RU2018133391A - 1,5-дигидро-4н-пиразоло[3,4-d]пиримидин-4-оны и 1,5-дигидро-4н-пиразоло[4,3-c]пиридин-4-оны в качестве ингибиторов pde1 - Google Patents
1,5-дигидро-4н-пиразоло[3,4-d]пиримидин-4-оны и 1,5-дигидро-4н-пиразоло[4,3-c]пиридин-4-оны в качестве ингибиторов pde1 Download PDFInfo
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- RU2018133391A RU2018133391A RU2018133391A RU2018133391A RU2018133391A RU 2018133391 A RU2018133391 A RU 2018133391A RU 2018133391 A RU2018133391 A RU 2018133391A RU 2018133391 A RU2018133391 A RU 2018133391A RU 2018133391 A RU2018133391 A RU 2018133391A
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- Prior art keywords
- methyl
- pyrazolo
- pyridin
- tetrahydropyran
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- SWENTSLBISOJDB-UHFFFAOYSA-N 1,5-dihydropyrazolo[4,3-c]pyridin-4-one Chemical compound OC1=NC=CC2=C1C=NN2 SWENTSLBISOJDB-UHFFFAOYSA-N 0.000 title 1
- 229940121836 Phosphodiesterase 1 inhibitor Drugs 0.000 title 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- AHHWIHXENZJRFG-UHFFFAOYSA-N oxetane Chemical compound C1COC1 AHHWIHXENZJRFG-UHFFFAOYSA-N 0.000 claims 3
- 125000003566 oxetanyl group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 2
- LWAQPJWARNOJEY-UHFFFAOYSA-N COC1=CC=C(CN2C(C3=C(C=C2C)N(N=C3)C2CCOCC2)=O)C=C1 Chemical compound COC1=CC=C(CN2C(C3=C(C=C2C)N(N=C3)C2CCOCC2)=O)C=C1 LWAQPJWARNOJEY-UHFFFAOYSA-N 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical compound O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 claims 1
- GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical compound OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 claims 1
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- -1 4-methyltetrahydro-2H-pyran-4-yl Chemical group 0.000 claims 1
- TXMZJMRBPNQFRI-UHFFFAOYSA-N 5-[(2-fluorophenyl)methyl]-6-methyl-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-one Chemical compound CC1=NC2=C(C=NN2C2CCOCC2)C(=O)N1CC1=C(F)C=CC=C1 TXMZJMRBPNQFRI-UHFFFAOYSA-N 0.000 claims 1
- VACQVANOFNLZEL-UHFFFAOYSA-N 5-[(3-fluorophenyl)methyl]-6-methyl-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-one Chemical compound CC1=NC2=C(C=NN2C2CCOCC2)C(=O)N1CC1=CC(F)=CC=C1 VACQVANOFNLZEL-UHFFFAOYSA-N 0.000 claims 1
- ZILNXTHNKXUETP-UHFFFAOYSA-N 5-[(4-chlorophenyl)methyl]-6-methyl-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-one Chemical compound CC1=NC2=C(C=NN2C2CCOCC2)C(=O)N1CC1=CC=C(Cl)C=C1 ZILNXTHNKXUETP-UHFFFAOYSA-N 0.000 claims 1
