (3s,5r)-3-(aminomethyl)-7-(2-chlorophenyl)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1=CC=CC=C1Cl SMNXTMSRSMKVKF-NEPJUHHUSA-N 0.000 claims 1
- UHGGXBVJHJAACY-NEPJUHHUSA-N (3s,5r)-3-(aminomethyl)-7-(2-fluorophenyl)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1=CC=CC=C1F UHGGXBVJHJAACY-NEPJUHHUSA-N 0.000 claims 1
- VLOKSFBDWGOMMO-OLZOCXBDSA-N (3s,5r)-3-(aminomethyl)-7-(2-methoxyphenyl)-5-methylheptanoic acid Chemical compound COC1=CC=CC=C1CC[C@@H](C)C[C@H](CN)CC(O)=O VLOKSFBDWGOMMO-OLZOCXBDSA-N 0.000 claims 1
- BCUGWHAHZHUTBT-YPMHNXCESA-N (3s,5r)-3-(aminomethyl)-7-(3-chlorophenyl)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1=CC=CC(Cl)=C1 BCUGWHAHZHUTBT-YPMHNXCESA-N 0.000 claims 1
- NIOLEXIXWFZQHF-YPMHNXCESA-N (3s,5r)-3-(aminomethyl)-7-(3-fluorophenyl)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1=CC=CC(F)=C1 NIOLEXIXWFZQHF-YPMHNXCESA-N 0.000 claims 1
- SNRGQBQIBPMKAD-OCCSQVGLSA-N (3s,5r)-3-(aminomethyl)-7-(3-methoxyphenyl)-5-methylheptanoic acid Chemical compound COC1=CC=CC(CC[C@@H](C)C[C@H](CN)CC(O)=O)=C1 SNRGQBQIBPMKAD-OCCSQVGLSA-N 0.000 claims 1
- PEJUAJWTYKBIOI-YPMHNXCESA-N (3s,5r)-3-(aminomethyl)-7-(4-chlorophenyl)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1=CC=C(Cl)C=C1 PEJUAJWTYKBIOI-YPMHNXCESA-N 0.000 claims 1
- CBBMTFZOSNWURO-YPMHNXCESA-N (3s,5r)-3-(aminomethyl)-7-(4-fluorophenyl)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1=CC=C(F)C=C1 CBBMTFZOSNWURO-YPMHNXCESA-N 0.000 claims 1
- FLMJSJAQAYYKDH-OCCSQVGLSA-N (3s,5r)-3-(aminomethyl)-7-(4-methoxyphenyl)-5-methylheptanoic acid Chemical compound COC1=CC=C(CC[C@@H](C)C[C@H](CN)CC(O)=O)C=C1 FLMJSJAQAYYKDH-OCCSQVGLSA-N 0.000 claims 1
- PMLSDYKLDFLDFE-PWSUYJOCSA-N (3s,5r)-3-(aminomethyl)-7-cyclobutyl-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1CCC1 PMLSDYKLDFLDFE-PWSUYJOCSA-N 0.000 claims 1
- MUDLFVXEGNVOKP-OCCSQVGLSA-N (3s,5r)-3-(aminomethyl)-7-cyclohexyl-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1CCCCC1 MUDLFVXEGNVOKP-OCCSQVGLSA-N 0.000 claims 1
- YBMHFGVRIJZSSK-YPMHNXCESA-N (3s,5r)-3-(aminomethyl)-7-cyclopentyl-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1CCCC1 YBMHFGVRIJZSSK-YPMHNXCESA-N 0.000 claims 1
- SVXSTEONTBDCKH-KOLCDFICSA-N (3s,5r)-3-(aminomethyl)-7-cyclopropyl-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCC1CC1 SVXSTEONTBDCKH-KOLCDFICSA-N 0.000 claims 1
- HOFQYLXJJCNSDJ-SFYZADRCSA-N (3s,5r)-3-(aminomethyl)-8,8,8-trifluoro-5-methyloctanoic acid Chemical compound FC(F)(F)CC[C@@H](C)C[C@H](CN)CC(O)=O HOFQYLXJJCNSDJ-SFYZADRCSA-N 0.000 claims 1
- JHCIIQNMXAQHQC-YPMHNXCESA-N (3s,5r)-3-(aminomethyl)-8-cyclobutyl-5-methyloctanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCCC1CCC1 JHCIIQNMXAQHQC-YPMHNXCESA-N 0.000 claims 1
- CREXEHWDFHWRIL-HIFRSBDPSA-N (3s,5r)-3-(aminomethyl)-8-cyclohexyl-5-methyloctanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCCC1CCCCC1 CREXEHWDFHWRIL-HIFRSBDPSA-N 0.000 claims 1
- NMURPDGMDUUFIQ-OCCSQVGLSA-N (3s,5r)-3-(aminomethyl)-8-cyclopentyl-5-methyloctanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCCC1CCCC1 NMURPDGMDUUFIQ-OCCSQVGLSA-N 0.000 claims 1
- DOHRVCLEAFTHHH-PWSUYJOCSA-N (3s,5r)-3-(aminomethyl)-8-cyclopropyl-5-methyloctanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCCC1CC1 DOHRVCLEAFTHHH-PWSUYJOCSA-N 0.000 claims 1
- LGPVGEYDVBVKIW-BDAKNGLRSA-N (3s,5r)-3-(aminomethyl)-8-fluoro-5-methyloctanoic acid Chemical compound FCCC[C@@H](C)C[C@H](CN)CC(O)=O LGPVGEYDVBVKIW-BDAKNGLRSA-N 0.000 claims 1
- IYMWWHAMHAYMGK-ZJUUUORDSA-N (3s,5r)-3-(aminomethyl)-9-fluoro-5-methylnonanoic acid Chemical compound FCCCC[C@@H](C)C[C@H](CN)CC(O)=O IYMWWHAMHAYMGK-ZJUUUORDSA-N 0.000 claims 1
- LYHACJSMVUYWEN-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-5,6,6-trimethylheptanoic acid Chemical compound CC(C)(C)[C@@H](C)C[C@H](CN)CC(O)=O LYHACJSMVUYWEN-IUCAKERBSA-N 0.000 claims 1
- RCSXHVBXPNZMAM-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-5,6-dimethylheptanoic acid Chemical compound CC(C)[C@@H](C)C[C@H](CN)CC(O)=O RCSXHVBXPNZMAM-IUCAKERBSA-N 0.000 claims 1
- WFZVNCOAWKCUAL-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(2-chlorophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=CC=C1Cl WFZVNCOAWKCUAL-UWVGGRQHSA-N 0.000 claims 1
- JHWOUEWSTXRSMC-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(2-fluorophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=CC=C1F JHWOUEWSTXRSMC-UWVGGRQHSA-N 0.000 claims 1
- BNDAKBMXSSJUEC-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-(2-methoxyphenoxy)hexanoic acid Chemical compound COC1=CC=CC=C1O[C@@H](C)C[C@H](CN)CC(O)=O BNDAKBMXSSJUEC-QWRGUYRKSA-N 0.000 claims 1
- XFVKCZVIDAAGDL-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(2-nitrophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=CC=C1[N+]([O-])=O XFVKCZVIDAAGDL-UWVGGRQHSA-N 0.000 claims 1
- LUTANLWSGGTECK-YUMQZZPRSA-N (3s,5s)-3-(aminomethyl)-5-(3,3,3-trifluoropropoxy)hexanoic acid Chemical class OC(=O)C[C@@H](CN)C[C@H](C)OCCC(F)(F)F LUTANLWSGGTECK-YUMQZZPRSA-N 0.000 claims 1
- AKJUMQCGMWXTRU-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(3-chlorophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=CC(Cl)=C1 AKJUMQCGMWXTRU-UWVGGRQHSA-N 0.000 claims 1
- CQARKITVLVJYGA-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(3-fluorophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=CC(F)=C1 CQARKITVLVJYGA-UWVGGRQHSA-N 0.000 claims 1
- LCTKKGWISDWDSR-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-(3-methoxyphenoxy)hexanoic acid Chemical compound COC1=CC=CC(O[C@@H](C)C[C@H](CN)CC(O)=O)=C1 LCTKKGWISDWDSR-QWRGUYRKSA-N 0.000 claims 1
- OGJYFMMWUJZBAA-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(3-nitrophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=CC([N+]([O-])=O)=C1 OGJYFMMWUJZBAA-UWVGGRQHSA-N 0.000 claims 1
- NHOXILWDZJCMST-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(4-chlorophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=C(Cl)C=C1 NHOXILWDZJCMST-UWVGGRQHSA-N 0.000 claims 1
- LNMPASBDSUFMIR-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(4-fluorophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=C(F)C=C1 LNMPASBDSUFMIR-UWVGGRQHSA-N 0.000 claims 1
- YEQRFDBTIIEENH-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-(4-methoxyphenoxy)hexanoic acid Chemical compound COC1=CC=C(O[C@@H](C)C[C@H](CN)CC(O)=O)C=C1 YEQRFDBTIIEENH-QWRGUYRKSA-N 0.000 claims 1
- JDDJTUPXDBEZQR-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-(4-nitrophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=C([N+]([O-])=O)C=C1 JDDJTUPXDBEZQR-UWVGGRQHSA-N 0.000 claims 1
