JP2007533985A5 - - Google Patents
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- Publication number
- JP2007533985A5 JP2007533985A5 JP2007508840A JP2007508840A JP2007533985A5 JP 2007533985 A5 JP2007533985 A5 JP 2007533985A5 JP 2007508840 A JP2007508840 A JP 2007508840A JP 2007508840 A JP2007508840 A JP 2007508840A JP 2007533985 A5 JP2007533985 A5 JP 2007533985A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- compound
- concentration
- combination
- trauma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000003550 marker Substances 0.000 claims 8
- 102000003141 Tachykinin Human genes 0.000 claims 5
- 210000001124 body fluid Anatomy 0.000 claims 5
- 239000010839 body fluid Substances 0.000 claims 5
- 108060008037 tachykinin Proteins 0.000 claims 5
- 239000012620 biological material Substances 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000014674 injury Diseases 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 230000008733 trauma Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000009906 Meningitis Diseases 0.000 claims 2
- 208000004221 Multiple Trauma Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 102100024304 Protachykinin-1 Human genes 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 101800003906 Substance P Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 238000010324 immunological assay Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 108010030540 protachykinin Proteins 0.000 claims 1
- 238000010200 validation analysis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04009284.3 | 2004-04-20 | ||
| EP04009284 | 2004-04-20 | ||
| PCT/EP2005/004254 WO2005103712A2 (en) | 2004-04-20 | 2005-04-20 | Use of precursors of tachykinins and/or their fragments in medical diagnostic |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012055452A Division JP5607094B2 (ja) | 2004-04-20 | 2012-03-13 | 医療診断におけるタキキニンの前駆体および／またはその断片の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007533985A JP2007533985A (ja) | 2007-11-22 |
| JP2007533985A5 true JP2007533985A5 (https=) | 2010-10-21 |
| JP5095391B2 JP5095391B2 (ja) | 2012-12-12 |
Family
ID=34924661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508840A Expired - Fee Related JP5095391B2 (ja) | 2004-04-20 | 2005-04-20 | 医療診断におけるタキキニンの前駆体および／またはその断片の使用 |
| JP2012055452A Expired - Fee Related JP5607094B2 (ja) | 2004-04-20 | 2012-03-13 | 医療診断におけるタキキニンの前駆体および／またはその断片の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012055452A Expired - Fee Related JP5607094B2 (ja) | 2004-04-20 | 2012-03-13 | 医療診断におけるタキキニンの前駆体および／またはその断片の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7838245B2 (https=) |
| EP (3) | EP2369350B1 (https=) |
| JP (2) | JP5095391B2 (https=) |
| ES (2) | ES2524309T3 (https=) |
| WO (1) | WO2005103712A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2369350B1 (en) | 2004-04-20 | 2014-08-20 | SphingoTec GmbH | Use of precursors of tachykinins and/or their fragments in medical diagnostic |
| JP2009092550A (ja) * | 2007-10-10 | 2009-04-30 | Japan Health Science Foundation | うつ病またはうつ状態の同定方法 |
| MX340916B (es) | 2008-01-18 | 2016-07-29 | President And Fellows Of Harvard College * | Metodos para detectar señales de identificacion de enfermedad o condiciones en fluidos corporales. |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| TW201209171A (en) | 2010-07-23 | 2012-03-01 | Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| EP2596132A4 (en) | 2010-07-23 | 2013-12-18 | Harvard College | METHOD FOR DETECTING SIGNS FOR ILLNESS OR SUFFERING IN BODY FLUIDS |
| CA2818887A1 (en) * | 2010-11-26 | 2012-05-31 | Immunexpress Pty Ltd | Diagnostic and/or screening agents and uses therefor |
| JP2015522260A (ja) | 2012-06-15 | 2015-08-06 | ハリー スティリ， | 疾患または状態を検出する方法 |
| MX2014015434A (es) | 2012-06-15 | 2015-07-14 | Harry Stylli | Metodos para detectar enfermedades o condiciones utilizando celulas enfermas en circulacion. |
| JP6317763B2 (ja) * | 2013-01-08 | 2018-04-25 | シュピーンゴテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 対象における癌となる危険性を予測し又は癌と診断する方法 |
