JP2010106028A5 - - Google Patents
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- JP2010106028A5 JP2010106028A5 JP2009271611A JP2009271611A JP2010106028A5 JP 2010106028 A5 JP2010106028 A5 JP 2010106028A5 JP 2009271611 A JP2009271611 A JP 2009271611A JP 2009271611 A JP2009271611 A JP 2009271611A JP 2010106028 A5 JP2010106028 A5 JP 2010106028A5
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- JP
- Japan
- Prior art keywords
- cancer
- cell surface
- kit
- binding region
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 176
- 108010001857 Cell Surface Receptors Proteins 0.000 claims description 112
- 102000006240 membrane receptors Human genes 0.000 claims description 112
- 230000027455 binding Effects 0.000 claims description 107
- 210000004027 cell Anatomy 0.000 claims description 62
- 206010028980 Neoplasm Diseases 0.000 claims description 52
- 201000011510 cancer Diseases 0.000 claims description 52
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 47
- 102100034256 Mucin-1 Human genes 0.000 claims description 47
- 239000000523 sample Substances 0.000 claims description 42
- 150000001413 amino acids Chemical class 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 23
- 230000011664 signaling Effects 0.000 claims description 20
- 210000001519 tissue Anatomy 0.000 claims description 19
- 238000003556 assay Methods 0.000 claims description 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 239000000084 colloidal system Substances 0.000 claims description 15
- 230000002159 abnormal effect Effects 0.000 claims description 10
- 239000011324 bead Substances 0.000 claims description 9
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 238000013188 needle biopsy Methods 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 230000001351 cycling effect Effects 0.000 claims description 4
- 238000001502 gel electrophoresis Methods 0.000 claims description 4
- 238000007898 magnetic cell sorting Methods 0.000 claims description 4
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 4
- 238000001262 western blot Methods 0.000 claims description 4
- 230000002776 aggregation Effects 0.000 claims description 3
- 238000004220 aggregation Methods 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 3
- 230000002062 proliferating effect Effects 0.000 claims description 3
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 2
- 238000002965 ELISA Methods 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 description 41
- 108090000765 processed proteins & peptides Proteins 0.000 description 35
- 230000003213 activating effect Effects 0.000 description 32
- 241000894007 species Species 0.000 description 31
- 239000003814 drug Substances 0.000 description 23
- 102000005962 receptors Human genes 0.000 description 21
- 108020003175 receptors Proteins 0.000 description 21
- 239000003795 chemical substances by application Substances 0.000 description 18
- 230000003993 interaction Effects 0.000 description 18
- 238000003776 cleavage reaction Methods 0.000 description 17
- 229940079593 drug Drugs 0.000 description 17
- 230000007017 scission Effects 0.000 description 17
- DGMPVYSXXIOGJY-UHFFFAOYSA-N Fusaric acid Chemical compound CCCCC1=CC=C(C(O)=O)N=C1 DGMPVYSXXIOGJY-UHFFFAOYSA-N 0.000 description 13
- 239000012634 fragment Substances 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 230000004663 cell proliferation Effects 0.000 description 9
- HIYAVKIYRIFSCZ-CVXKHCKVSA-N Calcimycin Chemical compound CC([C@H]1OC2([C@@H](C[C@H]1C)C)O[C@H]([C@H](CC2)C)CC=1OC2=CC=C(C(=C2N=1)C(O)=O)NC)C(=O)C1=CC=CN1 HIYAVKIYRIFSCZ-CVXKHCKVSA-N 0.000 description 8
- 230000000903 blocking effect Effects 0.000 description 8
- HIYAVKIYRIFSCZ-UHFFFAOYSA-N calcium ionophore A23187 Natural products N=1C2=C(C(O)=O)C(NC)=CC=C2OC=1CC(C(CC1)C)OC1(C(CC1C)C)OC1C(C)C(=O)C1=CC=CN1 HIYAVKIYRIFSCZ-UHFFFAOYSA-N 0.000 description 8
- 239000013610 patient sample Substances 0.000 description 7
- 101100346929 Homo sapiens MUC1 gene Proteins 0.000 description 6
