JP2013539032A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013539032A5 JP2013539032A5 JP2013530408A JP2013530408A JP2013539032A5 JP 2013539032 A5 JP2013539032 A5 JP 2013539032A5 JP 2013530408 A JP2013530408 A JP 2013530408A JP 2013530408 A JP2013530408 A JP 2013530408A JP 2013539032 A5 JP2013539032 A5 JP 2013539032A5
- Authority
- JP
- Japan
- Prior art keywords
- antibodies
- lyme disease
- ospf
- ospc
- ospa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000016604 Lyme disease Diseases 0.000 claims description 38
- 108700023315 OspC Proteins 0.000 claims description 31
- 241000124008 Mammalia Species 0.000 claims description 28
- 108700006640 OspA Proteins 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 14
- 208000031732 Post-Lyme Disease Syndrome Diseases 0.000 claims description 7
- 230000031864 metaphase Effects 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 239000011324 bead Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 241000589969 Borreliella burgdorferi Species 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 208000037581 Persistent Infection Diseases 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38669410P | 2010-09-27 | 2010-09-27 | |
| US61/386,694 | 2010-09-27 | ||
| PCT/US2011/053359 WO2012047607A2 (en) | 2010-09-27 | 2011-09-27 | Methods for diagnosing lyme disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013539032A JP2013539032A (ja) | 2013-10-17 |
| JP2013539032A5 true JP2013539032A5 (https=) | 2014-11-20 |
Family
ID=45928310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530408A Pending JP2013539032A (ja) | 2010-09-27 | 2011-09-27 | ライム病の診断方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8946393B2 (https=) |
| EP (1) | EP2622346A4 (https=) |
| JP (1) | JP2013539032A (https=) |
| KR (1) | KR20130101067A (https=) |
| CN (1) | CN103229055A (https=) |
| BR (1) | BR112013007329A2 (https=) |
| CA (1) | CA2812759A1 (https=) |
| MX (1) | MX2013003609A (https=) |
| RU (1) | RU2013118647A (https=) |
| WO (1) | WO2012047607A2 (https=) |
| ZA (1) | ZA201302402B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT106942B (pt) | 2013-05-15 | 2020-09-10 | STAB VIDA, Investigação e Serviços em Ciências Biológicas, Lda | Biochip (1) e bouquet de 16 antigénios (2) para a deteção da doença de lyme aguda e crónica |
| EP4108256A1 (en) * | 2014-08-11 | 2022-12-28 | University of Massachusetts | Anti-ospa antibodies and methods of use |
| CN104374921B (zh) * | 2014-11-21 | 2016-09-07 | 安徽医科大学 | 一种用于莱姆病鞭毛抗原免疫血清学诊断的蛋白质芯片及其制备方法和应用 |
| CN108139401B (zh) | 2015-09-25 | 2022-02-18 | 凯杰科技有限公司 | 诊断莱姆病并用于预测治疗后莱姆病螺旋体消除的组合物和方法 |
| CN105524989A (zh) * | 2015-12-31 | 2016-04-27 | 中国疾病预防控制中心传染病预防控制所 | 用于检测莱姆病螺旋体的rpa引物和探针及检测方法 |
| CN105628918A (zh) * | 2016-02-04 | 2016-06-01 | 浙江大学 | 一种蜱传莱姆病伯氏疏螺旋体检测试剂及应用 |
| CA3114668A1 (en) * | 2018-10-01 | 2020-04-09 | The Board Of Trustees Of The Leland Stanford Junior University | High specificity and sensitivity immunosorbent diagnostic assays with simultaneous resolution of multiple antibody isotypes |
| CA3164344A1 (en) * | 2020-01-10 | 2021-07-15 | Samantha Chang | Test strip with structured substrate for multiplex lateral flow assay for disease diagnostics |
| CA3175297A1 (en) | 2020-04-13 | 2021-10-21 | Jyotsna Shah | Detection of lyme disease |
| US20230324382A1 (en) * | 2022-02-01 | 2023-10-12 | Trustees Of Tufts College | Antiphospholipid antibodies for the diagnosis of lyme disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK590288D0 (da) | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| US6143872A (en) * | 1988-10-24 | 2000-11-07 | Symbicom Aktiebolag | Borrelia burdorferi Osp A and B proteins and immunogenic peptides |
| US5777095A (en) * | 1988-10-24 | 1998-07-07 | Symbicom Aktiebolag | Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90 |