| NZ771629A (en) | 2013-03-09 | 2022-12-23 | Harry Stylli | Methods of detecting cancer |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| TR201905773T4 (tr) * | 2013-10-01 | 2019-05-21 | Sphingotec Gmbh | Bir majör advers kardiyak olayla karşılaşma riskinin tahmin edilmesi için bir usul. |
| US10626464B2 (en) | 2014-09-11 | 2020-04-21 | Cell Mdx, Llc | Methods of detecting prostate cancer |
| CN117529664A (zh) * | 2021-06-18 | 2024-02-06 | 思芬构技术有限公司 | 用于预测脓毒症和脓毒性休克的方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8613431D0 (en) * | 1986-06-03 | 1986-07-09 | Medical Res Council | Human tachykinins |
| US5434050A (en) * | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
| JPH082798B2 (ja) * | 1991-12-13 | 1996-01-17 | 日本全薬工業株式会社 | 抗体を利用した新しいタイプの鎮痛薬 |
| KR100430960B1 (ko) * | 1995-05-11 | 2004-10-28 | 거번먼트오브더유나이티드스테이츠오브아메리카,애즈리프리젠티드바이더세크러트리오브디아미 | 매우약독화된재조합일본뇌염바이러스를생성하는감염성일본뇌염바이러스cDNA클론및이의백신 |
| EP0951541B1 (en) * | 1995-07-31 | 2005-11-30 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| GB9606736D0 (en) * | 1996-02-19 | 1996-06-05 | Shire International Licensing | Therapeutic method |
| CA2190679A1 (en) * | 1996-11-19 | 1998-05-19 | Christopher J. Paige | Lymphocyte tachykinin |
| US6372440B2 (en) * | 1999-03-10 | 2002-04-16 | Magnesium Diagnostics, Inc. | Method for detecting deficient cellular membrane tightly bound magnesium for disease diagnoses |
| CA2373680C (en) * | 1999-05-17 | 2008-07-29 | Conjuchem Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| CA2311201A1 (en) * | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
| WO2001034637A1 (fr) * | 1999-11-08 | 2001-05-17 | Suntory Limited | Peptides physiologiquement actifs et procede relatif a leur elaboration |
| US7235531B2 (en) * | 1999-12-21 | 2007-06-26 | Takeda Pharmaceutical Company | Tachykinin-like polypeptides and use thereof |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| US7425217B2 (en) * | 2000-11-16 | 2008-09-16 | Maier Nathan C | System and method for inhibiting cellular proliferation with tachykinins |
| EP1379648A1 (en) * | 2001-04-18 | 2004-01-14 | Genset S.A. | Full-length human cdnas encoding potentially secreted proteins |
| US20040241639A1 (en) * | 2001-05-01 | 2004-12-02 | Lydie Bougueleret | Human tachykinin-related splice variants and compositions thereof |
| AU2002326769A1 (en) * | 2001-08-24 | 2003-03-10 | Incyte Genomics, Inc. | Extracellular messengers |
| WO2003025547A1 (en) * | 2001-09-21 | 2003-03-27 | Biomedlab Corporation | Method and device for screening analytes using surface plasmon resonance |
| US20030114763A1 (en) * | 2001-12-13 | 2003-06-19 | Reddy Shankara B. | Fusion of computerized medical data |
| CA2500978A1 (en) * | 2002-10-03 | 2004-04-15 | Mcgill University | Antibodies and cyclic peptides which bind cea (carcinoembryonic antigen) and their use as cancer therapeutics |
| WO2004076614A2 (de) | 2003-02-27 | 2004-09-10 | Bernd Hinzmann | Humane nukleinsäuresequenzen aus prostatakarzinomen |
| WO2005043111A2 (en) * | 2003-07-14 | 2005-05-12 | Ciphergen Biosystems, Inc. | Serum biomarkers for sars |
| EP2369350B1 (en) | 2004-04-20 | 2014-08-20 | SphingoTec GmbH | Use of precursors of tachykinins and/or their fragments in medical diagnostic |
-
2005
- 2005-04-20 EP EP11165586.6A patent/EP2369350B1/en not_active Expired - Lifetime
- 2005-04-20 EP EP05747755.6A patent/EP1740957B1/en not_active Expired - Lifetime
- 2005-04-20 JP JP2007508840A patent/JP5095391B2/ja not_active Expired - Fee Related
- 2005-04-20 EP EP12164004A patent/EP2518510A1/en not_active Withdrawn
- 2005-04-20 ES ES11165586.6T patent/ES2524309T3/es not_active Expired - Lifetime
- 2005-04-20 US US11/568,146 patent/US7838245B2/en not_active Expired - Lifetime
- 2005-04-20 WO PCT/EP2005/004254 patent/WO2005103712A2/en not_active Ceased
- 2005-04-20 ES ES05747755.6T patent/ES2471403T3/es not_active Expired - Lifetime
-
2010
- 2010-11-04 US US12/939,390 patent/US9188591B2/en not_active Expired - Fee Related
-
2012
- 2012-03-13 JP JP2012055452A patent/JP5607094B2/ja not_active Expired - Fee Related
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