MX2019012878A - Terapias para el tratamiento de enfermedades asociadas con la toxicidad del aldehido. - Google Patents

Terapias para el tratamiento de enfermedades asociadas con la toxicidad del aldehido.

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Publication number
MX2019012878A
MX2019012878A MX2019012878A MX2019012878A MX2019012878A MX 2019012878 A MX2019012878 A MX 2019012878A MX 2019012878 A MX2019012878 A MX 2019012878A MX 2019012878 A MX2019012878 A MX 2019012878A MX 2019012878 A MX2019012878 A MX 2019012878A
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MX
Mexico
Prior art keywords
treatment
related diseases
toxic aldehyde
aldehyde related
toxic
Prior art date
Application number
MX2019012878A
Other languages
English (en)
Inventor
A Kinney William
brady Todd
J Mandell Kenneth
Young Scott
Original Assignee
Aldeyra Therapeutics Inc
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Publication date
Application filed by Aldeyra Therapeutics Inc filed Critical Aldeyra Therapeutics Inc
Publication of MX2019012878A publication Critical patent/MX2019012878A/es

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    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Polymers & Plastics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

La presente invención proporciona tratamiento, prevención, y/o reducción de un riesgo de una enfermedad, trastorno o condición en los cuales la toxicidad del aldehído está implicada en la patogénesis, incluyendo trastornos oculares, trastornos de la piel, condiciones asociadas con efectos dañinos de agentes vesicantes, y enfermedades autoinmune, inflamatoria, neurológica y cardiovascular con el uso de aminas primarias para atrapar aldehídos tóxicos, tales como MDA y HNE.
MX2019012878A 2013-01-23 2015-07-21 Terapias para el tratamiento de enfermedades asociadas con la toxicidad del aldehido. MX2019012878A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361755613P 2013-01-23 2013-01-23
US201361901796P 2013-11-08 2013-11-08

Publications (1)

Publication Number Publication Date
MX2019012878A true MX2019012878A (es) 2020-01-14

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ID=51228191

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015009383A MX2015009383A (es) 2013-01-23 2014-01-23 Enfermedades relacionadas con aldehido toxico y tratamiento.
MX2019012878A MX2019012878A (es) 2013-01-23 2015-07-21 Terapias para el tratamiento de enfermedades asociadas con la toxicidad del aldehido.

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MX2015009383A MX2015009383A (es) 2013-01-23 2014-01-23 Enfermedades relacionadas con aldehido toxico y tratamiento.

