RU2013118647A - Способы диагностики болезни лайма - Google Patents
Способы диагностики болезни лайма Download PDFInfo
- Publication number
- RU2013118647A RU2013118647A RU2013118647/15A RU2013118647A RU2013118647A RU 2013118647 A RU2013118647 A RU 2013118647A RU 2013118647/15 A RU2013118647/15 A RU 2013118647/15A RU 2013118647 A RU2013118647 A RU 2013118647A RU 2013118647 A RU2013118647 A RU 2013118647A
- Authority
- RU
- Russia
- Prior art keywords
- burgdorferi
- antibodies
- mammal
- absence
- ospf
- Prior art date
Links
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 241000589969 Borreliella burgdorferi Species 0.000 claims abstract 30
- 241000124008 Mammalia Species 0.000 claims abstract 26
- 238000000034 method Methods 0.000 claims abstract 26
- 108700023315 OspC Proteins 0.000 claims abstract 19
- 108700006640 OspA Proteins 0.000 claims abstract 18
- 208000016604 Lyme disease Diseases 0.000 claims abstract 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract 6
- 102000004169 proteins and genes Human genes 0.000 claims abstract 6
- 239000000427 antigen Substances 0.000 claims abstract 5
- 102000036639 antigens Human genes 0.000 claims abstract 5
- 108091007433 antigens Proteins 0.000 claims abstract 5
- 210000004027 cell Anatomy 0.000 claims abstract 5
- 241001465754 Metazoa Species 0.000 claims abstract 4
- 238000004458 analytical method Methods 0.000 claims abstract 3
- 239000011324 bead Substances 0.000 claims abstract 3
- 230000001684 chronic effect Effects 0.000 claims abstract 3
- 238000005206 flow analysis Methods 0.000 claims abstract 2
- 208000037581 Persistent Infection Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38669410P | 2010-09-27 | 2010-09-27 | |
| US61/386,694 | 2010-09-27 | ||
| PCT/US2011/053359 WO2012047607A2 (en) | 2010-09-27 | 2011-09-27 | Methods for diagnosing lyme disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013118647A true RU2013118647A (ru) | 2014-11-10 |
Family
ID=45928310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013118647/15A RU2013118647A (ru) | 2010-09-27 | 2011-09-27 | Способы диагностики болезни лайма |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8946393B2 (https=) |
| EP (1) | EP2622346A4 (https=) |
| JP (1) | JP2013539032A (https=) |
| KR (1) | KR20130101067A (https=) |
| CN (1) | CN103229055A (https=) |
| BR (1) | BR112013007329A2 (https=) |
| CA (1) | CA2812759A1 (https=) |
| MX (1) | MX2013003609A (https=) |
| RU (1) | RU2013118647A (https=) |
| WO (1) | WO2012047607A2 (https=) |
| ZA (1) | ZA201302402B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT106942B (pt) | 2013-05-15 | 2020-09-10 | STAB VIDA, Investigação e Serviços em Ciências Biológicas, Lda | Biochip (1) e bouquet de 16 antigénios (2) para a deteção da doença de lyme aguda e crónica |
| EP4108256A1 (en) * | 2014-08-11 | 2022-12-28 | University of Massachusetts | Anti-ospa antibodies and methods of use |
| CN104374921B (zh) * | 2014-11-21 | 2016-09-07 | 安徽医科大学 | 一种用于莱姆病鞭毛抗原免疫血清学诊断的蛋白质芯片及其制备方法和应用 |
| CN108139401B (zh) | 2015-09-25 | 2022-02-18 | 凯杰科技有限公司 | 诊断莱姆病并用于预测治疗后莱姆病螺旋体消除的组合物和方法 |
| CN105524989A (zh) * | 2015-12-31 | 2016-04-27 | 中国疾病预防控制中心传染病预防控制所 | 用于检测莱姆病螺旋体的rpa引物和探针及检测方法 |
| CN105628918A (zh) * | 2016-02-04 | 2016-06-01 | 浙江大学 | 一种蜱传莱姆病伯氏疏螺旋体检测试剂及应用 |
| CA3114668A1 (en) * | 2018-10-01 | 2020-04-09 | The Board Of Trustees Of The Leland Stanford Junior University | High specificity and sensitivity immunosorbent diagnostic assays with simultaneous resolution of multiple antibody isotypes |