- XSZFKKIBBCFNRZ-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-5-[(2-methylpropan-2-yl)oxy]hexanoic acid Chemical compound CC(C)(C)O[C@@H](C)C[C@H](CN)CC(O)=O XSZFKKIBBCFNRZ-IUCAKERBSA-N 0.000 claims 1
- NECOLRNJBIIURC-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-5-cyclobutylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)C1CCC1 NECOLRNJBIIURC-IUCAKERBSA-N 0.000 claims 1
- QIVMNCBZDTZSSL-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-cyclohexylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)C1CCCCC1 QIVMNCBZDTZSSL-QWRGUYRKSA-N 0.000 claims 1
- SCUJBZYQUHOYMH-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-cyclopentylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)C1CCCC1 SCUJBZYQUHOYMH-UWVGGRQHSA-N 0.000 claims 1
- KPXGGTAOFKPJCB-YUMQZZPRSA-N (3s,5s)-3-(aminomethyl)-5-cyclopropylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)C1CC1 KPXGGTAOFKPJCB-YUMQZZPRSA-N 0.000 claims 1
- JYZTVBQUSVRZIU-YUMQZZPRSA-N (3s,5s)-3-(aminomethyl)-5-ethoxyhexanoic acid Chemical compound CCO[C@@H](C)C[C@H](CN)CC(O)=O JYZTVBQUSVRZIU-YUMQZZPRSA-N 0.000 claims 1
- ZXQGVLZCFOPLIL-BQBZGAKWSA-N (3s,5s)-3-(aminomethyl)-5-methoxyhexanoic acid Chemical compound CO[C@@H](C)C[C@H](CN)CC(O)=O ZXQGVLZCFOPLIL-BQBZGAKWSA-N 0.000 claims 1
- UGDSFDKUWFNIQC-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-(2-nitrophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC=C1[N+]([O-])=O UGDSFDKUWFNIQC-QWRGUYRKSA-N 0.000 claims 1
- UMCMKOJZNISTMJ-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-(3,3,3-trifluoropropoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COCCC(F)(F)F UMCMKOJZNISTMJ-IUCAKERBSA-N 0.000 claims 1
- VEGDYCVGBXZOCI-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-(3-nitrophenoxy)hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC([N+]([O-])=O)=C1 VEGDYCVGBXZOCI-QWRGUYRKSA-N 0.000 claims 1
- RUAJTZOFBHDMLR-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-[(2-methylpropan-2-yl)oxy]hexanoic acid Chemical compound CC(C)(C)OC[C@@H](C)C[C@H](CN)CC(O)=O RUAJTZOFBHDMLR-UWVGGRQHSA-N 0.000 claims 1
- GVEBXLCIMGRADW-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-[2-(trifluoromethyl)phenoxy]hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC=C1C(F)(F)F GVEBXLCIMGRADW-QWRGUYRKSA-N 0.000 claims 1
- AVQINEYZXFUJAE-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-[3-(trifluoromethyl)phenoxy]hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC(C(F)(F)F)=C1 AVQINEYZXFUJAE-QWRGUYRKSA-N 0.000 claims 1
- GABLMMUZBCSETM-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-[4-(trifluoromethyl)phenoxy]hexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=C(C(F)(F)F)C=C1 GABLMMUZBCSETM-QWRGUYRKSA-N 0.000 claims 1
- BJWHSIOTKMHQKJ-RYUDHWBXSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-phenoxyhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC=C1 BJWHSIOTKMHQKJ-RYUDHWBXSA-N 0.000 claims 1
- DRIURBCCQVCUNG-JSGCOSHPSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-phenylmethoxyhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COCC1=CC=CC=C1 DRIURBCCQVCUNG-JSGCOSHPSA-N 0.000 claims 1
- UFLWTYULDKQWKG-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-propan-2-yloxyhexanoic acid Chemical compound CC(C)OC[C@@H](C)C[C@H](CN)CC(O)=O UFLWTYULDKQWKG-UWVGGRQHSA-N 0.000 claims 1
- BEYSDHKTOVCIOB-UWVGGRQHSA-N (3s,5s)-3-(aminomethyl)-5-methyl-6-propoxyhexanoic acid Chemical compound CCCOC[C@@H](C)C[C@H](CN)CC(O)=O BEYSDHKTOVCIOB-UWVGGRQHSA-N 0.000 claims 1
- FUMMVDSYJMVECH-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-(2-nitrophenoxy)heptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC=C1[N+]([O-])=O FUMMVDSYJMVECH-NEPJUHHUSA-N 0.000 claims 1
- SNQMAXBEHFPZCZ-ZJUUUORDSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-(3,3,3-trifluoropropoxy)heptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOCCC(F)(F)F SNQMAXBEHFPZCZ-ZJUUUORDSA-N 0.000 claims 1
- ZTSGAKHFFATMAK-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-(4-nitrophenoxy)heptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=C([N+]([O-])=O)C=C1 ZTSGAKHFFATMAK-NEPJUHHUSA-N 0.000 claims 1
- VBNZQEATURTZIC-MNOVXSKESA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-[(2-methylpropan-2-yl)oxy]heptanoic acid Chemical compound CC(C)(C)OCC[C@@H](C)C[C@H](CN)CC(O)=O VBNZQEATURTZIC-MNOVXSKESA-N 0.000 claims 1
- SHVBXBWRDPXTKX-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-[2-(trifluoromethyl)phenoxy]heptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC=C1C(F)(F)F SHVBXBWRDPXTKX-NEPJUHHUSA-N 0.000 claims 1
- OFGWHKIYXBXOJA-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-[3-(trifluoromethyl)phenoxy]heptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC(C(F)(F)F)=C1 OFGWHKIYXBXOJA-NEPJUHHUSA-N 0.000 claims 1
- OCUYTLPGBDGFJX-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-[4-(trifluoromethyl)phenoxy]heptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=C(C(F)(F)F)C=C1 OCUYTLPGBDGFJX-NEPJUHHUSA-N 0.000 claims 1
- UFZIRWJCIMWPCS-OLZOCXBDSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-phenoxyheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC=C1 UFZIRWJCIMWPCS-OLZOCXBDSA-N 0.000 claims 1
- CZDWSLQQEXYPEZ-HIFRSBDPSA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-phenylmethoxyheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOCC1=CC=CC=C1 CZDWSLQQEXYPEZ-HIFRSBDPSA-N 0.000 claims 1
- JFSPWJQYNAIJDM-MNOVXSKESA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-propan-2-yloxyheptanoic acid Chemical compound CC(C)OCC[C@@H](C)C[C@H](CN)CC(O)=O JFSPWJQYNAIJDM-MNOVXSKESA-N 0.000 claims 1
- SQOWNMIWVUTXJT-MNOVXSKESA-N (3s,5s)-3-(aminomethyl)-5-methyl-7-propoxyheptanoic acid Chemical compound CCCOCC[C@@H](C)C[C@H](CN)CC(O)=O SQOWNMIWVUTXJT-MNOVXSKESA-N 0.000 claims 1
- MYAOGFDZMOXKAG-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-5-phenoxyhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)OC1=CC=CC=C1 MYAOGFDZMOXKAG-QWRGUYRKSA-N 0.000 claims 1
- HBKQWQFIUGDJOB-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-5-propan-2-yloxyhexanoic acid Chemical compound CC(C)O[C@@H](C)C[C@H](CN)CC(O)=O HBKQWQFIUGDJOB-IUCAKERBSA-N 0.000 claims 1
- AMBOZTYDXCXROW-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-5-propoxyhexanoic acid Chemical compound CCCO[C@@H](C)C[C@H](CN)CC(O)=O AMBOZTYDXCXROW-IUCAKERBSA-N 0.000 claims 1
- YEAUVJOYGXJVPQ-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-6-(2-chlorophenoxy)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC=C1Cl YEAUVJOYGXJVPQ-QWRGUYRKSA-N 0.000 claims 1