| US6300101B1 (en) | 1988-10-24 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions including a 13kD B. burgdorferi protein |
| US6872550B1 (en) * | 1991-07-11 | 2005-03-29 | Baxter Vaccine Ag | Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens |
| US6676942B1 (en) | 1991-08-15 | 2004-01-13 | Smithkline Beecham Biologicals (S.A.) | Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines |
| US7008625B2 (en) * | 1993-11-01 | 2006-03-07 | Research Foundation Of The State University Of New York | Recombinant constructs of Borrelia burgdorferi |
| US6248562B1 (en) * | 1993-11-01 | 2001-06-19 | Research Foundation State University Of New York | Chimeric proteins comprising borrelia polypeptides and uses therefor |
| US5620862A (en) | 1993-11-24 | 1997-04-15 | University Of Connecticut | Methods for diagnosing early Lyme disease |
| DE69535059T2 (de) * | 1994-04-11 | 2007-01-18 | Wyeth Holdings Corp. | Borrelia burgdorferi bacterin |
| US5558993A (en) * | 1994-06-17 | 1996-09-24 | The Regents Of The University Of California | Cloned Borrelia burgdorferi virulence protein |
| JPH10504455A (ja) * | 1994-08-17 | 1998-05-06 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・アインゲトラーゲナー・フェアアイン | ボレリア・ブルグドルフェリのＯｓｐＧを含有するワクチン |
| US5853987A (en) * | 1995-04-24 | 1998-12-29 | The Texas A & M University System | Decorin binding protein compositions and methods of use |
| EP0880543A4 (en) | 1995-10-26 | 2000-08-02 | Rhode Island Education | ANTIGENS AS VACCINE CANDIDATES FOR THE SPICK-INDUCED LYME DISEASE SPIROCHETES (BORRELIA BURGDORFERI) BY TICK VECTORS (IXODES SCAPULARIS) |
| US6716574B2 (en) * | 1996-05-02 | 2004-04-06 | Dako A/S | Osp-C derived peptide fragments |
| DE69718903T2 (de) | 1996-05-02 | 2003-12-04 | Dakocytomation Denmark A/S, Glostrup | Verwendung von aus osp-c abgeleiteten peptidefragmenten für diagnostische methoden |
| US6902893B1 (en) | 1997-06-20 | 2005-06-07 | Gil H. Choi | Lyme disease vaccines |
| US6660274B2 (en) | 1997-06-30 | 2003-12-09 | The Administrators Of The Tulane Educational Fund | Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease |
| US6610838B1 (en) * | 1997-09-10 | 2003-08-26 | Symbicom Aktiebolag | P13 antigens from Borrelia |
| EP1100922B1 (en) | 1998-07-31 | 2008-02-20 | Gundersen Lutheran Medical Foundation, Inc. | Uses of the borreliacidal epitope(s) of borrelia burgdorferi outer surface protein c (ospc) as vaccine |
| DE69912827T2 (de) * | 1998-09-29 | 2004-10-21 | Loke Diagnostics Aps Aarhus | "ligand presenting assembly" (lpa), verfahren zu dessen herstellung und verwendungen |
| US6475492B1 (en) | 1999-04-28 | 2002-11-05 | The Administrators Of The Tulane Educational Fund | Peptides and assays for the diagnosis of lyme disease |
| WO2000078800A2 (en) * | 1999-06-18 | 2000-12-28 | Medimmune, Inc. | Combined decorin binding protein and outer surface protein compositions and methods of use |
| US20030134345A1 (en) * | 2001-07-17 | 2003-07-17 | Michael Brunner | Serological assay for detection of antigens sequested within immune complexes |
| FI112544B (fi) * | 2001-11-26 | 2003-12-15 | Bortech Oy | Menetelmä varhais- ja myöhäisvaiheen Lymen borrelioosin diagnosoimiseksi |
| US20050058661A1 (en) | 2002-10-18 | 2005-03-17 | Sykes Kathryn F. | Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the genus Borrelia |
| US8821893B2 (en) | 2004-07-02 | 2014-09-02 | Bio Peptides, Corp. | Oral vaccine for Borrelia |
| US7390626B2 (en) | 2005-02-25 | 2008-06-24 | Immunosciences Lab., Inc. | Methods and kit for diagnosing tick borne illnesses |
| CN101374858A (zh) * | 2005-11-29 | 2009-02-25 | 弗吉尼亚州立大学 | 多价嵌合ospc疫苗原及诊断抗原 |
| JP5390189B2 (ja) * | 2005-11-29 | 2014-01-15 | ヴァージニア コモンウェルス ユニバーシティ | 多価キメラｏｓｐｃワクシノーゲンおよび診断用抗原 |
| WO2007133623A2 (en) | 2006-05-10 | 2007-11-22 | Biopeptides Corporation | Peptide diagnostic agent for lyme disease |