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US (7) US9687481B2 (es)
EP (1) EP2948149A4 (es)
JP (5) JP6514114B2 (es)
KR (2) KR102243169B1 (es)
CN (3) CN111135171B (es)
AU (2) AU2014209387B2 (es)
CA (2) CA3195807A1 (es)
HK (1) HK1217439A1 (es)
IL (1) IL239735B (es)
MX (2) MX2015009383A (es)
RU (2) RU2676694C9 (es)
SG (1) SG11201505587YA (es)
WO (1) WO2014116836A2 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1888548B1 (en) 2005-05-26 2012-08-22 Neuron Systems, Inc Quinoline derivative for the treatment of retinal diseases
US9814701B2 (en) 2009-12-11 2017-11-14 Aldeyra Therapeutics, Inc. Compositions and methods for the treatment of macular degeneration
KR20150118106A (ko) 2012-12-20 2015-10-21 알데이라 테라퓨틱스, 아이엔씨. 페리-카르비놀
RU2676694C9 (ru) 2013-01-23 2019-06-25 Альдейра Терапьютикс, Инк. Заболевания, связанные с токсичным альдегидом, и их лечение
EP2948436A4 (en) * 2013-01-25 2016-07-13 Aldeyra Therapeutics Inc NOVEL CASES IN THE TREATMENT OF MACULAR GENERATION
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物
JP6947406B2 (ja) * 2015-08-21 2021-10-13 アルデイラ セラピューティクス, インコーポレイテッド 重水素化化合物およびその使用
JP6959650B2 (ja) * 2015-08-21 2021-11-02 アルデイラ セラピューティクス, インコーポレイテッド アルデヒドコンジュゲートおよびその使用
CN105085427B (zh) * 2015-08-21 2018-06-05 中国科学院广州生物医药与健康研究院 一类苯并[d]异恶唑类化合物及其应用
CN116531400A (zh) 2016-02-28 2023-08-04 奥尔德拉医疗公司 用环糊精治疗过敏性眼部病状
AU2017264697A1 (en) * 2016-05-09 2018-11-22 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
EP3500256A4 (en) * 2016-08-22 2020-01-08 Aldeyra Therapeutics, Inc. ALDEHYDE CAPTURE CONNECTIONS AND USES THEREOF
EP3596040B1 (en) * 2017-03-16 2023-10-11 Aldeyra Therapeutics, Inc. Polymorphic salt of 6-chloro-3-amino-2(2-hydroxypropyl)quinoline and uses thereof
MX2020003425A (es) 2017-10-10 2020-07-29 Aldeyra Therapeutics Inc Tratamiento de trastornos inflamatorios.
TWI685338B (zh) 2017-12-14 2020-02-21 柯瑞 伊里阿斯 J 使用非可吸收性口服投予之化合物之包括第2型糖尿病、脂肪肝炎及相關病況之人類代謝症候群之預防及治療
US20200038392A1 (en) 2018-08-03 2020-02-06 Aldeyra Therapeutics, Inc. Topical compositions and methods of preparation and use
JP2021533154A (ja) 2018-08-06 2021-12-02 アルデイラ セラピューティクス, インコーポレイテッド 多形化合物およびその使用
WO2020068986A1 (en) 2018-09-25 2020-04-02 Aldeyra Therapeutics, Inc. Formulations for treatment of dry eye disease
WO2020198064A1 (en) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
WO2020223685A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
EP3785694A1 (en) * 2019-08-30 2021-03-03 Hangzhou Ocean Pearl Industrial Co., Ltd. Eyeliner product and method thereof
KR20220122978A (ko) * 2019-12-30 2022-09-05 더 내셔널 인스티튜츠 오브 파마슈티컬 알앤디 컴퍼니 리미티드 삼환식 화합물, 및 그의 제조 방법 및 그의 의학적 용도
WO2021211625A1 (en) * 2020-04-13 2021-10-21 Aldeyra Therapeutics, Inc. Quinoline compounds for treating lung, liver, and kidney diseases, disorders, or conditions
JP7488166B2 (ja) 2020-09-25 2024-05-21 Jswアフティ株式会社 ターゲットおよび成膜装置
US20240092744A1 (en) * 2020-12-29 2024-03-21 The National Institutes of Pharmaceutical R&D Co., Ltd. Tricyclic compound, and preparation method therefor and medical use thereof
CN115843293A (zh) * 2021-06-25 2023-03-24 中国医药研究开发中心有限公司 三环化合物及其制备方法和医药用途
CN117580569A (zh) * 2021-07-02 2024-02-20 奥尔德拉医疗公司 杂环型醛捕获化合物和其用途