- ZVAKZSCJKNCURF-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-6-(2-chlorophenyl)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1=CC=CC=C1Cl ZVAKZSCJKNCURF-QWRGUYRKSA-N 0.000 claims 1
- XKHPYADDLBOYCB-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-6-(2-fluoroethoxy)-5-methylhexanoic acid Chemical compound FCCOC[C@@H](C)C[C@H](CN)CC(O)=O XKHPYADDLBOYCB-IUCAKERBSA-N 0.000 claims 1
- ILLWSZLMKZNZPN-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-6-(2-fluorophenoxy)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC=C1F ILLWSZLMKZNZPN-QWRGUYRKSA-N 0.000 claims 1
- BDBBMYYIQJOZRO-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-6-(2-fluorophenyl)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1=CC=CC=C1F BDBBMYYIQJOZRO-QWRGUYRKSA-N 0.000 claims 1
- PTLPNAYVPVGVNV-RYUDHWBXSA-N (3s,5s)-3-(aminomethyl)-6-(2-methoxyphenoxy)-5-methylhexanoic acid Chemical compound COC1=CC=CC=C1OC[C@@H](C)C[C@H](CN)CC(O)=O PTLPNAYVPVGVNV-RYUDHWBXSA-N 0.000 claims 1
- RXUNPZIYFFDPIM-RYUDHWBXSA-N (3s,5s)-3-(aminomethyl)-6-(2-methoxyphenyl)-5-methylhexanoic acid Chemical compound COC1=CC=CC=C1C[C@@H](C)C[C@H](CN)CC(O)=O RXUNPZIYFFDPIM-RYUDHWBXSA-N 0.000 claims 1
- SYEGAVIXXAKPJU-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-6-(3-chlorophenoxy)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=CC(Cl)=C1 SYEGAVIXXAKPJU-QWRGUYRKSA-N 0.000 claims 1
- NHLRGBJJTDTMMO-PWSUYJOCSA-N (3s,5s)-3-(aminomethyl)-6-(3-chlorophenyl)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1=CC=CC(Cl)=C1 NHLRGBJJTDTMMO-PWSUYJOCSA-N 0.000 claims 1
- QNLPCHJCQBHOFT-RYUDHWBXSA-N (3s,5s)-3-(aminomethyl)-6-(3-methoxyphenoxy)-5-methylhexanoic acid Chemical compound COC1=CC=CC(OC[C@@H](C)C[C@H](CN)CC(O)=O)=C1 QNLPCHJCQBHOFT-RYUDHWBXSA-N 0.000 claims 1
- REMVOPFUXXGFNX-YPMHNXCESA-N (3s,5s)-3-(aminomethyl)-6-(3-methoxyphenyl)-5-methylhexanoic acid Chemical compound COC1=CC=CC(C[C@@H](C)C[C@H](CN)CC(O)=O)=C1 REMVOPFUXXGFNX-YPMHNXCESA-N 0.000 claims 1
- LSACENQGZOTOGG-PWSUYJOCSA-N (3s,5s)-3-(aminomethyl)-6-(4-chlorophenyl)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CC1=CC=C(Cl)C=C1 LSACENQGZOTOGG-PWSUYJOCSA-N 0.000 claims 1
- OESSABKVIANOLH-QWRGUYRKSA-N (3s,5s)-3-(aminomethyl)-6-(4-fluorophenoxy)-5-methylhexanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)COC1=CC=C(F)C=C1 OESSABKVIANOLH-QWRGUYRKSA-N 0.000 claims 1
- ZSVBYGMZVSRDFL-RYUDHWBXSA-N (3s,5s)-3-(aminomethyl)-6-(4-methoxyphenoxy)-5-methylhexanoic acid Chemical compound COC1=CC=C(OC[C@@H](C)C[C@H](CN)CC(O)=O)C=C1 ZSVBYGMZVSRDFL-RYUDHWBXSA-N 0.000 claims 1
- PQJCGTNFSFNAGC-YPMHNXCESA-N (3s,5s)-3-(aminomethyl)-6-(4-methoxyphenyl)-5-methylhexanoic acid Chemical compound COC1=CC=C(C[C@@H](C)C[C@H](CN)CC(O)=O)C=C1 PQJCGTNFSFNAGC-YPMHNXCESA-N 0.000 claims 1
- OLNFZYBQOUBMKG-YUMQZZPRSA-N (3s,5s)-3-(aminomethyl)-6-(fluoromethoxy)-5-methylhexanoic acid Chemical compound FCOC[C@@H](C)C[C@H](CN)CC(O)=O OLNFZYBQOUBMKG-YUMQZZPRSA-N 0.000 claims 1
- MLTLRMPTBXSGIZ-IUCAKERBSA-N (3s,5s)-3-(aminomethyl)-6-ethoxy-5-methylhexanoic acid Chemical compound CCOC[C@@H](C)C[C@H](CN)CC(O)=O MLTLRMPTBXSGIZ-IUCAKERBSA-N 0.000 claims 1
- FLXDBXNBVCOMNM-BQBZGAKWSA-N (3s,5s)-3-(aminomethyl)-6-fluoro-5-methylhexanoic acid Chemical compound FC[C@@H](C)C[C@H](CN)CC(O)=O FLXDBXNBVCOMNM-BQBZGAKWSA-N 0.000 claims 1
- OJKUJPIRCGOCSG-BQBZGAKWSA-N (3s,5s)-3-(aminomethyl)-6-hydroxy-5-methylhexanoic acid Chemical compound OC[C@@H](C)C[C@H](CN)CC(O)=O OJKUJPIRCGOCSG-BQBZGAKWSA-N 0.000 claims 1
- KNHVAHZLVNDEFH-YUMQZZPRSA-N (3s,5s)-3-(aminomethyl)-6-methoxy-5-methylhexanoic acid Chemical compound COC[C@@H](C)C[C@H](CN)CC(O)=O KNHVAHZLVNDEFH-YUMQZZPRSA-N 0.000 claims 1
- JAKCHAABXQZLJL-BQBZGAKWSA-N (3s,5s)-3-(aminomethyl)-7,7,7-trifluoro-5-methylheptanoic acid Chemical compound FC(F)(F)C[C@@H](C)C[C@H](CN)CC(O)=O JAKCHAABXQZLJL-BQBZGAKWSA-N 0.000 claims 1
- UXADRPDGLMXORZ-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-7-(2-chlorophenoxy)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC=C1Cl UXADRPDGLMXORZ-NEPJUHHUSA-N 0.000 claims 1
- AYQQVGAVUXFTQT-ZJUUUORDSA-N (3s,5s)-3-(aminomethyl)-7-(2-fluoroethoxy)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOCCF AYQQVGAVUXFTQT-ZJUUUORDSA-N 0.000 claims 1
- WSJXJYHCQWTQQO-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-7-(2-fluorophenoxy)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC=C1F WSJXJYHCQWTQQO-NEPJUHHUSA-N 0.000 claims 1
- VQVPILUHTBGANF-OLZOCXBDSA-N (3s,5s)-3-(aminomethyl)-7-(2-methoxyphenoxy)-5-methylheptanoic acid Chemical compound COC1=CC=CC=C1OCC[C@@H](C)C[C@H](CN)CC(O)=O VQVPILUHTBGANF-OLZOCXBDSA-N 0.000 claims 1
- LJXDNFZTTZQSKO-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-7-(3-chlorophenoxy)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC(Cl)=C1 LJXDNFZTTZQSKO-NEPJUHHUSA-N 0.000 claims 1
- JHKPYIKSXQNDJF-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-7-(3-fluorophenoxy)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=CC(F)=C1 JHKPYIKSXQNDJF-NEPJUHHUSA-N 0.000 claims 1
- MSXHKKCCRAYPPX-OLZOCXBDSA-N (3s,5s)-3-(aminomethyl)-7-(3-methoxyphenoxy)-5-methylheptanoic acid Chemical compound COC1=CC=CC(OCC[C@@H](C)C[C@H](CN)CC(O)=O)=C1 MSXHKKCCRAYPPX-OLZOCXBDSA-N 0.000 claims 1
- ILGDLVFKEURNOD-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-7-(4-chlorophenoxy)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=C(Cl)C=C1 ILGDLVFKEURNOD-NEPJUHHUSA-N 0.000 claims 1
- YJDWLYFZXSNACU-NEPJUHHUSA-N (3s,5s)-3-(aminomethyl)-7-(4-fluorophenoxy)-5-methylheptanoic acid Chemical compound OC(=O)C[C@@H](CN)C[C@H](C)CCOC1=CC=C(F)C=C1 YJDWLYFZXSNACU-NEPJUHHUSA-N 0.000 claims 1
- AFFYXOJEDVNKNJ-OLZOCXBDSA-N (3s,5s)-3-(aminomethyl)-7-(4-methoxyphenoxy)-5-methylheptanoic acid Chemical compound COC1=CC=C(OCC[C@@H](C)C[C@H](CN)CC(O)=O)C=C1 AFFYXOJEDVNKNJ-OLZOCXBDSA-N 0.000 claims 1
- UKCMEZKOGLCILO-ZJUUUORDSA-N (3s,5s)-3-(aminomethyl)-7-ethoxy-5-methylheptanoic acid Chemical compound CCOCC[C@@H](C)C[C@H](CN)CC(O)=O UKCMEZKOGLCILO-ZJUUUORDSA-N 0.000 claims 1
- GEYGHNUUWOVRDW-SFYZADRCSA-N (3s,5s)-3-(aminomethyl)-7-fluoro-5-methylheptanoic acid Chemical compound FCC[C@@H](C)C[C@H](CN)CC(O)=O GEYGHNUUWOVRDW-SFYZADRCSA-N 0.000 claims 1
- WGDYBZSHIFLGMT-SFYZADRCSA-N (3s,5s)-3-(aminomethyl)-7-hydroxy-5-methylheptanoic acid Chemical compound OCC[C@@H](C)C[C@H](CN)CC(O)=O WGDYBZSHIFLGMT-SFYZADRCSA-N 0.000 claims 1
- GZZGIZGZNKGONB-BDAKNGLRSA-N (3s,5s)-3-(aminomethyl)-7-methoxy-5-methylheptanoic acid Chemical compound COCC[C@@H](C)C[C@H](CN)CC(O)=O GZZGIZGZNKGONB-BDAKNGLRSA-N 0.000 claims 1