| JP2010503384A (ja) | 2006-09-15 | 2010-02-04 | インターセル アーゲー | ボレリア（Ｂｏｒｒｅｌｉａ）抗原 |
| EP2191266A4 (en) | 2007-09-07 | 2011-08-03 | Univ California | BORRELIA DIAGNOSTIC AND SCREENING METHOD |
| US20110105355A1 (en) | 2008-04-22 | 2011-05-05 | Research Foundation Of State University Of New York | Borrelia burgdorferi cell envelope protein array |
| US8565892B2 (en) * | 2009-10-31 | 2013-10-22 | Qteris, Inc. | Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment |
| WO2011068844A1 (en) | 2009-12-01 | 2011-06-09 | Temple Douglas | Borrelia burgdorferi bacterial antigen diagnostic test using polymeric bait containing capture particles |
| EP2542696B1 (en) | 2010-03-01 | 2016-09-28 | Caris Life Sciences Switzerland Holdings GmbH | Biomarkers for theranostics |
-
2011
- 2011-09-27 CN CN2011800562501A patent/CN103229055A/zh active Pending
- 2011-09-27 EP EP11831265.1A patent/EP2622346A4/en not_active Withdrawn
- 2011-09-27 US US13/876,077 patent/US8946393B2/en active Active
- 2011-09-27 RU RU2013118647/15A patent/RU2013118647A/ru not_active Application Discontinuation
- 2011-09-27 WO PCT/US2011/053359 patent/WO2012047607A2/en not_active Ceased
- 2011-09-27 MX MX2013003609A patent/MX2013003609A/es not_active Application Discontinuation
- 2011-09-27 CA CA2812759A patent/CA2812759A1/en not_active Abandoned
- 2011-09-27 BR BR112013007329A patent/BR112013007329A2/pt not_active IP Right Cessation
- 2011-09-27 JP JP2013530408A patent/JP2013539032A/ja active Pending
- 2011-09-27 KR KR1020137010849A patent/KR20130101067A/ko not_active Withdrawn
-
2013
- 2013-04-03 ZA ZA2013/02402A patent/ZA201302402B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013539032A5 (https=) | ||
| Ferreira-Gomes et al. | SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself | |
| RU2013118647A (ru) | Способы диагностики болезни лайма | |
| JP2010514805A5 (https=) | ||
| JP5805368B2 (ja) | Ｉｐ−１０に基づく免疫学的モニタリング | |
| JP2011509676A5 (https=) | ||
| US20100261208A1 (en) | Elispot method having two filter systems | |
| NZ619883A (en) | Methods and compositions for diagnosis and prognosis of renal injury and renal failure | |
| WO2007117444A3 (en) | Protein detection by aptamers | |
| JP2010115195A5 (https=) | ||
| EA201291314A1 (ru) | Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности | |
| NZ600828A (en) | Methods and compositions for diagnosis and prognosis of renal injury and renal failure | |
| EA201290629A1 (ru) | Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности | |
| AR085282A1 (es) | Antigeno de maduracion de celulas b que se utiliza para fines diagnosticos y terapeuticos | |
| RU2017115663A (ru) | Способы и системы для отличия синдрома раздраженного кишечника от воспалительного заболевания кишечника и глютеновой болезни | |
| JP2011515091A5 (https=) | ||
| JP2017505436A5 (https=) | ||
| JP2009524829A5 (https=) | ||
| BR112013021056A2 (pt) | anticorpo monoclonal, linhagem de células de hibridoma, kit para diagnóstico, métodos para a produção de um anticorpo monoclonal e de um agente de ligação, agente de ligação sequência de aminoácidos purificada, método para a obtenção de uma sequência do ácido nucleico codificante, molécula do ácido nucleico isolado codificante, vetor, célula hospedeira isolada, proteína de fusão, método de triagem para a presença de uma doença, de uma condição, métodos de diagnóstico de um indivíduo, de prognóstico para um indivíduo, e de monitoramento de um indivúdo, e, método para detecção da presença ou ausência de um câncer cervical | |
| JP2024096748A (ja) | アルファ－シヌクレイン病のアッセイ、方法、及び治療 | |
| WO2015054319A9 (en) | Method, kits and materials for detection of lyme disease borrelia sp. infection | |
| JP2017535794A5 (https=) | ||
| JP2024059621A (ja) | がんの診断及び治療のための組成物及び方法 | |
| JP2007533985A5 (https=) | ||
| JP2011518338A5 (https=) |