RU2018100944A - Противораковое средство - Google Patents
Противораковое средство Download PDFInfo
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- RU2018100944A RU2018100944A RU2018100944A RU2018100944A RU2018100944A RU 2018100944 A RU2018100944 A RU 2018100944A RU 2018100944 A RU2018100944 A RU 2018100944A RU 2018100944 A RU2018100944 A RU 2018100944A RU 2018100944 A RU2018100944 A RU 2018100944A
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- antagonist
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (14)
1. Терапевтическое лекарственное средство для лечения рака, содержащее ингибитор CBP/катенина и ингибитор контрольной точки иммунного ответа в комбинации.
2. Терапевтическое лекарственное средство для лечения рака по п. 1, где ингибитор контрольной точки иммунного ответа представляет собой один или более типов ингибиторов контрольной точки иммунного ответа, выбираемых из антагониста PD-1, антагониста PD-L1, антагониста PD-L2, антагониста CTLA-4, антагониста KIR, антагониста CD137, антагониста LAG3 и антагониста OX40.
3. Терапевтическое лекарственное средство для лечения рака по п. 1, где ингибитор контрольной точки иммунного ответа представляет собой один или более типов ингибиторов контрольной точки иммунного ответа, выбираемых из анти-PD-1 антитела, анти-PD-L1 антитела, анти-PD-L2 антитела, анти-CTLA-4 антитела, анти-KIR антитела, анти-LAG3 антитела и анти-OX40 антитела.
4. Терапевтическое лекарственное средство для лечения рака по любому из пп. 1-3, где ингибитор CBP/катенина представляет собой α-спиральное миметическое соединение, обладающее ингибирующей активностью в отношении CBP/катенина.
5. Терапевтическое лекарственное средство для лечения рака по п.4, где α-спиральное миметическое соединение представляет собой один или более видов любых α-спиральных миметических соединений, описанных в WO 2003/031448, WO 2004/093828, WO 2005/116032, WO 2009/148192, WO 2010/044485, WO 2010/128685, WO 2012/115286 и/или WO 2015/098853.
6. Терапевтическое лекарственное средство для лечения рака по любому из пп. 1-4, где ингибитором CBP/катенина является один или более видов, выбираемых из следующих соединений:
(6S,9aS)-N-бензил-6-[(4-гидроксифенил)метил]-8-(нафталин-1-илметил)-4,7-диоксо-3,6,9,9a-тетрагидро-2H-пиразино[1,2-a]пиримидин-1-карбоксамид (ICG-001), 4-(((6S,9S,9aS)-1-(бензилкарбамоил)-2,9-диметил-4,7-диоксо-8-(хинолин-8-илметил)октагидро-1H-пиразино[2,1-c][1,2,4]триазин-6-ил)метил)фенилдигидрофосфат, (6S,9S,9aS)-N-бензил-6-(4-гидроксибензил)-2,9-диметил-4,7-диоксо-8-(хинолин-8-илметил)октагидро-1H-пиразино[2,1-c][1,2,4]триазин-1-карбоксамид и (6S,9aS)-N-бензил-8-((6-(3-(4-этилпиперазин-1-ил)азетидин-1-ил)пиридин-2-ил)метил)-6-((2-фтор-4-гидроксифенил)метил)-4,7-диоксо-2-(проп-2-ен-1-ил)-октагидро-1H-пиразино[2,1-c][1,2,4]триазин-1-карбоксамид.
7. Способ лечения рака, включающий введение эффективного количества ингибитора CBP/катенина и эффективного количества ингибитора контрольной точки иммунного ответа пациенту, нуждающемуся в этом.
8. Способ по п. 7, где ингибитором контрольной точки иммунного ответа является один или более видов ингибиторов контрольной точки иммунного ответа, выбираемых из антагониста PD-1, антагониста PD-L1, антагониста PD-L2, антагониста CTLA-4, антагониста KIR, антагониста CD137, антагониста LAG3 и антагониста OX40.
9. Способ по п. 7, где ингибитором контрольной точки иммунного ответа является один или более видов ингибиторов контрольной точки иммунного ответа, выбираемых из анти-PD-1 антитела, анти-PD-L1 антитела, анти-PD-L2 антитела, анти-CTLA-4 антитела, анти-KIR антитела, анти-LAG3 антитела и анти-OX40 антитела.
10. Способ по любому из пп. 7-9, где ингибитором CBP/катенина является α-спиральное миметическое соединение, обладающее ингибирующей активностью в отношении CBP/катенина.
11. Способ по п. 10, где α-спиральное миметическое соединение представляет собой один или более видов любых α-спиральных миметических соединений, описанных в WO 2003/031448, WO 2004/093828, WO 2005/116032, WO 2009/148192, WO 2010/044485, WO 2010/128685, WO 2012/115286 и/или WO 2015/098853.