- VVQCRZGVHVDBMB-OKWQPMOJSA-N (e,3s,5r)-3-(aminomethyl)-5-methylnon-7-enoic acid Chemical compound C\C=C\C[C@@H](C)C[C@H](CN)CC(O)=O VVQCRZGVHVDBMB-OKWQPMOJSA-N 0.000 claims 1
- YQAUPMUIFNJUOC-AIIUZBJTSA-N (e,3s,5r)-3-(aminomethyl)-5-methylundec-7-enoic acid Chemical compound CCC\C=C\C[C@@H](C)C[C@H](CN)CC(O)=O YQAUPMUIFNJUOC-AIIUZBJTSA-N 0.000 claims 1
- HEHWAGOHHVUWGC-BKIAHZASSA-N (e,3s,5s)-3-(aminomethyl)-5-methyloct-6-enoic acid Chemical compound C\C=C\[C@@H](C)C[C@H](CN)CC(O)=O HEHWAGOHHVUWGC-BKIAHZASSA-N 0.000 claims 1
- INGBDMMBKJIDFL-KWKBKKAHSA-N (z,3s,5r)-3-(aminomethyl)-5-methyldec-7-enoic acid Chemical compound CC\C=C/C[C@@H](C)C[C@H](CN)CC(O)=O INGBDMMBKJIDFL-KWKBKKAHSA-N 0.000 claims 1
- ZMUPGDMHVPLGIG-OOMSKYPHSA-N (z,3s,5s)-3-(aminomethyl)-5-methylnon-6-enoic acid Chemical compound CC\C=C/[C@@H](C)C[C@H](CN)CC(O)=O ZMUPGDMHVPLGIG-OOMSKYPHSA-N 0.000 claims 1
- KDCBMCJRMVNJSC-UHFFFAOYSA-N 3-(aminomethyl)-4-ethyl-5-methylhexanoic acid Chemical compound CCC(C(C)C)C(CN)CC(O)=O KDCBMCJRMVNJSC-UHFFFAOYSA-N 0.000 claims 1
- WQOCZIJPIVWQEL-UHFFFAOYSA-N 3-(aminomethyl)-4-propan-2-yldecanoic acid Chemical compound CCCCCCC(C(C)C)C(CN)CC(O)=O WQOCZIJPIVWQEL-UHFFFAOYSA-N 0.000 claims 1
- MANPXHGDIYSTEN-UHFFFAOYSA-N 3-(aminomethyl)-4-propan-2-ylheptanoic acid Chemical compound CCCC(C(C)C)C(CN)CC(O)=O MANPXHGDIYSTEN-UHFFFAOYSA-N 0.000 claims 1
- FNKFLSKSEWXIJR-UHFFFAOYSA-N 3-(aminomethyl)-4-propan-2-yloctanoic acid Chemical compound CCCCC(C(C)C)C(CN)CC(O)=O FNKFLSKSEWXIJR-UHFFFAOYSA-N 0.000 claims 1
- MZXNUBDMHKYIDC-UHFFFAOYSA-N 3-(aminomethyl)-5-(2-chlorophenyl)hexanoic acid Chemical compound OC(=O)CC(CN)CC(C)C1=CC=CC=C1Cl MZXNUBDMHKYIDC-UHFFFAOYSA-N 0.000 claims 1
- AVDPWOUCNFZVNY-UHFFFAOYSA-N 3-(aminomethyl)-5-(2-methoxyphenyl)hexanoic acid Chemical compound COC1=CC=CC=C1C(C)CC(CN)CC(O)=O AVDPWOUCNFZVNY-UHFFFAOYSA-N 0.000 claims 1
- YODGVKRANQWMHX-UHFFFAOYSA-N 3-(aminomethyl)-5-(3-chlorophenyl)hexanoic acid Chemical compound OC(=O)CC(CN)CC(C)C1=CC=CC(Cl)=C1 YODGVKRANQWMHX-UHFFFAOYSA-N 0.000 claims 1
- WIXDCNGDWLJMRA-UHFFFAOYSA-N 3-(aminomethyl)-5-(3-methoxyphenyl)hexanoic acid Chemical compound COC1=CC=CC(C(C)CC(CN)CC(O)=O)=C1 WIXDCNGDWLJMRA-UHFFFAOYSA-N 0.000 claims 1
- GMEHPYLOPWSWPM-UHFFFAOYSA-N 3-(aminomethyl)-5-(4-chlorophenyl)hexanoic acid Chemical class OC(=O)CC(CN)CC(C)C1=CC=C(Cl)C=C1 GMEHPYLOPWSWPM-UHFFFAOYSA-N 0.000 claims 1
- OILXZDNEKPMMNR-UHFFFAOYSA-N 3-(aminomethyl)-5-(4-methoxyphenyl)hexanoic acid Chemical compound COC1=CC=C(C(C)CC(CN)CC(O)=O)C=C1 OILXZDNEKPMMNR-UHFFFAOYSA-N 0.000 claims 1
- NECOLRNJBIIURC-UHFFFAOYSA-N 3-(aminomethyl)-5-cyclobutylhexanoic acid Chemical compound OC(=O)CC(CN)CC(C)C1CCC1 NECOLRNJBIIURC-UHFFFAOYSA-N 0.000 claims 1
- KPXGGTAOFKPJCB-UHFFFAOYSA-N 3-(aminomethyl)-5-cyclopropylhexanoic acid Chemical compound OC(=O)CC(CN)CC(C)C1CC1 KPXGGTAOFKPJCB-UHFFFAOYSA-N 0.000 claims 1
- JBBFMHZVKGOWPT-UHFFFAOYSA-N 3-(aminomethyl)-5-methyl-6-phenylhexanoic acid Chemical compound OC(=O)CC(CN)CC(C)CC1=CC=CC=C1 JBBFMHZVKGOWPT-UHFFFAOYSA-N 0.000 claims 1
- JETOEPZFEWLXBK-UHFFFAOYSA-N 3-(aminomethyl)-5-methyldecanoic acid Chemical compound CCCCCC(C)CC(CN)CC(O)=O JETOEPZFEWLXBK-UHFFFAOYSA-N 0.000 claims 1
- IMLWGNYZSUWXIA-UHFFFAOYSA-N 3-(aminomethyl)-5-methyldodecanoic acid Chemical compound CCCCCCCC(C)CC(CN)CC(O)=O IMLWGNYZSUWXIA-UHFFFAOYSA-N 0.000 claims 1
- SIRQBZJUYVPMIC-UHFFFAOYSA-N 3-(aminomethyl)-5-methylheptanoic acid Chemical compound CCC(C)CC(CN)CC(O)=O SIRQBZJUYVPMIC-UHFFFAOYSA-N 0.000 claims 1
- KUSIIZRBOLFILF-UHFFFAOYSA-N 3-(aminomethyl)-5-methylnonanoic acid Chemical compound CCCCC(C)CC(CN)CC(O)=O KUSIIZRBOLFILF-UHFFFAOYSA-N 0.000 claims 1
- KKXFMWXZXDUYBF-UHFFFAOYSA-N 3-(aminomethyl)-5-methyloctanoic acid Chemical compound CCCC(C)CC(CN)CC(O)=O KKXFMWXZXDUYBF-UHFFFAOYSA-N 0.000 claims 1
- TZOKXKRKSNVJGE-UHFFFAOYSA-N 3-(aminomethyl)-5-methyltridecanoic acid Chemical compound CCCCCCCCC(C)CC(CN)CC(O)=O TZOKXKRKSNVJGE-UHFFFAOYSA-N 0.000 claims 1
- HLRPRVFNTZZSHY-UHFFFAOYSA-N 3-(aminomethyl)-5-methylundecanoic acid Chemical compound CCCCCCC(C)CC(CN)CC(O)=O HLRPRVFNTZZSHY-UHFFFAOYSA-N 0.000 claims 1
- ACARJIZTCQNHBW-UHFFFAOYSA-N 3-(aminomethyl)-5-phenylhexanoic acid Chemical compound OC(=O)CC(CN)CC(C)C1=CC=CC=C1 ACARJIZTCQNHBW-UHFFFAOYSA-N 0.000 claims 1
- USSUQFWPXUAXPB-UHFFFAOYSA-N 3-(aminomethyl)-6,6,6-trifluoro-5-methylhexanoic acid Chemical compound FC(F)(F)C(C)CC(CN)CC(O)=O USSUQFWPXUAXPB-UHFFFAOYSA-N 0.000 claims 1
- AYXYPKUFHZROOJ-UHFFFAOYSA-N 3-(azaniumylmethyl)-5-methylhexanoate Chemical compound CC(C)CC(CN)CC(O)=O AYXYPKUFHZROOJ-UHFFFAOYSA-N 0.000 claims 1
- IASDTUBNBCYCJG-UHFFFAOYSA-N 4-methylpregabalin Chemical compound CC(C)C(C)C(CN)CC(O)=O IASDTUBNBCYCJG-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- JMSUZVAPRKDIMY-UHFFFAOYSA-N CC(C)CCC(C1=CC=CC(=C1)CN)C(=O)O Chemical compound CC(C)CCC(C1=CC=CC(=C1)CN)C(=O)O JMSUZVAPRKDIMY-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000012192 Mucous membrane pemphigoid Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 235000011941 Tilia x europaea Nutrition 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 201000010002 cicatricial pemphigoid Diseases 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000002085 irritant Substances 0.000 claims 1
- 231100000021 irritant Toxicity 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 239000004571 lime Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 1
- 229960004961 mechlorethamine Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- JIRJHEXNDQBKRZ-UHFFFAOYSA-N phosgene oxime Chemical compound ON=C(Cl)Cl JIRJHEXNDQBKRZ-UHFFFAOYSA-N 0.000 claims 1
- 230000007096 poisonous effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/07—Aldehydes; Ketones
- C08K5/08—Quinones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/17—Amines; Quaternary ammonium compounds
- C08K5/18—Amines; Quaternary ammonium compounds with aromatically bound amino groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Polymers & Plastics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361755613P | 2013-01-23 | 2013-01-23 | |
| US61/755,613 | 2013-01-23 | ||
| US201361901796P | 2013-11-08 | 2013-11-08 | |
| US61/901,796 | 2013-11-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015126016A Division RU2676694C9 (ru) | 2013-01-23 | 2014-01-23 | Заболевания, связанные с токсичным альдегидом, и их лечение |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018145691A true RU2018145691A (ru) | 2019-04-01 |
Family
ID=51228191
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018145691A RU2018145691A (ru) | 2013-01-23 | 2014-01-23 | Заболевания, связанные с токсичным альдегидом, и их лечение |
