CY1123269T1 - 1,5-διυδρο-4η-πυραζολο[3,4-d]πυριμιδιν-4-ονες καi 1,5- διυδρο-4η-πυραζολο[4,3-c]πυριδiν-4-ονες ως αναστολεις pde1 - Google Patents

1,5-διυδρο-4η-πυραζολο[3,4-d]πυριμιδιν-4-ονες καi 1,5- διυδρο-4η-πυραζολο[4,3-c]πυριδiν-4-ονες ως αναστολεις pde1

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Publication number
CY1123269T1
CY1123269T1 CY20201100779T CY201100779T CY1123269T1 CY 1123269 T1 CY1123269 T1 CY 1123269T1 CY 20201100779 T CY20201100779 T CY 20201100779T CY 201100779 T CY201100779 T CY 201100779T CY 1123269 T1 CY1123269 T1 CY 1123269T1
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CY
Cyprus
Prior art keywords
pyrazolo
dihydro
ones
pyrimidin
pyridin
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CY20201100779T
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English (en)
Inventor
Karsten Juhl
Mikkel JESSING
Morten LANGGÅRD
Paulo Jorge Vieira VITAL
Mauro Marigo
Jan Kehler
Lars Kyhn Rasmussen
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H. Lundbeck A/S
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Publication of CY1123269T1 publication Critical patent/CY1123269T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση προβλέπει 1,5-διυδρο-4Η-πυραζολο[3,4-d]πυριμιδιν-4-όνες και 1,5-διυδρο-4Η-πυραζολο[4,3-c]πυριδιν-4-όνες του τύπου (Ι) ως αναστολείς PDE1 και τη χρήση τους ως φάρμακο, ειδικότερα για τη θεραπεία των νευροεκφυλιστικών διαταραχών και των ψυχιατρικών διαταραχών.
CY20201100779T 2016-04-12 2020-08-20 1,5-διυδρο-4η-πυραζολο[3,4-d]πυριμιδιν-4-ονες καi 1,5- διυδρο-4η-πυραζολο[4,3-c]πυριδiν-4-ονες ως αναστολεις pde1 CY1123269T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201600221 2016-04-12
PCT/EP2017/058332 WO2017178350A1 (en) 2016-04-12 2017-04-07 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones as pde1 inhibitors

Publications (1)

Publication Number Publication Date
CY1123269T1 true CY1123269T1 (el) 2021-12-31

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ID=58489694

Family Applications (1)

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CY20201100779T CY1123269T1 (el) 2016-04-12 2020-08-20 1,5-διυδρο-4η-πυραζολο[3,4-d]πυριμιδιν-4-ονες καi 1,5- διυδρο-4η-πυραζολο[4,3-c]πυριδiν-4-ονες ως αναστολεις pde1

Country Status (42)

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US (3) US20170291901A1 (el)
EP (1) EP3442975B1 (el)
JP (1) JP7093306B2 (el)
KR (1) KR20180133413A (el)
CN (1) CN109071549B (el)
AR (1) AR108109A1 (el)
AU (1) AU2017250431B2 (el)
BR (1) BR112017026278A2 (el)
CA (1) CA3020053A1 (el)
CL (1) CL2018002881A1 (el)
CO (1) CO2018010323A2 (el)
CR (1) CR20180470A (el)
CY (1) CY1123269T1 (el)
DK (1) DK3442975T3 (el)
DO (1) DOP2018000201A (el)
EA (1) EA035197B1 (el)
EC (1) ECSP18074641A (el)
ES (1) ES2814289T3 (el)
GE (1) GEP20207057B (el)
HR (1) HRP20201331T1 (el)
HU (1) HUE050320T2 (el)
IL (1) IL262257B (el)
LT (1) LT3442975T (el)
MA (1) MA44656B1 (el)
ME (1) ME03820B (el)
MX (1) MX2018012496A (el)
MY (1) MY194722A (el)
NI (1) NI201800092A (el)
PE (1) PE20181853A1 (el)
PH (1) PH12018502168A1 (el)
PL (1) PL3442975T3 (el)
PT (1) PT3442975T (el)
RS (1) RS60714B1 (el)
RU (1) RU2018133391A (el)
SG (1) SG11201808221QA (el)
SI (1) SI3442975T1 (el)
SV (1) SV2018005753A (el)
TN (1) TN2018000321A1 (el)
TW (1) TWI729109B (el)
UA (1) UA121925C2 (el)
WO (1) WO2017178350A1 (el)
ZA (1) ZA201806407B (el)

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JP2020500841A (ja) 2016-10-28 2020-01-16 ハー・ルンドベック・アクチエゼルスカベット イミダゾピラジノンの投与を含む併用療法
SI3532064T1 (sl) 2016-10-28 2020-10-30 H. Lundbeck A/S Kombinirana zdravljenja, ki obsegajo imidazopirazinone za zdravljenje psihiatričnih in/ali kognitivnih motenj

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US10538525B2 (en) 2020-01-21
UA121925C2 (uk) 2020-08-10
ES2814289T3 (es) 2021-03-26
HRP20201331T1 (hr) 2020-11-27
CN109071549A (zh) 2018-12-21
JP7093306B2 (ja) 2022-06-29
DOP2018000201A (es) 2018-11-15
EP3442975B1 (en) 2020-07-29
MY194722A (en) 2022-12-15
TN2018000321A1 (en) 2020-01-16
SG11201808221QA (en) 2018-10-30
EA035197B1 (ru) 2020-05-14
ZA201806407B (en) 2019-12-18
MA44656A (fr) 2019-02-20
ME03820B (me) 2021-04-20
SV2018005753A (es) 2018-11-27
JP2019517996A (ja) 2019-06-27
US20200102316A1 (en) 2020-04-02
CN109071549B (zh) 2021-11-30
AR108109A1 (es) 2018-07-18
MA44656B1 (fr) 2020-10-28
PE20181853A1 (es) 2018-12-03
IL262257B (en) 2020-11-30
NI201800092A (es) 2019-03-14
BR112017026278A2 (pt) 2018-09-11
RU2018133391A (ru) 2020-05-12
TWI729109B (zh) 2021-06-01
CA3020053A1 (en) 2017-10-19
CR20180470A (es) 2018-12-21
PT3442975T (pt) 2020-09-03
TW201738242A (zh) 2017-11-01
KR20180133413A (ko) 2018-12-14
RU2018133391A3 (el) 2020-06-23
WO2017178350A1 (en) 2017-10-19
HUE050320T2 (hu) 2020-11-30
IL262257A (en) 2018-11-29
EP3442975A1 (en) 2019-02-20
GEP20207057B (en) 2020-01-27
SI3442975T1 (sl) 2020-10-30
AU2017250431A1 (en) 2018-10-11
EA201891897A1 (ru) 2019-03-29
PL3442975T3 (pl) 2020-11-16
CO2018010323A2 (es) 2018-12-14
RS60714B1 (sr) 2020-09-30
DK3442975T3 (da) 2020-08-24
PH12018502168A1 (en) 2019-08-19
LT3442975T (lt) 2020-09-25
MX2018012496A (es) 2019-02-21
AU2017250431B2 (en) 2020-07-16
ECSP18074641A (es) 2018-10-31
CL2018002881A1 (es) 2018-12-14
US20190194204A1 (en) 2019-06-27
US20170291901A1 (en) 2017-10-12

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