12. Способ по любому из пп. 7-10, где ингибитором CBP/катенина является один или более видов, выбираемых из следующих соединений:
(6S,9aS)-N-бензил-6-[(4-гидроксифенил)метил]-8-(нафталин-1-илметил)-4,7-диоксо-3,6,9,9a-тетрагидро-2H-пиразино[1,2-a]пиримидин-1-карбоксамид (ICG-001), 4-(((6S,9S,9aS)-1-(бензилкарбамоил)-2,9-диметил-4,7-диоксо-8-(хинолин-8-илметил)октагидро-1H-пиразино[2,1-c][1,2,4]триазин-6-ил)метил)фенил дигидрофосфат, (6S,9S,9aS)-N-бензил-6-(4-гидроксибензил)-2,9-диметил-4,7-диоксо-8-(хинолин-8-илметил)октагидро-1H-пиразино[2,1-c][1,2,4]триазин-1-карбоксамид и (6S,9aS)-N-бензил-8-((6-(3-(4-этилпиперазин-1-yl)азетидин-1-ил)пиридин-2-ил)метил)-6-((2-фтор-4-гидроксифенил)метил)-4,7-диоксо-2-(проп-2-ен-1-ил)-октагидро-1H-пиразино[2,1-c][1,2,4]триазин-1-карбоксамид.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2015121479 | 2015-06-16 | ||
JP2015-121479 | 2015-06-16 | ||
PCT/JP2016/067843 WO2016204193A1 (ja) | 2015-06-16 | 2016-06-15 | 抗がん剤 |
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RU2018100944A true RU2018100944A (ru) | 2019-07-16 |
RU2018100944A3 RU2018100944A3 (ru) | 2019-12-18 |
RU2729936C2 RU2729936C2 (ru) | 2020-08-13 |
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RU2018100944A RU2729936C2 (ru) | 2015-06-16 | 2016-06-15 | Противораковое средство |
Country Status (14)
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US (1) | US11369623B2 (ru) |
EP (1) | EP3311841B1 (ru) |
JP (1) | JP6757959B2 (ru) |
KR (1) | KR20180018695A (ru) |
CN (1) | CN107801379B (ru) |
AU (1) | AU2016279474B2 (ru) |
BR (1) | BR112017027227B1 (ru) |
CA (1) | CA2988707C (ru) |
ES (1) | ES2886107T3 (ru) |
IL (1) | IL256148B (ru) |
MX (1) | MX2017015896A (ru) |
RU (1) | RU2729936C2 (ru) |
SG (1) | SG11201710198YA (ru) |
WO (1) | WO2016204193A1 (ru) |
Families Citing this family (11)
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RS63559B1 (sr) | 2014-08-28 | 2022-10-31 | Eisai R&D Man Co Ltd | Derivat hinolina velike čistoće i postupak za njegovu proizvodnju |
PL3263106T3 (pl) | 2015-02-25 | 2024-04-02 | Eisai R&D Management Co., Ltd. | Sposób tłumienia goryczy pochodnej chinoliny |
AU2015384801B2 (en) | 2015-03-04 | 2022-01-06 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer |
BR112017027227B1 (pt) | 2015-06-16 | 2023-12-12 | Eisai R&D Management Co., Ltd | Agente anti-câncer |
BR112019014127A2 (pt) * | 2017-02-08 | 2020-02-11 | Eisai R&D Management Co., Ltd. | Composição farmacêutica para tratamento de tumores |
KR20200106513A (ko) * | 2018-01-05 | 2020-09-14 | 다이서나 파마수이티컬, 인크. | 면역요법을 강화시키기 위하여 베타-카테닌 및 ido 발현의 감소 |
CN110522926A (zh) * | 2019-08-06 | 2019-12-03 | 天津大学 | 一种可视化纳米免疫制剂及其制备方法、应用 |
AU2020374883A1 (en) | 2019-10-29 | 2022-05-26 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist, a VEGFR/FGFR/RET tyrosine kinase inhibitor and a CBP/beta-catenin inhibitor for treating cancer |
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JP6757959B2 (ja) | 2020-09-23 |
EP3311841B1 (en) | 2021-07-28 |
BR112017027227B1 (pt) | 2023-12-12 |
CN107801379A (zh) | 2018-03-13 |
CA2988707A1 (en) | 2016-12-22 |
KR20180018695A (ko) | 2018-02-21 |
EP3311841A4 (en) | 2019-02-13 |
EP3311841A1 (en) | 2018-04-25 |
RU2018100944A3 (ru) | 2019-12-18 |
IL256148B (en) | 2022-04-01 |
AU2016279474A1 (en) | 2018-02-01 |
JPWO2016204193A1 (ja) | 2018-04-05 |
IL256148A (en) | 2018-02-28 |
CA2988707C (en) | 2023-10-10 |
MX2017015896A (es) | 2018-08-09 |
US11369623B2 (en) | 2022-06-28 |
RU2729936C2 (ru) | 2020-08-13 |
US20180185395A1 (en) | 2018-07-05 |
ES2886107T3 (es) | 2021-12-16 |
AU2016279474B2 (en) | 2021-09-09 |
CN107801379B (zh) | 2021-05-25 |
BR112017027227A2 (pt) | 2018-08-21 |
SG11201710198YA (en) | 2018-01-30 |
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