| CA3164344A1 (en) * | 2020-01-10 | 2021-07-15 | Samantha Chang | Test strip with structured substrate for multiplex lateral flow assay for disease diagnostics |
| CA3175297A1 (en) | 2020-04-13 | 2021-10-21 | Jyotsna Shah | Detection of lyme disease |
| US20230324382A1 (en) * | 2022-02-01 | 2023-10-12 | Trustees Of Tufts College | Antiphospholipid antibodies for the diagnosis of lyme disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK590288D0 (da) | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| US6143872A (en) * | 1988-10-24 | 2000-11-07 | Symbicom Aktiebolag | Borrelia burdorferi Osp A and B proteins and immunogenic peptides |
| US5777095A (en) * | 1988-10-24 | 1998-07-07 | Symbicom Aktiebolag | Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90 |
| US6300101B1 (en) | 1988-10-24 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions including a 13kD B. burgdorferi protein |
| US6872550B1 (en) * | 1991-07-11 | 2005-03-29 | Baxter Vaccine Ag | Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens |
| US6676942B1 (en) | 1991-08-15 | 2004-01-13 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
| US7008625B2 (en) * | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
| US6248562B1 (en) * | 1993-11-01 | 2001-06-19 | Research Foundation State University Of New York | Chimeric proteins comprising borrelia polypeptides and uses therefor |
| US5620862A (en) | 1993-11-24 | 1997-04-15 | University Of Connecticut | Methods for diagnosing early Lyme disease |
| DE69535059T2 (de) * | 1994-04-11 | 2007-01-18 | Wyeth Holdings Corp. | Borrelia burgdorferi bacterin |
| US5558993A (en) * | 1994-06-17 | 1996-09-24 | The Regents Of The University Of California | Cloned Borrelia burgdorferi virulence protein |
| JPH10504455A (ja) * | 1994-08-17 | 1998-05-06 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・アインゲトラーゲナー・フェアアイン | ボレリア・ブルグドルフェリのＯｓｐＧを含有するワクチン |
| US5853987A (en) * | 1995-04-24 | 1998-12-29 | The Texas A & M University System | Decorin binding protein compositions and methods of use |
| EP0880543A4 (en) | 1995-10-26 | 2000-08-02 | Rhode Island Education | ANTIGENS AS VACCINE CANDIDATES FOR THE SPICK-INDUCED LYME DISEASE SPIROCHETES (BORRELIA BURGDORFERI) BY TICK VECTORS (IXODES SCAPULARIS) |
| US6716574B2 (en) * | 1996-05-02 | 2004-04-06 | Dako A/S | Osp-C derived peptide fragments |
| DE69718903T2 (de) | 1996-05-02 | 2003-12-04 | Dakocytomation Denmark A/S, Glostrup | Verwendung von aus osp-c abgeleiteten peptidefragmenten für diagnostische methoden |
| US6902893B1 (en) | 1997-06-20 | 2005-06-07 | Gil H. Choi | Lyme disease vaccines |
| US6660274B2 (en) | 1997-06-30 | 2003-12-09 | The Administrators Of The Tulane Educational Fund | Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease |
| US6610838B1 (en) * | 1997-09-10 | 2003-08-26 | Symbicom Aktiebolag | P13 antigens from Borrelia |
| EP1100922B1 (en) | 1998-07-31 | 2008-02-20 | Gundersen Lutheran Medical Foundation, Inc. | Uses of the borreliacidal epitope(s) of borrelia burgdorferi outer surface protein c (ospc) as vaccine |
| DE69912827T2 (de) * | 1998-09-29 | 2004-10-21 | Loke Diagnostics Aps Aarhus | "ligand presenting assembly" (lpa), verfahren zu dessen herstellung und verwendungen |