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1020234A (en) 1911-12-27 1912-03-12 Charles Ward Water-tube boiler.
US2086186A (en) 1933-10-10 1937-07-06 Us Rubber Co Treatment of rubber
SU50906A1 (ru) 1935-12-20 1936-11-30 А.И. Бурляев Веретено дл пр дильных машин
GB1435721A (en) 1972-05-18 1976-05-12 Lilly Industries Ltd Benzoxazole derivatives
SU509046A1 (ru) 1975-02-21 1984-06-23 Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе Производные 2-карбэтокси-3-аминоиндола,про вл ющие противовоспалительную активность, и способ их получени
JPS6192592A (ja) 1984-10-12 1986-05-10 Norin Suisansyo Shokuhin Sogo Kenkyusho 分岐サイクロデキストリンの製造方法
US4675332A (en) 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
GB8610981D0 (en) 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
US5032392A (en) 1986-09-04 1991-07-16 Vision Pharmaceuticals Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes
NZ225045A (en) 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
CA2072001C (en) 1990-10-22 1998-11-03 Nimai C. De Method and composition for cleaning contact lenses
CA2054339C (en) 1990-11-02 2002-12-24 Francesco G. Salituro 3-amidoindolyl derivatives
US5668117A (en) 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US6444221B1 (en) 1992-06-30 2002-09-03 Howard K. Shapiro Methods of treating chronic inflammatory diseases using carbonyl trapping agents
US20050090553A1 (en) 1992-06-30 2005-04-28 Shapiro Howard K. Compositions and method for treatment of chronic inflammatory diseases
US5472954A (en) 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
TW401300B (en) 1992-12-25 2000-08-11 Senju Pharma Co Antiallergic composition for ophthalmic or nasal use
US5493027A (en) 1993-01-22 1996-02-20 Board Of Regents, The University Of Texas System Anticonvulsive agents and uses thereof
US5767109A (en) 1993-10-20 1998-06-16 Sanchez; Robert A. Complexing urushiols
US5576311A (en) 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
JP3297969B2 (ja) 1994-12-26 2002-07-02 ライオン株式会社 点眼剤
US5597823A (en) 1995-01-27 1997-01-28 Abbott Laboratories Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists
JP3736916B2 (ja) 1996-02-19 2006-01-18 株式会社サンコンタクトレンズ 含水性ソフトコンタクトレンズの消毒用組成物とその用途
CA2261916A1 (en) 1996-08-01 1998-02-12 Dowelanco Llc 4-substituted quinoline derivatives having fungicidal activity
US5742954A (en) 1996-11-22 1998-04-28 Softub, Inc. Electrically powered spa jet unit
JP2001524115A (ja) 1997-05-02 2001-11-27 シェリング アクチェンゲゼルシャフト 置換された複素環式化合物及び医薬におけるその使用
KR20010041811A (ko) 1998-03-12 2001-05-25 온토젠 코포레이션 단백질 티로신 포스파타제의 조절제
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
JP3568108B2 (ja) 1999-07-28 2004-09-22 松下電器産業株式会社 デジタル地図の位置情報伝達方法とそれを実施する装置
WO2001041757A1 (fr) 1999-12-10 2001-06-14 Senju Pharmaceutical Co., Ltd. Composition pharmaceutique contenant de la cyclodextrine
US6569879B2 (en) 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
JP4748289B2 (ja) 2000-06-23 2011-08-17 ライオン株式会社 点眼剤、眼科用組成物及び吸着抑制方法
FR2827599A1 (fr) * 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US20060014786A1 (en) 2002-05-17 2006-01-19 Rajeev Raut Opthalmic pharmaceutical compositions and methods for treating ocular inflammation
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
US20040198828A1 (en) 2003-01-17 2004-10-07 Abelson Mark B. Combinational use of long-acting and short-acting anti-histamines for ocular allergies
AU2004222279B2 (en) 2003-03-14 2010-01-21 University Of Washington Retinoid replacements and opsin agonists and methods for the use thereof
WO2004091630A1 (ja) 2003-04-18 2004-10-28 Advanced Medicine Research Institute 眼に適用する疾患治療剤
US20060111318A1 (en) 2003-04-18 2006-05-25 Advanced Medicine Research Institute Agent for treating eye diseases
US7297709B2 (en) 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
US20040235892A1 (en) 2003-05-22 2004-11-25 Yujia Dai Indazole and benzisoxazole kinase inhibitors
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
JP2005132834A (ja) 2003-10-09 2005-05-26 Kyowa Hakko Kogyo Co Ltd キノリン誘導体
ES2426288T3 (es) 2003-10-15 2013-10-22 Ube Industries, Ltd. Novedoso derivado de imidazol