| RU2015126016A RU2676694C9 (ru) | 2013-01-23 | 2014-01-23 | Заболевания, связанные с токсичным альдегидом, и их лечение |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015126016A RU2676694C9 (ru) | 2013-01-23 | 2014-01-23 | Заболевания, связанные с токсичным альдегидом, и их лечение |
Country Status (13)
| Country | Link |
|---|---|
| US (9) | US9687481B2 (https=) |
| EP (1) | EP2948149B1 (https=) |
| JP (5) | JP6514114B2 (https=) |
| KR (2) | KR102435676B1 (https=) |
| CN (3) | CN105120866B (https=) |
| AU (2) | AU2014209387B2 (https=) |
| CA (2) | CA2898631C (https=) |
| HK (1) | HK1217439A1 (https=) |
| IL (1) | IL239735B (https=) |
| MX (2) | MX383535B (https=) |
| RU (2) | RU2018145691A (https=) |
| SG (1) | SG11201505587YA (https=) |
| WO (1) | WO2014116836A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1888548E (pt) | 2005-05-26 | 2012-10-30 | Neuron Systems Inc | Derivado de quinolina para o tratamento de doenças da retina |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| RU2015120478A (ru) | 2012-12-20 | 2017-01-25 | Альдейра Терапьютикс, Инк. | Пери-карбинолы |
| CA2898631C (en) | 2013-01-23 | 2023-06-13 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| SG11201505599YA (en) * | 2013-01-25 | 2015-08-28 | Aldeyra Therapeutics Inc | Novel traps in the treatment of macular degeneration |
| US20170298081A1 (en) * | 2014-08-08 | 2017-10-19 | Kasuma Partners Inc. | Condensed heterocyclic compound |
| CN105085427B (zh) * | 2015-08-21 | 2018-06-05 | 中国科学院广州生物医药与健康研究院 | 一类苯并[d]异恶唑类化合物及其应用 |
| KR20180073553A (ko) * | 2015-08-21 | 2018-07-02 | 알데이라 테라퓨틱스, 아이엔씨. | 알데히드 접합체 및 이의 용도 |
| CN118724806A (zh) | 2015-08-21 | 2024-10-01 | 奥尔德拉医疗公司 | 氘化化合物和其用途 |
| CA3016759A1 (en) | 2016-02-28 | 2017-08-31 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
| US11129823B2 (en) * | 2016-05-09 | 2021-09-28 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| JP2019532029A (ja) * | 2016-08-22 | 2019-11-07 | アルデイラ セラピューティクス， インコーポレイテッド | アルデヒド補足化合物およびその使用 |
| MX2019010576A (es) * | 2017-03-16 | 2019-10-07 | Aldeyra Therapeutics Inc | Compuestos polimorficos y usos de los mismos. |
| JP7311162B2 (ja) | 2017-10-10 | 2023-07-19 | アルデイラ セラピューティクス， インコーポレイテッド | 炎症性障害の処置 |
| TWI685338B (zh) * | 2017-12-14 | 2020-02-21 | 柯瑞 伊里阿斯 Ｊ | 使用非可吸收性口服投予之化合物之包括第2型糖尿病、脂肪肝炎及相關病況之人類代謝症候群之預防及治療 |
| WO2020028820A1 (en) | 2018-08-03 | 2020-02-06 | Aldeyra Therapeutics, Inc. | Topical compositions and methods of preparation and use |
| WO2020033344A1 (en) | 2018-08-06 | 2020-02-13 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| EP3856478A4 (en) | 2018-09-25 | 2022-06-08 | Aldeyra Therapeutics, Inc. | FORMULATIONS FOR THE TREATMENT OF DRY EYE |
| US11786518B2 (en) * | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| CN113784954A (zh) | 2019-05-02 | 2021-12-10 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
| EP3785694A1 (en) * | 2019-08-30 | 2021-03-03 | Hangzhou Ocean Pearl Industrial Co., Ltd. | Eyeliner product and method thereof |
| CA3159453A1 (en) * | 2019-12-30 | 2021-07-08 | Huijun YIN | Tricyclic compound, and preparation method therefor and medical use thereof |
| EP4135697A4 (en) * | 2020-04-13 | 2024-05-15 | Aldeyra Therapeutics, Inc. | Quinoline compounds for treating lung, liver, and kidney diseases, disorders, or conditions |
| CA3175856A1 (en) | 2020-05-13 | 2021-11-18 | Todd Brady | Pharmaceutical formulations and uses thereof |
| JP7488166B2 (ja) * | 2020-09-25 | 2024-05-21 | Ｊｓｗアフティ株式会社 | ターゲットおよび成膜装置 |
| CN114981275B (zh) * | 2020-12-29 | 2023-12-19 | 中国医药研究开发中心有限公司 | 三环化合物及其制备方法和医药用途 |
| CN115843293B (zh) * | 2021-06-25 | 2025-01-24 | 中国医药研究开发中心有限公司 | 三环化合物及其制备方法和医药用途 |
| AU2022303386A1 (en) * | 2021-07-02 | 2023-12-14 | Aldeyra Therapeutics, Inc. | Heterocyclic aldehyde trapping compounds and uses thereof |
Family Cites Families (172)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1020234A (en) | 1911-12-27 | 1912-03-12 | Charles Ward | Water-tube boiler. |
| US2086186A (en) | 1933-10-10 | 1937-07-06 | Us Rubber Co | Treatment of rubber |
| SU50906A1 (ru) | 1935-12-20 | 1936-11-30 | А.И. Бурляев | Веретено дл пр дильных машин |
| GB1435721A (en) | 1972-05-18 | 1976-05-12 | Lilly Industries Ltd | Benzoxazole derivatives |
| SU509046A1 (ru) | 1975-02-21 | 1984-06-23 | Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе | Производные 2-карбэтокси-3-аминоиндола,про вл ющие противовоспалительную активность, и способ их получени |
| JPS6192592A (ja) | 1984-10-12 | 1986-05-10 | Norin Suisansyo Shokuhin Sogo Kenkyusho | 分岐サイクロデキストリンの製造方法 |
| US4675332A (en) | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| GB8610981D0 (en) | 1986-05-06 | 1986-06-11 | Ici America Inc | Quinoline amides |
| US5032392A (en) | 1986-09-04 | 1991-07-16 | Vision Pharmaceuticals | Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes |
| NZ225045A (en) | 1987-07-01 | 1990-06-26 | Janssen Pharmaceutica Nv | Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| AU8942491A (en) | 1990-10-22 | 1992-05-20 | Bausch & Lomb Incorporated | Method and composition for cleaning contact lenses |
| CA2054339C (en) | 1990-11-02 | 2002-12-24 | Francesco G. Salituro | 3-amidoindolyl derivatives |
| US5668117A (en) | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| US6444221B1 (en) | 1992-06-30 | 2002-09-03 | Howard K. Shapiro | Methods of treating chronic inflammatory diseases using carbonyl trapping agents |
| US20050090553A1 (en) | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
| US5472954A (en) | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| TW401300B (en) | 1992-12-25 | 2000-08-11 | Senju Pharma Co | Antiallergic composition for ophthalmic or nasal use |
| US5493027A (en) | 1993-01-22 | 1996-02-20 | Board Of Regents, The University Of Texas System | Anticonvulsive agents and uses thereof |
| JP2746832B2 (ja) | 1993-05-14 | 1998-05-06 | 大鵬薬品工業株式会社 | 眼局所抗アレルギー剤 |
| GB9318431D0 (en) | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| US5767109A (en) | 1993-10-20 | 1998-06-16 | Sanchez; Robert A. | Complexing urushiols |
| US5576311A (en) | 1994-11-30 | 1996-11-19 | Pharmos Corporation | Cyclodextrins as suspending agents for pharmaceutical suspensions |
| JP3297969B2 (ja) | 1994-12-26 | 2002-07-02 | ライオン株式会社 | 点眼剤 |
| JPH08175985A (ja) | 1994-12-26 | 1996-07-09 | Lion Corp | 点眼剤 |
| US5597823A (en) | 1995-01-27 | 1997-01-28 | Abbott Laboratories | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
