RU2016112549A - Способ для повторного использования хроматографии - Google Patents
Способ для повторного использования хроматографии Download PDFInfo
- Publication number
- RU2016112549A RU2016112549A RU2016112549A RU2016112549A RU2016112549A RU 2016112549 A RU2016112549 A RU 2016112549A RU 2016112549 A RU2016112549 A RU 2016112549A RU 2016112549 A RU2016112549 A RU 2016112549A RU 2016112549 A RU2016112549 A RU 2016112549A
- Authority
- RU
- Russia
- Prior art keywords
- approximately
- buffer
- passing
- volumes
- chromatographic
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 41
- 238000004587 chromatography analysis Methods 0.000 title 1
- 239000000463 material Substances 0.000 claims 132
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 48
- 239000012149 elution buffer Substances 0.000 claims 24
- 239000012557 regeneration buffer Substances 0.000 claims 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 18
- 230000003068 static effect Effects 0.000 claims 16
- 239000000872 buffer Substances 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 238000005342 ion exchange Methods 0.000 claims 4
- 239000012536 storage buffer Substances 0.000 claims 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 3
- 238000004140 cleaning Methods 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- IZXGZAJMDLJLMF-UHFFFAOYSA-N methylaminomethanol Chemical compound CNCO IZXGZAJMDLJLMF-UHFFFAOYSA-N 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 239000001632 sodium acetate Substances 0.000 claims 3
- 235000017281 sodium acetate Nutrition 0.000 claims 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 239000012515 MabSelect SuRe Substances 0.000 claims 2
- 238000005349 anion exchange Methods 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000005341 cation exchange Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 230000016784 immunoglobulin production Effects 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 239000012564 Q sepharose fast flow resin Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000003480 eluent Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- -1 immunoconjugate Proteins 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 238000011031 large-scale manufacturing process Methods 0.000 claims 1
- 239000012516 mab select resin Substances 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/203—Equilibration or regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/60—Cleaning or rinsing ion-exchange beds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874305P | 2013-09-05 | 2013-09-05 | |
| US61/874,305 | 2013-09-05 | ||
| PCT/US2014/054313 WO2015035180A1 (en) | 2013-09-05 | 2014-09-05 | Method for chromatography reuse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016112549A true RU2016112549A (ru) | 2017-10-10 |
Family
ID=52628962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016112549A RU2016112549A (ru) | 2013-09-05 | 2014-09-05 | Способ для повторного использования хроматографии |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20150093800A1 (enExample) |
| EP (1) | EP3041593B1 (enExample) |
| JP (4) | JP6602765B2 (enExample) |
| KR (1) | KR20160050062A (enExample) |
| CN (1) | CN105848746B (enExample) |
| CA (1) | CA2922832A1 (enExample) |
| MX (1) | MX2016002798A (enExample) |
| RU (1) | RU2016112549A (enExample) |
| WO (1) | WO2015035180A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3041857B1 (en) * | 2013-09-04 | 2019-05-08 | EMD Millipore Corporation | Protein a chromatography |
| CN106460027B (zh) * | 2014-03-24 | 2020-07-31 | 日东纺绩株式会社 | 使用阳离子性接枝聚合物的目标物分离浓缩方法 |
| US10550148B2 (en) | 2014-06-16 | 2020-02-04 | Emd Millipore Corporation | Methods for increasing the capacity of flow-through processes |
| WO2015195452A2 (en) | 2014-06-16 | 2015-12-23 | Emd Millipore Corporation | Single-pass filtration systems and processes |
| SG11201508171RA (en) | 2014-06-25 | 2016-01-28 | Emd Millipore Corp | Compact spiral-wound filter elements, modules and systems |
| US10350518B2 (en) | 2014-08-29 | 2019-07-16 | Emd Millipore Corporation | Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate |
| KR102188947B1 (ko) | 2014-08-29 | 2020-12-09 | 이엠디 밀리포어 코포레이션 | 잔류물의 재순환을 이용한 싱글 패스 접선 유동 여과 시스템 및 접선 유동 여과 시스템 |
| TW201628649A (zh) | 2014-10-09 | 2016-08-16 | 再生元醫藥公司 | 減少醫藥調配物中微可見顆粒之方法 |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| EP3455243B1 (en) | 2016-05-11 | 2021-03-24 | Cytiva BioProcess R&D AB | Separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| ES2909833T3 (es) | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
| EP4066927B1 (en) | 2016-06-09 | 2024-10-09 | EMD Millipore Corporation | Methods of using radial-path filter elements |
| KR102369014B1 (ko) | 2016-08-16 | 2022-03-02 | 리제너론 파아마슈티컬스, 인크. | 혼합물로부터 개별 항체들을 정량하는 방법 |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| ES3032778T3 (en) | 2016-10-25 | 2025-07-24 | Regeneron Pharma | Methods for chromatography data analysis |
| CN110267721B (zh) * | 2017-01-30 | 2022-03-01 | 瑞泽恩制药公司 | 用于降低色谱中生物负载的组合物和方法 |
| MY203415A (en) | 2017-09-19 | 2024-06-27 | Regeneron Pharma | Methods of reducing particle formation and compositions formed thereby |
| TW202448568A (zh) | 2018-07-02 | 2024-12-16 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| KR20210148349A (ko) * | 2019-04-17 | 2021-12-07 | 브리스톨-마이어스 스큅 컴퍼니 | 크로마토그래피 수지의 재생 방법 |
| CN110075569B (zh) * | 2019-05-07 | 2021-04-23 | 世瑞纳科(北京)科技有限责任公司 | 糖化血红蛋白分析仪高效液相色谱柱的再生方法 |
| AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
| MA56197A (fr) * | 2019-06-13 | 2022-04-20 | Regeneron Pharma | Procédés d'élimination de composants indésirables pendant des processus chromatographiques en plusieurs étapes |
| CN120334439A (zh) * | 2019-09-24 | 2025-07-18 | 里珍纳龙药品有限公司 | 用于色谱介质的使用和再生的系统及方法 |
| EP3862078A1 (de) * | 2020-02-05 | 2021-08-11 | Pentracor GmbH | Verwendung einer alkalihydroxid-lösung zur regeneration einer apheresesäule |
| CN112843789A (zh) * | 2020-12-29 | 2021-05-28 | 上海赛梵科分离技术有限公司 | 大麻二酚纯化中色谱填料和层析介质的再生方法 |
| CN112646045A (zh) * | 2021-01-06 | 2021-04-13 | 海默斯（重庆）医学生物技术有限公司 | 一种重组角蛋白分离纯化方法 |
| JP2024518400A (ja) * | 2021-05-07 | 2024-05-01 | ジェンザイム・コーポレーション | 衛生化のための組成物および方法 |
| CN113842673B (zh) * | 2021-09-07 | 2023-01-06 | 济宁海关综合技术服务中心 | 液相色谱柱再生方法 |
| TW202337900A (zh) * | 2022-01-12 | 2023-10-01 | 美商再生元醫藥公司 | 改良使用親和層析的異二聚蛋白質自雜質之解析的方法 |
| WO2024137698A1 (en) * | 2022-12-19 | 2024-06-27 | Eli Lilly And Company | Methods of cleaning chromatography matrices |
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| EP3041857B1 (en) * | 2013-09-04 | 2019-05-08 | EMD Millipore Corporation | Protein a chromatography |
-
2014
- 2014-09-05 EP EP14841863.5A patent/EP3041593B1/en active Active
- 2014-09-05 JP JP2016540425A patent/JP6602765B2/ja active Active
- 2014-09-05 CA CA2922832A patent/CA2922832A1/en not_active Abandoned
- 2014-09-05 CN CN201480048900.1A patent/CN105848746B/zh active Active
- 2014-09-05 WO PCT/US2014/054313 patent/WO2015035180A1/en not_active Ceased
- 2014-09-05 RU RU2016112549A patent/RU2016112549A/ru not_active Application Discontinuation
- 2014-09-05 KR KR1020167008540A patent/KR20160050062A/ko not_active Withdrawn
- 2014-09-05 MX MX2016002798A patent/MX2016002798A/es unknown
- 2014-09-05 US US14/479,092 patent/US20150093800A1/en not_active Abandoned
-
2018
- 2018-03-13 US US15/920,237 patent/US10940401B2/en active Active
- 2018-12-26 JP JP2018242197A patent/JP2019094334A/ja not_active Withdrawn
-
2021
- 2021-05-26 JP JP2021088108A patent/JP2021155421A/ja not_active Withdrawn
-
2023
- 2023-03-08 JP JP2023035358A patent/JP2023085273A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN105848746B (zh) | 2019-07-09 |
| US20190054396A1 (en) | 2019-02-21 |
| US20150093800A1 (en) | 2015-04-02 |
| US10940401B2 (en) | 2021-03-09 |
| JP2021155421A (ja) | 2021-10-07 |
| MX2016002798A (es) | 2016-07-21 |
| JP2016530533A (ja) | 2016-09-29 |
| JP6602765B2 (ja) | 2019-11-06 |
| EP3041593B1 (en) | 2025-01-29 |
| CA2922832A1 (en) | 2015-03-12 |
| WO2015035180A1 (en) | 2015-03-12 |
| EP3041593A1 (en) | 2016-07-13 |
| KR20160050062A (ko) | 2016-05-10 |
| CN105848746A (zh) | 2016-08-10 |
| JP2019094334A (ja) | 2019-06-20 |
| JP2023085273A (ja) | 2023-06-20 |
| EP3041593A4 (en) | 2017-08-30 |
| EP3041593C0 (en) | 2025-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20170906 |