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 6
- CJCSPKMFHVPWAR-JTQLQIEISA-N alpha-methyl-L-dopa Chemical compound OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 CJCSPKMFHVPWAR-JTQLQIEISA-N 0.000 description 6
- 239000013068 control sample Substances 0.000 description 6
- 239000003102 growth factor Substances 0.000 description 6
- 102000057860 human MUC1 Human genes 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000004614 tumor growth Effects 0.000 description 6
- QVZVEEALAXDABJ-UHFFFAOYSA-N 4-(trifluoromethyl)-2-[5-(trifluoromethyl)-2,3-dihydrobenzimidazol-1-yl]phenol Chemical compound OC1=CC=C(C(F)(F)F)C=C1N1C2=CC=C(C(F)(F)F)C=C2NC1 QVZVEEALAXDABJ-UHFFFAOYSA-N 0.000 description 5
- 102000004899 14-3-3 Proteins Human genes 0.000 description 4
- CSJRQRBMUOOMFH-UHFFFAOYSA-N 3-butyl-2h-indazole Chemical compound C1=CC=C2C(CCCC)=NNC2=C1 CSJRQRBMUOOMFH-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 108700020469 14-3-3 Proteins 0.000 description 3
- 208000005623 Carcinogenesis Diseases 0.000 description 3
- 102000003908 Cathepsin D Human genes 0.000 description 3
- 108090000258 Cathepsin D Proteins 0.000 description 3
- 238000012286 ELISA Assay Methods 0.000 description 3
- 101000780122 Homo sapiens Annexin A5 Proteins 0.000 description 3
- 101000979629 Homo sapiens Nucleoside diphosphate kinase A Proteins 0.000 description 3
- 102100023252 Nucleoside diphosphate kinase A Human genes 0.000 description 3
- 108010069820 Pro-Opiomelanocortin Proteins 0.000 description 3
- 239000000683 Pro-Opiomelanocortin Substances 0.000 description 3
- 108010042362 beta-Lipotropin Proteins 0.000 description 3
- 230000036952 cancer formation Effects 0.000 description 3
- 231100000504 carcinogenesis Toxicity 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- 102000002933 Thioredoxin Human genes 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
Applications Claiming Priority (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25336100P | 2000-11-27 | 2000-11-27 | |
| US60/253,361 | 2000-11-27 | ||
| US25537000P | 2000-12-13 | 2000-12-13 | |
| US60/255,370 | 2000-12-13 | ||
| US25602700P | 2000-12-15 | 2000-12-15 | |
| US60/256,027 | 2000-12-15 | ||
| US25815700P | 2000-12-22 | 2000-12-22 | |
| US60/258,157 | 2000-12-22 | ||
| US25961501P | 2001-01-03 | 2001-01-03 | |
| US60/259,615 | 2001-01-03 | ||
| US26018601P | 2001-01-05 | 2001-01-05 | |
| US60/260,186 | 2001-01-05 | ||
| US26616901P | 2001-02-02 | 2001-02-02 | |
| US60/266,169 | 2001-02-02 | ||
| US26692901P | 2001-02-06 | 2001-02-06 | |
| US60/266,929 | 2001-02-06 | ||
| US27809301P | 2001-03-23 | 2001-03-23 | |
| US60/278,093 | 2001-03-23 | ||
| US28944401P | 2001-05-07 | 2001-05-07 | |
| US60/289,444 | 2001-05-07 | ||
| US29488701P | 2001-05-31 | 2001-05-31 | |
| US60/294,887 | 2001-05-31 | ||
| US29827201P | 2001-06-14 | 2001-06-14 | |
| US60/298,272 | 2001-06-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002556226A Division JP4564714B2 (ja) | 2000-11-27 | 2001-11-27 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014205598A Division JP6124856B2 (ja) | 2000-11-27 | 2014-10-06 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010106028A JP2010106028A (ja) | 2010-05-13 |
| JP2010106028A5 true JP2010106028A5 (https=) | 2011-03-03 |
| JP5926474B2 JP5926474B2 (ja) | 2016-05-25 |
Family
ID=27583824
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002556226A Expired - Lifetime JP4564714B2 (ja) | 2000-11-27 | 2001-11-27 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
| JP2009271611A Expired - Lifetime JP5926474B2 (ja) | 2000-11-27 | 2009-11-30 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
| JP2014205598A Expired - Lifetime JP6124856B2 (ja) | 2000-11-27 | 2014-10-06 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
