JP2011509676A5 - - Google Patents
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- JP2011509676A5 JP2011509676A5 JP2010543306A JP2010543306A JP2011509676A5 JP 2011509676 A5 JP2011509676 A5 JP 2011509676A5 JP 2010543306 A JP2010543306 A JP 2010543306A JP 2010543306 A JP2010543306 A JP 2010543306A JP 2011509676 A5 JP2011509676 A5 JP 2011509676A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- composition
- blt1
- test kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000523 sample Substances 0.000 claims description 56
- 210000000068 Th17 cell Anatomy 0.000 claims description 53
- 210000004027 cell Anatomy 0.000 claims description 52
- 238000000034 method Methods 0.000 claims description 44
- 238000002405 diagnostic procedure Methods 0.000 claims description 42
- 101100236208 Homo sapiens LTB4R gene Proteins 0.000 claims description 29
- 102100033374 Leukotriene B4 receptor 1 Human genes 0.000 claims description 29
- 101100437750 Schizosaccharomyces pombe (strain 972 / ATCC 24843) blt1 gene Proteins 0.000 claims description 29
- 102100037265 Podoplanin Human genes 0.000 claims description 28
- 101710118150 Podoplanin Proteins 0.000 claims description 28
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 28
- 230000000694 effects Effects 0.000 claims description 27
- 239000005557 antagonist Substances 0.000 claims description 26
- 239000012472 biological sample Substances 0.000 claims description 26
- 208000023275 Autoimmune disease Diseases 0.000 claims description 22
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 22
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 22
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 22
- 102000013691 Interleukin-17 Human genes 0.000 claims description 18
- 230000004069 differentiation Effects 0.000 claims description 14
- 230000014509 gene expression Effects 0.000 claims description 14
- 239000000556 agonist Substances 0.000 claims description 13
- 108091033319 polynucleotide Proteins 0.000 claims description 12
- 102000040430 polynucleotide Human genes 0.000 claims description 12
- 239000002157 polynucleotide Substances 0.000 claims description 12
- 230000028327 secretion Effects 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 238000009007 Diagnostic Kit Methods 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 230000024245 cell differentiation Effects 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 210000001978 pro-t lymphocyte Anatomy 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 238000001262 western blot Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 229940125388 beta agonist Drugs 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 208000037976 chronic inflammation Diseases 0.000 claims description 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims description 2
- 239000007850 fluorescent dye Substances 0.000 claims description 2
- 238000003119 immunoblot Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 30
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 239000002876 beta blocker Substances 0.000 claims 1
- 238000004163 cytometry Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 102000008640 interleukin-21 receptor activity proteins Human genes 0.000 description 1
- 108040002099 interleukin-21 receptor activity proteins Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US654108P | 2008-01-18 | 2008-01-18 | |
| US3182408P | 2008-02-27 | 2008-02-27 | |
| PCT/US2009/031477 WO2009092087A2 (en) | 2008-01-18 | 2009-01-21 | Selective differentiation, identification, and modulation of human th17 cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011509676A JP2011509676A (ja) | 2011-03-31 |
| JP2011509676A5 true JP2011509676A5 (https=) | 2013-02-28 |
Family
ID=40885916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543306A Pending JP2011509676A (ja) | 2008-01-18 | 2009-01-21 | ヒトＴｈ１７細胞の選択的分化、同定および調節 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110245107A1 (https=) |
| EP (1) | EP2238241B1 (https=) |
| JP (1) | JP2011509676A (https=) |
| WO (1) | WO2009092087A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6702949B2 (en) | 1997-10-24 | 2004-03-09 | Microdiffusion, Inc. | Diffuser/emulsifier for aquaculture applications |
| US8445546B2 (en) | 2006-10-25 | 2013-05-21 | Revalesio Corporation | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures |
| US8784897B2 (en) | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
| US8609148B2 (en) | 2006-10-25 | 2013-12-17 | Revalesio Corporation | Methods of therapeutic treatment of eyes |
| CA2667791A1 (en) * | 2006-10-25 | 2008-05-02 | Revalesio Corporation | Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution |
| EP2083876A4 (en) | 2006-10-25 | 2012-09-19 | Revalesio Corp | WOUND CARE AND TREATMENT METHOD |
| US8784898B2 (en) * | 2006-10-25 | 2014-07-22 | Revalesio Corporation | Methods of wound care and treatment |
| JP5306214B2 (ja) | 2006-10-25 | 2013-10-02 | リバルシオ コーポレイション | 混合装置 |
| US10125359B2 (en) | 2007-10-25 | 2018-11-13 | Revalesio Corporation | Compositions and methods for treating inflammation |