| FR2742053B1 (fr) | 1995-12-06 | 1998-03-06 | Chauvin Lab Sa | Compositions pharmaceutiques a base de mequitazine |
| JP3736916B2 (ja) | 1996-02-19 | 2006-01-18 | 株式会社サンコンタクトレンズ | 含水性ソフトコンタクトレンズの消毒用組成物とその用途 |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| KR20000029694A (ko) | 1996-08-01 | 2000-05-25 | 케네쓰 엘. 로에르트셔 | 살진균활성을갖는4-치환된퀴놀린유도체 |
| US6492520B1 (en) | 1996-08-06 | 2002-12-10 | Pfizer Inc | Substituted pyrido-or pyrimido-containing 6,6- or 6,7-bicyclic derivatives |
| US5742954A (en) | 1996-11-22 | 1998-04-28 | Softub, Inc. | Electrically powered spa jet unit |
| WO1998050372A1 (de) | 1997-05-02 | 1998-11-12 | Schering Aktiengesellschaft | Substituierte heterocyclen und deren verwendung in arzneimitteln |
| JPH10306022A (ja) | 1997-05-06 | 1998-11-17 | Lion Corp | 点眼剤 |
| GB2327672A (en) | 1997-07-23 | 1999-02-03 | Merck & Co Inc | 4-(1,2,3,4-Tetrahydro-1,8-naphthyridin-7-yl)butanoyl-glycyl-3(S)-quinolin-3-yl-beta-alanine |
| EP1012151B1 (en) | 1997-09-02 | 2002-08-07 | Bristol-Myers Squibb Pharma Company | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders |
| WO1999046237A1 (en) | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases |
| US6358948B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| US6498154B1 (en) | 1999-05-04 | 2002-12-24 | Wyeth | Cyclic regimens using quinazolinone and benzoxazine derivatives |
| JP3568108B2 (ja) | 1999-07-28 | 2004-09-22 | 松下電器産業株式会社 | デジタル地図の位置情報伝達方法とそれを実施する装置 |
| EP1233768A1 (en) | 1999-11-15 | 2002-08-28 | Smithkline Beecham | Carvedilol methanesulfonate |
| AU1735001A (en) | 1999-12-10 | 2001-06-18 | Senju Pharmaceutical Co., Ltd. | Cyclodextrin-containing pharmaceutical composition |
| WO2001051919A2 (en) | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| US6569879B2 (en) | 2000-02-18 | 2003-05-27 | Merck & Co., Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| JP2001318350A (ja) | 2000-05-11 | 2001-11-16 | Lion Corp | コンタクトレンズ用溶液 |
| JP4748289B2 (ja) | 2000-06-23 | 2011-08-17 | ライオン株式会社 | 点眼剤、眼科用組成物及び吸着抑制方法 |
| FR2827599A1 (fr) * | 2001-07-20 | 2003-01-24 | Neuro3D | Composes derives de quinoleine et quinoxaline,preparation et utilisations |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| US20060014786A1 (en) | 2002-05-17 | 2006-01-19 | Rajeev Raut | Opthalmic pharmaceutical compositions and methods for treating ocular inflammation |
| CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| WO2004069157A2 (en) | 2003-01-17 | 2004-08-19 | Ophthalmic Research Associates, Inc. | Combinational use of long-acting and short-acting anti-histamines for ocular allergies |
| US20040242704A1 (en) | 2003-03-14 | 2004-12-02 | University Of Washington, Techtransfer - Invention Licensing | Stabilized mutant opsin proteins |
| EP2301549A1 (en) | 2003-04-18 | 2011-03-30 | Advanced Medicine Research Institute | Remedies for diseases to be applied to eye |
| US20060111318A1 (en) | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
| US20040235892A1 (en) | 2003-05-22 | 2004-11-25 | Yujia Dai | Indazole and benzisoxazole kinase inhibitors |
| US7297709B2 (en) | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| JP2005132834A (ja) | 2003-10-09 | 2005-05-26 | Kyowa Hakko Kogyo Co Ltd | キノリン誘導体 |
| EP2468729B1 (en) | 2003-10-15 | 2013-12-25 | Ube Industries, Ltd. | Novel indazole derivative |
| CA2543644A1 (en) | 2003-10-27 | 2005-05-06 | Astellas Pharma Inc. | Pyrazine derivatives and pharmaceutical use thereof |
| KR20060109947A (ko) * | 2003-11-20 | 2006-10-23 | 오쎄라 파마슈티걸즈, 인크. | 황반 변성 및 다른 안과 질환의 개선 |
| JP2005187407A (ja) | 2003-12-25 | 2005-07-14 | Lion Corp | アレルギー眼疾患用眼科組成物 |
| US20050197292A1 (en) | 2004-01-30 | 2005-09-08 | Glennda Smithson | Compositions and methods for treating T-cell mediated pathological conditions |
| EP1722766A2 (en) | 2004-02-17 | 2006-11-22 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| US20050234018A1 (en) | 2004-04-15 | 2005-10-20 | Allergan, Inc. | Drug delivery to the back of the eye |
| JP2006008568A (ja) | 2004-06-24 | 2006-01-12 | Cyclochem:Kk | ＩｇＥ抗体抑制剤および食品 |
| WO2006002473A1 (en) | 2004-07-02 | 2006-01-12 | Adelaide Research & Innovation Pty Ltd | Method of controlling damage mediated by alpha, beta-unsaturated aldehydes |
| FR2875409B1 (fr) | 2004-09-17 | 2010-05-07 | Sanofi Aventis | Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose |
| CN101048384A (zh) | 2004-10-28 | 2007-10-03 | 默克公司 | 促代谢型谷氨酸盐受体的嘧啶和喹啉增效剂 |
| WO2006077821A1 (ja) | 2005-01-19 | 2006-07-27 | Dainippon Sumitomo Pharma Co., Ltd. | アルドステロン受容体調節剤としての芳香族スルホン化合物 |
| TW200640443A (en) | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| CN1830964B (zh) * | 2005-03-11 | 2011-06-15 | 中国科学院上海药物研究所 | 4-取代苯氨基-3-硝基喹啉类化合物及其制备方法和用途 |
| EP1893174A2 (en) | 2005-05-10 | 2008-03-05 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
| PT1888548E (pt) | 2005-05-26 | 2012-10-30 | Neuron Systems Inc | Derivado de quinolina para o tratamento de doenças da retina |
| US8435965B2 (en) | 2005-12-27 | 2013-05-07 | Lion Corporation | Composition for soft contact lens and adsorption suppressing method |
| US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
| US20070297981A1 (en) | 2006-01-25 | 2007-12-27 | Ousler George W Iii | Formulations and methods for treating dry eye |
| JP4466875B2 (ja) | 2006-04-05 | 2010-05-26 | ライオン株式会社 | ソフトコンタクトレンズ用点眼剤 |
| KR20080109096A (ko) | 2006-04-14 | 2008-12-16 | 프라나 바이오테크놀로지 리미티드 | 연령 관련 황반 변성（에이엠디）의 치료 방법 |
| JP5194218B2 (ja) | 2006-06-05 | 2013-05-08 | 株式会社メニコンネクト | 含水性コンタクトレンズの保存方法ならびに該保存方法により保存された含水性コンタクトレンズ |
| RU2009106461A (ru) | 2006-07-25 | 2010-08-27 | Энвиво Фармасьютикалз, Инк. (Us) | Хинолиновые производные |
| JP2010500406A (ja) | 2006-08-14 | 2010-01-07 | シェーリング コーポレイション | ５−（１（ｓ）−アミノ−２−ヒドロキシエチル）−ｎ−［（２，４−ジフルオロフェニル）−メチル］−２−［８−メトキシ−２−（トリフルオロメチル）−５−キノリン］−４−オキサゾールカルボキサミドの塩 |
| RU2434630C2 (ru) | 2006-08-31 | 2011-11-27 | Юранд, Инк. | Системы доставки лекарственных средств, включающие в себя твердые растворы слабоосновных лекарственных средств |
| TW200823187A (en) | 2006-10-24 | 2008-06-01 | Wyeth Corp | Benzodioxane derivatives and uses thereof |
| US8158609B1 (en) | 2006-11-02 | 2012-04-17 | Novartis Ag | Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen |
| US20080241256A1 (en) | 2007-03-30 | 2008-10-02 | Liisa Kuhn | Targeted active agent delivery system based on calcium phosphate nanoparticles |
| US8490764B2 (en) | 2007-05-30 | 2013-07-23 | Margaret Simester | Portable storage and changing station |
| TW200914437A (en) | 2007-06-20 | 2009-04-01 | Ironwood Pharmaceuticals Inc | FAAH inhibitors |