| JP2017013054A Expired - Lifetime JP6516778B2 (ja) | 2000-11-27 | 2017-01-27 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002556226A Expired - Lifetime JP4564714B2 (ja) | 2000-11-27 | 2001-11-27 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014205598A Expired - Lifetime JP6124856B2 (ja) | 2000-11-27 | 2014-10-06 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
| JP2017013054A Expired - Lifetime JP6516778B2 (ja) | 2000-11-27 | 2017-01-27 | 診断用腫瘍マーカー、腫瘍形成の阻害のための薬物スクリーニング、並びにがん治療用の組成物及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7700715B2 (https=) |
| EP (4) | EP2322929B1 (https=) |
| JP (4) | JP4564714B2 (https=) |
| AT (1) | ATE481640T1 (https=) |
| CA (1) | CA2430060C (https=) |
| DK (1) | DK2322929T3 (https=) |
| WO (1) | WO2002056022A2 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050148101A1 (en) * | 1999-01-23 | 2005-07-07 | Bamdad Cynthia C. | Interaction of colloid-immobilized species with species on non-colloidal structures |
| WO2002029411A2 (en) | 2000-10-03 | 2002-04-11 | Minerva Biotechnologies Corporation | Magnetic in situ dilution |
| EP2322929B1 (en) | 2000-11-27 | 2016-04-06 | Minerva Biotechnologies Corporation | diagnostics, drug screening and treatment for cancer |
| WO2002076248A2 (en) * | 2001-03-22 | 2002-10-03 | Minerva Biotechnologies Corporation | Customized therapeutics and in situ diagnostics |
| JP2005507876A (ja) | 2001-09-05 | 2005-03-24 | ミナーバ バイオテクノロジーズ コーポレイション | 癌を治療する組成物および方法 |
| US20060280730A1 (en) * | 2001-10-12 | 2006-12-14 | Cedars-Sinai Medical Center | Induction of apoptosis of malignant cells by activation of calcium-activated potassium channels |
| US7211561B2 (en) * | 2001-10-12 | 2007-05-01 | Cedars-Sinai Medical Center | Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa) |
| US20090118605A1 (en) * | 2002-08-30 | 2009-05-07 | Northwestern University | Surface-enhanced raman nanobiosensor |
| US20040180379A1 (en) * | 2002-08-30 | 2004-09-16 | Northwestern University | Surface-enhanced raman nanobiosensor |
| CA2499484A1 (en) * | 2002-09-19 | 2004-04-01 | Medigene Aktiengesellschaft | Inhibitors of the fatty acid oxidation for the prophylaxis and/or the treatment of chronic and/or atopic skin diseases |
| CA2537263C (en) * | 2002-11-27 | 2017-05-30 | Minerva Biotechnologies Corporation | Techniques and compositions for the diagnosis and treatment of cancer (muc1) |
| CN1964630A (zh) * | 2003-02-13 | 2007-05-16 | 耶希瓦大学艾伯塔·爱恩斯坦医学院 | 通过控制下丘脑的长链脂肪酰基－辅酶A(LC－CoA)的水平来调控食物摄取和葡萄糖产生 |
| US20070059761A1 (en) * | 2003-05-13 | 2007-03-15 | Bambad Cynthia C | Storage and use of colloids |
| CA2534816A1 (en) | 2003-06-12 | 2004-12-23 | Evan Newell | Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors |
| DK2363410T3 (en) * | 2003-08-26 | 2018-01-15 | Minerva Biotechnologies Corp | ISOFORMER OF MUC1 |
| US20060173171A1 (en) * | 2003-08-26 | 2006-08-03 | Bamdad Cynthia C | Techniques and compositions for diagnosis and treatment of cancer (muci) |
| US20100028339A1 (en) * | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| AU2005228410A1 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20080064680A1 (en) * | 2004-09-14 | 2008-03-13 | Bamdad Cynthia C | Methods for Diagnosis and Treatment of Cancer |
| WO2006041922A2 (en) * | 2004-10-08 | 2006-04-20 | Dara Biosciences, Inc. | Agents and methods for administration to the central nervous system |
| CA2595778A1 (en) * | 2005-01-28 | 2006-08-03 | Ramot At Tel Aviv University, Ltd. | Anti-muc1 .alpha..beta. antibodies |
| US20070026079A1 (en) * | 2005-02-14 | 2007-02-01 | Louis Herlands | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels |
| CA2610292C (en) * | 2005-03-30 | 2015-06-02 | Minerva Biotechnologies Corporation | Proliferation of muc1 expressing cells |
| DK1875244T3 (en) | 2005-03-30 | 2019-04-29 | Minerva Biotechnologies Corp | Proliferation of MUC1-Expressing Cells |
| CN1870631B (zh) * | 2005-11-11 | 2010-04-14 | 华为技术有限公司 | 媒体网关的门控方法 |
| US20070224638A1 (en) * | 2006-03-27 | 2007-09-27 | Institut Pasteur | Secreted proteins as early markers and drug targets for autoimmunity, tumorigenesis and infections |