| US20100004189A1 (en) * | 2007-10-25 | 2010-01-07 | Revalesio Corporation | Compositions and methods for treating cystic fibrosis |
| US20100008997A1 (en) * | 2007-10-25 | 2010-01-14 | Revalesio Corporation | Compositions and methods for treating asthma and other lung disorders |
| US9523090B2 (en) * | 2007-10-25 | 2016-12-20 | Revalesio Corporation | Compositions and methods for treating inflammation |
| US20100310609A1 (en) * | 2007-10-25 | 2010-12-09 | Revalesio Corporation | Compositions and methods for treatment of neurodegenerative diseases |
| US9745567B2 (en) | 2008-04-28 | 2017-08-29 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
| US20100303871A1 (en) * | 2007-10-25 | 2010-12-02 | Revalesio Corporation | Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction |
| CA2723215A1 (en) | 2008-05-01 | 2009-11-05 | Revalesio Corporation | Compositions and methods for treating digestive disorders |
| US20100098687A1 (en) * | 2008-10-22 | 2010-04-22 | Revalesio Corporation | Compositions and methods for treating thymic stromal lymphopoietin (tslp)-mediated conditions |
| US8815292B2 (en) | 2009-04-27 | 2014-08-26 | Revalesio Corporation | Compositions and methods for treating insulin resistance and diabetes mellitus |
| JP5858785B2 (ja) | 2009-07-29 | 2016-02-10 | シスメックス株式会社 | ヒトｉｌ−１７産生ヘルパーｔ細胞検出用マーカーおよび試薬、並びにヒトｉｌ−１７産生ヘルパーｔ細胞の検出方法 |
| EP2459184A1 (en) * | 2009-07-31 | 2012-06-06 | The Brigham and Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
| JP5481677B2 (ja) * | 2009-12-10 | 2014-04-23 | シャープ株式会社 | 生体内に蓄積した粒子の分析方法 |
| CN104983740A (zh) | 2010-05-07 | 2015-10-21 | 利发利希奥公司 | 用于增强生理性能和恢复时间的组合物和方法 |
| CA2801509A1 (en) * | 2010-06-02 | 2011-12-08 | Dainippon Sumitomo Pharma Co., Ltd. | Treatment drug for autoimmune diseases and allergic diseases |
| FR2960882B1 (fr) * | 2010-06-04 | 2012-11-16 | Hospices Civils Lyon | Co-culture de cellules mononucleees et de cellules mesenchymateuses pour l'obtention de cellules productrices d'il-17 |
| JP2013533320A (ja) | 2010-08-12 | 2013-08-22 | レバレジオ コーポレイション | タウオパチーを治療するための組成物および方法 |
| CN103561722A (zh) * | 2011-04-13 | 2014-02-05 | 利发利希奥公司 | 用于抑制和／或调整炎性神经变性疾病中涉及到的效应t细胞的组合物和方法 |
| EP3524258B1 (en) | 2011-06-22 | 2025-10-01 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| AU2014223344A1 (en) | 2013-02-27 | 2015-10-01 | Massachusetts Institute Of Technology | T cell balance gene expression, compositions of matters and methods of use thereof |
| EP3024485B1 (en) * | 2013-07-23 | 2020-11-18 | Biocon Limited | Use of a cd6 binding partner and method based thereon |
| HK1225740A1 (zh) | 2013-08-22 | 2017-09-15 | Acceleron Pharma Inc. | TGF-β受体II型变体及其用途 |
| CN108348578B (zh) | 2015-08-04 | 2022-08-09 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
| US12241053B2 (en) | 2015-10-09 | 2025-03-04 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| ES2948647T3 (es) | 2017-05-04 | 2023-09-15 | Acceleron Pharma Inc | Proteínas de fusión del receptor TGF-beta tipo II y usos de las mismas |
| US12226449B2 (en) * | 2018-11-15 | 2025-02-18 | The University Of Toledo | Materials and methods for the prevention of rheumatoid arthritis |
| WO2021168376A1 (en) * | 2020-02-20 | 2021-08-26 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
| US20230323296A1 (en) * | 2020-08-21 | 2023-10-12 | Georgetown University | Stem cell-like memory t cells and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| ES2334338T3 (es) | 2001-11-05 | 2010-03-09 | Zymogenetics, Inc. | Antagonistas de il-21. |
| US7622443B2 (en) * | 2002-04-26 | 2009-11-24 | California Institute Of Technology | Method for inhibiting pro-angiogenic activities of endothelial cells selectively at a site of neoangiogenesis in a mammal by administration of the extracellular domain of D1-1 polypeptides |
| US7314623B2 (en) | 2002-07-15 | 2008-01-01 | Wyeth | Methods and compositions for modulating T helper (Th) cell development and function |
| ES2389258T3 (es) | 2003-06-17 | 2012-10-24 | Millennium Pharmaceuticals, Inc. | Composiciones y métodos para inhibir TGF-s |
| GB0410103D0 (en) * | 2004-05-06 | 2004-06-09 | Biolipox Ab | New method |
| CA2572334A1 (en) * | 2004-07-01 | 2006-01-19 | New York University | Compositions and methods for modulation of ror.gamma.t |
| WO2007149814A1 (en) * | 2006-06-19 | 2007-12-27 | Wyeth | Methods of modulating il-22 and il-17 |
| EP2043696B1 (en) * | 2006-07-13 | 2015-02-25 | Burnham Institute for Medical Research | Methods and compositions for targeting gc1qr/p32 |
| US8288357B2 (en) * | 2007-03-23 | 2012-10-16 | Korea University Research & Business Foundation | Use of inhibitors of leukotriene B4 receptor BLT2 for treating human cancers |
| US20110136113A1 (en) * | 2008-08-27 | 2011-06-09 | Sysmex Corporation | Marker for detecting il-17-producing helper t cell, and method for detecting il-17-producing helper t cell |
-
2009
- 2009-01-21 WO PCT/US2009/031477 patent/WO2009092087A2/en not_active Ceased
- 2009-01-21 EP EP09702239.6A patent/EP2238241B1/en not_active Not-in-force
- 2009-01-21 US US12/863,373 patent/US20110245107A1/en not_active Abandoned
- 2009-01-21 JP JP2010543306A patent/JP2011509676A/ja active Pending
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