| US6475492B1 (en) | 1999-04-28 | 2002-11-05 | The Administrators Of The Tulane Educational Fund | Peptides and assays for the diagnosis of lyme disease |
| WO2000078800A2 (en) * | 1999-06-18 | 2000-12-28 | Medimmune, Inc. | Combined decorin binding protein and outer surface protein compositions and methods of use |
| US20030134345A1 (en) * | 2001-07-17 | 2003-07-17 | Michael Brunner | Serological assay for detection of antigens sequested within immune complexes |
| FI112544B (fi) * | 2001-11-26 | 2003-12-15 | Bortech Oy | Menetelmä varhais- ja myöhäisvaiheen Lymen borrelioosin diagnosoimiseksi |
| US20050058661A1 (en) | 2002-10-18 | 2005-03-17 | Sykes Kathryn F. | Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the genus Borrelia |
| US8821893B2 (en) | 2004-07-02 | 2014-09-02 | Bio Peptides, Corp. | Oral vaccine for Borrelia |
| US7390626B2 (en) | 2005-02-25 | 2008-06-24 | Immunosciences Lab., Inc. | Methods and kit for diagnosing tick borne illnesses |
| CN101374858A (zh) * | 2005-11-29 | 2009-02-25 | 弗吉尼亚州立大学 | 多价嵌合ospc疫苗原及诊断抗原 |
| JP5390189B2 (ja) * | 2005-11-29 | 2014-01-15 | ヴァージニア コモンウェルス ユニバーシティ | 多価キメラｏｓｐｃワクシノーゲンおよび診断用抗原 |
| WO2007133623A2 (en) | 2006-05-10 | 2007-11-22 | Biopeptides Corporation | Peptide diagnostic agent for lyme disease |
| JP2010503384A (ja) | 2006-09-15 | 2010-02-04 | インターセル アーゲー | ボレリア（Ｂｏｒｒｅｌｉａ）抗原 |
| EP2191266A4 (en) | 2007-09-07 | 2011-08-03 | Univ California | BORRELIA DIAGNOSTIC AND SCREENING METHOD |
| US20110105355A1 (en) | 2008-04-22 | 2011-05-05 | Research Foundation Of State University Of New York | Borrelia burgdorferi cell envelope protein array |
| US8565892B2 (en) * | 2009-10-31 | 2013-10-22 | Qteris, Inc. | Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment |
| WO2011068844A1 (en) | 2009-12-01 | 2011-06-09 | Temple Douglas | Borrelia burgdorferi bacterial antigen diagnostic test using polymeric bait containing capture particles |
| EP2542696B1 (en) | 2010-03-01 | 2016-09-28 | Caris Life Sciences Switzerland Holdings GmbH | Biomarkers for theranostics |
-
2011
- 2011-09-27 CN CN2011800562501A patent/CN103229055A/zh active Pending
- 2011-09-27 EP EP11831265.1A patent/EP2622346A4/en not_active Withdrawn
- 2011-09-27 US US13/876,077 patent/US8946393B2/en active Active
- 2011-09-27 RU RU2013118647/15A patent/RU2013118647A/ru not_active Application Discontinuation
- 2011-09-27 WO PCT/US2011/053359 patent/WO2012047607A2/en not_active Ceased
- 2011-09-27 MX MX2013003609A patent/MX2013003609A/es not_active Application Discontinuation
- 2011-09-27 CA CA2812759A patent/CA2812759A1/en not_active Abandoned
- 2011-09-27 BR BR112013007329A patent/BR112013007329A2/pt not_active IP Right Cessation
- 2011-09-27 JP JP2013530408A patent/JP2013539032A/ja active Pending
- 2011-09-27 KR KR1020137010849A patent/KR20130101067A/ko not_active Withdrawn
-
2013
- 2013-04-03 ZA ZA2013/02402A patent/ZA201302402B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012047607A3 (en) | 2012-08-16 |
| KR20130101067A (ko) | 2013-09-12 |
| MX2013003609A (es) | 2013-10-17 |
| JP2013539032A (ja) | 2013-10-17 |
| EP2622346A4 (en) | 2014-04-16 |
| US8946393B2 (en) | 2015-02-03 |
| US20130273572A1 (en) | 2013-10-17 |
| BR112013007329A2 (pt) | 2016-07-19 |
| WO2012047607A2 (en) | 2012-04-12 |
| CA2812759A1 (en) | 2012-04-12 |
| CN103229055A (zh) | 2013-07-31 |
| EP2622346A2 (en) | 2013-08-07 |
| ZA201302402B (en) | 2014-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160524 |