RU2006118325A (ru) 2003-10-27 2007-12-10 Астеллас Фарма Инк. (Jp) Производные пиразина и их фармацевтическое применение
WO2005051328A2 (en) 2003-11-20 2005-06-09 Othera Pharmaceuticals, Inc. Amelioration of macular degeneration and other ophthalmic diseases
US20050197292A1 (en) 2004-01-30 2005-09-08 Glennda Smithson Compositions and methods for treating T-cell mediated pathological conditions
KR20060135819A (ko) 2004-02-17 2006-12-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 황반변성을 포함하는 안과질환의 관리
US20050234018A1 (en) 2004-04-15 2005-10-20 Allergan, Inc. Drug delivery to the back of the eye
JP2006008568A (ja) 2004-06-24 2006-01-12 Cyclochem:Kk IgE抗体抑制剤および食品
WO2006002473A1 (en) 2004-07-02 2006-01-12 Adelaide Research & Innovation Pty Ltd Method of controlling damage mediated by alpha, beta-unsaturated aldehydes
FR2875409B1 (fr) 2004-09-17 2010-05-07 Sanofi Aventis Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose
US20070287716A1 (en) 2004-10-28 2007-12-13 Hu Essa H Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors
JPWO2006077821A1 (ja) 2005-01-19 2008-06-19 大日本住友製薬株式会社 アルドステロン受容体調節剤としての芳香族スルホン化合物
TW200640443A (en) 2005-02-23 2006-12-01 Alcon Inc Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors
CN1830964B (zh) * 2005-03-11 2011-06-15 中国科学院上海药物研究所 4-取代苯氨基-3-硝基喹啉类化合物及其制备方法和用途
EP1888548B1 (en) * 2005-05-26 2012-08-22 Neuron Systems, Inc Quinoline derivative for the treatment of retinal diseases
WO2007077783A1 (ja) 2005-12-27 2007-07-12 Lion Corporation ソフトコンタクトレンズ用組成物及び吸着抑制方法
US20070297981A1 (en) 2006-01-25 2007-12-27 Ousler George W Iii Formulations and methods for treating dry eye
JP4466875B2 (ja) 2006-04-05 2010-05-26 ライオン株式会社 ソフトコンタクトレンズ用点眼剤
NZ590271A (en) 2006-04-14 2011-12-22 Prana Biotechnology Ltd 9-hydroxy-3-substituted-4H-pyrido[1,2-a]pyrimidin-4-ones and 9-hydroxy-3-substituted-4H-pyrido[1,2-a]pyrimidin-4-thiones
JP5194218B2 (ja) 2006-06-05 2013-05-08 株式会社メニコンネクト 含水性コンタクトレンズの保存方法ならびに該保存方法により保存された含水性コンタクトレンズ
EP2079699A1 (en) 2006-07-25 2009-07-22 Envivo Pharmaceuticals, Inc. Quinoline derivatives
MX2009002166A (es) 2006-08-31 2009-03-12 Eurand Inc Sistema de distribucion de farmacos, que comprenden soluciones solidas de farmacos debilmente basicos.
US8158609B1 (en) 2006-11-02 2012-04-17 Novartis Ag Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen
US20090118503A1 (en) 2007-06-20 2009-05-07 Kevin Sprott Faah inhibitors
CA2701116C (en) * 2007-10-05 2013-02-05 Acucela Inc. Alkoxy compounds for disease treatment
CA2714530C (en) 2008-02-11 2018-09-25 University Of Washington Methods for the treatment and prevention of age-related retinal dysfunction
WO2010019606A1 (en) 2008-08-12 2010-02-18 Sirtris Pharmaceuticals, Inc. Benzoxazoles, benzthiazoles and related analogs as sirtuin modulators
US20100240624A1 (en) 2009-03-17 2010-09-23 Aciex Therapeutics, Inc. Ophthalmic Formulations of Ketotifen and Methods of Use
WO2010133672A1 (en) 2009-05-20 2010-11-25 Clanotech Ab Derivatives of quinoline-3-carboxylic acid and their medical use
US20110105450A1 (en) 2009-06-05 2011-05-05 Aciex Therapeutics, Inc. Ophthalmic formulations of fluticasone and methods of use
US20100331315A1 (en) 2009-06-18 2010-12-30 Mustapha Haddach Rhodanines and related heterocycles as kinase inhibitors
WO2011008202A1 (en) 2009-07-15 2011-01-20 Vanderbilt University Isoketal scavengers and mitigation of disorders involving oxidative injury
TWI492769B (zh) 2009-09-23 2015-07-21 Alcon Res Ltd 可注射的水性眼用組成物及其使用之方法
EP2509596B1 (en) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminoacids for treating ocular disorders
US9814701B2 (en) 2009-12-11 2017-11-14 Aldeyra Therapeutics, Inc. Compositions and methods for the treatment of macular degeneration
WO2011078204A1 (ja) * 2009-12-24 2011-06-30 浜理薬品工業株式会社 高脂血症の予防または治療剤、および抗疲労剤
US8575221B2 (en) 2010-03-17 2013-11-05 Concert Pharmaceuticals, Inc. Derivatives of dimethylcurcumin
BR112013017943A2 (pt) 2011-01-12 2018-12-18 Array Biopharma Inc benzoazepinas substituídas como moduladores receptores do tipo toll
US10463687B2 (en) 2011-01-20 2019-11-05 Cornell University Treatments for retinal disorders
