JP2016525546A5 - - Google Patents
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- Publication number
- JP2016525546A5 JP2016525546A5 JP2016529856A JP2016529856A JP2016525546A5 JP 2016525546 A5 JP2016525546 A5 JP 2016525546A5 JP 2016529856 A JP2016529856 A JP 2016529856A JP 2016529856 A JP2016529856 A JP 2016529856A JP 2016525546 A5 JP2016525546 A5 JP 2016525546A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- subject
- administered
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 32
- 125000004430 oxygen atom Chemical group O* 0.000 claims 6
- 239000007909 solid dosage form Substances 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 4
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 3
- 239000008297 liquid dosage form Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 230000036765 blood level Effects 0.000 claims 1
- 230000003312 cholesterol blood level Effects 0.000 claims 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361858450P | 2013-07-25 | 2013-07-25 | |
| US61/858,450 | 2013-07-25 | ||
| PCT/US2014/047797 WO2015013395A1 (en) | 2013-07-25 | 2014-07-23 | Methods for reducing triglyceride, total cholesterol and low density lipoprotein blood levels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525546A JP2016525546A (ja) | 2016-08-25 |
| JP2016525546A5 true JP2016525546A5 (https=) | 2017-09-21 |
| JP6363192B2 JP6363192B2 (ja) | 2018-07-25 |
Family
ID=52391020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016529856A Active JP6363192B2 (ja) | 2013-07-25 | 2014-07-23 | トリグリセリド、総コレステロール、及び低密度リポタンパク質の血中濃度を低減する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20150031769A1 (https=) |
| EP (1) | EP3024454B1 (https=) |
| JP (1) | JP6363192B2 (https=) |
| KR (1) | KR102352728B1 (https=) |
| CN (1) | CN105407884B (https=) |
| BR (1) | BR112016001400B1 (https=) |
| CA (1) | CA2917780C (https=) |
| ES (1) | ES2843511T3 (https=) |
| WO (1) | WO2015013395A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3217719A1 (en) | 2021-05-28 | 2022-12-01 | Kazuko Matsuda | Phenoxyalkylcarboxylic acid derivatives and their use in lowering triglyceride levels |
| CN120379658A (zh) | 2022-11-30 | 2025-07-25 | 花王株式会社 | 发痒的预防或改善剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2585246A1 (fr) | 1985-07-26 | 1987-01-30 | Cortial | Procede d'obtention de formes pharmaceutiques solides a liberation prolongee |
| US4788055A (en) | 1985-12-09 | 1988-11-29 | Ciba-Geigy Corporation | Resinate sustained release dextromethorphan composition |
| GB8613689D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB8613688D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US4816264A (en) | 1986-06-06 | 1989-03-28 | Warner-Lambert Company | Sustained release formulations |
| US4985585A (en) | 1988-03-07 | 1991-01-15 | Kyorin Pharmaceutical Co., Ltd. | Phenoxyalkylcarboxylic acid derivatives and process for their preparations |
| US4996047A (en) | 1988-11-02 | 1991-02-26 | Richardson-Vicks, Inc. | Sustained release drug-resin complexes |
| CA2002492A1 (en) | 1988-11-11 | 1990-05-11 | Sandra T. A. Malkowska | Pharmaceutical ion exchange resin composition |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5290812A (en) | 1991-01-18 | 1994-03-01 | Kyorin Pharmaceutical Co., Ltd. | Phenoxyalkylcarboxylic acid derivatives and process of preparing the same |
| US7064146B2 (en) | 2003-06-24 | 2006-06-20 | Medicinova, Inc. | Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use |
| US7060854B2 (en) | 2003-06-24 | 2006-06-13 | Medicinova, Inc. | Process for making polymorphic form A of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid |
| US7429617B2 (en) * | 2004-04-27 | 2008-09-30 | Medicinova, Inc. | Phenoxyalkycarboxylic acid derivatives in the treatment of interstitial cystitis |
| EP1781303A4 (en) * | 2004-06-30 | 2008-07-02 | Combinatorx Inc | METHOD AND REAGENTS FOR THE TREATMENT OF METABOLISM DISEASES |
| PT1894576E (pt) * | 2005-06-08 | 2011-07-29 | Kowa Co | Novo agente redutor dos níveis de triglicéridos |
| WO2009002746A1 (en) * | 2007-06-22 | 2008-12-31 | Decode Genetics Ehf. | Dosing schedules of leukotriene synthesis inhibitors for human therapy |
-
2014
- 2014-07-23 BR BR112016001400-6A patent/BR112016001400B1/pt active IP Right Grant
- 2014-07-23 US US14/339,331 patent/US20150031769A1/en not_active Abandoned
- 2014-07-23 CN CN201480041441.4A patent/CN105407884B/zh active Active
- 2014-07-23 ES ES14829314T patent/ES2843511T3/es active Active
- 2014-07-23 KR KR1020167002772A patent/KR102352728B1/ko active Active
- 2014-07-23 CA CA2917780A patent/CA2917780C/en active Active
- 2014-07-23 WO PCT/US2014/047797 patent/WO2015013395A1/en not_active Ceased
- 2014-07-23 EP EP14829314.5A patent/EP3024454B1/en active Active
- 2014-07-23 JP JP2016529856A patent/JP6363192B2/ja active Active
- 2014-11-13 US US14/540,766 patent/US9358217B2/en active Active
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