| MX2010003667A (es) * | 2007-10-05 | 2010-09-28 | Acucela Inc | Compuestos alcoxi para el tratamiento de enfermedades. |
| JP6022746B2 (ja) * | 2008-02-11 | 2016-11-09 | ユニヴァーシティ オブ ワシントン | 加齢関連性網膜機能不全の治療及び予防方法 |
| CN102177157A (zh) | 2008-08-12 | 2011-09-07 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的苯并*唑类、苯并噻唑类和相关的类似物 |
| JP5773877B2 (ja) | 2008-10-22 | 2015-09-02 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する化合物 |
| MX2011004924A (es) | 2008-11-11 | 2011-05-30 | Novartis Ag | Sales de fingolimod. |
| AU2010226249A1 (en) | 2009-03-17 | 2011-10-13 | Aciex Therapeutics, Inc. | Ophthalmic formulations of ketotifen and methods of use |
| WO2010133672A1 (en) | 2009-05-20 | 2010-11-25 | Clanotech Ab | Derivatives of quinoline-3-carboxylic acid and their medical use |
| WO2010141834A1 (en) | 2009-06-05 | 2010-12-09 | Aciex Therapeutics, Inc. | Ophthalmic formulations of fluticasone and methods of use |
| US20100331315A1 (en) | 2009-06-18 | 2010-12-30 | Mustapha Haddach | Rhodanines and related heterocycles as kinase inhibitors |
| EP2477594A4 (en) | 2009-07-15 | 2013-03-13 | Univ Vanderbilt | ISOKETAL CATCHER AND TREATMENT OF DISEASES WITH OXIDATIVE INJURY |
| TWI492769B (zh) | 2009-09-23 | 2015-07-21 | Alcon Res Ltd | 可注射的水性眼用組成物及其使用之方法 |
| EP2509596B1 (en) * | 2009-12-08 | 2019-08-28 | Case Western Reserve University | Gamma aminoacids for treating ocular disorders |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| WO2011078204A1 (ja) * | 2009-12-24 | 2011-06-30 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
| CA2788440A1 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| WO2011116066A1 (en) | 2010-03-17 | 2011-09-22 | Concert Pharmaceuticals, Inc. | Derivatives of dimethylcurcumin |
| JP2011203665A (ja) | 2010-03-26 | 2011-10-13 | Ophtecs Corp | コンタクトレンズの白濁解消用製剤及び白濁解消方法 |
| KR20130138770A (ko) | 2010-09-01 | 2013-12-19 | 아레나 파마슈티칼스, 인크. | 광학적으로 활성 산을 갖는 로르카세린의 염 |
| EP2632441A4 (en) | 2010-10-29 | 2015-04-01 | Relmada Therapeutics Inc | COMPOSITIONS OF (-) - 17- (CYCLOBUTYLMETHYL-) MORPHINAN-3,14-DIOL |
| DK2663550T3 (en) | 2011-01-12 | 2017-03-27 | Ventirx Pharmaceuticals Inc | SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS |
| US10463687B2 (en) | 2011-01-20 | 2019-11-05 | Cornell University | Treatments for retinal disorders |
| CN103442735B (zh) * | 2011-01-31 | 2016-11-09 | 特米拉公司 | 用于减轻技术领域中所不希望的医学状况的有效要素 |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| HK1202064A1 (en) | 2011-10-13 | 2015-09-18 | 托马斯．盖德克 | Topical formulations of chemerin c15 peptides for the treatment of dermatological conditions |
| WO2015187942A1 (en) | 2014-06-04 | 2015-12-10 | Case Western Reserve University | Compositions and methods of treating diabetic retinopathy |
| US20130190500A1 (en) | 2011-12-12 | 2013-07-25 | Neuron Systems, Inc. | Process to prepare 6-chloro-3-amino-2-(2-hydroxypropyl)-1-azanaphthalene |
| US9817701B2 (en) | 2011-12-12 | 2017-11-14 | International Business Machines Corporation | Threshold computing in a distributed computing system |
| US20130165419A1 (en) | 2011-12-21 | 2013-06-27 | Insite Vision Incorporated | Combination anti-inflammatory ophthalmic compositions |
| GB201200192D0 (en) | 2012-01-06 | 2012-02-22 | Rosemont Pharmaceuticals Ltd | Methotrexate composition |
| IN2015DN00538A (https=) | 2012-08-01 | 2015-06-26 | Lewis And Clark Pharmaceuticals Inc | |
| EP2916827B1 (en) | 2012-11-08 | 2020-06-10 | Clearside Biomedical Inc. | Methods for the treatment of ocular disease in human subjects |
| RU2015120478A (ru) | 2012-12-20 | 2017-01-25 | Альдейра Терапьютикс, Инк. | Пери-карбинолы |
| CA2898631C (en) | 2013-01-23 | 2023-06-13 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| TWI624262B (zh) | 2013-01-23 | 2018-05-21 | 桑紐爾製藥公司 | 醫藥配方 |
| SG11201505599YA (en) | 2013-01-25 | 2015-08-28 | Aldeyra Therapeutics Inc | Novel traps in the treatment of macular degeneration |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| US9713330B1 (en) | 2013-03-15 | 2017-07-25 | Deuteria Agrochemicals, Llc | Deuterium-enriched aldehydes |
| US20160151410A1 (en) | 2013-07-02 | 2016-06-02 | The Trustees Of Columbia University In The City Of New York | Clearance of bioactive lipids from membrane structures by cyclodextrins |
| WO2015198350A1 (en) | 2014-06-25 | 2015-12-30 | Synergia Bio Sciences Private Limited | A pharmaceutical oil-in-water nano-emulsion |
| RU2016141135A (ru) | 2014-07-29 | 2018-08-28 | Терапьютиксмд, Инк. | Трансдермальный крем |
| NO2721710T3 (https=) | 2014-08-21 | 2018-03-31 | ||
| EP3628640B1 (en) | 2014-09-02 | 2023-08-09 | Hub Therapeutics | Methods of making a deuterated or a non-deuterated molecule and pharmaceutical formulations for treatment |
| TW201628622A (zh) | 2014-11-17 | 2016-08-16 | 製藥公司 | Tlr抑制劑與布魯頓氏(bruton's)酪胺酸激酶抑制劑之組合 |
| WO2016085939A2 (en) | 2014-11-24 | 2016-06-02 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
| US9953187B2 (en) | 2014-11-25 | 2018-04-24 | Honeywell International Inc. | System and method of contextual adjustment of video fidelity to protect privacy |
| NZ735715A (en) | 2015-04-15 | 2022-09-30 | Beigene Ltd | Maleate salts of a b-raf kinase inhibitor, crystalline forms, methods of preparation, and uses therefore |
| CN118724806A (zh) | 2015-08-21 | 2024-10-01 | 奥尔德拉医疗公司 | 氘化化合物和其用途 |
| KR20180073553A (ko) | 2015-08-21 | 2018-07-02 | 알데이라 테라퓨틱스, 아이엔씨. | 알데히드 접합체 및 이의 용도 |
| GB201522441D0 (en) | 2015-12-18 | 2016-02-03 | Midatech Pharma Wales Ltd | Sustained release cyclosporine-loaded microparticles |
| CA3016759A1 (en) | 2016-02-28 | 2017-08-31 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
| US11129823B2 (en) | 2016-05-09 | 2021-09-28 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| WO2017214201A1 (en) | 2016-06-06 | 2017-12-14 | Thesan Pharmaceuticals, Inc. | Formulations for substituted 3-pyrrolidines, compositions containing, and uses of, same |
| CN109642009B (zh) | 2016-08-09 | 2021-12-10 | 科思创德国股份有限公司 | 硅烷官能的聚合聚氨酯 |
| AU2017317529A1 (en) | 2016-08-22 | 2019-02-21 | Aldeyra Therapeutics, Inc. | Aldehyde trapping compounds and methods of use thereof |
| JP2019532029A (ja) | 2016-08-22 | 2019-11-07 | アルデイラ セラピューティクス， インコーポレイテッド | アルデヒド補足化合物およびその使用 |
| US11510931B2 (en) | 2016-09-28 | 2022-11-29 | Medicon Pharmaceuticals, Inc. | Compositions and methods for treating ophthalmic conditions |
| PL3523283T3 (pl) | 2016-10-05 | 2021-12-13 | Mitobridge, Inc. | Postacie krystaliczne i postacie soli związków stanowiących agonistów ppar |
| CN110114119B (zh) | 2016-10-12 | 2022-05-31 | Ps治疗有限公司 | 人工泪液、隐形眼镜和药物载体组合物及其使用方法 |
