CN105848746B - 用于层析重复利用的方法 - Google Patents

用于层析重复利用的方法 Download PDF

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Publication number
CN105848746B
CN105848746B CN201480048900.1A CN201480048900A CN105848746B CN 105848746 B CN105848746 B CN 105848746B CN 201480048900 A CN201480048900 A CN 201480048900A CN 105848746 B CN105848746 B CN 105848746B
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buffer
antibody
volumes
protein
polypeptide
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Chinese (zh)
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CN105848746A (zh
Inventor
E·马哈延
K·科塔里
J·索
J·韦伯
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203—Equilibration or regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
    • B01J49/60—Cleaning or rinsing ion-exchange beds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480048900.1A 2013-09-05 2014-09-05 用于层析重复利用的方法 Active CN105848746B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361874305P 2013-09-05 2013-09-05
US61/874,305 2013-09-05
PCT/US2014/054313 WO2015035180A1 (en) 2013-09-05 2014-09-05 Method for chromatography reuse

Publications (2)

Publication Number Publication Date
CN105848746A CN105848746A (zh) 2016-08-10
CN105848746B true CN105848746B (zh) 2019-07-09

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US (2) US20150093800A1 (enExample)
EP (1) EP3041593B1 (enExample)
JP (5) JP6602765B2 (enExample)
KR (1) KR20160050062A (enExample)
CN (1) CN105848746B (enExample)
CA (1) CA2922832A1 (enExample)
MX (1) MX2016002798A (enExample)
RU (1) RU2016112549A (enExample)
WO (1) WO2015035180A1 (enExample)

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JP2024518400A (ja) * 2021-05-07 2024-05-01 ジェンザイム・コーポレーション 衛生化のための組成物および方法
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JP2021155421A (ja) 2021-10-07
KR20160050062A (ko) 2016-05-10
EP3041593C0 (en) 2025-01-29
MX2016002798A (es) 2016-07-21
CA2922832A1 (en) 2015-03-12
JP2025186245A (ja) 2025-12-23
EP3041593A4 (en) 2017-08-30
US20150093800A1 (en) 2015-04-02
EP3041593B1 (en) 2025-01-29
JP6602765B2 (ja) 2019-11-06
WO2015035180A1 (en) 2015-03-12
JP2016530533A (ja) 2016-09-29
US20190054396A1 (en) 2019-02-21
RU2016112549A (ru) 2017-10-10
CN105848746A (zh) 2016-08-10
US10940401B2 (en) 2021-03-09
JP2019094334A (ja) 2019-06-20
EP3041593A1 (en) 2016-07-13
JP2023085273A (ja) 2023-06-20

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