CY1124850T1 - Συνδυαστικες αγωγες οι οποιες περιλαμβανουν χορηγηση 1η-πυραζολο[4,3-b]πυριδινων - Google Patents

Συνδυαστικες αγωγες οι οποιες περιλαμβανουν χορηγηση 1η-πυραζολο[4,3-b]πυριδινων

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Publication number
CY1124850T1
CY1124850T1 CY20211101019T CY211101019T CY1124850T1 CY 1124850 T1 CY1124850 T1 CY 1124850T1 CY 20211101019 T CY20211101019 T CY 20211101019T CY 211101019 T CY211101019 T CY 211101019T CY 1124850 T1 CY1124850 T1 CY 1124850T1
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CY
Cyprus
Prior art keywords
pyrazolo
pyridines
combination treatments
involving administration
treatments involving
Prior art date
Application number
CY20211101019T
Other languages
English (en)
Inventor
Jan Kehler
Karsten Juhl
Mauro Marigo
Paulo Jorge Vieira VITAL
Mikkel JESSING
Morten LANGGÅRD
Lars Kyhn Rasmussen
Carl Martin Sebastian CLEMENTSON
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1124850T1 publication Critical patent/CY1124850T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει 1Η-πυραζολο[4,3-b]πυριδιν-7-αμίνες του τύπου (Ι) ως PDE1 αναστολείς μαζί με μια δεύτερη ένωση χρήσιμη στην αντιμετώπιση μιας νευροεκφυλιστικής διαταραχής και τη συνδυαστική χρήση τους ως ένα φάρμακο, πιο συγκεκριμένα για την αντιμετώπιση νευροεκφυλιστικών και/ή γνωστικών διαταραχών.
CY20211101019T 2017-12-14 2021-11-24 Συνδυαστικες αγωγες οι οποιες περιλαμβανουν χορηγηση 1η-πυραζολο[4,3-b]πυριδινων CY1124850T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700711 2017-12-14
PCT/EP2018/084434 WO2019115567A1 (en) 2017-12-14 2018-12-12 Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines

Publications (1)

Publication Number Publication Date
CY1124850T1 true CY1124850T1 (el) 2022-11-25

Family

ID=64959284

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211101019T CY1124850T1 (el) 2017-12-14 2021-11-24 Συνδυαστικες αγωγες οι οποιες περιλαμβανουν χορηγηση 1η-πυραζολο[4,3-b]πυριδινων

Country Status (25)

Country Link
US (1) US11851425B2 (el)
EP (1) EP3723808B1 (el)
JP (1) JP2021506780A (el)
KR (1) KR20200099155A (el)
CN (1) CN111526890B (el)
AR (1) AR113926A1 (el)
AU (1) AU2018385454C1 (el)
BR (1) BR112019016839A2 (el)
CA (1) CA3085202A1 (el)
CL (1) CL2020001550A1 (el)
CO (1) CO2020007130A2 (el)
CY (1) CY1124850T1 (el)
ES (1) ES2900561T3 (el)
HR (1) HRP20211785T1 (el)
HU (1) HUE056882T2 (el)
IL (1) IL275293B2 (el)
LT (1) LT3723808T (el)
MX (1) MX2020006228A (el)
PL (1) PL3723808T3 (el)
PT (1) PT3723808T (el)
RS (1) RS62552B1 (el)
RU (1) RU2020119080A (el)
SG (1) SG11202005333TA (el)
SI (1) SI3723808T1 (el)
WO (1) WO2019115567A1 (el)

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AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
WO2019121840A1 (en) 2017-12-20 2019-06-27 H. Lundbeck A/S Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors

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AR113926A1 (es) 2020-07-01
SG11202005333TA (en) 2020-07-29
IL275293B2 (en) 2023-07-01
CA3085202A1 (en) 2019-06-20
BR112019016839A2 (pt) 2020-04-07
WO2019115567A1 (en) 2019-06-20
RS62552B1 (sr) 2021-12-31
US11851425B2 (en) 2023-12-26
AU2018385454A1 (en) 2020-07-02
AU2018385454B2 (en) 2024-02-29
CO2020007130A2 (es) 2020-06-19
EP3723808A1 (en) 2020-10-21
US20200385372A1 (en) 2020-12-10
CN111526890B (zh) 2022-10-14
CN111526890A (zh) 2020-08-11
KR20200099155A (ko) 2020-08-21
MX2020006228A (es) 2022-09-27
AU2018385454C1 (en) 2024-06-27
ES2900561T3 (es) 2022-03-17
PL3723808T3 (pl) 2022-01-24
LT3723808T (lt) 2021-11-25
JP2021506780A (ja) 2021-02-22
HUE056882T2 (hu) 2022-03-28
PT3723808T (pt) 2021-11-25
EP3723808B1 (en) 2021-10-20
HRP20211785T1 (hr) 2022-02-18
RU2020119080A (ru) 2022-01-14
IL275293A (en) 2020-07-30
IL275293B1 (en) 2023-03-01
SI3723808T1 (sl) 2022-01-31
CL2020001550A1 (es) 2020-09-25

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