- WRYMSMMHCLFPFM-UHFFFAOYSA-N 5-benzyl-6-methyl-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-one Chemical compound CC1=NC2=C(C=NN2C2CCOCC2)C(=O)N1CC1=CC=CC=C1 WRYMSMMHCLFPFM-UHFFFAOYSA-N 0.000 claims 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- IVICMAQJTMYPDI-UHFFFAOYSA-N C(C)(C)C=1N(C(C2=C(N=1)N(N=C2)C1CCOCC1)=O)CC1=CC=C(C=C1)OC Chemical compound C(C)(C)C=1N(C(C2=C(N=1)N(N=C2)C1CCOCC1)=O)CC1=CC=C(C=C1)OC IVICMAQJTMYPDI-UHFFFAOYSA-N 0.000 claims 1
- LCELOTJXOWMXKN-UHFFFAOYSA-N C(C)(C)N1N=CC=2C(N(C(=CC=21)C)CC1=CC=C(C=C1)OC)=O Chemical compound C(C)(C)N1N=CC=2C(N(C(=CC=21)C)CC1=CC=C(C=C1)OC)=O LCELOTJXOWMXKN-UHFFFAOYSA-N 0.000 claims 1
- KVMXASWJIZJMBZ-UHFFFAOYSA-N C(C)C=1N(C(C2=C(N=1)N(N=C2)C1CCOCC1)=O)CC1=CC=C(C=C1)OC Chemical compound C(C)C=1N(C(C2=C(N=1)N(N=C2)C1CCOCC1)=O)CC1=CC=C(C=C1)OC KVMXASWJIZJMBZ-UHFFFAOYSA-N 0.000 claims 1
- LZTQRMBMZGEDRE-UHFFFAOYSA-N C(C)N1N=CC=2C(N(C(=CC=21)C)CC1=CC=C(C=C1)OC)=O Chemical compound C(C)N1N=CC=2C(N(C(=CC=21)C)CC1=CC=C(C=C1)OC)=O LZTQRMBMZGEDRE-UHFFFAOYSA-N 0.000 claims 1
- YXOLEIZBMQWRJW-UHFFFAOYSA-N C(C1=CC=CC=C1)C=1N(C(C2=C(N=1)N(N=C2)C1CCOCC1)=O)CC1CCCCC1 Chemical compound C(C1=CC=CC=C1)C=1N(C(C2=C(N=1)N(N=C2)C1CCOCC1)=O)CC1CCCCC1 YXOLEIZBMQWRJW-UHFFFAOYSA-N 0.000 claims 1
- RQVFLKLHPKLTIO-UHFFFAOYSA-N C1(CC1)N1N=CC=2C(N(C(=CC=21)C)CC1=CC=C(C=C1)OC)=O Chemical compound C1(CC1)N1N=CC=2C(N(C(=CC=21)C)CC1=CC=C(C=C1)OC)=O RQVFLKLHPKLTIO-UHFFFAOYSA-N 0.000 claims 1
- FKFYCHHMKLLPQY-UHFFFAOYSA-N C1(CCCCC1)CN1C(=NC2=C(C1=O)C=NN2C1CCOCC1)C Chemical compound C1(CCCCC1)CN1C(=NC2=C(C1=O)C=NN2C1CCOCC1)C FKFYCHHMKLLPQY-UHFFFAOYSA-N 0.000 claims 1
- TYMBPQQASYCWEH-UHFFFAOYSA-N C1(CCCCC1)CN1C(=NC2=C(C1=O)C=NN2CCC)C Chemical compound C1(CCCCC1)CN1C(=NC2=C(C1=O)C=NN2CCC)C TYMBPQQASYCWEH-UHFFFAOYSA-N 0.000 claims 1
- CXGGCYJPLGSTBH-UHFFFAOYSA-N CC1=CC2=C(C(N1CC1=CC=C(C=C1)C)=O)C=NN2C1CCOCC1 Chemical compound CC1=CC2=C(C(N1CC1=CC=C(C=C1)C)=O)C=NN2C1CCOCC1 CXGGCYJPLGSTBH-UHFFFAOYSA-N 0.000 claims 1
- MWPSAGRFLKLXIM-UHFFFAOYSA-N COC1=CC=C(C=C1)CN1C(=NC2=C(C1=O)C=NN2C1CCOCC1)CC1COC1 Chemical compound COC1=CC=C(C=C1)CN1C(=NC2=C(C1=O)C=NN2C1CCOCC1)CC1COC1 MWPSAGRFLKLXIM-UHFFFAOYSA-N 0.000 claims 1
- PBXYUGSYGCBAKT-UHFFFAOYSA-N COC1=CC=C(C=C1)CN1C(=NC2=C(C1=O)C=NN2CCC)C Chemical compound COC1=CC=C(C=C1)CN1C(=NC2=C(C1=O)C=NN2CCC)C PBXYUGSYGCBAKT-UHFFFAOYSA-N 0.000 claims 1
- OHTPHQPYCOLWAE-UHFFFAOYSA-N COC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1COC1)=O Chemical compound COC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1COC1)=O OHTPHQPYCOLWAE-UHFFFAOYSA-N 0.000 claims 1
- VJXIKYZGNVVTHA-UHFFFAOYSA-N COC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1COCC1)=O Chemical compound COC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1COCC1)=O VJXIKYZGNVVTHA-UHFFFAOYSA-N 0.000 claims 1