| GB2556082A (en) | 2016-11-18 | 2018-05-23 | Warneford Healthcare Ltd | Ophthalmic composition |
| MX2019010576A (es) | 2017-03-16 | 2019-10-07 | Aldeyra Therapeutics Inc | Compuestos polimorficos y usos de los mismos. |
| US10664688B2 (en) | 2017-09-20 | 2020-05-26 | Google Llc | Systems and methods of detecting and responding to a visitor to a smart home environment |
| JP7311162B2 (ja) | 2017-10-10 | 2023-07-19 | アルデイラ セラピューティクス， インコーポレイテッド | 炎症性障害の処置 |
| CN111527530B (zh) | 2017-12-14 | 2022-06-21 | 路创技术有限责任公司 | 无线音频设备的隐私模式 |
| WO2020018498A1 (en) | 2018-07-16 | 2020-01-23 | Aldeyra Therapeutics, Inc. | Cyclodextrin formulations |
| WO2020028820A1 (en) | 2018-08-03 | 2020-02-06 | Aldeyra Therapeutics, Inc. | Topical compositions and methods of preparation and use |
| WO2020033344A1 (en) | 2018-08-06 | 2020-02-13 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US10915995B2 (en) | 2018-09-24 | 2021-02-09 | Movidius Ltd. | Methods and apparatus to generate masked images based on selective privacy and/or location tracking |
| EP3856478A4 (en) | 2018-09-25 | 2022-06-08 | Aldeyra Therapeutics, Inc. | FORMULATIONS FOR THE TREATMENT OF DRY EYE |
| WO2020072621A1 (en) | 2018-10-02 | 2020-04-09 | Aldeyra Therapeutics, Inc. | Contact lens solutions and kits |
| JP2022511030A (ja) | 2018-12-05 | 2022-01-28 | アルデイラ セラピューティクス， インコーポレイテッド | 注射可能な製剤 |
| US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| CN113784954A (zh) | 2019-05-02 | 2021-12-10 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
| EP4028015A4 (en) | 2019-09-13 | 2023-11-15 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations of methotrexate |
| WO2021195211A1 (en) | 2020-03-24 | 2021-09-30 | Aldeyra Therapeutics, Inc. | Quinoline compounds for treating respiratory disorders and viral infections |
| EP4135697A4 (en) | 2020-04-13 | 2024-05-15 | Aldeyra Therapeutics, Inc. | Quinoline compounds for treating lung, liver, and kidney diseases, disorders, or conditions |
| CA3175856A1 (en) | 2020-05-13 | 2021-11-18 | Todd Brady | Pharmaceutical formulations and uses thereof |
| US20230228744A1 (en) | 2020-06-04 | 2023-07-20 | Aldeyra Therapeutics, Inc. | Dry eye disease biomarkers and their use for treatment |
| CN112541870A (zh) | 2020-12-07 | 2021-03-23 | 北京大米科技有限公司 | 一种视频处理的方法、装置、可读存储介质和电子设备 |
| US20220211691A1 (en) | 2021-01-07 | 2022-07-07 | Aldeyra Therapeutics, Inc. | Treatment of dry eye disease |
| WO2022150580A1 (en) | 2021-01-07 | 2022-07-14 | Aldeyra Therapeutics, Inc. | Treatment of dry eye disease |
| CN112800947A (zh) | 2021-01-27 | 2021-05-14 | 上海电气集团股份有限公司 | 视频监控方法、系统、电子设备及存储介质 |
| AU2022303386A1 (en) | 2021-07-02 | 2023-12-14 | Aldeyra Therapeutics, Inc. | Heterocyclic aldehyde trapping compounds and uses thereof |
-
2014
- 2014-01-23 CA CA2898631A patent/CA2898631C/en active Active
- 2014-01-23 EP EP14743711.5A patent/EP2948149B1/en active Active
- 2014-01-23 WO PCT/US2014/012762 patent/WO2014116836A2/en not_active Ceased
- 2014-01-23 CN CN201480005853.2A patent/CN105120866B/zh active Active
- 2014-01-23 KR KR1020217011262A patent/KR102435676B1/ko active Active
- 2014-01-23 US US14/760,039 patent/US9687481B2/en active Active
- 2014-01-23 MX MX2015009383A patent/MX383535B/es unknown
- 2014-01-23 AU AU2014209387A patent/AU2014209387B2/en active Active
- 2014-01-23 JP JP2015553925A patent/JP6514114B2/ja active Active
- 2014-01-23 SG SG11201505587YA patent/SG11201505587YA/en unknown
- 2014-01-23 HK HK16105462.0A patent/HK1217439A1/zh unknown
- 2014-01-23 KR KR1020157022673A patent/KR102243169B1/ko active Active
- 2014-01-23 RU RU2018145691A patent/RU2018145691A/ru not_active Application Discontinuation
- 2014-01-23 RU RU2015126016A patent/RU2676694C9/ru active
- 2014-01-23 CN CN202010058756.7A patent/CN111135171B/zh active Active
- 2014-01-23 CA CA3195807A patent/CA3195807A1/en active Pending
- 2014-01-23 CN CN202311132218.8A patent/CN117045653A/zh active Pending
-
2015
- 2015-07-01 IL IL239735A patent/IL239735B/en active IP Right Grant
- 2015-07-21 MX MX2019012878A patent/MX2019012878A/es unknown
-
2017
- 2017-05-09 US US15/590,708 patent/US10213395B2/en active Active
-
2018
- 2018-10-05 AU AU2018241154A patent/AU2018241154A1/en not_active Abandoned
- 2018-10-22 JP JP2018198154A patent/JP7221021B2/ja active Active
-
2019
- 2019-01-30 US US16/262,364 patent/US10543181B2/en active Active
- 2019-02-15 US US16/277,865 patent/US10588874B2/en active Active
-
2020
- 2020-01-27 US US16/773,654 patent/US11007157B2/en active Active
- 2020-02-25 JP JP2020029608A patent/JP2020079305A/ja not_active Withdrawn
-
2021
- 2021-04-12 US US17/227,568 patent/US11701331B2/en active Active
-
2022
- 2022-03-07 US US17/653,827 patent/US11771664B2/en active Active
- 2022-09-22 JP JP2022151228A patent/JP7457401B2/ja active Active
-
2023
- 2023-08-22 US US18/236,795 patent/US12128013B2/en active Active
-
2024
- 2024-03-08 JP JP2024036019A patent/JP2024057103A/ja active Pending
- 2024-10-02 US US18/904,373 patent/US20250127733A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018145691A (ru) | Заболевания, связанные с токсичным альдегидом, и их лечение | |
| JP2016508994A5 (https=) | ||
| AU2019394947B2 (en) | Compositions and methods for the treatment of liver disorders | |
| JP2019532029A5 (https=) | ||
| JP2016506391A5 (https=) | ||
| JP2018523700A5 (https=) | ||
| JP2013512966A5 (https=) | ||
| TWI407955B (zh) | 高脂血症之預防及／或治療劑 | |
| RU2018106914A (ru) | 1,3,4,-оксадизоламидное производное соединение в качестве ингибитора гистондеацетилазы 6 и содержащая его фармацевтическая композиция | |
| KR20160093000A (ko) | 창자 과투과성을 치료하기 위한 티로신 하이드록실라제 억제제 | |
| PH12015502011B1 (en) | Substituted aromatic compounds and related method for the treatment of fibrosis | |
| WO2010004435A3 (en) | Ph specific solutions of sodium mycophenolic acid for the treatment of eye disorders | |
| JP2014518853A5 (https=) | ||
| RU2015150287A (ru) | Новые соединения 3,4-дигидро-2н-изохинолин-1-она и 2,3-дигидроизоиндол-1-она | |
| RU2014119705A (ru) | Пиридин-сульфоксимины в качестве ингибиторов киназы | |
| EA201101305A1 (ru) | Лечение рака поджелудочной железы | |
| JP2015527999A5 (ja) | 安定化された多機能抗酸化化合物およびその使用方法 | |
| JP2016525546A5 (https=) | ||
| WO2024168231A1 (en) | Aminothiols for the treatment of conditions characterized by protein misfolding or aggregation, mitochondrial dysfunction, or chronic inflammation | |
| RU2023132257A (ru) | Фармацевтическая композиция для предупреждения или лечения системного склероза |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20170124 |