EP2670439B1 (en) * 2011-01-31 2019-03-13 PVAC Medical Technologies Ltd. Active principle for mitigating undesired medical conditions
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠(olopatadine)眼用組成物
US20130190500A1 (en) 2011-12-12 2013-07-25 Neuron Systems, Inc. Process to prepare 6-chloro-3-amino-2-(2-hydroxypropyl)-1-azanaphthalene
US9067963B2 (en) 2012-08-01 2015-06-30 Lewis and Clark Pharmaceuticals, LLC N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
KR20150118106A (ko) 2012-12-20 2015-10-21 알데이라 테라퓨틱스, 아이엔씨. 페리-카르비놀
RU2676694C9 (ru) 2013-01-23 2019-06-25 Альдейра Терапьютикс, Инк. Заболевания, связанные с токсичным альдегидом, и их лечение
EP2948436A4 (en) 2013-01-25 2016-07-13 Aldeyra Therapeutics Inc NOVEL CASES IN THE TREATMENT OF MACULAR GENERATION
US9713330B1 (en) 2013-03-15 2017-07-25 Deuteria Agrochemicals, Llc Deuterium-enriched aldehydes
US20160151410A1 (en) 2013-07-02 2016-06-02 The Trustees Of Columbia University In The City Of New York Clearance of bioactive lipids from membrane structures by cyclodextrins
EP3151818A4 (en) 2014-06-04 2018-05-30 Case Western Reserve University Compositions and methods of treating diabetic retinopathy
NO2721710T3 (es) 2014-08-21 2018-03-31
MX2017002750A (es) 2014-09-02 2017-08-02 Singh Bhupinder Metodo para marcar una molecula deuterada o no deuterada y formulaciones farmaceuticas para tratamiento.
TW201628622A (zh) 2014-11-17 2016-08-16 製藥公司 Tlr抑制劑與布魯頓氏(bruton's)酪胺酸激酶抑制劑之組合
WO2016085939A2 (en) 2014-11-24 2016-06-02 Case Western Reserve University Compounds and methods of treating ocular disorders
JP6959650B2 (ja) 2015-08-21 2021-11-02 アルデイラ セラピューティクス, インコーポレイテッド アルデヒドコンジュゲートおよびその使用
JP6947406B2 (ja) 2015-08-21 2021-10-13 アルデイラ セラピューティクス, インコーポレイテッド 重水素化化合物およびその使用
CN116531400A (zh) 2016-02-28 2023-08-04 奥尔德拉医疗公司 用环糊精治疗过敏性眼部病状
AU2017264697A1 (en) 2016-05-09 2018-11-22 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
KR102442964B1 (ko) 2016-08-09 2022-09-14 코베스트로 도이칠란트 아게 실란-관능성 중합체성 폴리우레탄
WO2018039197A1 (en) 2016-08-22 2018-03-01 Aldeyra Therapeutics, Inc. Aldehyde trapping compounds and methods of use thereof
EP3500256A4 (en) 2016-08-22 2020-01-08 Aldeyra Therapeutics, Inc. ALDEHYDE CAPTURE CONNECTIONS AND USES THEREOF
BR112019006160A2 (pt) 2016-09-28 2019-06-18 Medicon Pharmaceuticals Inc composições e métodos para o tratamento das condições oftálmicas
EP3596040B1 (en) 2017-03-16 2023-10-11 Aldeyra Therapeutics, Inc. Polymorphic salt of 6-chloro-3-amino-2(2-hydroxypropyl)quinoline and uses thereof
MX2020003425A (es) 2017-10-10 2020-07-29 Aldeyra Therapeutics Inc Tratamiento de trastornos inflamatorios.
WO2020018498A1 (en) 2018-07-16 2020-01-23 Aldeyra Therapeutics, Inc. Cyclodextrin formulations
US20200038392A1 (en) 2018-08-03 2020-02-06 Aldeyra Therapeutics, Inc. Topical compositions and methods of preparation and use
JP2021533154A (ja) 2018-08-06 2021-12-02 アルデイラ セラピューティクス, インコーポレイテッド 多形化合物およびその使用
WO2020068986A1 (en) 2018-09-25 2020-04-02 Aldeyra Therapeutics, Inc. Formulations for treatment of dry eye disease
US20210317385A1 (en) 2018-10-02 2021-10-14 Aldeyra Therapeutics, Inc. Contact lens solutions and kits
WO2020118045A1 (en) 2018-12-05 2020-06-11 Aldeyra Therapeutics, Inc. Injectable formulations
WO2020198064A1 (en) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
US20220089542A1 (en) 2019-05-02 2022-03-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
WO2020223685A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
US20230131929A1 (en) 2020-03-24 2023-04-27 Aldeyra Therapeutics, Inc. Quinoline compounds for treating respiratory disorders and viral infections
WO2021211625A1 (en) 2020-04-13 2021-10-21 Aldeyra Therapeutics, Inc. Quinoline compounds for treating lung, liver, and kidney diseases, disorders, or conditions
EP4149470A4 (en) 2020-05-13 2024-04-24 Aldeyra Therapeutics Inc PHARMACEUTICAL FORMULATIONS AND USES THEREOF
JP2023529840A (ja) 2020-06-04 2023-07-12 アルデイラ セラピューティクス, インコーポレイテッド ドライアイ疾患バイオマーカーおよび処置するための該バイオマーカーの使用

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