| CN101652469B (zh) * | 2006-12-06 | 2014-04-16 | 米纳瓦生物技术公司 | 用于鉴定和操作细胞的方法 |
| WO2009042814A1 (en) * | 2007-09-25 | 2009-04-02 | Minerva Biotechnologies Corp. | Early diagnosis and treatment of drug resistance in muc1-positive cancer |
| US20170204191A1 (en) * | 2008-10-06 | 2017-07-20 | Cynthia C. Bamdad | Muc1* antibodies |
| WO2010042891A2 (en) | 2008-10-09 | 2010-04-15 | Minerva Biotechnologies Corporation | Method for inducing pluripotency in cells |
| SG176801A1 (en) * | 2009-06-11 | 2012-01-30 | Minerva Biotechnologies Corp | Methods for culturing stem and progenitor cells |
| JP5783043B2 (ja) * | 2009-06-12 | 2015-09-24 | 株式会社ニコン | 細胞塊の状態判別手法、この手法を用いた画像処理プログラム及び画像処理装置、並びに細胞塊の製造方法 |
| EP2463379A1 (en) * | 2009-07-31 | 2012-06-13 | Nikon Corporation | Technique for determining maturity of cell mass, and image processing program and image processing device which use the technique, and method for producing cell mass |
| US8450090B2 (en) | 2009-10-06 | 2013-05-28 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for promoting fatty acid production in plants |
| JP5066615B2 (ja) | 2011-01-31 | 2012-11-07 | 株式会社日立製作所 | フェニルボロン酸基と特異的に結合するオリゴペプチド配列 |
| EP2686418A4 (en) | 2011-03-17 | 2015-04-22 | Minerva Biotechnologies Corp | METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS |
| EP2768945B1 (en) | 2011-10-17 | 2022-01-05 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
| JP2016514954A (ja) * | 2013-03-08 | 2016-05-26 | クロンズ ホールディングズ カンパニー リミテッドＣｕｒｏｎｚ Ｈｏｌｄｉｎｇｓ Ｃｏｍｐａｎｙ Ｌｉｍｉｔｅｄ | 神経再生ペプチドおよびその使用 |
| US10059775B2 (en) | 2014-01-29 | 2018-08-28 | Dana-Farber Cancer Institute, Inc. | Antibodies against the MUC1-C/extracellular domain (MUC1-C/ECD) |
| CN104297442B (zh) * | 2014-11-03 | 2016-08-17 | 天津中医药大学 | 内源性小分子物质在快速检测早期心脏毒性方面的应用 |
| US11123366B1 (en) * | 2014-12-15 | 2021-09-21 | Children's Hospital Of Orange County | Methods, materials, and systems for treating injuries to the central nervous system using light emitting nanoparticles |
| CA2976089C (en) | 2015-02-10 | 2026-01-13 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies |
| US10617773B2 (en) | 2016-08-05 | 2020-04-14 | Dana-Farber Cancer Institute, Inc. | Antibodies against the MUC1-C/extracellular domain (MUC1-C/ECD) |
| SG11201903254PA (en) * | 2016-10-17 | 2019-05-30 | Univ Keio | Undifferentiated stem cell-removing agent, and method for removing undifferentiated stem cells |
| KR20230028796A (ko) | 2020-06-26 | 2023-03-02 | 미네르바 바이오테크놀로지 코포레이션 | 항-nme 항체 및 암 또는 암 전이의 치료 방법 |
| CN111875712A (zh) * | 2020-07-31 | 2020-11-03 | 广东昭泰体内生物医药科技有限公司 | 一种增强型靶向muc1的嵌合抗原受体及其应用 |
| KR20250009592A (ko) | 2022-04-12 | 2025-01-17 | 미네르바 바이오테크놀로지 코포레이션 | 항-가변 muc1* 항체 및 그의 용도 |
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2001
- 2001-11-27 EP EP10183954.6A patent/EP2322929B1/en not_active Expired - Lifetime
- 2001-11-27 EP EP10162600.0A patent/EP2241887B1/en not_active Expired - Lifetime
- 2001-11-27 WO PCT/US2001/044782 patent/WO2002056022A2/en not_active Ceased
- 2001-11-27 US US09/996,069 patent/US7700715B2/en active Active
- 2001-11-27 CA CA2430060A patent/CA2430060C/en not_active Expired - Lifetime
- 2001-11-27 EP EP01989135A patent/EP1354196B1/en not_active Expired - Lifetime
- 2001-11-27 DK DK10183954.6T patent/DK2322929T3/en active
- 2001-11-27 EP EP10184605.3A patent/EP2386859B1/en not_active Expired - Lifetime
- 2001-11-27 AT AT01989135T patent/ATE481640T1/de not_active IP Right Cessation
- 2001-11-27 JP JP2002556226A patent/JP4564714B2/ja not_active Expired - Lifetime
-
2009
- 2009-11-30 JP JP2009271611A patent/JP5926474B2/ja not_active Expired - Lifetime
-
2010
- 2010-01-27 US US12/695,070 patent/US8344113B2/en not_active Expired - Fee Related
-
2012
- 2012-12-07 US US13/708,790 patent/US20130323755A1/en not_active Abandoned
-
2014
- 2014-10-06 JP JP2014205598A patent/JP6124856B2/ja not_active Expired - Lifetime
-
2017
- 2017-01-27 JP JP2017013054A patent/JP6516778B2/ja not_active Expired - Lifetime
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