- XNNVZFHRPHCGHM-UHFFFAOYSA-N COC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1COCCC1)=O Chemical compound COC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1COCCC1)=O XNNVZFHRPHCGHM-UHFFFAOYSA-N 0.000 claims 1
- IAAHGVIRZIKPHA-UHFFFAOYSA-N COC1=CC=C(CN2C(=NC3=C(C2=O)C=NN3C2CCOCC2)C)C=C1 Chemical compound COC1=CC=C(CN2C(=NC3=C(C2=O)C=NN3C2CCOCC2)C)C=C1 IAAHGVIRZIKPHA-UHFFFAOYSA-N 0.000 claims 1
- GMPCYHZOARRAOF-UHFFFAOYSA-N COC1=CC=C(CN2C(C3=C(C=C2C)N(N=C3)CCC)=O)C=C1 Chemical compound COC1=CC=C(CN2C(C3=C(C=C2C)N(N=C3)CCC)=O)C=C1 GMPCYHZOARRAOF-UHFFFAOYSA-N 0.000 claims 1
- SBPLRPBAFIENJD-IKJXHCRLSA-N COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCO[C@@H]2C)cc1 Chemical compound COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCO[C@@H]2C)cc1 SBPLRPBAFIENJD-IKJXHCRLSA-N 0.000 claims 1
- SBPLRPBAFIENJD-PIVQAISJSA-N COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCO[C@H]2C)cc1 Chemical compound COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCO[C@H]2C)cc1 SBPLRPBAFIENJD-PIVQAISJSA-N 0.000 claims 1
- FZRPHLODQVQNHB-UHFFFAOYSA-N ClC=1C=C(C=CC=1)CN1C(C2=C(C=C1C)N(N=C2)C1CCOCC1)=O Chemical compound ClC=1C=C(C=CC=1)CN1C(C2=C(C=C1C)N(N=C2)C1CCOCC1)=O FZRPHLODQVQNHB-UHFFFAOYSA-N 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- LUDIBRFXTWLUSU-UHFFFAOYSA-N FC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1CCOCC1)=O Chemical compound FC1=CC=C(C=C1)CN1C(C2=C(C=C1C)N(N=C2)C1CCOCC1)=O LUDIBRFXTWLUSU-UHFFFAOYSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- APQLMNUUGPWXRZ-UHFFFAOYSA-N O1COC2=C1C=CC(=C2)CN1C(C2=C(C=C1C)N(N=C2)C1CCOCC1)=O Chemical compound O1COC2=C1C=CC(=C2)CN1C(C2=C(C=C1C)N(N=C2)C1CCOCC1)=O APQLMNUUGPWXRZ-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000005265 dialkylamine group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201600221 | 2016-04-12 | ||
| DKPA201600221 | 2016-04-12 | ||
| PCT/EP2017/058332 WO2017178350A1 (en) | 2016-04-12 | 2017-04-07 | 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones as pde1 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018133391A true RU2018133391A (ru) | 2020-05-12 |
| RU2018133391A3 RU2018133391A3 (enExample) | 2020-06-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018133391A RU2018133391A (ru) | 2016-04-12 | 2017-04-07 | 1,5-дигидро-4н-пиразоло[3,4-d]пиримидин-4-оны и 1,5-дигидро-4н-пиразоло[4,3-c]пиридин-4-оны в качестве ингибиторов pde1 |
Country Status (43)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201629064A (zh) | 2014-10-10 | 2016-08-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之三唑並吡酮 |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
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